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  1. Article ; Online: A role for tubular Na

    Onishi, Akira / Fu, Yiling / Patel, Rohit / Darshi, Manjula / Crespo-Masip, Maria / Huang, Winnie / Song, Panai / Freeman, Brent / Kim, Young Chul / Soleimani, Manoocher / Sharma, Kumar / Thomson, Scott Culver / Vallon, Volker

    American journal of physiology. Renal physiology

    2020  Volume 319, Issue 4, Page(s) F712–F728

    Abstract: Inhibitors of proximal tubular ... ...

    Abstract Inhibitors of proximal tubular Na
    MeSH term(s) Acid-Base Equilibrium/drug effects ; Animals ; Benzhydryl Compounds/pharmacology ; Blood Glucose/metabolism ; Blood Pressure/drug effects ; Diabetes Mellitus/drug therapy ; Diabetes Mellitus/metabolism ; Diabetes Mellitus/physiopathology ; Disease Models, Animal ; Glucosides/pharmacology ; Glycosuria/metabolism ; Glycosuria/physiopathology ; Kidney Tubules, Proximal/drug effects ; Kidney Tubules, Proximal/metabolism ; Kidney Tubules, Proximal/physiopathology ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Natriuresis/drug effects ; Natriuretic Agents/pharmacology ; Phosphorylation ; Sodium-Glucose Transporter 2/metabolism ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology ; Sodium-Hydrogen Exchanger 3/deficiency ; Sodium-Hydrogen Exchanger 3/genetics ; Sodium-Hydrogen Exchanger 3/metabolism
    Chemical Substances Benzhydryl Compounds ; Blood Glucose ; Glucosides ; Natriuretic Agents ; Slc5a2 protein, mouse ; Slc9a3 protein, mouse ; Sodium-Glucose Transporter 2 ; Sodium-Glucose Transporter 2 Inhibitors ; Sodium-Hydrogen Exchanger 3 ; empagliflozin (HDC1R2M35U)
    Language English
    Publishing date 2020-09-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00264.2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Case report and review of minocycline-induced cutaneous polyarteritis nodosa.

    Culver, Brent / Itkin, Aleksandr / Pischel, Ken

    Arthritis and rheumatism

    2005  Volume 53, Issue 3, Page(s) 468–470

    MeSH term(s) Acne Vulgaris/drug therapy ; Adult ; Anti-Bacterial Agents/adverse effects ; Female ; Humans ; Minocycline/adverse effects ; Polyarteritis Nodosa/chemically induced ; Skin Diseases/chemically induced
    Chemical Substances Anti-Bacterial Agents ; Minocycline (FYY3R43WGO)
    Language English
    Publishing date 2005-06-15
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 127294-9
    ISSN 1529-0131 ; 0004-3591 ; 2326-5191
    ISSN (online) 1529-0131
    ISSN 0004-3591 ; 2326-5191
    DOI 10.1002/art.21186
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 24: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 523: Show issues

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  3. Article ; Online: Multicenter Prospective Cohort Study of the Diagnostic Yield and Patient Experience of Multiplex Gene Panel Testing For Hereditary Cancer Risk.

    Idos, Gregory E / Kurian, Allison W / Ricker, Charité / Sturgeon, Duveen / Culver, Julie O / Kingham, Kerry E / Koff, Rachel / Chun, Nicolette M / Rowe-Teeter, Courtney / Lebensohn, Alexandra P / Levonian, Peter / Lowstuter, Katrina / Partynski, Katlyn / Hong, Christine / Mills, Meredith A / Petrovchich, Iva / Ma, Cindy S / Hartman, Anne-Renee / Allen, Brian /
    Wenstrup, Richard J / Lancaster, Johnathan M / Brown, Krystal / Kidd, John / Evans, Brent / Mukherjee, Bhramar / McDonnell, Kevin J / Ladabaum, Uri / Ford, James M / Gruber, Stephen B

    JCO precision oncology

    2019  Volume 3

    Abstract: Purpose: Multiplex gene panel testing (MGPT) allows for the simultaneous analysis of germline cancer susceptibility genes. This study describes the diagnostic yield and patient experiences of MGPT in diverse populations.: Patients and methods: This ... ...

    Abstract Purpose: Multiplex gene panel testing (MGPT) allows for the simultaneous analysis of germline cancer susceptibility genes. This study describes the diagnostic yield and patient experiences of MGPT in diverse populations.
    Patients and methods: This multicenter, prospective cohort study enrolled participants from three cancer genetics clinics-University of Southern California Norris Comprehensive Cancer Center, Los Angeles County and University of Southern California Medical Center, and Stanford Cancer Institute-who met testing guidelines or had a 2.5% or greater probability of a pathogenic variant (N = 2,000). All patients underwent 25- or 28-gene MGPT and results were compared with differential genetic diagnoses generated by pretest expert clinical assessment. Post-test surveys on distress, uncertainty, and positive experiences were administered at 3 months (69% response rate) and 1 year (57% response rate).
    Results: Of 2,000 participants, 81% were female, 41% were Hispanic, 26% were Spanish speaking only, and 30% completed high school or less education. A total of 242 participants (12%) carried one or more pathogenic variant (positive), 689 (34%) carried one or more variant of uncertain significance (VUS), and 1,069 (53%) carried no pathogenic variants or VUS (negative). More than one third of pathogenic variants (34%) were not included in the differential diagnosis. After testing, few patients (4%) had prophylactic surgery, most (92%) never regretted testing, and most (80%) wanted to know all results, even those of uncertain significance. Positive patients were twice as likely as negative/VUS patients (83%
    Conclusion: In a racially/ethnically and socioeconomically diverse cohort, MGPT increased diagnostic yield. More than one third of identified pathogenic variants were not clinically anticipated. Patient regret and prophylactic surgery use were low, and patients appropriately encouraged relatives to be tested for clinically relevant results.
    Language English
    Publishing date 2019-03-28
    Publishing country United States
    Document type Journal Article
    ISSN 2473-4284
    ISSN (online) 2473-4284
    DOI 10.1200/PO.18.00217
    Database MEDical Literature Analysis and Retrieval System OnLINE

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