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  1. Book ; Online: Technology, Policy, and Inclusion

    Prakash, Anjal / Jain, Aarushi / Singh, Puran / Sarkar, Avik

    An Intersection of Ideas for Public Policy

    (Innovations, Practice and the Future of Public Policy in India)

    2024  

    Series title Innovations, Practice and the Future of Public Policy in India
    Keywords Society & culture: general ; Central government policies ; Political structure & processes ; Sociology ; Social welfare & social services ; Digital census;Digital Divide;Farming and eMarkets;financial inclusion;technology for all
    Language English
    Size 1 electronic resource (284 pages)
    Publisher Taylor and Francis
    Document type Book ; Online
    Note English
    HBZ-ID HT030613400
    ISBN 9781032225456 ; 1032225459
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Floating Block Method for Quantum Monte Carlo Simulations.

    Sarkar, Avik / Lee, Dean / Meißner, Ulf-G

    Physical review letters

    2024  Volume 131, Issue 24, Page(s) 242503

    Abstract: Quantum Monte Carlo simulations are powerful and versatile tools for the quantum many-body problem. In addition to the usual calculations of energies and eigenstate observables, quantum Monte Carlo simulations can in principle be used to build fast and ... ...

    Abstract Quantum Monte Carlo simulations are powerful and versatile tools for the quantum many-body problem. In addition to the usual calculations of energies and eigenstate observables, quantum Monte Carlo simulations can in principle be used to build fast and accurate many-body emulators using eigenvector continuation or design time-dependent Hamiltonians for adiabatic quantum computing. These new applications require something that is missing from the published literature, an efficient quantum Monte Carlo scheme for computing the inner product of ground state eigenvectors corresponding to different Hamiltonians. In this work, we introduce an algorithm called the floating block method, which solves the problem by performing Euclidean time evolution with two different Hamiltonians and interleaving the corresponding time blocks. We use the floating block method and nuclear lattice simulations to build eigenvector continuation emulators for energies of ^{4}He, ^{8}Be, ^{12}C, and ^{16}O nuclei over a range of local and nonlocal interaction couplings. From the emulator data, we identify the quantum phase transition line from a Bose gas of alpha particles to a nuclear liquid.
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.131.242503
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Anti-Leukemic Attributes of Natural Compounds Targeting Autophagy: A Closer Look into the Molecular Mechanisms.

    Kundu, Sweta / Sarkar, Sampriti / Acharya Chowdhury, Avik

    Nutrition and cancer

    2024  Volume 76, Issue 3, Page(s) 236–251

    Abstract: Leukemia is a heterogeneous clonal cancer that affects millions of individuals around the world. Despite substantial breakthroughs in cancer treatment, traditional chemotherapy and radiotherapy remain ineffective, and therapeutic resistance still stands ... ...

    Abstract Leukemia is a heterogeneous clonal cancer that affects millions of individuals around the world. Despite substantial breakthroughs in cancer treatment, traditional chemotherapy and radiotherapy remain ineffective, and therapeutic resistance still stands as a big obstacle. As a result, there is an increasing attention being paid currently toward the potency of natural compounds as a complementary or alternative therapy for leukemia. Autophagy, a conserved cellular process where damaged or defective cytosolic components and macromolecules are destroyed and recycled, plays a dual role in promoting or suppressing the continuance of cancer at different junctures of its development. Current studies have reported that autophagy has a cardinal function in the genesis and progression of leukemia, making it a promising target for novel treatments. In this review, we have explored the effectiveness of certain natural compounds, such as curcumin, resveratrol, tanshinone IIA, quercetin, tetrandrine, parthenolide, berberine, pristimerin, and alantolactone, that modulate autophagy and regulate its associated signaling cascades at a molecular level in different types of leukemia. They have been shown to have synergistic effects with conventional chemotherapy, emphasizing their potential as supplementary medicines. However, additional research is required to fully comprehend their mechanisms of action and to maximize their role in clinical perspectives.
    MeSH term(s) Humans ; Neoplasms/drug therapy ; Leukemia/drug therapy ; Signal Transduction ; Resveratrol/pharmacology ; Autophagy
    Chemical Substances Resveratrol (Q369O8926L)
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 424433-3
    ISSN 1532-7914 ; 0163-5581
    ISSN (online) 1532-7914
    ISSN 0163-5581
    DOI 10.1080/01635581.2024.2306682
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1496: Show issues Location:
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  4. Article ; Online: Couching of cataractous lens in microphthalmic eyes with irido-fundal coloboma: revisiting the historical technique.

    Kannan, Naresh Babu / Goswami, Ananya / Vallinayagam, Muthukrishnan / Sarkar, Avik Dey

    International ophthalmology

    2024  Volume 44, Issue 1, Page(s) 198

    Abstract: Purpose: Cataract surgery in microphthalmic eyes is challenging due to anatomical restraints, hard bulky nucleus. This series aims to evaluate the safety and efficacy of couching of intraocular lens in irido-fundal coloboma with microphthalmos.: ... ...

    Abstract Purpose: Cataract surgery in microphthalmic eyes is challenging due to anatomical restraints, hard bulky nucleus. This series aims to evaluate the safety and efficacy of couching of intraocular lens in irido-fundal coloboma with microphthalmos.
    Setting: Tertiary care centre in South India.
    Design: Retrospective non-comparative study in eyes with irido-fundal coloboma, corneal diameter < 7 mm and brown cataract. Visual acuity less than 6/60 in other eye.
    Methods: Anterior chamber entry made, zonules broken and lens dislocated into the vitreous cavity in a controlled manner. Baseline Clinico-demographic details, corrected distance visual acuity (CDVA), Intra-ocular pressure (IOP), corneal diameter, axial length, lens status and post-surgery CDVA, IOP and complications recorded and followed up for atleast 6 months.
    Results: Fifteen eyes of 15 subjects were evaluated with a mean age 49.4 ± 10.9 years. At baseline, mean IOP 14.5 ± 3.8 mmHg, mean axial length 19.3 ± 0.5 mm, mean corneal diameter was 6.5 ± 0.34 mm and CDVA 2 logMAR which improved to 1.5 logMAR at 3 months (p value 0.002). Transient spike in IOP in 33.3% subjects was medically managed with no significant difference in IOP (p > 0.05) at baseline (14.5 ± 3.8 mmHg), 3 months post-surgery (16 ± 2.8 mmHg) and 6 months post-surgery (14.9 ± 2.5 mmHg). One patient underwent re-couching. No other major complications were noted.
    Conclusion: Couching of cataractous lens is an effective and safe method in microphthalmic eyes with irido-fundal coloboma as last resort procedure, where no other surgical procedure may work. It provides an ambulatory gain of visual acuity in previously non-ambulatory subjects. Corneal measurements help in determining the subset of patients where couching offers viable option.
    MeSH term(s) Humans ; Retrospective Studies ; Female ; Coloboma/diagnosis ; Coloboma/complications ; Coloboma/surgery ; Male ; Microphthalmos/complications ; Microphthalmos/diagnosis ; Microphthalmos/surgery ; Visual Acuity ; Cataract/complications ; Cataract/congenital ; Cataract/diagnosis ; Middle Aged ; Adult ; Iris/surgery ; Iris/abnormalities ; Lens Implantation, Intraocular/methods ; Cataract Extraction/methods ; Lens, Crystalline/abnormalities ; Lens, Crystalline/surgery ; Follow-Up Studies
    Language English
    Publishing date 2024-04-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 800087-6
    ISSN 1573-2630 ; 0165-5701
    ISSN (online) 1573-2630
    ISSN 0165-5701
    DOI 10.1007/s10792-024-03132-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1479: Show issues Location:
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  5. Article ; Online: Tips and tricks for endoscopic ultrasound-guided hepaticogastrostomy.

    Shah-Khan, Sardar M / Elfert, Khaled / Sarkar, Avik / Shahid, Haroon / Tyberg, Amy / Kahaleh, Michel

    Endoscopy

    2023  Volume 55, Issue S 01, Page(s) E643–E644

    MeSH term(s) Humans ; Endosonography ; Gallbladder ; Liver ; Ultrasonography, Interventional ; Stents ; Drainage ; Cholestasis
    Language English
    Publishing date 2023-04-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-2057-0460
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 162: Show issues

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  6. Article ; Online: Switchable Hydrophobic Pockets in DNA Protocells Enhance Chemical Conversion.

    Liu, Wei / Lupfer, Claudius / Samanta, Avik / Sarkar, Aritra / Walther, Andreas

    Journal of the American Chemical Society

    2023  Volume 145, Issue 13, Page(s) 7090–7094

    Abstract: Synthetic cell models help us understand living cells and the origin of life. Key aspects of living cells are crowded interiors where secondary structures, such as the cytoskeleton and membraneless organelles/condensates, can form. These can form ... ...

    Abstract Synthetic cell models help us understand living cells and the origin of life. Key aspects of living cells are crowded interiors where secondary structures, such as the cytoskeleton and membraneless organelles/condensates, can form. These can form dynamically and serve structural or functional purposes, such as protection from heat shock or as crucibles for various biochemical reactions. Inspired by these phenomena, we introduce a crowded all-DNA protocell and encapsulate a temperature-switchable DNA-
    MeSH term(s) Artificial Cells/chemistry ; Polymers/chemistry ; DNA ; Cell Physiological Phenomena ; Organelles
    Chemical Substances Polymers ; DNA (9007-49-2)
    Language English
    Publishing date 2023-03-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c00997
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Outbreak of toxic anterior segment syndrome following vitreoretinal surgery - A retrospective analysis.

    Kannan, Naresh B / Sivadarshan, M / Dey Sarkar, Avik / Vallinayagam, MuthuKrishnan / Ramaswamy, Kim

    Indian journal of ophthalmology

    2024  

    Abstract: Background: Toxic anterior segment syndrome (TASS) is an uncommon complication of vitreoretinal surgery and is characterized by severe anterior chamber reaction, hypopyon, and limbus-to-limbus corneal edema.: Methods: Twenty-nine vitreoretinal ... ...

    Abstract Background: Toxic anterior segment syndrome (TASS) is an uncommon complication of vitreoretinal surgery and is characterized by severe anterior chamber reaction, hypopyon, and limbus-to-limbus corneal edema.
    Methods: Twenty-nine vitreoretinal surgeries were performed, of which 14 developed TASS in the early postoperative period. The operative records were reviewed retrospectively.
    Results: The median age of patients was 49.07 ± 16.75 years and 14.28% of them were female. Also, 71.42% were operated in the left eye and 42.8% were pseudophakic. Recurrent retinal detachment, secondary scleral-fixating intraocular lens (SFIOL), and silicone oil removal (SOR) were the most common procedures. Severe anterior chamber reaction was seen in 14 patients, circumcorneal congestion in eight, corneal edema in 11 (78.6%), hypopyon in 13 (92.8%), and severe fibrin membrane in two patients.
    Conclusion: We describe the largest series of TASS following uneventful vitreoretinal surgery. Balanced salt solution was the instigating agent in this series. A prompt and thorough investigation is critical in obviating recurrences.
    Language English
    Publishing date 2024-03-08
    Publishing country India
    Document type Journal Article
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/IJO.IJO_1867_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Endoscopic bariatrics: current therapies and future directions.

    Reja, Debashis / Zhang, Clark / Sarkar, Avik

    Translational gastroenterology and hepatology

    2022  Volume 7, Page(s) 21

    Abstract: Endoscopic bariatric therapies (EBTs) are endoscopic procedures indicated for weight loss in the obese population. They are shown to be safe and effective for patients who do not quality for bariatric surgery. There are currently no randomized controlled ...

    Abstract Endoscopic bariatric therapies (EBTs) are endoscopic procedures indicated for weight loss in the obese population. They are shown to be safe and effective for patients who do not quality for bariatric surgery. There are currently no randomized controlled studies comparing bariatric surgery with EBTs. However, EBTs are more cost effective and have fewer complications. This review will examine currently available EBTs with published data.
    Language English
    Publishing date 2022-04-25
    Publishing country China
    Document type Journal Article ; Review
    ISSN 2415-1289
    ISSN (online) 2415-1289
    DOI 10.21037/tgh.2020.03.09
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Endoscopic full-thickness resection with reconstruction of the rectal wall.

    Gjeorgjievski, Mihajlo / Sarkar, Avik / Shahid, Haroon / Tyberg, Amy / Kahaleh, Michel

    Endoscopy

    2022  Volume 55, Issue S 01, Page(s) E133–E134

    MeSH term(s) Humans ; Rectum/surgery ; Endoscopic Mucosal Resection ; Rectal Neoplasms/surgery
    Language English
    Publishing date 2022-10-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-1948-2007
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  10. Article ; Online: Optimizing lyophilization primary Drying: A vaccine case study with experimental and modeling techniques.

    Najarian, Jeff / Metsi-Guckel, Efimia / Renawala, Harshil K / Grosse, Don / Sims, Alexander / Walter, Amanda / Sarkar, Avik / Karande, Atul

    International journal of pharmaceutics

    2024  , Page(s) 124168

    Abstract: In this study, we present the lyophilization process development efforts for a vaccine formulation aimed at optimizing the primary drying time (hence, the total cycle length) through comprehensive evaluation of its thermal characteristics, temperature ... ...

    Abstract In this study, we present the lyophilization process development efforts for a vaccine formulation aimed at optimizing the primary drying time (hence, the total cycle length) through comprehensive evaluation of its thermal characteristics, temperature profile, and critical quality attributes (CQAs). Differential scanning calorimetry (DSC) and freeze-drying microscopy (FDM) were used to experimentally determine the product-critical temperatures, viz., the glass transition temperature (T
    Language English
    Publishing date 2024-04-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 428962-6
    ISSN 1873-3476 ; 0378-5173
    ISSN (online) 1873-3476
    ISSN 0378-5173
    DOI 10.1016/j.ijpharm.2024.124168
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