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  1. Article ; Online: Case with psychotic disorder as a clinical presentation of COVID-19.

    Majadas, Susana / Pérez, Javier / Casado-Espada, Nerea M / Zambrana, Antonio / Bullón, Alberto / Roncero, Carlos

    Psychiatry and clinical neurosciences

    2020  Volume 74, Issue 10, Page(s) 551–552

    MeSH term(s) COVID-19 ; Coronavirus ; Humans ; Pandemics ; Psychotic Disorders ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-31
    Publishing country Australia
    Document type Letter ; Comment
    ZDB-ID 1292906-2
    ISSN 1440-1819 ; 1323-1316
    ISSN (online) 1440-1819
    ISSN 1323-1316
    DOI 10.1111/pcn.13107
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  2. Article: Case with psychotic disorder as a clinical presentation of COVID-19

    Majadas, Susana / Pérez, Javier / Casado-Espada, Nerea M / Zambrana, Antonio / Bullón, Alberto / Roncero, Carlos

    Psychiatry clin. neurosci

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #635100
    Database COVID19

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  3. Article ; Online: Case with psychotic disorder as a clinical presentation of COVID ‐19

    Majadas, Susana / Pérez, Javier / Casado‐Espada, Nerea M. / Zambrana, Antonio / Bullón, Alberto / Roncero, Carlos

    Psychiatry and Clinical Neurosciences

    2020  Volume 74, Issue 10, Page(s) 551–552

    Keywords General Neuroscience ; Neurology ; Psychiatry and Mental health ; Clinical Neurology ; General Medicine ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1292906-2
    ISSN 1440-1819 ; 1323-1316
    ISSN (online) 1440-1819
    ISSN 1323-1316
    DOI 10.1111/pcn.13107
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  4. Article ; Online: Prevalence of depression and its relationship with other clinical characteristics in a sample of patients with stable schizophrenia.

    Majadas, Susana / Olivares, Jose / Galan, Jaime / Diez, Teresa

    Comprehensive psychiatry

    2012  Volume 53, Issue 2, Page(s) 145–151

    Abstract: Aim: To evaluate the prevalence of depression using the Calgary Depression Scale for Schizophrenia (CDSS) in a sample of Spanish patients with stable schizophrenia and without a diagnosis of depression.: Methods: We included stable outpatients of 18 ... ...

    Abstract Aim: To evaluate the prevalence of depression using the Calgary Depression Scale for Schizophrenia (CDSS) in a sample of Spanish patients with stable schizophrenia and without a diagnosis of depression.
    Methods: We included stable outpatients of 18 to 50 years of age, with a diagnosis of schizophrenia, schizoaffective disorder, or schizophreniform disorder who had not been diagnosed with depression. In this cross-sectional study, we administered the CDSS, the Positive and Negative Syndrome Scale (PANSS), the Scale for the Assessment of Negative Symptoms (SANS), the Scale to Assess Unawareness of Mental Disorder (SUMD), the Simpson Angus Scale (SAS), and the Barnes Akathisia Rating Scale (BARS).
    Results: A total of 95 patients were recruited, 90 of them were included in the statistical analysis. Twenty-eight patients had a total score of 5 or more points on the CDSS, making the prevalence of depression 31% (95% confidence interval, 22-41). The CDSS had a high correlation with the depressive factor of the PANSS and a moderate correlation with the general psychopathology subscale of the PANSS. The correlation of the CDSS total score with negative symptoms was moderate using the SANS and low with the PANSS-negative. There was no correlation between depressive symptoms and positive symptoms, insight, and extrapyramidal symptoms; and the correlation with akathisia was low.
    Conclusion: Our results suggest that patients with stable schizophrenia who have not been diagnosed with depression frequently have clinically relevant symptoms of depression, and that these symptoms, with the possible exception of a contribution from negative symptoms, are not secondary to other symptoms of their disorder or to extrapyramidal adverse effects of medications.
    MeSH term(s) Adolescent ; Adult ; Cross-Sectional Studies ; Depressive Disorder/complications ; Depressive Disorder/diagnosis ; Depressive Disorder/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Prevalence ; Psychiatric Status Rating Scales ; Psychotic Disorders/complications ; Schizophrenia/complications
    Language English
    Publishing date 2012-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 127556-2
    ISSN 1532-8384 ; 0010-440X
    ISSN (online) 1532-8384
    ISSN 0010-440X
    DOI 10.1016/j.comppsych.2011.03.009
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  5. Article ; Online: The effects of agomelatine on sexual function in depressed patients and healthy volunteers.

    Montejo, Angel / Majadas, Susana / Rizvi, Sakina J / Kennedy, Sidney H

    Human psychopharmacology

    2011  Volume 26, Issue 8, Page(s) 537–542

    Abstract: Background: Selective serotonin reuptake inhibitor (SSRI) and serotonin and norepinephrine reuptake inhibitor antidepressants are associated with high rates of treatment-emergent sexual dysfunction (TESD) due to stimulation of serotonin receptors.: ... ...

    Abstract Background: Selective serotonin reuptake inhibitor (SSRI) and serotonin and norepinephrine reuptake inhibitor antidepressants are associated with high rates of treatment-emergent sexual dysfunction (TESD) due to stimulation of serotonin receptors.
    Objective: The objective is to evaluate the effect of agomelatine on sexual function in depressed patients.
    Methods: This paper reviews published and unpublished data on sexual function with agomelatine in depressed patients and healthy volunteers.
    Results: Agomelatine, an agonist of melatonergic MT1 and MT2 receptors and antagonist of 5-HT2 receptors, is associated with similar rates of sexual dysfunction compared with placebo and lower rates compared with other antidepressants. Twice as many sexually active depressed patients (n = 193) reported a deterioration of sexual function during 12 weeks of treatment with venlafaxine compared with agomelatine (15.2% vs. 8.2%, p < 0.0001); however, no differences were found with respect to arousal. Using the Arizona Sexual Experience Scale in depressed patients (n = 399), the incidence of treatment-emergent sexual dysfunction (TESD) with agomelatine (3%) was significantly lower than placebo (8.6%) and selective serotonin reuptake inhibitors (10.1%). Among healthy male volunteers (n = 92), TESD was not increased compared with placebo in either agomelatine (25 and 50 mg/day) group over 8 weeks, and both were significantly lower than TESD with paroxetine (p < 0.0001). Moderate or severe TESD occurred in less than 5% of subjects receiving agomelatine versus 62% who received paroxetine (p < 0.001).
    Conclusion: Agomelatine demonstrates favorable sexual acceptability.
    MeSH term(s) Acetamides/adverse effects ; Acetamides/therapeutic use ; Animals ; Antidepressive Agents/adverse effects ; Antidepressive Agents/therapeutic use ; Depression/drug therapy ; Depression/psychology ; Humans ; Melatonin/agonists ; Serotonin Uptake Inhibitors/adverse effects ; Serotonin Uptake Inhibitors/therapeutic use ; Sexual Behavior/drug effects ; Sexual Behavior/psychology ; Sexual Dysfunctions, Psychological/chemically induced ; Sexual Dysfunctions, Psychological/psychology ; Treatment Outcome
    Chemical Substances Acetamides ; Antidepressive Agents ; Serotonin Uptake Inhibitors ; agomelatine (137R1N49AD) ; Melatonin (JL5DK93RCL)
    Language English
    Publishing date 2011-11-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 632931-7
    ISSN 1099-1077 ; 0885-6222
    ISSN (online) 1099-1077
    ISSN 0885-6222
    DOI 10.1002/hup.1243
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  6. Article ; Online: Quetiapine in the treatment of sleep disturbances associated with addictive conditions: a retrospective study.

    Terán, Antonio / Majadas, Susana / Galan, Jaime

    Substance use & misuse

    2008  Volume 43, Issue 14, Page(s) 2169–2171

    Abstract: Sleep disturbances are a common finding in the clinical practice of addictions. Clinical management of insomnia is known to influence the prognosis of the addiction and the success of the detoxication process itself (Peles, Schreiber, and Adelson, 2006; ... ...

    Abstract Sleep disturbances are a common finding in the clinical practice of addictions. Clinical management of insomnia is known to influence the prognosis of the addiction and the success of the detoxication process itself (Peles, Schreiber, and Adelson, 2006; Pace-Schott, Stickgold, Muzur, Wigren, Ward, et al., 2005; Bootzin and Stevens, 2005; Maher, 2004). Thus the relevance of controlling sleep disturbances from the very beginning of the detoxification process. However, managing this situation is often not easy for the clinician. The classical option of using sedating-hypnotic drugs to treat insomnia in polydrug users presents objections: the tolerance associated to high doses of benzodiacepines chronic abuse in many drug addicts obliges the clinician to use high doses of hypnotics, both in acute detoxification and the following de-habituation, with the associated resulting risk of dependence and undesirable side effects (excessive sedation, nocturnal enuresis, ataxia, etc).
    MeSH term(s) Antipsychotic Agents/administration & dosage ; Antipsychotic Agents/therapeutic use ; Dibenzothiazepines/administration & dosage ; Dibenzothiazepines/therapeutic use ; Humans ; Quetiapine Fumarate ; Retrospective Studies ; Sleep Wake Disorders/drug therapy ; Sleep Wake Disorders/etiology ; Spain ; Substance-Related Disorders/complications
    Chemical Substances Antipsychotic Agents ; Dibenzothiazepines ; Quetiapine Fumarate (2S3PL1B6UJ)
    Language English
    Publishing date 2008-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1310358-1
    ISSN 1532-2491 ; 1082-6084
    ISSN (online) 1532-2491
    ISSN 1082-6084
    DOI 10.1080/10826080802290240
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  7. Article: A 6-month prospective observational study on the effects of quetiapine on sexual functioning.

    Montejo González, Angel Luis / Rico-Villademoros, F / Tafalla, M / Majadas, Susana

    Journal of clinical psychopharmacology

    2005  Volume 25, Issue 6, Page(s) 533–538

    Abstract: Objective: The aim of this study was to assess the long-term impact of quetiapine on sexual functioning of patients with schizophrenia treated in a real practice setting.: Methods: This was a multicenter, noncomparative, open-label, and naturalistic ... ...

    Abstract Objective: The aim of this study was to assess the long-term impact of quetiapine on sexual functioning of patients with schizophrenia treated in a real practice setting.
    Methods: This was a multicenter, noncomparative, open-label, and naturalistic study conducted in outpatients with a diagnosis of schizophrenia or schizophreniform disorder as defined by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Patients were evaluated at baseline, day 15, and at the end of months 1, 3, and 6 using the Brief Psychiatry Rating Scale, the Clinical Global Impression Severity and Improvement Scales, and the Psychotropic-Related Sexual Dysfunction Questionnaire. All primary effectiveness analyses were based on the intent-to-treat sample and consisted primarily of last-observation-carried-forward analysis of Psychotropic-Related Sexual Dysfunction Questionnaire, Brief Psychiatry Rating Scale, and Clinical Global Impression Improvement of Illness Scale.
    Results: Eighty-six patients were recruited by 19 investigators, and 82 patients were included in the intent-to-treat sample. Psychotropic-Related Sexual Dysfunction Questionnaire total scores for the patients decreased progressively and significantly from baseline to the study end point. When only patients who initiated quetiapine treatment without being switched from another antipsychotic (n = 28) were included in the intent-to-treat analysis, Psychotropic-Related Sexual Dysfunction Questionnaire scores remained almost unchanged throughout the study. Sexual dysfunction rates, defined as a change in the score of any item greater than 0, were 3.7%, 2.4%, 2.4%, and 4.9% for decreased libido, delayed ejaculation/orgasm, lack of ejaculation/orgasm, and difficulties with erection/lubrication, respectively. Overall, quetiapine was efficacious and well tolerated.
    Conclusion: Despite the limitations of the design, our results suggest that quetiapine shows a low frequency of sexual dysfunction during long-term treatment of patients with schizophrenia or schizophreniform disorder in the clinical practice setting.
    MeSH term(s) Adult ; Antipsychotic Agents/administration & dosage ; Antipsychotic Agents/adverse effects ; Brief Psychiatric Rating Scale ; Dibenzothiazepines/administration & dosage ; Dibenzothiazepines/adverse effects ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Prospective Studies ; Quetiapine Fumarate ; Schizophrenia/drug therapy ; Severity of Illness Index ; Sexual Dysfunctions, Psychological/chemically induced ; Time Factors
    Chemical Substances Antipsychotic Agents ; Dibenzothiazepines ; Quetiapine Fumarate (2S3PL1B6UJ)
    Language English
    Publishing date 2005-11-08
    Publishing country United States
    Document type Clinical Trial ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 604631-9
    ISSN 1533-712X ; 0271-0749
    ISSN (online) 1533-712X
    ISSN 0271-0749
    DOI 10.1097/01.jcp.0000186872.04984.56
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  8. Article ; Online: Frequency of sexual dysfunction in patients with a psychotic disorder receiving antipsychotics.

    Montejo, Angel L / Majadas, Susana / Rico-Villademoros, Fernando / Llorca, Ginés / De La Gándara, Jesús / Franco, Manuel / Martín-Carrasco, Manuel / Aguera, Luis / Prieto, Nieves

    The journal of sexual medicine

    2010  Volume 7, Issue 10, Page(s) 3404–3413

    Abstract: Introduction: Although it is a troublesome side effect, information on antipsychotic-induced sexual dysfunction is limited.: Aim: To evaluate the frequency of sexual dysfunction and its impact on treatment adherence in patients with a psychotic ... ...

    Abstract Introduction: Although it is a troublesome side effect, information on antipsychotic-induced sexual dysfunction is limited.
    Aim: To evaluate the frequency of sexual dysfunction and its impact on treatment adherence in patients with a psychotic disorder treated with various antipsychotics under routine clinical conditions.
    Methods: Subjects included were sexually active male and female patients 18 years of age or older with a diagnosis of schizophrenia, schizophreniform disorder, schizoaffective disorder, or other psychotic disorder. This was a multicenter, cross-sectional, and naturalistic study conducted by 18 investigators. In addition to sexual functioning, we recorded demographic data, psychiatric diagnosis according to the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition), and medication history.
    Main outcome measure: Pyschotropic-Related Sexual Dysfunction Questionnaire (PRSexDQ-SalSex).
    Results: All the analyses were performed in the 243 evaluable patients. Most patients were males (71%), and the most common diagnosis was schizophrenia (71%). Overall, 46% of the patients exhibited sexual dysfunction according to the assessment with the SalSex (50% of the males and 37% of the females). Only 37% of the patients with sexual dysfuntion spontaneously reported it. Among the patients exhibiting sexual dysfunction, 32% reported to have poor tolerance to the disturbance. With the exception of conventionals depot, which had a very important and greater effect on females' sexual funtioning, the severity and tolerance of sexual dysfunction were worse in males than in females regardless of the antipsychotic studied. In the univariate logistic regression analysis, using olanzapine as a reference category, risperidone (odds ratio [OR] 7.45, 95% confidence interval [CI] 3.73-14.89) and conventionals, depot (OR 4.57, 95% CI 1.72-12.13) and nondepot (OR 4.92, 95% CI 1.43-16.93), showed a significant increased risk of sexual dysfunction.
    Conclusions: Our results show that sexual dysfunction is very common in patients receiving long-term treatment with antipsychotics, and it is associated with a great impact in a substantial proportion of patients.
    MeSH term(s) Adult ; Antipsychotic Agents/adverse effects ; Antipsychotic Agents/therapeutic use ; Benzodiazepines/adverse effects ; Benzodiazepines/therapeutic use ; Confidence Intervals ; Cross-Sectional Studies ; Delayed-Action Preparations ; Female ; Humans ; Logistic Models ; Male ; Odds Ratio ; Psychotic Disorders/drug therapy ; Risk Factors ; Risperidone/adverse effects ; Risperidone/therapeutic use ; Schizophrenia/drug therapy ; Severity of Illness Index ; Sex Factors ; Sexual Dysfunction, Physiological/chemically induced
    Chemical Substances Antipsychotic Agents ; Delayed-Action Preparations ; Benzodiazepines (12794-10-4) ; Risperidone (L6UH7ZF8HC) ; olanzapine (N7U69T4SZR)
    Language English
    Publishing date 2010-10
    Publishing country Netherlands
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2251959-2
    ISSN 1743-6109 ; 1743-6095
    ISSN (online) 1743-6109
    ISSN 1743-6095
    DOI 10.1111/j.1743-6109.2010.01709.x
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