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  1. Article ; Online: Potential Efficacy of Janus Kinase Inhibitors in the Treatment of a Patient With Coexisting Peripheral and Axial Spondyloarthritis and Ulcerative Colitis.

    Ishigaki, Sho / Kajio, Nobuhiko / Yoshikawa, Noritada / Taguchi, Hiroaki

    The Journal of rheumatology

    2024  

    Abstract: Tumor necrosis factor inhibitors are effective and recommended in treating patients with coexisting spondyloarthritis (SpA) and ulcerative colitis (UC); however, the evidence of their superiority over other drugs is insufficient. ...

    Abstract Tumor necrosis factor inhibitors are effective and recommended in treating patients with coexisting spondyloarthritis (SpA) and ulcerative colitis (UC); however, the evidence of their superiority over other drugs is insufficient.
    Language English
    Publishing date 2024-05-01
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.2024-0055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1168: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 135: Show issues

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  2. Article ; Online: Ethambutol inhibited the growth of acid-fast bacteria and enhanced the detection of Legionella in environmental water samples.

    Inoue, Hiroaki / Taguchi, Marin / Kitazume, Manami / Saito, Yukie / Iwasawa, Tomoyuki

    Journal of microorganism control

    2024  Volume 29, Issue 1, Page(s) 1–7

    Abstract: The growth of acid-fast bacteria often hinders the detection of Legionella in water samples on agar plates by the plate culture method. We studied whether anti-tubercular agents inhibit acid-fast bacteria growth on agar plates. First, the antimicrobial ... ...

    Abstract The growth of acid-fast bacteria often hinders the detection of Legionella in water samples on agar plates by the plate culture method. We studied whether anti-tubercular agents inhibit acid-fast bacteria growth on agar plates. First, the antimicrobial activities of isoniazid, ethionamide, and ethambutol were evaluated against Mycobacterium and Legionella. We found that ethambutol at ≥ 100 μg/mL completely inhibited Mycobacterium growth, but ethambutol at 1,000 μg/mL did not inhibit Legionella growth. Next, the effect of ethambutol dissolved in acid buffer was examined. Cell suspensions of L. pneumophila and Mycobacterium spp. were mixed, and ethambutol-acid buffer was added. After 5 min, mixtures were inoculated on GVPC agar plates and incubated at 36℃ for 6 d. We found that ethambutol inhibited Mycobacterium growth on agar plates, but the Legionella colonies recovered. The effect of ethambutol was also significant in the evaluation using bathwaters. Comparing 1,302 bathwaters, the addition of ethambutol reduced the detection rate of acid-fast bacteria from 30.6% to 0% and increased the detection rate of Legionella from 7.1% to 7.5%. Ethambutol, which selectively inhibited acid-fast bacteria growth, enhanced the detection of Legionella on agar plates and will contribute to improving the accuracy of Legionella testing by the plate culture method.
    MeSH term(s) Legionella ; Ethambutol/pharmacology ; Agar ; Water Microbiology ; Water
    Chemical Substances Ethambutol (8G167061QZ) ; Agar (9002-18-0) ; Water (059QF0KO0R)
    Language English
    Publishing date 2024-03-20
    Publishing country Japan
    Document type Journal Article
    ISSN 2758-6391
    ISSN (online) 2758-6391
    DOI 10.4265/jmc.29.1_1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Direct conversion of a general antibody to its catalytic antibody and corresponding applications -Importance and role of Pro95 in CDR-3.

    Hifumi, Emi / Taguchi, Hiroaki / Nonaka, Tamami / Uda, Taizo

    Proceedings of the Japan Academy. Series B, Physical and biological sciences

    2023  Volume 99, Issue 6, Page(s) 155–172

    Abstract: Catalytic antibodies possess unique features capable of both recognizing and enzymatically degrading antigens. Therefore, they are more beneficial than monoclonal antibodies (mAbs). Catalytic antibodies exhibit the ability to degrade peptides, antigenic ... ...

    Abstract Catalytic antibodies possess unique features capable of both recognizing and enzymatically degrading antigens. Therefore, they are more beneficial than monoclonal antibodies (mAbs). Catalytic antibodies exhibit the ability to degrade peptides, antigenic proteins, DNA, and physiologically active molecules. However, they have a significant drawback in terms of their production. The production of a desired catalytic antibody has extensive costs, in terms of time and effort. We herein describe an evolutionary method to produce a desired catalytic antibody via conversion of a general antibody by the deletion of Pro95, which resides in complementarity-determining region-3. As over thousands of mAbs have been produced since 1975, using the novel technology discussed herein, the catalytic feature cleaving the antigen can be conferred to the mAb. In this review article, we discussed in detail not only the role of Pro95 but also the unique features of the converted catalytic antibodies. This technique will accelerate research on therapeutic application of catalytic antibodies.
    MeSH term(s) Antibodies, Catalytic/chemistry ; Amino Acid Sequence ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/metabolism
    Chemical Substances Antibodies, Catalytic ; Antibodies, Monoclonal
    Language English
    Publishing date 2023-01-25
    Publishing country Japan
    Document type Review ; Journal Article
    ZDB-ID 161781-3
    ISSN 1349-2896 ; 0386-2208
    ISSN (online) 1349-2896
    ISSN 0386-2208
    DOI 10.2183/pjab.99.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 4' 46/60 b: Show issues
    Z PRO 15: Show issues

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  4. Article ; Online: Gold(I)-Catalyzed Cascade Cyclization of Alkynyl Indoles for the Stereoselective Construction of the Quaternary Carbon Center of Akuammiline Alkaloids.

    Hashimoto, Naoki / Taguchi, Junichi / Arichi, Norihito / Inuki, Shinsuke / Ohno, Hiroaki

    The Journal of organic chemistry

    2023  Volume 88, Issue 24, Page(s) 17306–17321

    Abstract: A gold-catalyzed cyclization reaction of alkynyl-indoles has been developed for the stereoselective construction of the quaternary carbon center of fused indolines. This reaction efficiently produces fused indolines via diastereoselective 6- ...

    Abstract A gold-catalyzed cyclization reaction of alkynyl-indoles has been developed for the stereoselective construction of the quaternary carbon center of fused indolines. This reaction efficiently produces fused indolines via diastereoselective 6-
    Language English
    Publishing date 2023-12-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.3c02142
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4473: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Ion Tracks and Nanohillocks Created in Natural Zirconia Irradiated with Swift Heavy Ions.

    Ishikawa, Norito / Fukuda, Shoma / Nakajima, Toru / Ogawa, Hiroaki / Fujimura, Yuki / Taguchi, Tomitsugu

    Materials (Basel, Switzerland)

    2024  Volume 17, Issue 3

    Abstract: Natural monoclinic zirconia (baddeleyite) was irradiated with 340 MeV Au ions, and the irradiation-induced nanostructures (i.e., ion tracks and nanohillocks) were observed using transmission electron microscopy. The diameter of the nanohillocks was ... ...

    Abstract Natural monoclinic zirconia (baddeleyite) was irradiated with 340 MeV Au ions, and the irradiation-induced nanostructures (i.e., ion tracks and nanohillocks) were observed using transmission electron microscopy. The diameter of the nanohillocks was approximately 10 nm, which was similar to the maximum molten region size calculated using the analytical thermal spike model. Ion tracks were imaged as strained regions that maintained their crystalline structure. The cross-sections of most of the ion tracks were imaged as rectangular contrasts as large as 10 nm. These results strongly indicated that the molten region was recrystallized anisotropically, reflecting the lattice structure. Furthermore, low-density track cores were formed in the center of the ion tracks. The formation of low-density track cores can be attributed to the ejection of molten matter toward the surface. A comparison of the ion tracks in the synthetic zirconia nanoparticles and those in larger natural zirconia samples showed that the interface between the strained track contrast and the matrix was less clear in the former than in the latter. These findings suggest that the recrystallization process was affected by the size of the irradiated samples.
    Language English
    Publishing date 2024-01-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma17030547
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  6. Article: Amikacin Liposome Inhalation Suspension in the Real-World Management of Refractory Mycobacterium avium Complex Pulmonary Disease.

    Yanagihara, Toyoshi / Ogata, Hiroaki / Mori, Asami / Kadowaki, Masako / Moriuchi, Yuki / Ishimatsu, Akiko / Otsuka, Junji / Taguchi, Kazuhito / Moriwaki, Atushi / Yoshida, Makoto

    Cureus

    2024  Volume 16, Issue 3, Page(s) e56622

    Abstract: The increasing prevalence ... ...

    Abstract The increasing prevalence of
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.56622
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  7. Article ; Online: Improved tissue adhesion property of a hydrophobically modified Alaska pollock derived gelatin sheet by UV treatment.

    Ichimaru, Hiroaki / Taguchi, Tetsushi

    International journal of biological macromolecules

    2021  Volume 172, Page(s) 580–588

    Abstract: Tissue adhesives have been developed for sealing tissue damaged in surgery. Among these, sheet-type adhesives require a relatively long time to adhere to biological tissue under wet conditions. To address this clinical problem, we fabricated a tissue- ... ...

    Abstract Tissue adhesives have been developed for sealing tissue damaged in surgery. Among these, sheet-type adhesives require a relatively long time to adhere to biological tissue under wet conditions. To address this clinical problem, we fabricated a tissue-adhesive fiber sheet (AdFS) based on decanyl group (C10) modified Alaska pollock-derived gelatin (C10-ApGltn) using electrospinning. Ultraviolet (UV) irradiation of the AdFS was performed to increase the affinity between the AdFS and wet biological tissue by introducing hydrophilic functional groups. The UV irradiated AdFS (UV-C10-AdFS) strongly adhered to porcine pleura within 2 min under wet conditions and showed higher burst strength compared with the original ApGltn (Org-ApGltn) sheet. Hematoxylin-eosin stained sections revealed that a dense UV-C10-AdFS layer remained on the surface of the porcine pleura even after burst strength measurement. Moreover, UV-C10-AdFS has excellent cytocompatibility and efficiently supports the growth of L929 cells. UV-C10-AdFS is a promising adhesive material for sealing wet biological tissue.
    MeSH term(s) Alaska ; Animals ; Cell Line ; Electrochemical Techniques ; Fibroblasts/cytology ; Fibroblasts/drug effects ; Gadiformes/metabolism ; Gelatin/chemistry ; Gelatin/radiation effects ; Hydrophobic and Hydrophilic Interactions ; Materials Testing ; Mice ; Pleura/drug effects ; Pleura/radiation effects ; Polyethylene Glycols/chemistry ; Swine ; Tensile Strength ; Tissue Adhesives/chemistry ; Tissue Adhesives/pharmacology ; Tissue Adhesives/radiation effects ; Ultraviolet Rays
    Chemical Substances Tissue Adhesives ; Polyethylene Glycols (3WJQ0SDW1A) ; Gelatin (9000-70-8)
    Language English
    Publishing date 2021-01-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2021.01.085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2374: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Targeting of extracellular protein-protein interactions with macrocyclic peptides.

    Taguchi, Shota / Suga, Hiroaki

    Current opinion in chemical biology

    2021  Volume 62, Page(s) 82–89

    Abstract: Targeting of extracellular protein-protein interactions (PPI) is emerging as a major application for de novo discovered macrocyclic peptides. Modern discovery platforms can routinely identify macrocyclic peptide ligands capable of highly selective ... ...

    Abstract Targeting of extracellular protein-protein interactions (PPI) is emerging as a major application for de novo discovered macrocyclic peptides. Modern discovery platforms can routinely identify macrocyclic peptide ligands capable of highly selective modulation of extracellular signaling pathways; amenability to chemical synthesis and natural modularity of peptides additionally provides an avenue for their further structural elaboration, while the challenge of cell internalization can be minimized. Here, we discuss the recent progress in targeting extracellular PPIs with macrocyclic peptides by focusing on a number of recent case studies. We analyze the scope and potential limitations of the discovery systems in identifying functional macrocyclic ligands. We also highlight the recent technical advancements allowing for a more streamlined discovery pipeline and our brief perspective in this field.
    MeSH term(s) Allosteric Regulation ; Animals ; Drug Discovery ; Gene Expression Regulation/drug effects ; Humans ; Ligands ; Peptide Library ; Peptides, Cyclic/chemistry ; Peptides, Cyclic/metabolism ; Protein Binding ; Receptors, Cell Surface/antagonists & inhibitors ; Receptors, Cell Surface/chemistry ; Receptors, Cell Surface/genetics ; Receptors, Cell Surface/metabolism ; Signal Transduction ; Structure-Activity Relationship
    Chemical Substances Ligands ; Peptide Library ; Peptides, Cyclic ; Receptors, Cell Surface
    Language English
    Publishing date 2021-03-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1439176-4
    ISSN 1879-0402 ; 1367-5931
    ISSN (online) 1879-0402
    ISSN 1367-5931
    DOI 10.1016/j.cbpa.2021.02.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4986: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Clinical Images: Epistaxis may be a warning sign of lymphoproliferative disorder during methotrexate treatment for dermatomyositis.

    Ishigaki, Sho / Kajio, Nobuhiko / Okayama, Mikio / Orikasa, Hideki / Tanaka, Shoko / Yoshikawa, Noritada / Taguchi, Hiroaki

    ACR open rheumatology

    2023  Volume 6, Issue 3, Page(s) 123

    Language English
    Publishing date 2023-12-20
    Publishing country United States
    Document type Journal Article
    ISSN 2578-5745
    ISSN (online) 2578-5745
    DOI 10.1002/acr2.11647
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: A Case of Pneumocystis Pneumonia Developed During Rheumatoid Arthritis Treatment With Methotrexate and Golimumab.

    Yanagihara, Toyoshi / Oka, Yusuke / Moriwaki, Atushi / Moriuchi, Yuki / Ogata, Hiroaki / Ishimatsu, Akiko / Otsuka, Junji / Taguchi, Kazuhito / Yoshida, Makoto

    Cureus

    2024  Volume 16, Issue 1, Page(s) e52944

    Abstract: Here, we report a case of an 87-year-old female patient with rheumatoid arthritis (RA) treated with methotrexate (MTX) and golimumab who developed severe pneumocystis pneumonia (PCP), also known ... ...

    Abstract Here, we report a case of an 87-year-old female patient with rheumatoid arthritis (RA) treated with methotrexate (MTX) and golimumab who developed severe pneumocystis pneumonia (PCP), also known as
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.52944
    Database MEDical Literature Analysis and Retrieval System OnLINE

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