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Article ; Online: Efficacy of single antibiotic therapy versus antibiotic combination in implant-free staphylococcal post-surgical spinal infections: a retrospective observational study.

Lombès, Amélie / Fernandez-Gerlinger, Marie-Paule / Khalifé, Marc / Kassis-Chikhani, Najiby / Jomli, Amira / Mainardi, Jean-Luc / Lebeaux, David / Dubert, Marie

BMC infectious diseases

2024 Volume 24, Issue 1, Page(s) 62

Abstract: Background: Post-surgical spinal infections (pSSIs) are a serious complication of spinal surgeries, with Staphylococcus spp. being one of the most prominent bacteria identified. Optimal antimicrobial therapy for staphylococcal spinal infections without ... ...

Abstract	Background: Post-surgical spinal infections (pSSIs) are a serious complication of spinal surgeries, with Staphylococcus spp. being one of the most prominent bacteria identified. Optimal antimicrobial therapy for staphylococcal spinal infections without spinal implants is not well documented. Methods: This single center retrospective 7-year observational study described and compared the outcome (treatment failure or mortality rate one year after diagnosis) of 20 patients with staphylococcal-implant-free pSSI treated with single or combination antibiotics. Results: Median duration of treatment was 40 days (IQR 38-42), with 6 days (IQR 5-7) on intravenous antibiotics and 34 days (IQR 30-36) on oral therapy. Four patients (20%) underwent new surgical debridement, all due to surgical failure, and 1 patient died within the first year without significant differences between both treatment group. Conclusion: This study raises the possibility of single antibiotic therapy for patients with implant-free post-surgical spinal infections due to Staphylococcus spp.
MeSH term(s)	Humans ; Retrospective Studies ; Postoperative Complications ; Staphylococcal Infections/drug therapy ; Staphylococcus ; Anti-Bacterial Agents/therapeutic use
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2024-01-08
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-024-08977-y
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Article ; Online: Suboptimal dalbavancin dosages in an adult with sickle-cell disease and glomerular hyperfiltration.

Abdellaoui, Salomé / Gregoire, Matthieu / Dubert, Marie / Cheminet, Geoffrey / Arlet, Jean-Benoît / Lafont, Emmanuel

publication RETRACTED

The Journal of antimicrobial chemotherapy

2023 Volume 78, Issue 3, Page(s) 851–852

MeSH term(s)	Adult ; Humans ; Kidney Diseases ; Anemia, Sickle Cell ; Teicoplanin ; Glomerular Filtration Rate
Chemical Substances	dalbavancin (808UI9MS5K) ; Teicoplanin (61036-62-2)
Language	English
Publishing date	2023-01-23
Publishing country	England
Document type	Journal Article ; Retracted Publication
ZDB-ID	191709-2
ISSN	1460-2091 ; 0305-7453
ISSN (online)	1460-2091
ISSN	0305-7453
DOI	10.1093/jac/dkad013
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Zs.A 1197: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 124: Show issues

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Article ; Online: Infectious native aortic aneurysm with negative blood cultures: do not forget the pneumococcal urinary antigen test!

Dubert, Marie / Derycke, Lucie / Bidaud, Anne-Laure / Gibault, Laure / Le Pendu, Claire / Pogdlajen, Isabelle / Lebeaux, David

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

2023 Volume 131, Issue 3, Page(s) 125–127

Abstract: Infectious native aortic aneurysm (INAA) are rare but life-threatening infections. Early microbiological identification is crucial to initiate adequate therapy and decrease the peri-operative risk, but can be challenging when blood cultures remain ... ...

Abstract	Infectious native aortic aneurysm (INAA) are rare but life-threatening infections. Early microbiological identification is crucial to initiate adequate therapy and decrease the peri-operative risk, but can be challenging when blood cultures remain negative. We describe two cases of pneumococcal INAA with negative blood cultures, diagnosed in the with the pneumococcal urinary antigen test.
MeSH term(s)	Humans ; Anti-Bacterial Agents/therapeutic use ; Blood Culture ; Streptococcus pneumoniae ; Pneumococcal Infections/diagnosis ; Pneumococcal Infections/microbiology ; Pneumococcal Infections/surgery ; Aortic Aneurysm/drug therapy ; Communicable Diseases/drug therapy ; Antigens, Bacterial/urine
Chemical Substances	Anti-Bacterial Agents ; Antigens, Bacterial
Language	English
Publishing date	2023-01-26
Publishing country	Denmark
Document type	Case Reports
ZDB-ID	93340-5
ISSN	1600-0463 ; 0903-4641
ISSN (online)	1600-0463
ISSN	0903-4641
DOI	10.1111/apm.13287
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Ud II Zs.73: Show issues

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Article ; Online: Frequency and factors associated with infusion-related local complications of vancomycin on peripheral venous catheters.

Ammar, Helmi / Rolland, Simon / Jouffroy, Romain / Dubert, Marie / Le Beller, Christine / Podglajen, Isabelle / Lillo-Lelouet, Agnès / Lebeaux, David / Bensaid, Samuel

The Journal of antimicrobial chemotherapy

2023 Volume 78, Issue 4, Page(s) 1050–1054

Abstract: Background: Vancomycin is a reference antibiotic against methicillin-resistant staphylococci. Its administration is associated with infusion-related local complications (IRLC). To reduce this risk, it has been proposed to increase vancomycin dilution in ...

Abstract	Background: Vancomycin is a reference antibiotic against methicillin-resistant staphylococci. Its administration is associated with infusion-related local complications (IRLC). To reduce this risk, it has been proposed to increase vancomycin dilution in the IV bag and to perform continuous infusion using the volumetric pump. The aim of our study was to assess the safety of peripheral infusion of vancomycin with the volumetric pump. Objectives: To compare the frequency of IRLC between patients receiving vancomycin and those receiving β-lactam (BL) antibiotics. Our secondary objective was to assess factors associated with the occurrence of IRLC. Patients and methods: We conducted a prospective observational study in a French tertiary hospital. Between February 2021 and November 2021, we included all patients receiving continuous infusions of vancomycin or BL through a peripherally inserted venous catheter (PIVC). The primary endpoint was the occurrence of IRLC on Day 1 (D1). Results: We included 168 patients (56 vancomycin, 112 BL). At D1, 14 patients (25%) presented IRLC in the vancomycin group versus 11 patients (10%) in the BL group (P = 0.01). There was significantly more IRLC in the group receiving vancomycin at an infused concentration above 5 mg/mL than those receiving BL (8/15, 53.3% versus 11/112, 10%, respectively, P < 0.01). However, no significant difference was observed between patients receiving infused vancomycin concentration ≤5 mg/mL and patients receiving BL (P = 0.4). Conclusion: Our data support safe administration of vancomycin if infused at a concentration under 5 mg/mL, through the volumetric pump on PIVC.
MeSH term(s)	Humans ; Vancomycin/adverse effects ; Anti-Bacterial Agents/therapeutic use ; Infusions, Intravenous ; Staphylococcus ; Catheters
Chemical Substances	Vancomycin (6Q205EH1VU) ; Anti-Bacterial Agents
Language	English
Publishing date	2023-03-07
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	191709-2
ISSN	1460-2091 ; 0305-7453
ISSN (online)	1460-2091
ISSN	0305-7453
DOI	10.1093/jac/dkad044
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Zs.A 1197: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 124: Show issues

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Article ; Online: Evaluating the heart valve tissue diffusion of amoxicillin in infective endocarditis: a pilot prospective observational non-comparative study.

Dubert, Marie / Kably, Benjamin / Derobertmasure, Audrey / Podglajen, Isabelle / Munte, Laura / Clauss, Darless / Blez, Damien / Dahdah, Pierre / Billaud, Eliane / Lebeaux, David / Mainardi, Jean-Luc

The Journal of antimicrobial chemotherapy

2023 Volume 78, Issue 12, Page(s) 2915–2918

Abstract: Objectives: Treating patients with infective endocarditis (IE) due to streptococci and enterococci currently involves high-dosage antibiotics. Recent literature suggests a 30%-70% diffusion rate could be extrapolated to human heart valve tissue. The ... ...

Abstract	Objectives: Treating patients with infective endocarditis (IE) due to streptococci and enterococci currently involves high-dosage antibiotics. Recent literature suggests a 30%-70% diffusion rate could be extrapolated to human heart valve tissue. The objective of this study was to evaluate the diffusion coefficient of amoxicillin in heart valve tissue of patients operated for IE. Methods: Adult patients were prospectively included that underwent surgery at the European Hospital Georges Pompidou for IE due to streptococci and enterococci and had previous IV amoxicillin treatment. Plasma (taken 48 h preoperatively) and heart valve tissue amoxicillin concentrations were measured with a validated LC-MS/MS method. The MIC values of amoxicillin were measured for all available isolates. Results: Seventeen patients were included. Eleven (64.7%) patients had native valve IE and six (35.3%) had prosthetic valve IE. Fourteen IE cases (82.4%) were due to streptococci, one (5.9%) was due to enterococci and two (11.8%) were Haemophilus spp, Aggregatibacter actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, Kingella kingae group infections. Median (IQR) amoxicillin dose administered was 10.5 (8.0-12.0) g/day corresponding to 138.2 (112.5-160.0) mg/kg/day. The median amoxicillin plasma concentrations pre-surgery and intra-tissular weighted concentrations were 31.9 (25.9-51.9) mg/L and 19.0 (7.9-31.4) µg/g, respectively. Median tissue/plasma concentration ratio was 0.47 (0.24-0.67), with a median amoxicillin plasma/MIC ratio of 487 (179-745), and median amoxicillin tissue/MIC ratio of 42 (14-116). Conclusions: With a significant diffusion coefficient, amoxicillin dosage in heart valve tissues showed a concentration/MIC ratio well above current recommendations for bactericidal activity. Our study suggests that lower doses can be considered for susceptible bacteria.
MeSH term(s)	Adult ; Humans ; Amoxicillin/therapeutic use ; Chromatography, Liquid ; Tandem Mass Spectrometry ; Endocarditis, Bacterial/drug therapy ; Endocarditis, Bacterial/microbiology ; Endocarditis ; Streptococcus ; Enterococcus ; Heart Valves/surgery
Chemical Substances	Amoxicillin (804826J2HU)
Language	English
Publishing date	2023-10-26
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	191709-2
ISSN	1460-2091 ; 0305-7453
ISSN (online)	1460-2091
ISSN	0305-7453
DOI	10.1093/jac/dkad330
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Zs.A 1197: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 124: Show issues

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Article ; Online: TIVAP-related infection due to Gram-negative aerobic bacilli: should TIVAP stay or should it go?

Rolland, Simon / Kassis-Chikhani, Najiby / Auclin, Edouard / Bensaid, Samuel / Bidaud, Anne-Laure / Gerlinger, Marie-Paule / Blez, Damien / Mainardi, Jean-Luc / Lebeaux, David / Dubert, Marie

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

2022

Abstract: We aimed to describe the outcome of totally implantable venous-access port (TIVAP)-related infections due to Gram-negative aerobic bacilli (Pseudomonas aeruginosa and other Pseudomonas spp., Acinetobacter spp., and Stenotrophomonas maltophilia), or GNAB, ...

Abstract	We aimed to describe the outcome of totally implantable venous-access port (TIVAP)-related infections due to Gram-negative aerobic bacilli (Pseudomonas aeruginosa and other Pseudomonas spp., Acinetobacter spp., and Stenotrophomonas maltophilia), or GNAB, and assess the safety of conservative treatment. We conducted a retrospective study in a French teaching hospital, from January 2016 to December 2020, including adult patients treated for TIVAP-related infection due to GNAB. Success of conservative treatment was defined as a functional TIVAP 3 months after infection with no recurrence. We performed a bivariate analysis and analyzed causes for treatment failure. We included 68 patients (53 TIVAP-related bloodstream infections, 11 TIVAP-related infections, and 4 probable TIVAP-related infections) due to GNAB, mostly P. aeruginosa (50/68, 74%). TIVAP removal was initially decided for 49/68 patients (72%). Among the 19/68 (28%) patients with conservative treatment (all for infections caused by P. aeruginosa), 5/19 (26%) had successful treatment, 7/19 (37%) experienced failure (without sepsis or septic shock), 6/19 (32%) died within 3 months without TIVAP removal and no signs of infection recurrence, and 1 patient had TIVAP removal as it was no longer required. TIVAP-related infections caused by GNAB frequently require TIVAP removal. Conservative treatment can be performed in selected patients with a non-complicated infection caused by P. aeruginosa, who can benefit from the continuation of antineoplastic chemotherapy or palliative care. Treatment failures were not associated with sepsis or septic shock.
Language	English
Publishing date	2022-12-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	603155-9
ISSN	1435-4373 ; 0934-9723 ; 0722-2211
ISSN (online)	1435-4373
ISSN	0934-9723 ; 0722-2211
DOI	10.1007/s10096-022-04537-x
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Zs.A 1732: Show issues

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Article: Amikacin pharmacokinetic/pharmacodynamic in intensive care unit: a prospective database.

Logre, Elsa / Enser, Maya / Tanaka, Sébastien / Dubert, Marie / Claudinon, Aurore / Grall, Nathalie / Mentec, Hervé / Montravers, Philippe / Pajot, Olivier

Annals of intensive care

2020 Volume 10, Issue 1, Page(s) 75

Abstract: Background: Aminoglycosides have a concentration-dependent therapeutic effect when peak serum concentration (C: Methods: Retrospective analysis from February 2016 to December 2017 of a prospective database conducted in 2 intensive care units (ICU). ... ...

Abstract	Background: Aminoglycosides have a concentration-dependent therapeutic effect when peak serum concentration (C Methods: Retrospective analysis from February 2016 to December 2017 of a prospective database conducted in 2 intensive care units (ICU). All patients with documented severe GNB infections treated with amikacin (single daily dose of 25 mg/kg of total body weight (TBW)) with both MIC and C Results: 93 patients with 98 GNB-documented infections were included. The median C Conclusion: According to PK/PD parameters observed in our study, single daily dose of amikacin 25 mg/kg of TBW appears to be sufficient in most critically ill patients treated for severe GNB infections.
Keywords	covid19
Language	English
Publishing date	2020-06-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2617094-2
ISSN	2110-5820
ISSN	2110-5820
DOI	10.1186/s13613-020-00685-5
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Article ; Online: Rapidly progressive kidney failure induced by fungal mycelia obstructing indwelling ureteral stents.

Dubert, Marie / Loi, Valeria / Tligui, Mohamed / Hertig, Alexandre

BMJ case reports

2012 Volume 2012

Abstract: Antibiotics reduce the commensal flora in the gut, thereby facilitating the overgrowth of undesirable microorganisms such as Candida albicans. Here, we report the case of a 48-year-old woman with a history of obstructive uropathy consecutive to a ... ...

Abstract	Antibiotics reduce the commensal flora in the gut, thereby facilitating the overgrowth of undesirable microorganisms such as Candida albicans. Here, we report the case of a 48-year-old woman with a history of obstructive uropathy consecutive to a radiation therapy, in whom both indwelling ureteral stents were rapidly occluded by fungal mycelia, resulting in a rapidly progressive kidney failure. Ascendant infection by C albicans had occurred after a 2- week course of antibiotics, prescribed for a perforative peritonitis also due to radiation-induced colitis. As shown by iterative CT scans made before (at the time of the diagnosis of peritonitis) and after the antibiotic course, kidney failure was explained by a sudden and bilateral pyelocaliceal dilation, due to the obstruction of the ureteral stents. Fungal mycelia were objectivised during the replacement procedure. Intravenous fluconazole was started, and renal function recovered ad integrum with the relief of the obstruction.
MeSH term(s)	Antifungal Agents/therapeutic use ; Candida albicans ; Candidiasis/complications ; Candidiasis/drug therapy ; Candidiasis/microbiology ; Female ; Fluconazole/therapeutic use ; Humans ; Middle Aged ; Prosthesis Failure/adverse effects ; Renal Insufficiency/microbiology ; Stents/microbiology ; Ureteral Obstruction/complications ; Ureteral Obstruction/microbiology
Chemical Substances	Antifungal Agents ; Fluconazole (8VZV102JFY)
Language	English
Publishing date	2012-12-14
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2012-007504
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Article ; Online: Mycobacterium bovis infection of an aortobifemoral bypass graft with Streptococcus intermedius superinfection after intravesical bacillus Calmette-Guérin immunotherapy for bladder cancer.

Dubert, Marie / Abihssira, Sharon / Diamantis, Sylvain / Guenin, Remi / Messaoudi, Rabah / Roux, Anne-Laure / Rouis, Karama / Lillo, Agnès / Surgers, Laure / Douard, Richard / Julia, Pierre / Lebeaux, David

Infection

2020 Volume 49, Issue 2, Page(s) 345–348

Abstract: Background: The Bacillus Calmette-Guerin (BCG) is a life-attenuated form of Mycobacterium bovis widely used as immunotherapy for localized bladder cancer. Adverse reactions to intravesical BCG instillations are rare.: Case: We describe a 70-year-old ... ...

Abstract	Background: The Bacillus Calmette-Guerin (BCG) is a life-attenuated form of Mycobacterium bovis widely used as immunotherapy for localized bladder cancer. Adverse reactions to intravesical BCG instillations are rare. Case: We describe a 70-year-old man with a history of an aortobifemoral bypass graft, placement of a synthetic mesh for treatment of a ventral hernia and, most recently, superficial bladder cancer treated with BCG therapy. Ten months after his final intravesical BCG instillation, he complained of fever and asthenia. After 12 months of investigation, he was diagnosed with Mycobacterium bovis infection of his aortobifemoral bypass graft and abdominal mesh, with Streptococcus intermedius superinfection. The bypass graft was excised and replaced with an in situ arterial allograft, the abdominal mesh was removed, and treatment started with amoxicillin, isoniazid, rifampicin and ethambutol. Several additional vascular interventions were needed for allograft degradation, but 12 months after the final procedure, outcome was good. Discussion and conclusions: Among 35 cases of mycotic aneurysm reported after BCG therapy in the last 10 years, only one involved a vascular prosthesis. Surgical repair of such aneurysms using prosthetic grafts is commonly performed, associated with anti-mycobacterial treatment. Prognosis is poor with mortality of 14% (4/35) and a 26% rate of aneurysm recurrence under treatment (9/35).
MeSH term(s)	Administration, Intravesical ; Aged ; BCG Vaccine/adverse effects ; Humans ; Immunotherapy ; Male ; Mycobacterium bovis ; Streptococcus intermedius ; Superinfection ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder Neoplasms/surgery
Chemical Substances	BCG Vaccine
Language	English
Publishing date	2020-08-04
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	185104-4
ISSN	1439-0973 ; 0300-8126 ; 0173-2129
ISSN (online)	1439-0973
ISSN	0300-8126 ; 0173-2129
DOI	10.1007/s15010-020-01495-4
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Zs.A 881: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 528: Show issues

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Article ; Online: Late viral or bacterial respiratory infections in lung transplanted patients: impact on respiratory function.

Dubert, Marie / Visseaux, Benoit / Birgy, André / Mordant, Pierre / Metivier, Anne-Cécile / Dauriat, Gaelle / Fidouh, Nadhira / Yazdanpanah, Yazdan / Grall, Nathalie / Castier, Yves / Mal, Hervé / Thabut, Gabriel / Lescure, François-Xavier

BMC infectious diseases

2020 Volume 20, Issue 1, Page(s) 176

Abstract: Background: Respiratory infections are a major threat for lung recipients. We aimed to compare with a monocentric study the impact of late viral and bacterial respiratory infections on the graft function.: Methods: Patients, who survived 6 months or ... ...

Abstract	Background: Respiratory infections are a major threat for lung recipients. We aimed to compare with a monocentric study the impact of late viral and bacterial respiratory infections on the graft function. Methods: Patients, who survived 6 months or more following lung transplantation that took place between 2009 and 2014, were classified into three groups: a viral infection group (VIG) (without any respiratory bacteria), a bacterial infection group (BIG) (with or without any respiratory viruses), and a control group (CG) (no documented infection). Chronic lung allograft dysfunction (CLAD) and acute rejection were analysed 6 months after the inclusion in the study. Results: Among 99 included lung recipients, 57 (58%) had at least one positive virological respiratory sample during the study period. Patients were classified as follows: 38 in the VIG, 25 in the BIG (among which 19 co-infections with a virus) and 36 in the CG. The BIG presented a higher initial deterioration in lung function (p = 0.05) than the VIG. But 6 months after the infection, only the VIG presented a median decrease of forced expiratory volume in 1 s; - 35 mL (IQR; - 340; + 80) in the VIG, + 140 mL (+ 60;+ 330) in the BIG and + 10 (- 84;+ 160) in the CG, p < 0.01. Acute rejection was more frequent in the VIG (n = 12 (32%)), than the BIG (n = 6 (24%)) and CG (n = 3 (8%)), p < 0.05, despite presenting no more CLAD (p = 0.21). Conclusions: Despite a less severe initial presentation, single viral respiratory infections seem to lead to a greater deterioration in lung function, and to more acute rejection, than bacterial infections.
MeSH term(s)	Bacterial Infections/diagnosis ; Female ; Forced Expiratory Volume ; Graft Rejection/diagnosis ; Graft Rejection/etiology ; Humans ; Lung/physiopathology ; Lung Transplantation ; Male ; Middle Aged ; Picornaviridae/isolation & purification ; Pseudomonas aeruginosa/isolation & purification ; Respiratory Tract Infections/diagnosis ; Respiratory Tract Infections/microbiology ; Respiratory Tract Infections/virology ; Virus Diseases/diagnosis
Keywords	covid19
Language	English
Publishing date	2020-02-24
Publishing country	England
Document type	Journal Article
ISSN	1471-2334
ISSN (online)	1471-2334
DOI	10.1186/s12879-020-4877-3
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