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  1. Book: BCL-2 protein family

    Hetz, Claudio

    essential regulators of cell death

    (Advances in experimental medicine and biology ; 687)

    2010  

    Author's details ed. by Claudio Hetz
    Series title Advances in experimental medicine and biology ; 687
    Collection
    Keywords Proto-Oncogene Proteins c-bcl-2 / physiology ; Proto-Oncogene Proteins c-bcl-2 / metabolism ; Apoptosis / physiology ; Neoplasms / pathology ; Neoplasms / metabolism
    Language English
    Size XVII, 145 S. : Ill., graph. Darst.
    Publisher Springer u.a.
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT016514384
    ISBN 978-1-441-96705-3 ; 1-441-96705-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    Zs A 3192 -687- not available for loan Zeitschriften-Lesesaal

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  2. Article ; Online: Adapting the proteostasis capacity to sustain brain healthspan.

    Hetz, Claudio

    Cell

    2021  Volume 184, Issue 6, Page(s) 1545–1560

    Abstract: Sustaining neuronal proteostasis during the course of our life is a central aspect required for brain function. The dynamic nature of synaptic composition and abundance is a requisite to drive cognitive and motor processes involving a tight control of ... ...

    Abstract Sustaining neuronal proteostasis during the course of our life is a central aspect required for brain function. The dynamic nature of synaptic composition and abundance is a requisite to drive cognitive and motor processes involving a tight control of many aspects of protein biosynthesis and degradation. Through the concerted action of specialized stress sensors, the proteostasis network monitors and limits the accumulation of damaged, misfolded, or aggregated proteins. These stress pathways signal to the cytosol and nucleus to reprogram gene expression, enabling adaptive programs to recover cell function. During aging, the activity of the proteostasis network declines, which may increase the risk of accumulating abnormal protein aggregates, a hallmark of most neurodegenerative diseases. Here, I discuss emerging concepts illustrating the functional significance of adaptive signaling pathways to normal brain physiology and their contribution to age-related disorders. Pharmacological and gene therapy strategies to intervene and boost proteostasis are expected to extend brain healthspan and ameliorate disease states.
    MeSH term(s) Adaptation, Physiological ; Animals ; Brain/physiology ; Humans ; Mental Health ; Proteostasis ; Signal Transduction ; Stress, Physiological
    Language English
    Publishing date 2021-03-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2021.02.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Preventing brain aging by the artificial enforcement of the unfolded protein response: future directions.

    Cabral-Miranda, Felipe / Hetz, Claudio

    Neural regeneration research

    2023  Volume 19, Issue 2, Page(s) 393–394

    Language English
    Publishing date 2023-07-24
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.377608
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A chosen STING with a PERKy trail.

    Hazari, Younis / Hetz, Claudio

    Nature cell biology

    2022  Volume 24, Issue 5, Page(s) 602–604

    Language English
    Publishing date 2022-05-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1474722-4
    ISSN 1476-4679 ; 1465-7392
    ISSN (online) 1476-4679
    ISSN 1465-7392
    DOI 10.1038/s41556-022-00905-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: ER stress signaling at the interphase between MASH and hepatocellular carcinoma.

    Hazari, Younis / Chevet, Eric / Bailly-Maitre, Béatrice / Hetz, Claudio

    Hepatology (Baltimore, Md.)

    2024  

    Abstract: Hepato-cellular carcinoma (HCC) is the most frequent primary liver cancer with an extremely poor prognosis and often develops on preset of chronic liver diseases. Major risk factors for HCC include metabolic dysfunction-associated steatohepatitis (MASH), ...

    Abstract Hepato-cellular carcinoma (HCC) is the most frequent primary liver cancer with an extremely poor prognosis and often develops on preset of chronic liver diseases. Major risk factors for HCC include metabolic dysfunction-associated steatohepatitis (MASH), a complex multifactorial condition associated with abnormal endoplasmic reticulum (ER) proteostasis. To cope with ER stress, the unfolded protein response (UPR) engages adaptive reactions to restore the secretory capacity of the cell. Recent advances revealed that ER stress signaling plays a critical role in HCC progression. Here we propose that chronic ER stress is a common transversal factor contributing to the transition from liver disease (risk factor) to HCC. Interventional strategies to target the UPR in HCC as cancer therapy are also discussed.
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1097/HEP.0000000000000893
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  6. Article ; Online: Calcium signaling in lysosome-dependent cell death.

    Milani, Mateus / Pihán, Philippe / Hetz, Claudio

    Cell calcium

    2023  Volume 113, Page(s) 102751

    Abstract: Calcium is a crucial messenger of intracellular and extracellular signals, regulating a great variety of cellular processes such as cell death, proliferation, and metabolism. Inside the cell, calcium signaling is one of the main interorganelle ... ...

    Abstract Calcium is a crucial messenger of intracellular and extracellular signals, regulating a great variety of cellular processes such as cell death, proliferation, and metabolism. Inside the cell, calcium signaling is one of the main interorganelle communication mediators, with central functional roles at the endoplasmic reticulum (ER), mitochondria, Golgi complex, and lysosomes. Lysosomal function is highly dependent on lumenal calcium and most of the lysosomal membrane-localised ion channels regulate several lysosomal functions and properties such as lumenal pH. One of these functions configures a specific type of cell death involving lysosomes, named lysosome-dependent cell death (LDCD), which contributes to maintenance of tissue homeostasis, development and pathology when deregulated. Here, we cover the fundamental aspects of LDCD with a special focus on recent advances in calcium signaling in LDCD.
    MeSH term(s) Calcium Signaling ; Calcium/metabolism ; Cell Death ; Lysosomes/metabolism ; Intracellular Membranes/metabolism
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2023-05-05
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 757687-0
    ISSN 1532-1991 ; 0143-4160
    ISSN (online) 1532-1991
    ISSN 0143-4160
    DOI 10.1016/j.ceca.2023.102751
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Proapoptotic RECS1: a requisite gateway to lysosomal dysfunction and death.

    Pihán, Philippe / Milani, Mateus / Hetz, Claudio

    Neural regeneration research

    2022  Volume 17, Issue 12, Page(s) 2695–2696

    Language English
    Publishing date 2022-05-17
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.339487
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Correction: Prion Protein Misfolding Affects Calcium Homeostasis and Sensitizes Cells to Endoplasmic Reticulum Stress.

    Torres, Mauricio / Castillo, Karen / Armisén, Ricardo / Stutzin, Andrés / Soto, Claudio / Hetz, Claudio

    PloS one

    2022  Volume 17, Issue 1, Page(s) e0262628

    Abstract: This corrects the article DOI: 10.1371/journal.pone.0015658.]. ...

    Abstract [This corrects the article DOI: 10.1371/journal.pone.0015658.].
    Language English
    Publishing date 2022-01-11
    Publishing country United States
    Document type Published Erratum
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0262628
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Mitochondria-associated niches in health and disease.

    Milani, Mateus / Pihán, Philippe / Hetz, Claudio

    Journal of cell science

    2022  Volume 135, Issue 23

    Abstract: The appreciation of the importance of interorganelle contacts has steadily increased over the past decades. Advances in imaging, molecular biology and bioinformatic techniques allowed the discovery of new mechanisms involved in the interaction and ... ...

    Abstract The appreciation of the importance of interorganelle contacts has steadily increased over the past decades. Advances in imaging, molecular biology and bioinformatic techniques allowed the discovery of new mechanisms involved in the interaction and communication between organelles, providing novel insights into the inner works of a cell. In this Review, with the mitochondria under the spotlight, we discuss the most recent findings on the mechanisms mediating the communication between organelles, focusing on Ca2+ signaling, lipid exchange, cell death and stress responses. Notably, we introduce a new integrative perspective to signaling networks that is regulated by interorganelle interactions - the mitochondria-associated niches - focusing on the link between the molecular determinants of contact sites and their functional outputs, rather than simply physical and structural communication. In addition, we highlight the neuropathological and metabolic implications of alterations in mitochondria-associated niches and outline how this concept might improve our understanding of multi-organelle interactions.
    MeSH term(s) Mitochondria ; Mitochondrial Membranes ; Cell Death ; Signal Transduction ; Computational Biology
    Language English
    Publishing date 2022-11-30
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2993-2
    ISSN 1477-9137 ; 0021-9533
    ISSN (online) 1477-9137
    ISSN 0021-9533
    DOI 10.1242/jcs.259634
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Proteostasis and resilience: on the interphase between individual's and intracellular stress.

    Díaz-Hung, Mei-Li / Hetz, Claudio

    Trends in endocrinology and metabolism: TEM

    2022  Volume 33, Issue 5, Page(s) 305–317

    Abstract: A long proportion of the population is resilient to the negative consequences of stress. Glucocorticoids resulting from endocrine responses to stress are essential adaptive mediators, but also drive alterations to brain function, negatively impacting ... ...

    Abstract A long proportion of the population is resilient to the negative consequences of stress. Glucocorticoids resulting from endocrine responses to stress are essential adaptive mediators, but also drive alterations to brain function, negatively impacting neuronal connectivity, synaptic plasticity, and memory-related processes. Recent evidence has indicated that organelle function and cellular stress responses are relevant determinant of vulnerability and resistance to environmental stress. At the molecular level, a fundamental mechanism of cellular stress adaptation is the maintenance of proteostasis, which also have key roles in sustaining basal neuronal function. Here, we discuss recent evidence suggesting that proteostasis unbalance at the level of the endoplasmic reticulum, the main site for protein folding in the cell, represents a possible mechanistic link between individuals and cellular stress.
    MeSH term(s) Endoplasmic Reticulum/metabolism ; Endoplasmic Reticulum Stress/physiology ; Humans ; Interphase ; Neurons/metabolism ; Proteostasis/physiology ; Unfolded Protein Response
    Language English
    Publishing date 2022-03-22
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 1042384-9
    ISSN 1879-3061 ; 1043-2760
    ISSN (online) 1879-3061
    ISSN 1043-2760
    DOI 10.1016/j.tem.2022.02.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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