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Article ; Online: Loss of SUR1 subtype K

Sakamaki, Gerald / Johnson, Kayla / Mensinger, Megan / Hmu, Eindray / Klein, Amanda H

2021 Volume 414, Page(s) 113467

Abstract: ... as reward mechanisms in the nervous system. K ...

Abstract	Opioid signaling can occur through several downstream mediators and influence analgesia as well as reward mechanisms in the nervous system. K
MeSH term(s)	Analgesics, Opioid/pharmacology ; Animals ; Behavior, Animal/drug effects ; Behavior, Animal/physiology ; Female ; Locomotion/drug effects ; Locomotion/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Nociception/drug effects ; Nociception/physiology ; Sulfonylurea Receptors/deficiency ; Sulfonylurea Receptors/metabolism
Chemical Substances	Abcc8 protein, mouse ; Analgesics, Opioid ; Sulfonylurea Receptors
Language	English
Publishing date	2021-07-15
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	449927-x
ISSN	1872-7549 ; 0166-4328
ISSN (online)	1872-7549
ISSN	0166-4328
DOI	10.1016/j.bbr.2021.113467
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Article: [Determination of vitamin K in aojiru (green juice) products by HPLC].

Sakamaki, Narue / Nakazato, Mitsuo / Matsumoto, Hiroko / Hagino, Kayo / Yasuda, Kazuo / Nagayama, Toshihiro

Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan

2006 Volume 47, Issue 2, Page(s) 85–88

Abstract: A survey of vitamin K contents was carried out on 41 aojiru products and 10 vegetable juice ... forms, such as frozen, powder and tablet. Vitamin K in samples was extracted with n-hexane, and ... separated on a C18 column with methanol-ethanol (95 : 5). After separation, vitamin K was converted ...

Abstract	A survey of vitamin K contents was carried out on 41 aojiru products and 10 vegetable juice products that were purchased from local markets. Aojiru is a health food made from green vegetables such as kale, ashitaba, mulberry leaf, barley grass and the like. The products are usually provided in various forms, such as frozen, powder and tablet. Vitamin K in samples was extracted with n-hexane, and separated on a C18 column with methanol-ethanol (95 : 5). After separation, vitamin K was converted to the hydroquinone form on a reduction column and determined with a fluorescence detector at lambdaex 240 nm and lambdaem 430 nm. The contents of vitamin K1 (phylloquinone) in frozen samples (n = 8), powder samples (n = 26) and tablet samples (n=7) were 90-190, 410-3,300, and 640-3,100 microg/100 g, respectively, and that in vegetable juice (n= 10) was 1-12 microg/100 g. Vitamin K2 (menaquinone) was not detected. The daily intake of vitamin K from aojiru products was estimated to be 99-380, 20-250 and 27-210 microg/day for frozen, powder and tablet types, respectively. These results suggest that patients prescribed warfarin should take care about their intake of vitamin K from aojiru products.
MeSH term(s)	Chromatography, High Pressure Liquid ; Food, Organic/analysis ; Vitamin K/analysis ; Vitamin K 1/analysis ; Vitamin K 2/analysis
Chemical Substances	Vitamin K 2 (11032-49-8) ; Vitamin K (12001-79-5) ; Vitamin K 1 (84-80-0)
Language	Japanese
Publishing date	2006-05-23
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	604314-8
ISSN	1882-1006 ; 0015-6426
ISSN (online)	1882-1006
ISSN	0015-6426
DOI	10.3358/shokueishi.47.85
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Book ; Online: K$_2$Cr$_8$O$_{16}$ predicted as a half-metallic ferromagnet

Sakamaki, M. / Konishi, T. / Ohta, Y.

Scenario for a metal-insulator transition

2009

Abstract: ... K$_2$Cr$_8$O$_{16}$ of hollandite type should be a half-metallic ferromagnet where the Fermi level ...

Abstract	Based on the first-principles electronic structure calculations, we predict that a chromium oxide K$_2$Cr$_8$O$_{16}$ of hollandite type should be a half-metallic ferromagnet where the Fermi level crosses only the majority-spin band, whereas the minority-spin band has a semiconducting gap. We show that the double-exchange mechanism is responsible for the observed saturated ferromagnetism. We discuss possible scenarios of the metal-insulator transition observed at low temperature and we argue that the formation of the incommensurate, long-wavelength density wave of spinless fermions caused by the Fermi-surface nesting may be the origin of the opening of the charge gap. Comment: 7 pages, 7 figures; minor modifications; Phys. Rev. B, in press
Keywords	Condensed Matter - Strongly Correlated Electrons ; Condensed Matter - Materials Science
Publishing date	2009-06-08
Publishing country	us
Document type	Book ; Online
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Article: Glutathione S-transferase-pi overexpression is closely associated with K-ras mutation during human colon carcinogenesis.

Miyanishi, K / Takayama, T / Ohi, M / Hayashi, T / Nobuoka, A / Nakajima, T / Takimoto, R / Kogawa, K / Kato, J / Sakamaki, S / Niitsu, Y

Gastroenterology

2001 Volume 121, Issue 4, Page(s) 865–874

Abstract: ... highly expressed. K-ras mutation is also known to occur frequently in colorectal adenoma and carcinoma ... K-ras mutation in these lesions.: Methods: Twenty-seven specimens of colorectal carcinoma, 24 ... of adenoma, and 28 of ACF were examined in this study. The expression of GSTP1-1 or p21(K-ras) was examined ...

Abstract	Background & aims: In colorectal adenoma and carcinoma, glutathione S-transferase-pi (GSTP1-1) is highly expressed. K-ras mutation is also known to occur frequently in colorectal adenoma and carcinoma, as well as in the putative precursor of adenoma, aberrant crypt foci (ACF). Further, forced expression of v-H-ras in rat liver epithelial cells has been shown to enhance rat pi-class GST expression. The aim of the present study is, therefore, to investigate the causative relationship between GSTP1-1 overexpression and K-ras mutation in these lesions. Methods: Twenty-seven specimens of colorectal carcinoma, 24 of adenoma, and 28 of ACF were examined in this study. The expression of GSTP1-1 or p21(K-ras) was examined by immunohistochemistry. The GSTP1-1 messenger RNA levels were measured by TaqMan reverse-transcription polymerase chain reaction (PCR). K-ras mutation was detected by two-step PCR restriction fragment length polymorphism. v-K-ras transfection to RPMI-4788 colon carcinoma cells was carried out by the lipofection method. Activities of GSTP1-1 promoters containing AP-1 and Sp1 responsive elements in the v-K-ras transfectants were measured by a secreted form of human placental alkaline phosphatase (SEAP) assay. Nuclear protein from these transfectants bound to the GSTP1-1 promoter was analyzed by electrophoretic mobility shift assay (EMSA). Results: In human colorectal carcinoma, adenoma, and ACF, close association of increased expression of GSTP1-1 with K-ras mutation was observed. v-K-ras transfectants showed significantly higher SEAP activity than that of mock-transfectant activity. EMSA showed specific interaction of AP-1 with promoter of GSTP1-1. Conclusions: It is highly plausible that GSTP1-1 overexpression in ACF, colorectal adenoma, and carcinoma is induced by K-ras mutation via AP-1 activation.
MeSH term(s)	Adenoma/enzymology ; Adenoma/pathology ; Base Sequence ; Carcinoma/enzymology ; Carcinoma/pathology ; Colonic Neoplasms/enzymology ; Colonic Neoplasms/pathology ; Colorectal Neoplasms/enzymology ; Colorectal Neoplasms/pathology ; Enzyme-Linked Immunosorbent Assay ; Gene Expression Regulation, Enzymologic ; Genes, ras ; Glutathione S-Transferase pi ; Glutathione Transferase/genetics ; Humans ; Isoenzymes/genetics ; Molecular Sequence Data ; Mutation ; Polymorphism, Restriction Fragment Length ; Promoter Regions, Genetic ; RNA, Messenger/genetics ; Reverse Transcriptase Polymerase Chain Reaction ; Transcription, Genetic ; Transfection ; Tumor Cells, Cultured
Chemical Substances	Isoenzymes ; RNA, Messenger ; GSTP1 protein, human (EC 2.5.1.18) ; Glutathione S-Transferase pi (EC 2.5.1.18) ; Glutathione Transferase (EC 2.5.1.18)
Language	English
Publishing date	2001-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80112-4
ISSN	1528-0012 ; 0016-5085
ISSN (online)	1528-0012
ISSN	0016-5085
DOI	10.1053/gast.2001.27982
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Article ; Online: Statistical methods and graphical displays of quality of life with survival outcomes in oncology clinical trials for supporting the estimand framework.

Sakamaki, Kentaro / Kawahara, Takuya

BMC medical research methodology

2022 Volume 22, Issue 1, Page(s) 259

Abstract: Background: Although there are discussions regarding standards of the analysis of patient-reported outcomes and quality of life (QOL) in oncology clinical trials, that of QOL with death events is not within their scope. For example, ignoring death can ... ...

Abstract	Background: Although there are discussions regarding standards of the analysis of patient-reported outcomes and quality of life (QOL) in oncology clinical trials, that of QOL with death events is not within their scope. For example, ignoring death can lead to bias in the QOL analysis for patients with moderate or high mortality rates in the palliative care setting. This is discussed in the estimand framework but is controversial. Information loss by summary measures under the estimand framework may make it challenging for clinicians to interpret the QOL analysis results. This study illustrated the use of graphical displays in the framework. They can be helpful for discussions between clinicians and statisticians and decision-making by stakeholders. Methods: We reviewed the time-to-deterioration analysis, prioritized composite outcome approach, semi-competing risk analysis, survivor analysis, linear mixed model for repeated measures, and principal stratification approach. We summarized attributes of estimands and graphs in the statistical analysis and evaluated them in various hypothetical randomized controlled trials. Results: Graphs for each analysis method provide different information and impressions. In the time-to-deterioration analysis, it was not easy to interpret the difference in the curves as an effect on QOL. The prioritized composite outcome approach provided new insights for QOL considering death by defining better conditions based on the distinction of OS and QOL. The semi-competing risk analysis provided different insights compared with the time-to-deterioration analysis and prioritized composite outcome approach. Due to the missing assumption, graphs by the linear mixed model for repeated measures should be carefully interpreted, even for descriptive purposes. The principal stratification approach provided pure comparison, but the interpretation was difficult because the target population was unknown. Conclusions: Graphical displays can capture different aspects of treatment effects that should be described in the estimand framework.
MeSH term(s)	Humans ; Medical Oncology ; Neoplasms/therapy ; Patient Reported Outcome Measures ; Quality of Life ; Research Design
Language	English
Publishing date	2022-10-04
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2041362-2
ISSN	1471-2288 ; 1471-2288
ISSN (online)	1471-2288
ISSN	1471-2288
DOI	10.1186/s12874-022-01735-1
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Article ; Online: Solvent-free synthesis and chiroptical properties of a C-N axially chiral cruciform dimer of benzo[

Ishikawa, Shuhei / Sakamaki, Daisuke / Gon, Masayuki / Tanaka, Kazuo / Fujiwara, Hideki

Chemical communications (Cambridge, England)

2024

Abstract: A novel C-N axially chiral molecule composed of ... ...

Abstract	A novel C-N axially chiral molecule composed of two
Language	English
Publishing date	2024-04-17
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d4cc00977k
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Article ; Online: Three-dimensional chemical-state imaging with reflection-mode soft x-ray absorption spectroscopy.

Suzuki-Sakamaki, M / Amemiya, K

The Review of scientific instruments

2021 Volume 92, Issue 12, Page(s) 123702

Abstract: In this study, a method for reflection-mode soft x-ray absorption spectroscopy was developed to realize three-dimensional chemical-state imaging. Soft x rays from a pinhole were reflected by the sample, and the magnified image was observed with a two- ... ...

Abstract	In this study, a method for reflection-mode soft x-ray absorption spectroscopy was developed to realize three-dimensional chemical-state imaging. Soft x rays from a pinhole were reflected by the sample, and the magnified image was observed with a two-dimensional detector. This technique was applied to a Co film with an Au-island-covered surface to obtain the surface chemical state images with a spatial resolution of several tens of micrometers. Furthermore, the soft x-ray reflection spectra within and outside the Au layer were extracted from the images by changing the photon energy. Distinct differences were observed at the Co absorption edge. By considering anomalous x-ray scattering around the Co L-edges in the simulation, the reflection spectrum near the absorption edge in the nm depth resolution was reproduced. In the region without the Au layer, the results were well reproduced, assuming that 4 nm CoO was formed at the surface. These results demonstrate the feasibility of three-dimensional imaging of the chemical states in multilayer films.
MeSH term(s)	Photons ; X-Ray Absorption Spectroscopy ; X-Rays
Language	English
Publishing date	2021-12-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0069096
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Article: Analysis of K-ras, APC, and beta-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis.

Takayama, T / Ohi, M / Hayashi, T / Miyanishi, K / Nobuoka, A / Nakajima, T / Satoh, T / Takimoto, R / Kato, J / Sakamaki, S / Niitsu, Y

Gastroenterology

2001 Volume 121, Issue 3, Page(s) 599–611

Abstract: ... 4 FAP patients. Biopsies were performed on ACF by magnifying endoscopy. K-ras mutations were ... beta-catenin were detected by immunofluorescence.: Results: In non-FAP cases, K-ras mutations were detected ... and beta-catenin accumulation were 78% (24/31), and that of K-ras mutation was 65% (20/31). FAP ...

Abstract	Background & aims: We have previously shown that aberrant crypt foci (ACF) are the putative precursor lesions of colorectal adenomas and subsequent cancer in humans using magnifying endoscopy. The present study was designed to investigate these genetic alterations in ACF biopsy specimens from normal subjects, familial adenomatous polyposis (FAP) or sporadic patients. Methods: The non-FAP cases included 34 normal subjects, 35 colorectal adenoma patients, and 19 colorectal cancer patients; there were 4 FAP patients. Biopsies were performed on ACF by magnifying endoscopy. K-ras mutations were analyzed by 2-step polymerase chain reaction and restriction fragment length polymorphism, APC mutations by in vitro-synthesized protein assay, and beta-catenin mutations by direct sequencing. Full-length APC and beta-catenin were detected by immunofluorescence. Results: In non-FAP cases, K-ras mutations were detected in 82% (89/106) of nondysplastic ACF and 63% (17/27) of dysplastic ACF. APC mutation and beta-catenin accumulation were not detected in non-FAP ACF, whereas in adenoma of these patients, positivity of APC mutation and beta-catenin accumulation were 78% (24/31), and that of K-ras mutation was 65% (20/31). FAP patients showed K-ras mutations in only 13% (1/8) of dysplastic ACF, which is the predominant form of ACF found in FAP. In FAP patients, somatic APC mutations were found in 100% of dysplastic ACF, as they are in adenoma. The frequency of K-ras mutations was 73% (8 of 11) in FAP adenoma. Conclusions: The data suggest that in sporadic colorectal carcinogenesis, assuming the biological implication of ACF as a precursor of adenomas, there is a route where K-ras mutation mainly occurs during the formation of ACF, which then become adenomas wherein APC mutation occurs. In FAP, however, somatic mutation of APC predominantly occurs during ACF formation, followed by K-ras mutation.
MeSH term(s)	Adenomatous Polyposis Coli/genetics ; Adenomatous Polyposis Coli/pathology ; Adenomatous Polyposis Coli Protein ; Adult ; Aged ; Biopsy ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Cytoskeletal Proteins/analysis ; Cytoskeletal Proteins/genetics ; Disease Progression ; Endoscopy, Gastrointestinal ; Female ; Genes, ras/genetics ; Genetic Testing ; Humans ; Immunohistochemistry ; Intestinal Mucosa/chemistry ; Intestinal Mucosa/pathology ; Male ; Middle Aged ; Mutation ; Polymorphism, Restriction Fragment Length ; Trans-Activators ; beta Catenin
Chemical Substances	Adenomatous Polyposis Coli Protein ; CTNNB1 protein, human ; Cytoskeletal Proteins ; Trans-Activators ; beta Catenin
Language	English
Publishing date	2001-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80112-4
ISSN	1528-0012 ; 0016-5085
ISSN (online)	1528-0012
ISSN	0016-5085
DOI	10.1053/gast.2001.27203
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Article ; Online: Optimal dose escalation methods using deep reinforcement learning in phase I oncology trials.

Matsuura, Kentaro / Sakamaki, Kentaro / Honda, Junya / Sozu, Takashi

Journal of biopharmaceutical statistics

2023 Volume 33, Issue 5, Page(s) 639–652

Abstract: In phase I trials of a novel anticancer drug, one of the most important objectives is to identify the maximum tolerated dose (MTD). To this end, a number of methods have been proposed and evaluated under various scenarios. However, the percentages of ... ...

Abstract	In phase I trials of a novel anticancer drug, one of the most important objectives is to identify the maximum tolerated dose (MTD). To this end, a number of methods have been proposed and evaluated under various scenarios. However, the percentages of correct selection (PCS) of MTDs using previous methods are insufficient to determine the dose for late-phase trials. The purpose of this study is to construct an action rule for escalating or de-escalating the dose and continuing or stopping the trial to increase the PCS as much as possible. We show that deep reinforcement learning with an appropriately defined state, action, and reward can be used to construct such an action selection rule. The simulation study shows that the proposed method can improve the PCS compared with the 3 + 3 design, CRM, BLRM, BOIN, mTPI, and i3 + 3 methods.
MeSH term(s)	Humans ; Neoplasms/drug therapy ; Antineoplastic Agents/adverse effects ; Computer Simulation ; Medical Oncology ; Research Design ; Maximum Tolerated Dose ; Dose-Response Relationship, Drug ; Bayes Theorem
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2023-01-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1131763-2
ISSN	1520-5711 ; 1054-3406
ISSN (online)	1520-5711
ISSN	1054-3406
DOI	10.1080/10543406.2023.2170402
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Article ; Online: The net benefit for time-to-event outcome in oncology clinical trials with treatment switching.

Fukuda, Musashi / Sakamaki, Kentaro / Oba, Koji

Clinical trials (London, England)

2023 Volume 20, Issue 6, Page(s) 670–680

Abstract: Background: The net benefit is an effect measure for any type of endpoint, including the time-to-event outcome, and can provide intuitive and clinically meaningful interpretation. It is defined as the probability of a randomly selected subject from the ... ...

Abstract	Background: The net benefit is an effect measure for any type of endpoint, including the time-to-event outcome, and can provide intuitive and clinically meaningful interpretation. It is defined as the probability of a randomly selected subject from the experimental arm surviving by at least a clinically relevant time longer than a randomly selected subject from the control arm. In oncology clinical trials, an intercurrent event such as treatment switching is common, which potentially causes informative censoring; nevertheless, conventional methods for the net benefit are not able to deal with it. In this study, we proposed a new estimator using the inverse probability of censoring weighting (IPCW) method and illustrated an oncology clinical trial with treatment switching (the SHIVA study) to apply the proposed method under the estimand framework. Methods: The net benefit can be estimated using the survival functions of each treatment group. The proposed estimator was based on the survival functions estimated by the inverse probability of the censoring weighting method that can handle covariate-dependent censoring. The simulation study was undertaken to evaluate the operating characteristics of the proposed estimator under several scenarios; we varied the shapes of the survival curves, treatment effect, covariates effect on censoring, proportion of the censoring, threshold of the net benefit, and sample size. We also applied conventional methods (the scoring rules by Péron or Gehan) and the proposed method to the SHIVA study. Results: Our simulation study showed that the proposed estimator provided less biased results under the covariate-dependent censoring than existing estimators. When applying the proposed method to the SHIVA study, we were able to estimate the net benefit by incorporating the information of the covariates with different estimand strategies to address the intercurrent event of the treatment switching. However, the estimates of the proposed method and those of the aforementioned conventional methods were similar under the hypothetical strategy. Conclusions: We proposed a new estimator of the net benefit that can include covariates to account for the possibly informative censoring. We also provided an illustrative analysis of the proposed method for the oncology clinical trial with treatment switching using the estimand framework. Our proposed new estimator is suitable for handling the intercurrent events that can potentially cause covariate-dependent censoring.
MeSH term(s)	Humans ; Treatment Switching ; Neoplasms/therapy ; Computer Simulation ; Probability ; Sample Size ; Survival Analysis
Language	English
Publishing date	2023-07-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2138796-5
ISSN	1740-7753 ; 1740-7745
ISSN (online)	1740-7753
ISSN	1740-7745
DOI	10.1177/17407745231186081
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