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  1. Article ; Online: Should Calcineurin Inhibitors/Sirolimus Be Ceased Completely In Posterior Reversible Encephalopathy Syndrome?

    Karataş, Cihan / Akyollu, Başak / Arpalı, Emre / Kocak, Burak

    Transplantation proceedings

    2024  Volume 56, Issue 1, Page(s) 93–96

    Abstract: Background: To investigate the relationship between immunosuppressive treatments and posterior reversible encephalopathy syndrome (PRES) in transplant patients.: Methods: We presented a retrospective study of 4 cases of PRES in transplant patients. ... ...

    Abstract Background: To investigate the relationship between immunosuppressive treatments and posterior reversible encephalopathy syndrome (PRES) in transplant patients.
    Methods: We presented a retrospective study of 4 cases of PRES in transplant patients. Patient records were reviewed to identify potential risk factors, clinical presentations, radiological findings, and immunosuppressive treatments used.
    Results: Our analysis revealed a potential association between immunosuppressive treatments and the development of PRES in transplant patients. Specifically, we found that adjusting or switching immunosuppressive treatments can improve outcomes and prevent the recurrence of PRES.
    Conclusion: Our findings highlight the importance of recognizing PRES as a potential complication of immunosuppressive treatments in transplant patients. Early detection and management, including a review of immunosuppressive treatments, may improve patient outcomes and prevent further complications.
    MeSH term(s) Humans ; Calcineurin Inhibitors/adverse effects ; Immunosuppressive Agents/adverse effects ; Posterior Leukoencephalopathy Syndrome/chemically induced ; Posterior Leukoencephalopathy Syndrome/diagnostic imaging ; Retrospective Studies ; Sirolimus
    Chemical Substances Calcineurin Inhibitors ; Immunosuppressive Agents ; Sirolimus (W36ZG6FT64)
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2023.11.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Experience of kidney transplantation to a patient with Bernard Soulier syndrome: A case report.

    Karataş, Cihan / Akyollu, Başak / Arpalı, Emre / Yelken, Berna / Türkmen, Aydın / Koçak, Burak

    Turkish journal of surgery

    2023  Volume 39, Issue 1, Page(s) 86–88

    Abstract: Renal transplantation could be a challenging operation in patients with haemorrhagic diathesis, with predictable difficulties or even with unpredictable hurdles. Bernard Soulier Syndrome (BSS) is one of the ethiologies of the thrombocytopenia and it is a ...

    Abstract Renal transplantation could be a challenging operation in patients with haemorrhagic diathesis, with predictable difficulties or even with unpredictable hurdles. Bernard Soulier Syndrome (BSS) is one of the ethiologies of the thrombocytopenia and it is a rare hereditary disease associated with defects of the platelet glycoprotein complex glycoprotein Ib/V/IX and characterized by large platelets, thrombocytopenia, and severe bleeding symptoms. Here, we present a challenging renal transplantation in BSS.
    Language English
    Publishing date 2023-03-03
    Publishing country Turkey
    Document type Case Reports
    ISSN 2564-6850
    ISSN 2564-6850
    DOI 10.47717/turkjsurg.2022.4567
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Effects of erector spinae plane block on opioid consumption in patients undergoing hand-assisted laparoscopic donor nephrectomy: a randomized controlled trial.

    Özkalayci, Özlem / Karakaya, Muhammet A / Yenigün, Yılmaz / Çetin, Seçil / Darçin, Kamil / Akyollu, Başak / Arpali, Emre / Koçak, Burak / Gürkan, Yavuz

    Minerva anestesiologica

    2024  Volume 90, Issue 3, Page(s) 154–161

    Abstract: Background: The erector spinae plane block is a relatively new regional anesthesia technique that is expected to provide some benefits for postoperative analgesia. This study investigated the effects of erector spinae plane block on postoperative opioid ...

    Abstract Background: The erector spinae plane block is a relatively new regional anesthesia technique that is expected to provide some benefits for postoperative analgesia. This study investigated the effects of erector spinae plane block on postoperative opioid consumption in kidney donors undergoing hand-assisted laparoscopic donor nephrectomy for renal transplantation.
    Methods: Fifty-two donors scheduled for elective hand-assisted laparoscopic donor nephrectomy were randomly divided into the block (25 donors) and control (27 donors) groups. Donors in the block group received 30 mL of 0.25% bupivacaine under ultrasound guidance, whereas the control group received no block treatment. The primary outcome measure was the amount of fentanyl administered via patient-controlled analgesia at 24 h. Secondary outcomes included the duration of stay, opioid consumption in the post-anesthesia care unit, and pain scores during the recording hours.
    Results: No significant differences were observed between the groups regarding total opioid consumption converted to intravenous morphine equivalent administered via patient-controlled analgesia (33.3±21.4 mg vs. 37.5±18.5 mg; P=0.27) and in the postanesthesia care unit (1.5±0.9 mg vs. 1.4±0.8 mg; P=0.55). The duration of stay in the postanesthesia care unit (86.3±32.6 min vs. 85.7±33.6 min; P=0.87) was similar between the groups. There was no significant difference between the groups in the postoperative donor-reported NRS pain scores (P>0.05 for all the time points).
    Conclusions: Preoperative erector spinae plane block is not an effective strategy for reducing postoperative pain or opioid consumption in patients undergoing hand-assisted laparoscopic donor nephrectomy. Different block combinations are needed for optimal pain management in hand-assisted laparoscopic donor nephrectomy.
    MeSH term(s) Humans ; Analgesics, Opioid ; Anesthetics, Local ; Hand-Assisted Laparoscopy ; Nerve Block/methods ; Pain, Postoperative ; Nephrectomy ; Ultrasonography, Interventional/methods
    Chemical Substances Analgesics, Opioid ; Anesthetics, Local
    Language English
    Publishing date 2024-02-02
    Publishing country Italy
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 123584-9
    ISSN 1827-1596 ; 0026-4717 ; 0375-9393
    ISSN (online) 1827-1596
    ISSN 0026-4717 ; 0375-9393
    DOI 10.23736/S0375-9393.23.17706-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Utilization of single-use flexible ureterorenoscope for ex-vivo stone extraction in living kidney donors.

    Kiremit, Murat Can / Arpali, Emre / Koseoglu, Ersin / Kocak, Burak

    Central European journal of urology

    2021  Volume 74, Issue 2, Page(s) 269–270

    Language English
    Publishing date 2021-05-05
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2672528-9
    ISSN 2080-4873 ; 2080-4806
    ISSN (online) 2080-4873
    ISSN 2080-4806
    DOI 10.5173/ceju.2021.0353
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Hand-assisted laparoscopic donor nephrectomy: 1864 cases in 15 years of experience.

    Günaydın, Bilal / Uçar, Taha / Arpalı, Emre / Akyollu, Başak / Akıncı, Serkan / Karataş, Cihan / Öztorun, Kenan / Koçak, Burak

    Turkish journal of medical sciences

    2022  Volume 52, Issue 4, Page(s) 1322–1328

    Abstract: Background: To evaluate hand-assisted laparoscopic donor nephrectomy (HALDN) in terms of intraoperative and postoperative results.: Methods: After institutional review board approval was obtained, a total of 1864 HALDN operations performed between ... ...

    Abstract Background: To evaluate hand-assisted laparoscopic donor nephrectomy (HALDN) in terms of intraoperative and postoperative results.
    Methods: After institutional review board approval was obtained, a total of 1864 HALDN operations performed between March 2007 and January 2022 were retrospectively analyzed. Age, sex, body mass index (BMI), status of smoking and presence of previous abdominal surgery, laterality, operative time, transfusion requirement, port counts, length of extraction incision, time until mobilization, time until oral intake, donor serum creatinine levels before and one week after the surgery, length of postoperative hospital stay, intraoperative complications, and postoperative recovery and complications were recorded and statistically analyzed. Multiple renal arteries, BMI, right nephrectomy and male sex were also separately evaluated as risk factors for complications and operative time.
    Results: A total of 825 (44.26%) male and 1039 (55.74%) female patients were enrolled in the study. The mean age of the patients was 45.79 ± 12.88 years. There were a total of 143 complications (7.67% of the total 1864 cases) consisting of 68 (3.65%) intraoperative and 75 (4.02%) postoperative complications. Open conversion was necessary for 10 patients (0.53%) to manage intraoperative complications. Reoperation was needed for 1 patient due to bleeding 6 h after the operation. Multiple renal arteries were a risk factor for intraoperative complications and prolonged operative time. Right nephrectomy and male sex were also related with longer operative times.
    Discussion: HALDN is a safe procedure associated with low complication rates.
    MeSH term(s) Humans ; Male ; Female ; Adult ; Middle Aged ; Hand-Assisted Laparoscopy/adverse effects ; Hand-Assisted Laparoscopy/methods ; Living Donors ; Retrospective Studies ; Kidney Transplantation ; Nephrectomy/adverse effects ; Nephrectomy/methods ; Laparoscopy/adverse effects ; Laparoscopy/methods ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Intraoperative Complications/etiology
    Language English
    Publishing date 2022-08-10
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 1183461-4
    ISSN 1303-6165 ; 1300-0144
    ISSN (online) 1303-6165
    ISSN 1300-0144
    DOI 10.55730/1300-0144.5438
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Hand-assisted laparoscopic donor nephrectomy in kidneys with multiple renal arteries versus a single renal artery: An analysis of vascular complications from 1,350 cases.

    Arpalı, Emre / Karataş, Cihan / Akyollu, Başak / Yaprak, Doğukan / Günaydın, Bilal / Koçak, Burak

    Turkish journal of urology

    2020  

    Abstract: Objective: Laparoscopic donor nephrectomy (LDN) has been shown to be a safe approach with better morbidity results. Impact of multiple renal arteries (MRAs) and anatomical variations has been reviewed by many authors. In our study, the relationship ... ...

    Abstract Objective: Laparoscopic donor nephrectomy (LDN) has been shown to be a safe approach with better morbidity results. Impact of multiple renal arteries (MRAs) and anatomical variations has been reviewed by many authors. In our study, the relationship between the donors with MRAs and risk of perioperative vascular complications related to donor nephrectomy was investigated.
    Material and methods: Patients who underwent hand-assisted LDNs between January 2007 and February 2018 were reviewed retrospectively. Patient age, sex, body mass index (BMI), waist circumference, side of donor nephrectomies, donors with MRAs, intraoperative vascular complications, conversion rates, hospitalization durations, and operative times were extracted. Risk factors for perioperative vascular complications were defined.
    Results: There were MRAs in 288 kidney donors (21.3%). The number of patients who underwent a right donor nephrectomy was 113 (8.4%). BMI, waist circumference, and postoperative hospital stay were not significantly different between donors with one artery and those with MRAs (p>0.05). The renovascular complication rate and overall conversion rate to open surgery were significantly higher in donors with MRAs (p<0.05).
    Conclusion: Perioperative safety of the kidney donors is of crucial importance. Surgeons performing LDNs must be aware of the potential risks. Our analysis suggests that procurement of kidneys from donors with MRAs is a risk factor for renovascular complications.
    Language English
    Publishing date 2020-03-27
    Publishing country Turkey
    Document type Journal Article
    ISSN 2149-3235
    ISSN 2149-3235
    DOI 10.5152/tud.2020.19280
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: CONCISE REVIEW

    Umay Çelik / Özge Sezin Somuncu / Büşra Ergün / Emre Arpalı

    Trakya University Journal of Natural Sciences, Vol 20, Pp 45-

    β CELL REPLACEMENT THERAPIES IN TREATMENT OF DIABETES MELLITUS

    2019  Volume 54

    Abstract: Metabolic rate of glucose uptake is generally controlled by a feedback mechanism covering islet β cells and insulin-sensitive tissues, wherein tissue sensitivity to insulin influences the level of β-cell comeback. In case of insulin presence, β cells ... ...

    Abstract Metabolic rate of glucose uptake is generally controlled by a feedback mechanism covering islet β cells and insulin-sensitive tissues, wherein tissue sensitivity to insulin influences the level of β-cell comeback. In case of insulin presence, β cells preserve standard glucose tolerance via enhancing insulin production. Even though β-cell dysfunction has a strong hereditary component, environmental alterations carry an important part as well. Current research methods have facilitated to establish the important part of hexoses, amino acids, and fatty acids in the development of insulin resistance and β-cell dysfunction, therefore more operative treatments to slow the progressive loss of β-cell function are required. Latest discoveries from clinical research deliver significant information about approaches to stop and treat diabetes and some of the adversative properties of these interferences. Generation of satisfactory numbers of pancreatic endocrine cells that work in the same way as primary islets is of supreme prominence for the expansion of cell treatments to cure. In this study, we focused on different techniques starting from islet and pancreas transplantations individually and ending on new therapies such as stem cell technology and bioengineering. We aimed to establish a comprehensive and detailed explanation of treatment perspectives for islet cell loss. This review is carrying a novel potential for enlightening the current treatments and future-based therapies.
    Keywords stem cell therapy ; islet cells ; pancreas ; Science (General) ; Q1-390
    Subject code 571
    Language English
    Publishing date 2019-02-01T00:00:00Z
    Publisher Trakya University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Kidneys with small renal masses: Can they be utilized for kidney transplantation in the era of partial nephrectomy?

    Arpalı, Emre / Günaydın, Bilal / Turan, Turgay / Çaşkurlu, Turhan / Yıldırım, Asıf / Koçak, Burak

    Turkish journal of urology

    2018  Volume 44, Issue 6, Page(s) 503–507

    Abstract: Objective: To retrospectively evaluate our database to determine our partial nephrectomy and radical nephrectomy rates and to see percentage of the discarded kidneys which were suitable for transplantation after radical nephrectomy.: Material and ... ...

    Abstract Objective: To retrospectively evaluate our database to determine our partial nephrectomy and radical nephrectomy rates and to see percentage of the discarded kidneys which were suitable for transplantation after radical nephrectomy.
    Material and methods: Patients who underwent radical or partial nephrectomy between January 2000 and December 2016 were identified. Only stage I tumors according to tumor, node, metastasis classification were included in this review. Tumor size, location, proximity to renal collecting system and hilum were considered while deciding the suitability of a kidney for transplantation.
    Results: A statistically significant gradual increase in the number of patients treated with partial nephrectomy was observed (p=0.00001). Only 17 out of 181 kidneys with a tumor size smaller than 3 cm could be an appropriate candidate for a renal transplantation if they were to be transplanted.
    Conclusion: Exact number of the discarded kidneys with small renal masses which can be used for kidney transplantation should be determined by large scale studies. A national or governmental policy may only be developed to utilize these discarded organs after the magnitude of the wasted kidneys can be determined.
    Language English
    Publishing date 2018-07-27
    Publishing country Turkey
    Document type Journal Article
    ISSN 2149-3235
    ISSN 2149-3235
    DOI 10.5152/tud.2018.89264
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online: Oligosymptomatic kidney transplant patients with COVID-19

    Arpalı, Emre / Akyollu, Başak / Koçak, Burak / Yelken, Berna / Kalayoğlu, Münci / Türkmen, Aydın / Koruk, Süda Tekin / Kanbay, Mehmet (ORCID 0000-0002-1297-0675 & YÖK ID 110580)

    Transplantation Proceedings

    do they pose a risk to other recipients?

    2020  

    Abstract: The clinical course of viral infections in patients under immunosuppression can be atypical and/or fatal if not diagnosed and treated appropriately. The coronavirus disease 2019 (COVID-19) may also have an atypical presentation. Contrary to the general ... ...

    Abstract The clinical course of viral infections in patients under immunosuppression can be atypical and/or fatal if not diagnosed and treated appropriately. The coronavirus disease 2019 (COVID-19) may also have an atypical presentation. Contrary to the general opinion, transplant patients may be asymptomatic or oligosymptomatic, which could be a risk factor for underdiagnosis and the dissemination of this viral disease. This study presents the clinical features of 2 oligosymptomatic kidney transplant patients diagnosed with COVID-19. We suggest that new screening algorithms for COVID-19 should be reconsidered for the transplant patient population.
    Keywords Medicine ; Middle East respiratory syndrome coronavirus ; Coronavirus infections ; covid19
    Language English
    Publisher Elsevier
    Publishing country tr
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Case report: A kidney transplant patient with mild COVID-19.

    Arpali, Emre / Akyollu, Basak / Yelken, Berna / Tekin, Suda / Turkmen, Aydin / Kocak, Burak

    Transplant infectious disease : an official journal of the Transplantation Society

    2020  Volume 22, Issue 4, Page(s) e13296

    Abstract: Coronavirus Disease 2019 (COVID-19) is currently a pandemic with a mortality rate of 1%-6% in the general population. However, the mortality rate seems to be significantly higher in elderly patients, especially those hospitalized with comorbidities, such ...

    Abstract Coronavirus Disease 2019 (COVID-19) is currently a pandemic with a mortality rate of 1%-6% in the general population. However, the mortality rate seems to be significantly higher in elderly patients, especially those hospitalized with comorbidities, such as hypertension, diabetes, or coronary artery diseases. Because viral diseases may have atypical presentations in immunosuppressed patients, the course of the disease in the transplant patient population is unknown. Hence, the management of these patients with COVID-19 is an area of interest, and a unique approach is warranted. Here, we report the clinical features and our treatment approach for a kidney transplant patient with a diagnosis of COVID-19. We believe that screening protocols for SARS-Cov-2 should be re-evaluated in patients with solid-organ transplants.
    MeSH term(s) Adult ; Antiviral Agents/therapeutic use ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/drug therapy ; Cough/etiology ; Disease Management ; Female ; Fever/etiology ; Glucocorticoids ; Graft Rejection/prevention & control ; Humans ; Immunocompromised Host ; Immunosuppressive Agents/therapeutic use ; Kidney Failure, Chronic/surgery ; Kidney Transplantation ; Lupus Nephritis/surgery ; Oseltamivir/therapeutic use ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/drug therapy ; Prednisone/therapeutic use ; SARS-CoV-2 ; Severity of Illness Index ; Tacrolimus/therapeutic use
    Chemical Substances Antiviral Agents ; Glucocorticoids ; Immunosuppressive Agents ; Oseltamivir (20O93L6F9H) ; Prednisone (VB0R961HZT) ; Tacrolimus (WM0HAQ4WNM)
    Keywords covid19
    Language English
    Publishing date 2020-05-04
    Publishing country Denmark
    Document type Case Reports ; Journal Article
    ZDB-ID 1476094-0
    ISSN 1399-3062 ; 1398-2273
    ISSN (online) 1399-3062
    ISSN 1398-2273
    DOI 10.1111/tid.13296
    Database MEDical Literature Analysis and Retrieval System OnLINE

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