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  1. Article ; Online: Enhancing the Signal-to-Noise of Diagnostic Fragment Ions of Unsaturated Glycerophospholipids via Precursor Exclusion Ultraviolet Photodissociation Mass Spectrometry (PEx-UVPD-MS).

    Shields, Samuel W J / Sanders, James D / Brodbelt, Jennifer S

    Analytical chemistry

    2022  Volume 94, Issue 32, Page(s) 11352–11359

    Abstract: Understanding and elucidating the diverse structures and functions of lipids has motivated the development of many innovative tandem mass spectrometry (MS/MS) strategies. Higher-energy activation methods, such as ultraviolet photodissociation (UVPD), ... ...

    Abstract Understanding and elucidating the diverse structures and functions of lipids has motivated the development of many innovative tandem mass spectrometry (MS/MS) strategies. Higher-energy activation methods, such as ultraviolet photodissociation (UVPD), generate unique fragment ions from glycerophospholipids that can be used to perform in-depth structural analysis and facilitate the deconvolution of isomeric lipid structures in complex samples. Although detailed characterization is central to the correlation of lipid structure to biological function, it is often impeded by the lack of sufficient instrument sensitivity for highly bioactive but low-abundance phospholipids. Here, we present precursor exclusion (PEx) UVPD, a simple yet powerful technique to enhance the signal-to-noise (S/N) of informative low-abundance fragment ions produced from UVPD of glycerophospholipids. Through the exclusion of the large population of undissociated precursor ions with an MS
    MeSH term(s) Animals ; Cattle ; Chromatography, Liquid/methods ; Glycerophospholipids/chemistry ; Ions ; Tandem Mass Spectrometry/methods ; Ultraviolet Rays
    Chemical Substances Glycerophospholipids ; Ions
    Language English
    Publishing date 2022-08-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.2c02128
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4033: Show issues Location:
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  2. Article ; Online: Disruption of CD47-SIRPα signaling restores inflammatory function in tumor-associated myeloid-derived suppressor cells.

    Zimarino, Carlo / Moody, William / Davidson, Sarah E / Munir, Hafsa / Shields, Jacqueline D

    iScience

    2024  Volume 27, Issue 4, Page(s) 109546

    Abstract: Myeloid-derived suppressor cells (MDSCs) are a heterogeneous immune population with diverse immunosuppressive functions in solid tumors. Here, we explored the role of the tumor microenvironment in regulating MDSC differentiation and immunosuppressive ... ...

    Abstract Myeloid-derived suppressor cells (MDSCs) are a heterogeneous immune population with diverse immunosuppressive functions in solid tumors. Here, we explored the role of the tumor microenvironment in regulating MDSC differentiation and immunosuppressive properties via signal-regulatory protein alpha (SIRPα)/CD47 signaling. In a murine melanoma model, we observed progressive increases in monocytic MDSCs and monocyte-derived dendritic cells that exhibited potent T cell-suppressive capabilities. These adaptations could be recapitulated
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2024.109546
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  3. Article: Plant-Mediated Behavioural Avoidance of a Weevil Towards Its Biological Control Agent.

    Shields, Morgan W / Wratten, Steve D / Phillips, Craig B / Van Koten, Chikako / Goldson, Stephen L

    Frontiers in plant science

    2022  Volume 13, Page(s) 923237

    Abstract: New Zealand pastures largely ... ...

    Abstract New Zealand pastures largely comprising
    Language English
    Publishing date 2022-06-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2022.923237
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  4. Article ; Online: Multiple

    Robinson, Kelly A / St-Jacques, Antony D / Shields, Sam W / Sproule, Amanda / Demissie, Zerihun A / Overy, David P / Loewen, Michele C

    Journal of fungi (Basel, Switzerland)

    2023  Volume 9, Issue 7

    Abstract: Mycotoxins, derived from toxigenic fungi such ... ...

    Abstract Mycotoxins, derived from toxigenic fungi such as
    Language English
    Publishing date 2023-07-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof9070723
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  5. Article ; Online: Bilateral circumscribed choroidal hemangiomas in 2 patients: a rare finding.

    DeSimone, Joseph D / Dockery, Philip W / Vempuluru, Vijitha S / Konstantinou, Eleni K / Singla, Konica / Lally, Sara E / Shields, Carol L

    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

    2023  

    Language English
    Publishing date 2023-11-23
    Publishing country England
    Document type Letter
    ZDB-ID 80091-0
    ISSN 1715-3360 ; 0008-4182
    ISSN (online) 1715-3360
    ISSN 0008-4182
    DOI 10.1016/j.jcjo.2023.11.001
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 588: Show issues Location:
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  6. Article ; Online: Assessing the potential of invertebrate natural enemies of insect pests inhabiting Miscanthus x giganteus shelterbelts in pasture

    Shields, Morgan W. / Wratten, Steve D. / Buckley, Hannah L. / Cairns, Sarah M. / Goldson, Stephen L.

    New Zealand Journal of Agricultural Research. 2023 May 04, v. 66, no. 3 p.259-269

    2023  

    Abstract: Miscanthus x giganteus (Miscanthus) grass shelterbelts can deliver multiple ecosystem services on New Zealand commercial dairy farms. However, there has been little investigation into how these shelterbelts contribute to insect pest management. Here, on ... ...

    Abstract Miscanthus x giganteus (Miscanthus) grass shelterbelts can deliver multiple ecosystem services on New Zealand commercial dairy farms. However, there has been little investigation into how these shelterbelts contribute to insect pest management. Here, on a Canterbury dairy farm, we investigated what generalist surface-dwelling invertebrate natural enemies of insect pests inhabit three separate Miscanthus shelterbelts compared to three unmanipulated field margin plots. The potential contribution of these natural enemy assemblages to future biological control was also investigated. To measure this, live moth egg baits with associated pitfall trapping were deployed in autumn, winter and spring of 2015. Miscanthus and the field margin plots were found to have similar potential natural enemy richness but differed in their community composition. The potential predation rate of pests in Miscanthus was 85% higher than in the field margin. Infrared video and Sanger sequencing confirmed that the harvestman Phalangium opilio and the slug Deroceras reticulatum consumed the egg baits in Miscanthus. Conversely, no bait-consuming invertebrates were identified in the field margin. These preliminary results indicate potential natural enemies inhabit Miscanthus and may consume insect pest eggs on the soil-surface. However, to achieve anyinsect pest suppression, further habitat manipulation would be required.
    Keywords Deroceras reticulatum ; Miscanthus ; Phalangium opilio ; agricultural research ; autumn ; biological control ; community structure ; dairy farming ; ecosystems ; edge effects ; eggs ; grasses ; habitats ; insect control ; insect pests ; moths ; natural enemies ; pastures ; predation ; shelterbelts ; slugs ; spring ; winter ; New Zealand ; ecosystem services ; habitat manipulation ; Miscanthus x giganteus ; natural enemy ; shelterbelt
    Language English
    Dates of publication 2023-0504
    Size p. 259-269.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 415628-6
    ISSN 1175-8775 ; 0028-8233
    ISSN (online) 1175-8775
    ISSN 0028-8233
    DOI 10.1080/00288233.2022.2057555
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    In stock of ZB MED Bonn / Germany

    Z 976: Show issues

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  7. Article: The conserved and high

    Filipiak, Michał / Shields, Morgan W / Cairns, Sarah M / Grainger, Megan N C / Wratten, Stephen D

    Frontiers in plant science

    2022  Volume 13, Page(s) 1042348

    Abstract: Sodium (Na) concentrations are low in plant tissues, and its metabolic function in plants is minor; however, Na is a key nutrient for plant consumers. Previous studies have thus far focused on Na concentration. Nevertheless, a balanced potassium (K) to ... ...

    Abstract Sodium (Na) concentrations are low in plant tissues, and its metabolic function in plants is minor; however, Na is a key nutrient for plant consumers. Previous studies have thus far focused on Na concentration. Nevertheless, a balanced potassium (K) to Na ratio (
    Language English
    Publishing date 2022-11-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2022.1042348
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  8. Article ; Online: Identification of novel HLA alleles discovered in 2022-2023.

    Gautreaux, Michael D / O'Shields, Elaine F / Netherton, Eric M / Brown, Sharlie B / Stewart, Jennie W / Weavil, Kimberly N / Soulé, Hannah L / Sapkota, Hayley N / Kiger, David F

    Human immunology

    2024  , Page(s) 110772

    Abstract: In this paper, we describe 10 novel HLA alleles discovered, submitted and officially named in the calendar years 2022 through the end of 2023. ...

    Abstract In this paper, we describe 10 novel HLA alleles discovered, submitted and officially named in the calendar years 2022 through the end of 2023.
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 801524-7
    ISSN 1879-1166 ; 0198-8859
    ISSN (online) 1879-1166
    ISSN 0198-8859
    DOI 10.1016/j.humimm.2024.110772
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1597: Show issues Location:
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  9. Article: Enhancing the Signal-to-Noise of Diagnostic Fragment Ions of Unsaturated Glycerophospholipids via Precursor Exclusion Ultraviolet Photodissociation Mass Spectrometry (PEx-UVPD-MS)

    Shields, Samuel W. J. / Sanders, James D. / Brodbelt, Jennifer S.

    Analytical chemistry. 2022 Aug. 02, v. 94, no. 32

    2022  

    Abstract: Understanding and elucidating the diverse structures and functions of lipids has motivated the development of many innovative tandem mass spectrometry (MS/MS) strategies. Higher-energy activation methods, such as ultraviolet photodissociation (UVPD), ... ...

    Abstract Understanding and elucidating the diverse structures and functions of lipids has motivated the development of many innovative tandem mass spectrometry (MS/MS) strategies. Higher-energy activation methods, such as ultraviolet photodissociation (UVPD), generate unique fragment ions from glycerophospholipids that can be used to perform in-depth structural analysis and facilitate the deconvolution of isomeric lipid structures in complex samples. Although detailed characterization is central to the correlation of lipid structure to biological function, it is often impeded by the lack of sufficient instrument sensitivity for highly bioactive but low-abundance phospholipids. Here, we present precursor exclusion (PEx) UVPD, a simple yet powerful technique to enhance the signal-to-noise (S/N) of informative low-abundance fragment ions produced from UVPD of glycerophospholipids. Through the exclusion of the large population of undissociated precursor ions with an MS³ strategy, the S/N of diagnostic fragment ions from PC 18:0/18:2(9Z, 12Z) increased up to an average of 13x for PEx-UVPD compared to UVPD alone. These enhancements were extended to complex mixtures of lipids from bovine liver extract to confidently identify 35 unique structures using liquid chromatography PEx-UVPD. This methodology has the potential to advance lipidomics research by offering deeper structure elucidation and confident identification of biologically active lipids.
    Keywords analytical chemistry ; cattle ; glycerophospholipids ; lipidomics ; liquid chromatography ; liver ; photolysis ; tandem mass spectrometry
    Language English
    Dates of publication 2022-0802
    Size p. 11352-11359.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.2c02128
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  10. Article ; Online: Conditional Metastasis of Uveal Melanoma in 8091 Patients over Half-Century (51 Years) by Age Group: Assessing the Entire Population and the Extremes of Age.

    Shields, Carol L / Samuelson, Annika G / Oh, Glenn J / DeSimone, Joseph D / Sajjadi, Zaynab L / Bas, Zeynep / Kalafatis, Nicholas E / Lally, Sara E / Shields, Jerry A / Dockery, Philip W

    Investigative ophthalmology & visual science

    2023  Volume 64, Issue 10, Page(s) 7

    Abstract: Purpose: To evaluate cumulative incidence of metastasis at specific timepoints after treatment of uveal melanoma in a large cohort of patients and to provide comparison of conditional outcomes in the youngest and oldest cohorts (extremes of age).: ... ...

    Abstract Purpose: To evaluate cumulative incidence of metastasis at specific timepoints after treatment of uveal melanoma in a large cohort of patients and to provide comparison of conditional outcomes in the youngest and oldest cohorts (extremes of age).
    Methods: Retrospective analysis of 8091 consecutive patients with uveal melanoma at a single center over a 51-year period. The patients were categorized by age at presentation (0-29 years [n = 348, 4%], 30-59 years [n = 3859, 48%], 60-79 years [n = 3425, 42%], 80 to 99 years [n = 459, 6%]) and evaluated for nonconditional (from presentation date) and conditional (from specific timepoints after presentation) cumulative incidence of metastasis at five, 10, 20, and 30 years.
    Results: For the entire population of 8091 patients, five-year/10-year/20-year/30-year nonconditional cumulative incidence of metastasis was 15%/23%/32%/36%, and the conditional incidence improved to 6%/15%/25%/30% for patients who did not develop metastasis in the first three years. For the extremes of age (0-29 years and 80-99 years), the nonconditional cumulative incidence of metastasis revealed the younger cohort with superior outcomes at 8%/15%/19%/27% and 21%/29%/29%/29%, respectively (P < 0.001). The conditional incidence (at one-year and two-year timepoints with metastasis-free survival) showed persistent superior younger cohort survival (P < 0.001, P = 0.001), but no further benefit for patients with three-year metastasis-free survival at 4%/12%/16%/24% and 7%/18%/18%/18%, respectively (P = 0.09).
    Conclusions: Non-conditional metastasis-free survival analysis for patients with uveal melanoma revealed the youngest cohort to have significantly better survival than the oldest cohort, and this persisted into one-year and two-year conditional metastasis-free survival but diminished at the three-year conditional timepoint.
    MeSH term(s) Humans ; Infant, Newborn ; Infant ; Child, Preschool ; Child ; Adolescent ; Young Adult ; Adult ; Retrospective Studies ; Uveal Neoplasms/pathology ; Melanoma/pathology ; Survival Analysis ; Survival Rate
    Language English
    Publishing date 2023-05-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391794-0
    ISSN 1552-5783 ; 0146-0404
    ISSN (online) 1552-5783
    ISSN 0146-0404
    DOI 10.1167/iovs.64.10.7
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    Zs.A 45: Show issues Location:
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