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  1. Article ; Online: Relationship between silent brain infarction and rheumatic diseases

    Atalay Dogru

    Journal of Clinical and Analytical Medicine (2018)

    2018  

    Keywords Medicine ; R
    Language English
    Publishing date 2018-11-01T00:00:00Z
    Publisher Derman Medical Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Assessment of corneal parameters in patients with rheumatoid arthritis.

    Özkaya, Dilek / Doğru, Atalay / Baykal, Tuba

    Indian journal of ophthalmology

    2024  Volume 72, Issue 2, Page(s) 206–210

    Abstract: Purpose: To assess the corneal parameters in rheumatoid arthritis (RA) patients.: Methods: We enrolled 64 patients with RA (32 receiving biologic and 32 receiving conventional drugs) and 32 healthy subjects. Keratometric values (anterior flat [K1], ... ...

    Abstract Purpose: To assess the corneal parameters in rheumatoid arthritis (RA) patients.
    Methods: We enrolled 64 patients with RA (32 receiving biologic and 32 receiving conventional drugs) and 32 healthy subjects. Keratometric values (anterior flat [K1], steep [K2], and mean keratometry [Km]), corneal thickness from the pupil center (CCT), apex (ACT), and the thinnest point (TCT), and corneal volume (CV) were measured and compared between the groups.
    Results: K1, K2, and Km values were significantly higher in the RA group (P = 0.013, P = 0.048, P = 0.027, respectively). The means of CCT, ACT, TCT, and CV were significantly lower in RA patients (P < 0.001, P < 0.001, P < 0.001, P = 0.011, respectively). When we divided RA patients into two groups according to the treatment and compared them to controls, the differences in K1, CCT, ACT, TCT and CV were significant (P = 0.030, P = 0.005, P = 0.001, P = 0.001, P = 0.034, respectively). K1 and CV values of RA-biologic group were similar to the control group (P = 0.205 and P = 0.127, respectively).
    Conclusion: Biologic agents contribute to the improvement of K1 and CV values in patients with RA.
    MeSH term(s) Humans ; Corneal Topography ; Prospective Studies ; Cornea ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/drug therapy ; Biological Products
    Chemical Substances Biological Products
    Language English
    Publishing date 2024-01-25
    Publishing country India
    Document type Journal Article
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/ijo.IJO_2024_22
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  3. Article ; Online: Nutcracker Syndrome Mimicking Familial Mediterranean Fever

    Atalay Dogru

    Journal of Clinical and Analytical Medicine , Vol 7, Iss 113, Pp 417-

    2014  Volume 419

    Abstract: The Nutcracker syndrome (NCS) is a rare entrapment syndrome caused by compression of the left renal vein (LRV) between the abdominal aorta and the superior mesenteric artery. We present a case of Nutcracker syndrome in an 18-year-old patient with ... ...

    Abstract The Nutcracker syndrome (NCS) is a rare entrapment syndrome caused by compression of the left renal vein (LRV) between the abdominal aorta and the superior mesenteric artery. We present a case of Nutcracker syndrome in an 18-year-old patient with Familial Mediterranean fever.
    Keywords Amyloidosis ; Entrapment ; Nutcracker syndrome ; Medicine ; R
    Language English
    Publishing date 2014-12-01T00:00:00Z
    Publisher Derman Medical Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Modulator role of infliximab and methotrexate through the transient receptor potential melastatin 2 (TRPM2) channel in neutrophils of patients with rheumatoid arthritis

    Atalay Dogru / Mustafa Nazıroglu / Bilal Cig

    Archives of Medical Science, Vol 15, Iss 6, Pp 1415-

    a pilot study

    2018  Volume 1424

    Keywords apoptosis ; oxidative stress ; calcium signaling ; transient receptor potential melastatin 2 channel ; rheumatoid arthritis ; Medicine ; R
    Language English
    Publishing date 2018-11-01T00:00:00Z
    Publisher Termedia Publishing House
    Document type Article ; Online
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  5. Article: Modulator role of infliximab and methotrexate through the transient receptor potential melastatin 2 (TRPM2) channel in neutrophils of patients with rheumatoid arthritis: a pilot study.

    Dogru, Atalay / Nazıroglu, Mustafa / Cig, Bilal

    Archives of medical science : AMS

    2018  Volume 15, Issue 6, Page(s) 1415–1424

    Abstract: Introduction: Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory disease causing symmetric polyarthritis. In this study, we aimed to investigate the effects of infliximab (INF) and methotrexate (MTX) on apoptosis, oxidative stress, and ... ...

    Abstract Introduction: Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory disease causing symmetric polyarthritis. In this study, we aimed to investigate the effects of infliximab (INF) and methotrexate (MTX) on apoptosis, oxidative stress, and calcium signaling in the neutrophils of RA patients.
    Material and methods: Neutrophils were isolated from 10 patients with newly diagnosed RA and 10 healthy controls. They were divided into four groups (control, RA, RA + MTX, RA + INF) and incubated with MTX and INF. In the cell viability (MTT) test, the ideal non-toxic dose and incubation time of MTX were found to be 0.1 mM and 1 h, respectively. The neutrophils were also incubated with the TRPM2 channel blocker
    Results: Intracellular free Ca
    Conclusions: Our results suggest that INF and MTX are useful antagonists in apoptosis and mitochondrial oxidative stress in the neutrophils of RA patients. INF and MTX decreased the Ca
    Language English
    Publishing date 2018-11-19
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2203781-0
    ISSN 1734-1922
    ISSN 1734-1922
    DOI 10.5114/aoms.2018.79485
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  6. Article ; Online: Evaluation of histopathological results of minor salivary gland biopsies in patients with the diagnosis of Sjögren's syndrome.

    Erkılınç, Gamze / Doğru, Atalay / Arslan, Yaşar / Burak Öz, Rıza / Karahan, Nermin / Şahin, Mehmet / Çiriş, İbrahim Metin

    Archives of rheumatology

    2021  Volume 37, Issue 1, Page(s) 49–58

    Abstract: Objectives: This study aims to evaluate which of the histomorphological criteria defined in labial salivary gland biopsy are more valuable in diagnosing Sjögren's syndrome (SS) and to examine its correlation with clinical and laboratory findings.: ... ...

    Abstract Objectives: This study aims to evaluate which of the histomorphological criteria defined in labial salivary gland biopsy are more valuable in diagnosing Sjögren's syndrome (SS) and to examine its correlation with clinical and laboratory findings.
    Patients and methods: Between January 2005 and January 2019, a total of 927 patients (104 males, 823 females; mean age: 51 years; range, 19 to 85 years) who underwent minor salivary gland biopsies with the suspicion of SS were retrospectively analyzed. The American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) 2016 classification criteria were used for the classification of SS. We evaluated salivary gland biopsies histomorphologically for the presence and number of lymphocytic focus, as well as chronicity findings (acinar atrophy, ductal dilatation, fibrosis), the presence of lymphocytic infiltration, distribution, localization, ectopic germinal center, and mast cell count. The presence of accompanying diseases, clinical and laboratory findings including age, sex, the presence of dry eye and mouth, and autoantibodies for discriminating SS were noted. Histomorphologically, salivary gland biopsy which fulfilled the adequacy criteria for glandular tissue were compared with the other criteria used to diagnose SS.
    Results: Strong chronicity and diffuse lymphocytic infiltration were significantly higher in the SS group compared to the non-SS group (p<0.001). Lymphocytic focus score >1 was significantly higher in the SS group compared to the non-SS group (p<0.001). Strong chronicity, acinar atrophy, andductal dilatation were significantly higher in the SS group compared to the non-SS group (p<0.001).
    Conclusion: More than one lymphocytic focus is the most valuable finding in diagnosing SS. However, it should be kept in mind that, in cases of SS, ductal dilatation, acinar atrophy, and chronicity may be present without lymphocytic infiltration.
    Language English
    Publishing date 2021-10-18
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 3012972-2
    ISSN 2618-6500 ; 2148-5046
    ISSN (online) 2618-6500
    ISSN 2148-5046
    DOI 10.46497/ArchRheumatol.2022.8607
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  7. Article ; Online: Mutations of the CFTR gene and novel variants in Turkish patients with cystic fibrosis: 24-years experience.

    Dayangaç-Erden, Didem / Atalay, Merve / Emiralioğlu, Nagehan / Hızal, Mina / Polat, Sanem / Özçelik, Uğur / Yalçın, Ebru / Doğru, Deniz / Yılmaz, Engin / Kiper, Nural

    Clinica chimica acta; international journal of clinical chemistry

    2020  Volume 510, Page(s) 252–259

    Abstract: Background: Cystic fibrosis, the most prevalent autosomal recessive genetic disease, is caused by mutations in the CFTR gene. The spectrum and frequency of CFTR mutations in Turkish patients show heterogeneity.: Methods: We investigated CFTR gene ... ...

    Abstract Background: Cystic fibrosis, the most prevalent autosomal recessive genetic disease, is caused by mutations in the CFTR gene. The spectrum and frequency of CFTR mutations in Turkish patients show heterogeneity.
    Methods: We investigated CFTR gene mutations in samples from 604 cystic fibrosis patients diagnosed at Hacettepe University, the largest referral CF center in Turkey, by different techniques such as strip assay and direct sequencing. We also analyzed the effects of novel variants and predicted pathogenicity by integrating information from different insilico tools.
    Results: We showed that mutation detection rate increased to 76.7% with direct sequencing of the coding region and exon/intron boundaries. Ten variants were described for the first time. All variants except T788R were reported as pathogenic.
    Conclusion: Characterization of patients with CFTR mutations that occur at very low frequencies is necessary for mutation-based treatments. Population specific genetic screening panels should be designed since none of them are suitable for Turkish patients due to heterogeneous mutation distribution. The preliminary data obtained from in silico results of novel variants will pave the way for functional analysis by using samples obtained from patients. These observations will facilitate the discovery and development of new targeted and personalized therapies.
    MeSH term(s) Cystic Fibrosis/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Exons ; Humans ; Mutation ; Turkey
    Chemical Substances CFTR protein, human ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
    Language English
    Publishing date 2020-07-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80228-1
    ISSN 1873-3492 ; 0009-8981
    ISSN (online) 1873-3492
    ISSN 0009-8981
    DOI 10.1016/j.cca.2020.07.033
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  8. Article: Chronic Non-Productive Cough in Patients With Primary Sjögren's Syndrome.

    Doğru, Gonca / Balkarli, Ayşe / Dogru, Atalay

    Archives of rheumatology

    2017  Volume 32, Issue 4, Page(s) 303–308

    Abstract: Objectives: This study aims to evaluate the frequency of chronic cough due to dryness in the trachea and the relationship between depression and chronic cough in patients with primary Sjögren's syndrome (pSS).: Patients and methods: Eighty non- ... ...

    Abstract Objectives: This study aims to evaluate the frequency of chronic cough due to dryness in the trachea and the relationship between depression and chronic cough in patients with primary Sjögren's syndrome (pSS).
    Patients and methods: Eighty non-smoking patients (7 males, 73 females; mean age 47.6±9.2 years; range 18 to 70 years) with newly diagnosed pSS were included. All patients were evaluated clinically, radiologically, and physiologically. Patients with cough were assessed using the Leicester Cough Questionnaire and visual analog scale. Beck Depression Inventory was used to determine the risk of depression in patients with cough. Patients with asthma, rhinosinusitis, gastrooesophageal reflux, and drug use which cause cough and pulmonary involvement in pSS were excluded.
    Results: Non-productive cough was detected in 30 patients (37.5%). Fourteen patients (17.5%) were admitted to the hospital with cough at least once before the diagnosis of pSS. The median time between onset of symptoms and firm diagnosis was 24 months (25-75 interquartile ranges: 3-60 months). A significant difference was observed in the Beck Depression Inventory scores between patients with and without cough. There was a significant negative relationship between Leicester Cough Questionnaire and Beck Depression Inventory scores.
    Conclusion: Patients with pSS often have symptoms for a long duration that mimic those of more commonly encountered non-specific pulmonary conditions. Xerotrachea should be considered in the differential diagnosis of chronic cough, especially in patients with normal pulmonary function tests and pulmonary imaging.
    Language English
    Publishing date 2017-04-05
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 3012972-2
    ISSN 2618-6500 ; 2148-5046
    ISSN (online) 2618-6500
    ISSN 2148-5046
    DOI 10.5606/ArchRheumatol.2017.6160
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  9. Article ; Online: Bone mineral density and serum osteocalcin levels in patients with gout.

    Dogru, Atalay / Balkarli, Ayse / Karatay, Cemile Canan / Cobankara, Veli / Sahin, Mehmet

    Acta clinica Belgica

    2018  Volume 74, Issue 4, Page(s) 252–257

    Abstract: ... ...

    Abstract Objective
    MeSH term(s) Absorptiometry, Photon/methods ; Age Factors ; Allopurinol/therapeutic use ; Body Mass Index ; Bone Remodeling ; Correlation of Data ; Female ; Femur/diagnostic imaging ; Gout/blood ; Gout/diagnosis ; Gout/drug therapy ; Gout/epidemiology ; Gout Suppressants/therapeutic use ; Humans ; Lumbar Vertebrae/diagnostic imaging ; Male ; Middle Aged ; Osteocalcin/blood ; Osteoporosis/blood ; Osteoporosis/diagnosis ; Osteoporosis/epidemiology ; Turkey/epidemiology
    Chemical Substances Gout Suppressants ; Osteocalcin (104982-03-8) ; Allopurinol (63CZ7GJN5I)
    Language English
    Publishing date 2018-07-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 390201-8
    ISSN 2295-3337 ; 0001-5512 ; 1784-3286
    ISSN (online) 2295-3337
    ISSN 0001-5512 ; 1784-3286
    DOI 10.1080/17843286.2018.1495389
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  10. Article: A clinical threat in patients with granulomatosis polyangiitis in remission: Subglottic stenosis.

    Ugan, Yunus / Doğru, Atalay / Aynalı, Giray / Şahin, Mehmet / Tunç, Şevket Ercan

    European journal of rheumatology

    2017  Volume 5, Issue 1, Page(s) 69–71

    Abstract: Granulomatosis with polyangiitis (GPA) is a systemic necrotizing granulomatous disease that involves small- and medium-sized arteries and affects the main respiratory tracts and kidneys. Upper respiratory tract involvement usually occurs in 90% of ... ...

    Abstract Granulomatosis with polyangiitis (GPA) is a systemic necrotizing granulomatous disease that involves small- and medium-sized arteries and affects the main respiratory tracts and kidneys. Upper respiratory tract involvement usually occurs in 90% of patients, who most frequently present with symptoms of chronic sinusitis. Subglottic stenosis (SS) is a rare and severe complication that is usually observed in approximately 15% of patients. Here we present a case of SS in a patient with limited form of GPA during remission.
    Language English
    Publishing date 2017-04-11
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2873727-1
    ISSN 2148-4279 ; 2147-9720
    ISSN (online) 2148-4279
    ISSN 2147-9720
    DOI 10.5152/eurjrheum.2017.16025
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