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  1. Article ; Online: Pharmacogenomic study-A pilot study of the effect of pharmacogenomic phenotypes on the adequate dosing of verapamil for migraine prevention.

    Chen, Yi-Chieh / Wang, Han / Mandrekar, Jayawant N / Robertson, Carrie E / Starling, Amaal J / Cutrer, Fred M / Chiang, Chia-Chun

    The pharmacogenomics journal

    2024  Volume 24, Issue 3, Page(s) 11

    Abstract: Objective: To investigate factors affecting the efficacy and tolerability of verapamil for migraine prevention using individual pharmacogenomic phenotypes.: Background: Verapamil has a wide range of dosing in headache disorders without reliable tools ...

    Abstract Objective: To investigate factors affecting the efficacy and tolerability of verapamil for migraine prevention using individual pharmacogenomic phenotypes.
    Background: Verapamil has a wide range of dosing in headache disorders without reliable tools to predict the optimal doses for an individual.
    Methods: This is a retrospective chart review examining adults with existing pharmacogenomic reports at Mayo Clinic who had used verapamil for migraine. Effects of six cytochrome P450 phenotypes on the doses of verapamil for migraine prevention were assessed.
    Results: Our final analysis included 33 migraine patients (82% with aura). The mean minimum effective and maximum tolerable doses of verapamil were 178.2(20-320) mg and 227.9(20-480) mg. A variety of CYP2C9, CYP2D6, and CYP3A5 phenotypes were found, without significant association with the verapamil doses after adjusting for age, sex, body mass index, and smoking status.
    Conclusions: We demonstrated a wide range of effective and tolerable verapamil doses used for migraine in a cohort with various pharmacogenomic phenotypes.
    MeSH term(s) Adult ; Humans ; Pilot Projects ; Verapamil/therapeutic use ; Pharmacogenomic Testing ; Pharmacogenetics ; Retrospective Studies ; Migraine Disorders/drug therapy ; Migraine Disorders/genetics ; Migraine Disorders/prevention & control ; Phenotype
    Chemical Substances Verapamil (CJ0O37KU29)
    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2106831-8
    ISSN 1473-1150 ; 1470-269X
    ISSN (online) 1473-1150
    ISSN 1470-269X
    DOI 10.1038/s41397-024-00331-4
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  2. Article ; Online: Erratum for Marrero Rolon et al., "Clinical Evaluation of a Real-Time PCR Assay for Simultaneous Detection of

    Marrero Rolon, Rebecca / Cunningham, Scott A / Mandrekar, Jayawant N / Polo, Erin T / Patel, Robin

    Journal of clinical microbiology

    2022  Volume 60, Issue 2, Page(s) e0245221

    Language English
    Publishing date 2022-02-16
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/jcm.02452-21
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  3. Article: Preliminary Reproducibility Evaluation of a Phage Susceptibility Testing Method Using a Collection of Escherichia coli and Staphylococcus aureus Phages.

    Cunningham, Scott A / Mandrekar, Jayawant N / Suh, Gina / Patel, Robin

    The journal of applied laboratory medicine

    2022  Volume 7, Issue 6, Page(s) 1468–1475

    Abstract: Background: Increasing antimicrobial resistance combined with a lagging pipeline of novel antimicrobial compounds have resulted in a resurgence of interest in phage therapy. To select optimal phage or phage combinations for patients for whom phage ... ...

    Abstract Background: Increasing antimicrobial resistance combined with a lagging pipeline of novel antimicrobial compounds have resulted in a resurgence of interest in phage therapy. To select optimal phage or phage combinations for patients for whom phage therapy is considered, assessment of activity of a panel of phages against the patients' bacterial isolate(s) should ideally be performed. Classical phage susceptibility testing methods (i.e., agar overlay) may be laborious, with expertise outside of normal training and competency of medical laboratory science staff needed.
    Content: Adaptive Phage Therapeutics™ leveraged a commercially available phenotyping system (Biolog OmniLog®) to generate the PhageBank Susceptibility Test™, which uses a custom data analysis pipeline (PhageSelect™) to measure the delay in reaching log-phase metabolic activity ("hold time") when a given isolate is challenged with a specific phage. The goal of this study was to preliminarily assess reproducibility of this approach by testing 2 bacterial species at 2 sites, APT and an academic site. Nineteen Escherichia coli phages were tested against 18 bacterial isolates, and 21 Staphylococcus aureus phages, against 11 bacterial isolates. Result comparisons were statistically excellent for E. coli (κ = 0.7990) and good/fair for S. aureus (κ = 0.6360).
    Summary: The described method provides good/fair to excellent statistical reproducibility for assessment of phage susceptibility of 2 commonly encountered bacterial species.
    MeSH term(s) Humans ; Staphylococcus Phages ; Staphylococcus aureus ; Escherichia coli ; Reproducibility of Results ; Anti-Bacterial Agents
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-07-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2576-9456
    ISSN 2576-9456
    DOI 10.1093/jalm/jfac051
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  4. Article: HOCl-producing Electrochemical Bandage is Active in Murine Polymicrobial Wound Infection.

    Fleming, Derek / Bozyel, Ibrahim / Koscianski, Christina A / Ozdemir, Dilara / Karau, Melissa J / Cuello, Luz / Anoy, Md Monzurul Islam / Gelston, Suzanne / Schuetz, Audrey N / Greenwood-Quaintance, Kerryl E / Mandrekar, Jayawant N / Beyenal, Haluk / Patel, Robin

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Wound infections, exacerbated by the prevalence of antibiotic-resistant bacterial pathogens, necessitate innovative antimicrobial approaches. Polymicrobial infections, often ... ...

    Abstract Wound infections, exacerbated by the prevalence of antibiotic-resistant bacterial pathogens, necessitate innovative antimicrobial approaches. Polymicrobial infections, often involving
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.19.585100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: HOCl-producing electrochemical bandage for treating

    Fleming, Derek / Bozyel, Ibrahim / Ozdemir, Dilara / Otero, Judith Alvarez / Karau, Melissa J / Anoy, Md Monzurul Islam / Koscianski, Christina / Schuetz, Audrey N / Greenwood-Quaintance, Kerryl E / Mandrekar, Jayawant N / Beyenal, Haluk / Patel, Robin

    Antimicrobial agents and chemotherapy

    2024  Volume 68, Issue 2, Page(s) e0121623

    Abstract: The growing threat of antibiotic-resistant bacterial pathogens necessitates the development of alternative antimicrobial approaches. This is particularly true for chronic wound infections, which commonly harbor biofilm-dwelling bacteria. A novel ... ...

    Abstract The growing threat of antibiotic-resistant bacterial pathogens necessitates the development of alternative antimicrobial approaches. This is particularly true for chronic wound infections, which commonly harbor biofilm-dwelling bacteria. A novel electrochemical bandage (e-bandage) delivering low-levels of hypochlorous acid (HOCl) was evaluated against
    MeSH term(s) Animals ; Mice ; Pseudomonas aeruginosa ; Hypochlorous Acid ; Amikacin ; Pseudomonas Infections/microbiology ; Wound Infection/microbiology ; Bandages ; Anti-Bacterial Agents ; Biofilms
    Chemical Substances Hypochlorous Acid (712K4CDC10) ; Amikacin (84319SGC3C) ; Anti-Bacterial Agents
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/aac.01216-23
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  6. Article ; Online: In vitro activity of hypochlorous acid generating electrochemical bandage against monospecies and dual-species bacterial biofilms.

    Kletzer, Joseph / Raval, Yash S / Mohamed, Abdelrhman / Mandrekar, Jayawant N / Greenwood-Quaintance, Kerryl E / Beyenal, Haluk / Patel, Robin

    Journal of applied microbiology

    2023  Volume 134, Issue 9

    Abstract: Aims: As antimicrobial resistance is on the rise, treating chronic wound infections is becoming more complex. The presence of biofilms in wound beds contributes to this challenge. Here, the activity of a novel hypochlorous acid (HOCl) producing ... ...

    Abstract Aims: As antimicrobial resistance is on the rise, treating chronic wound infections is becoming more complex. The presence of biofilms in wound beds contributes to this challenge. Here, the activity of a novel hypochlorous acid (HOCl) producing electrochemical bandage (e-bandage) against monospecies and dual-species bacterial biofilms formed by bacteria commonly found in wound infections was assessed.
    Methods and results: The system was controlled by a wearable potentiostat powered by a 3V lithium-ion battery and maintaining a constant voltage of + 1.5V Ag/AgCl, allowing continuous generation of HOCl. A total of 19 monospecies and 10 dual-species bacterial biofilms grown on polycarbonate membranes placed on tryptic soy agar (TSA) plates were used as wound biofilm models, with HOCl producing e-bandages placed over the biofilms. Viable cell counts were quantified after e-bandages were continuously polarized for 2, 4, 6, and 12 hours. Time-dependent reductions in colony forming units (CFUs) were observed for all studied isolates. After 12 hours, average CFU reductions of 7.75 ± 1.37 and 7.74 ± 0.60 log10 CFU/cm2 were observed for monospecies and dual-species biofilms, respectively.
    Conclusions: HOCl producing e-bandages reduce viable cell counts of in vitro monospecies and dual-species bacterial biofilms in a time-dependent manner in vitro. After 12 hours, >99.999% reduction in cell viability was observed for both monospecies and dual-species biofilms.
    MeSH term(s) Humans ; Hypochlorous Acid/pharmacology ; Bacteria ; Bandages ; Biofilms ; Wound Infection
    Chemical Substances Hypochlorous Acid (712K4CDC10)
    Language English
    Publishing date 2023-09-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1358023-1
    ISSN 1365-2672 ; 1364-5072
    ISSN (online) 1365-2672
    ISSN 1364-5072
    DOI 10.1093/jambio/lxad194
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  7. Article: HOCl-producing Electrochemical Bandages for Treating

    Fleming, Derek / Bozyel, Ibrahim / Ozdemir, Dilara / Otero, Judith Alvarez / Karau, Melissa J / Islam Anoy, Md Monzurul / Koscianski, Christina / Schuetz, Audrey N / Greenwood-Quaintance, Kerryl E / Mandrekar, Jayawant N / Beyenal, Haluk / Patel, Robin

    bioRxiv : the preprint server for biology

    2023  

    Abstract: A novel electrochemical bandage (e-bandage) delivering low-level hypochlorous acid (HOCl) was evaluated ... ...

    Abstract A novel electrochemical bandage (e-bandage) delivering low-level hypochlorous acid (HOCl) was evaluated against
    Language English
    Publishing date 2023-09-21
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.09.20.558698
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  8. Article ; Online: In Vivo

    Raval, Yash S / Fleming, Derek / Mohamed, Abdelrhman / Karau, Melissa J / Mandrekar, Jayawant N / Schuetz, Audrey N / Greenwood Quaintance, Kerryl E / Beyenal, Haluk / Patel, Robin

    Advanced therapeutics

    2023  Volume 6, Issue 5

    Abstract: Biofilms formed by antibiotic-resistant bacteria in wound beds present unique challenges in terms of treating wound infections. In this work, ... ...

    Abstract Biofilms formed by antibiotic-resistant bacteria in wound beds present unique challenges in terms of treating wound infections. In this work, the
    Language English
    Publishing date 2023-03-03
    Publishing country Germany
    Document type Journal Article
    ISSN 2366-3987
    ISSN (online) 2366-3987
    DOI 10.1002/adtp.202300059
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  9. Article ; Online: In Vitro

    Kletzer, Joseph / Raval, Yash S / Mohamed, Abdelrhman / Mandrekar, Jayawant N / Greenwood-Quaintance, Kerryl E / Beyenal, Haluk / Patel, Robin

    Antimicrobial agents and chemotherapy

    2022  Volume 67, Issue 1, Page(s) e0116622

    Abstract: The antibiofilm activity of a hypochlorous acid (HOCl)-producing electrochemical bandage (e-bandage) was assessed against 14 yeast ... ...

    Abstract The antibiofilm activity of a hypochlorous acid (HOCl)-producing electrochemical bandage (e-bandage) was assessed against 14 yeast isolates
    MeSH term(s) Hypochlorous Acid/pharmacology ; Saccharomyces cerevisiae ; Antifungal Agents/pharmacology ; Bandages ; Biofilms
    Chemical Substances Hypochlorous Acid (712K4CDC10) ; Antifungal Agents
    Language English
    Publishing date 2022-12-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/aac.01166-22
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  10. Article: Anti-biofilm activity of antibiotic-loaded Hylomate®.

    Albano, Mariana / Greenwood-Quaintance, Kerryl E / Karau, Melissa J / Mandrekar, Jayawant N / Patel, Robin

    International journal of cardiology. Heart & vasculature

    2021  Volume 34, Page(s) 100801

    Abstract: Introduction: Antibiotic envelopes are being developed for cardiac implantable electronic device (CIED) wrapping to reduce the risk of infections.: Methods: Fifteen CIED infection-associated bacterial isolates of : Results: There was significantly ...

    Abstract Introduction: Antibiotic envelopes are being developed for cardiac implantable electronic device (CIED) wrapping to reduce the risk of infections.
    Methods: Fifteen CIED infection-associated bacterial isolates of
    Results: There was significantly less (p < 0.05)
    Conclusions: This study showed that Hylomate® coupons pre-treated with antibiotics reduced staphylococcal and
    Language English
    Publishing date 2021-06-08
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 2818464-6
    ISSN 2352-9067
    ISSN 2352-9067
    DOI 10.1016/j.ijcha.2021.100801
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