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Article ; Online: Integrated molecular docking, 3D QSAR and molecular dynamics simulation studies on indole derivatives for designing new Pim-1 inhibitors.

Peddi, Sudhir Reddy / Peddi, Saikiran Reddy / Sivan, Sreekanth / Veerati, Radhika / Manga, Vijjulatha

Journal of receptor and signal transduction research

2020 Volume 40, Issue 1, Page(s) 1–14

Abstract: ... The reliability of the models was established from conventional (r ...

Abstract	Pim-1 is one of the isoforms of pim proteins comprising pim-1, pim-2 and pim-3. It was basically recognized as proviral integration moloney murine leukemia virus which is associated with T-cell lymphomogenesis. Pim-1 is known to play a crucial role in cell cycle progression and acts as downstream target for the JAK/STAT signaling pathway. Recently it has emerged as a hopeful therapeutic target for cancer treatment as deregulation or over expression of pim causes hematologic cancers. In present article molecular docking based three dimensional quantitative structure and activity relationship and molecular dynamics simulation studies have been carried out on indole derivatives reported as pim-1 inhibitors. Initially docking was carried out to obtain the receptor specific orientation of the molecules and later to understand the structural requirements of pim-1 inhibitors robust 3 D QSAR models were built using CoMFA (comparative molecular field analysis) and CoMSIA (comparative molecular similarity indices analysis) methods. The reliability of the models was established from conventional (r
MeSH term(s)	Drug Design ; Hydrogen Bonding ; Hydrophobic and Hydrophilic Interactions ; Indoles/chemistry ; Indoles/pharmacology ; Inhibitory Concentration 50 ; Ligands ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins c-pim-1/antagonists & inhibitors ; Proto-Oncogene Proteins c-pim-1/metabolism ; Quantitative Structure-Activity Relationship ; Static Electricity
Chemical Substances	Indoles ; Ligands ; Protein Kinase Inhibitors ; Proto-Oncogene Proteins c-pim-1 (EC 2.7.11.1)
Language	English
Publishing date	2020-01-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1230969-2
ISSN	1532-4281 ; 1079-9893
ISSN (online)	1532-4281
ISSN	1079-9893
DOI	10.1080/10799893.2020.1713809
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Article ; Online: Secretome of Adipose-Derived Stem Cells Cultured in Platelet Lysate Improves Migration and Viability of Keratinocytes.

Hermann, Maike / Peddi, Ajay / Gerhards, Alexander / Schmid, Rafael / Schmitz, Deborah / Arkudas, Andreas / Weisbach, Volker / Horch, Raymund E / Kengelbach-Weigand, Annika

International journal of molecular sciences

2023 Volume 24, Issue 4

Abstract: Chronic wounds depict a silent epidemic challenging medical professionals worldwide. Regenerative medicine uses adipose-derived stem cells (ADSC) in promising new therapies. In this study, platelet lysate (PL) as a xenogen-free substitute for foetal ... ...

Abstract	Chronic wounds depict a silent epidemic challenging medical professionals worldwide. Regenerative medicine uses adipose-derived stem cells (ADSC) in promising new therapies. In this study, platelet lysate (PL) as a xenogen-free substitute for foetal bovine serum (FBS) in ADSC culture was used to create an ADSC secretome containing cytokines for optimal wound healing conditions. The ADSC secretome was tested on keratinocytes for migrational behaviour and viability. Therefore, human ADSC were characterized under FBS (10%) and PL (5% and 10%) substitution, regarding morphology, differentiation, viability, gene and protein expression. ADSC were then cultured in 5% PL and their secretome was used for stimulation of keratinocyte migration and viability. To enhance the effect, ADSC were treated with Epithelial Growth Factor (EGF, 100 ng/mL) and hypoxia (1% O₂). In both PL and FBS groups, ADSC expressed typical stem cell markers. PL induced a significantly higher increase in cell viability compared to FBS substitution. ADSC secretome contained various beneficial proteins which enhance the wound healing capacity of keratinocytes. This could be optimized treating ADSC with hypoxia and EGF. In conclusion, the study shows that ADSC cultivated in 5% PL can effectively support wound healing conditions and can be considered as a promising new therapy for individual treatment of chronic wound disorders.
MeSH term(s)	Humans ; Adipose Tissue/metabolism ; Cell Proliferation ; Epidermal Growth Factor/metabolism ; Hypoxia/metabolism ; Keratinocytes/metabolism ; Secretome/metabolism ; Stem Cells/metabolism ; Blood Platelets/metabolism ; Cell Extracts ; Cell Culture Techniques
Chemical Substances	Epidermal Growth Factor (62229-50-9) ; Cell Extracts
Language	English
Publishing date	2023-02-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24043522
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Article ; Online: Computational design, synthesis and evaluation of new sulphonamide derivatives targeting HIV-1 gp120.

Vangala, Radhika / Sivan, Sree Kanth / Peddi, Saikiran Reddy / Manga, Vijjulatha

Journal of computer-aided molecular design

2019 Volume 34, Issue 1, Page(s) 39–54

Abstract: Attachment of envelope glycoprotein gp120 to the host cell receptor CD4 is the first step during the human immunodeficiency virus-1 (HIV-1) entry into the host cells that makes it a promising target for drug design. To elucidate the crucial three ... ...

Abstract	Attachment of envelope glycoprotein gp120 to the host cell receptor CD4 is the first step during the human immunodeficiency virus-1 (HIV-1) entry into the host cells that makes it a promising target for drug design. To elucidate the crucial three dimensional (3D) structural features of reported HIV-1 gp120 CD4 binding inhibitors, 3D pharmacophores were generated and receptor based approach was employed to quantify these structural features. A four-partial least square factor model with good statistics and predictive ability was generated for the dataset of 100 molecules. To further ascertain the structural requirement for gp120-CD4 binding inhibition, molecular interaction studies of inhibitors with gp120 was carried out by performing molecular docking using Glide 5.6. Based on these studies, structural requirements were drawn and new molecules were designed accordingly to yield new sulphonamides derivatives. A water based green synthetic approach was adopted to obtain these compounds which were evaluated for their HIV-1 gp120 CD4 binding inhibition. The newly synthesized compounds exhibited remarkable activity (10-fold increase) when compared with the standard BMS 806. Further the stability of newly synthesized derivatives with HIV-1 gp120 was also investigated through molecular dynamics simulation studies. This provides a proof of concept for molecular modeling based design of new inhibitors for inhibition of HIV-1 gp120 CD4 interaction.
MeSH term(s)	Anti-HIV Agents/chemistry ; Anti-HIV Agents/pharmacology ; Drug Design ; HIV Envelope Protein gp120/antagonists & inhibitors ; HIV Envelope Protein gp120/chemistry ; HIV Envelope Protein gp120/metabolism ; HIV Infections/drug therapy ; HIV Infections/virology ; HIV-1/drug effects ; HIV-1/metabolism ; Humans ; Molecular Docking Simulation ; Sulfonamides/chemistry ; Sulfonamides/pharmacology
Chemical Substances	Anti-HIV Agents ; HIV Envelope Protein gp120 ; Sulfonamides
Language	English
Publishing date	2019-12-02
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	808166-9
ISSN	1573-4951 ; 0920-654X
ISSN (online)	1573-4951
ISSN	0920-654X
DOI	10.1007/s10822-019-00258-0
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Zs.A 2625: Show issues

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Article: Treatment of De Novo Renal Transplant Recipients With Calcineurin Inhibitor-free, Belatacept Plus Everolimus-based Immunosuppression.

Peddi, V Ram / Marder, Bradley / Gaite, Luis / Oberholzer, Jose / Goldberg, Ryan / Pearson, Thomas / Yang, Harold / Allamassey, Lisa / Polinsky, Martin / Formica, Richard N

Transplantation direct

2023 Volume 9, Issue 2, Page(s) e1419

Abstract: Compared with calcineurin inhibitor-based immunosuppression, belatacept (BELA)-based treatment has been associated with better renal function but higher acute rejection rates. This phase 2 study (NCT02137239) compared the antirejection efficacy of BELA ... ...

Abstract	Compared with calcineurin inhibitor-based immunosuppression, belatacept (BELA)-based treatment has been associated with better renal function but higher acute rejection rates. This phase 2 study (NCT02137239) compared the antirejection efficacy of BELA plus everolimus (EVL) with tacrolimus (TAC) plus mycophenolate mofetil (MMF), each following lymphocyte-depleting induction and rapid corticosteroid withdrawal. Methods: Patients who were de novo renal transplant recipients seropositive for Epstein-Barr virus were randomized to receive BELA+EVL or TAC+MMF maintenance therapy after rabbit antithymocyte globulin induction and up to 7 d of corticosteroids. The primary endpoint was the rate of biopsy-proven acute rejection at month 6. Results: Because of an unanticipated BELA supply constraint, enrollment was prematurely terminated at 68 patients, of whom 58 were randomized and transplanted (intention-to-treat [ITT] population: n = 26, BELA+EVL; n = 32, TAC+MMF). However, 25 patients received BELA+EVL' and 33 received TAC+MMF (modified ITT population). In the ITT population, the 6-mo biopsy-proven acute rejection rates were 7.7% versus 9.4% in the BELA+EVL versus TAC+MMF group. The corresponding 24-mo biopsy-proven acute rejection rates were 19.2% versus 12.5% in the ITT population and 16.0% versus 15.2% in the mITT population; all events were Banff severity grade ≤IIA and similar between groups. One patient in each group experienced graft loss unrelated to acute rejection. The 24-mo mean unadjusted estimated glomerular filtration rates were 71.8 versus 68.7 mL/min/1.73 m Conclusions: A steroid-free maintenance regimen of BELA+EVL may be associated with biopsy-proven acute rejection rates comparable to TAC+MMF.
Language	English
Publishing date	2023-01-06
Publishing country	United States
Document type	Journal Article
ISSN	2373-8731
ISSN	2373-8731
DOI	10.1097/TXD.0000000000001419
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Article ; Online: Tofacitinib use in ulcerative colitis: An expert consensus for day-to-day clinical practice.

Banerjee, Rupa / Sharma, Vishal / Patel, Rajendra / Jena, Anuraag / Pal, Partha / Raghunathan, Nalini / Kumar, Ajay / Sood, Ajit / Puri, Amarender S / Goswami, Bhabhadev / Desai, Devendra / Mekala, Dhanush / Ramesh, G N / Rao, G V / Peddi, Kiran / Philip, Mathew / Tandon, Manu / Bhatia, Shobna / Godbole, Shubhankar /

Bhatia, Sumit / Ghoshal, Uday C / Dutta, Usha / Midha, Vandana / Prasad, V G Mohan / Reddy, D Nageshwar

Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology

2024 Volume 43, Issue 1, Page(s) 22–35

Abstract: Rising number of inflammatory bowel disease (IBD) cases in developing countries necessitate clear guidance for clinicians for the appropriate use of advanced therapies. An expert consensus document was generated to guide the usage of tofacitinib, a Janus ...

Abstract	Rising number of inflammatory bowel disease (IBD) cases in developing countries necessitate clear guidance for clinicians for the appropriate use of advanced therapies. An expert consensus document was generated to guide the usage of tofacitinib, a Janus kinase inhibitor, in ulcerative colitis. Tofacitinib is a useful agent for the induction and maintenance of remission in ulcerative colitis. It can be used in the setting of biological failure or even steroid-dependent and thiopurine refractory disease. Typically, the induction dose is 10 mg BD orally. Usually, clinical response is evident within eight weeks of therapy. In those with clinical response, the dose can be reduced from 10 mg BD to 5 mg BD. Tofacitinib should be avoided or used cautiously in the elderly, patients with cardiovascular co-morbidity, uncontrolled cardiac risk factors, previous thrombotic episodes and those at high risk for venous thrombosis or previous malignancy. Baseline evaluation should include testing for and management of hepatitis B infection and latent tuberculosis. Where feasible, it is prudent to ensure complete adult vaccination, including Herpes zoster, before starting tofacitinib. The use of tofacitinib may be associated with an increased risk of infections such as herpes zoster and tuberculosis reactivation. Maternal exposure to tofacitinib should be avoided during pre-conception, pregnancy, and lactation. There is emerging evidence of tofacitinib in acute severe colitis, although the exact positioning (first-line with steroids or second-line) is uncertain.
MeSH term(s)	Adult ; Female ; Humans ; Aged ; Colitis, Ulcerative/drug therapy ; Consensus ; Piperidines/adverse effects ; Colitis ; Herpes Zoster/chemically induced ; Herpes Zoster/drug therapy ; Pyrimidines
Chemical Substances	tofacitinib (87LA6FU830) ; Piperidines ; Pyrimidines
Language	English
Publishing date	2024-02-12
Publishing country	India
Document type	Journal Article
ZDB-ID	632595-6
ISSN	0975-0711 ; 0254-8860
ISSN (online)	0975-0711
ISSN	0254-8860
DOI	10.1007/s12664-023-01507-9
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Zs.A 2085: Show issues

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Article: Advanced-Glycation End-Products Induce Podocyte Injury and Contribute to Proteinuria.

Nishad, Rajkishor / Tahaseen, Vazeeha / Kavvuri, Rajesh / Motrapu, Manga / Singh, Ashish K / Peddi, Kiranmayi / Pasupulati, Anil K

Frontiers in medicine

2021 Volume 8, Page(s) 685447

Abstract: The prevalence of diabetes reaches epidemic proportions. Diabetes is the leading cause of end-stage kidney disease (ESKD) since 30-40% of diabetic patients develop diabetic nephropathy. Albuminuria and glomerular filtration rate used to assess kidney ... ...

Abstract	The prevalence of diabetes reaches epidemic proportions. Diabetes is the leading cause of end-stage kidney disease (ESKD) since 30-40% of diabetic patients develop diabetic nephropathy. Albuminuria and glomerular filtration rate used to assess kidney function are considered surrogate outcomes of chronic kidney disease. The search for a biomarker that predicts progression to diabetic kidney disease is intense. We analyzed the association of serum advanced glycation end-products (AGEs) index (AGI) with impaired kidney function in poorly controlled type II diabetic patients. We observed an association between AGI and impaired kidney function in microalbuminuria patients with hyperglycemia. A significant association between AGEs, particularly carboxymethyl lysine (CML), and impaired kidney function were observed. Administration of AGEs to mice showed heavy proteinuria and glomerular abnormalities. Reduced podocyte number in mice administered with AGEs could be attributed to the epithelial-mesenchymal transition of podocytes. Our study suggests CML could be independently related to the podocyte injury and the risk of DN progression to ESKD in patients with microalbuminuria. AGEs in general or CML could be considered a prognostic marker to assess diabetic kidney disease.
Language	English
Publishing date	2021-07-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2021.685447
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Article ; Online: Computational studies on N-phenyl pyrrole derivatives as MmpL3 inhibitors in Mycobacterium tuberculosis.

Munnaluri, RamaKrishna / Reddy Peddi, Saikiran / Kanth Sivan, Sree / Manga, Vijjulatha

Computational biology and chemistry

2018 Volume 78, Page(s) 81–94

Abstract: The fight against tuberculosis (TB) is a time immemorial one and the emergence of new drug resistant strains of Mycobacterium tuberculosis keeps throwing new challenges to the scientific community immersed in finding mechanisms to control this dreaded ... ...

Abstract	The fight against tuberculosis (TB) is a time immemorial one and the emergence of new drug resistant strains of Mycobacterium tuberculosis keeps throwing new challenges to the scientific community immersed in finding mechanisms to control this dreaded disease. Computer aided drug designing (CADD) is one of the several approaches that can assist in identifying the potent actives against Mycobacterium. In this work, a series of 109 known Mycobacterial membrane proteins large 3 (MmpL3) inhibitors were pooled and atom based 3D QSAR analysis was performed to understand the structural features essential for inhibitory activity against the MmpL3, known to be a key player in transporting substances critical for cell wall integrity of Mycobacterium. The data set employed was randomly split into training set and test set molecules. The training set of 74 molecules was used to derive CoMFA and CoMSIA models that were statistically reliable (CoMFA: q
MeSH term(s)	Bacterial Proteins/antagonists & inhibitors ; Bacterial Proteins/metabolism ; Computer-Aided Design ; Membrane Transport Proteins/metabolism ; Microbial Sensitivity Tests ; Models, Molecular ; Molecular Structure ; Mycobacterium tuberculosis/drug effects ; Pyrroles/chemistry ; Pyrroles/pharmacology
Chemical Substances	Bacterial Proteins ; Membrane Transport Proteins ; MmpL3 protein, Mycobacterium tuberculosis ; Pyrroles
Language	English
Publishing date	2018-11-19
Publishing country	England
Document type	Journal Article
ISSN	1476-928X
ISSN (online)	1476-928X
DOI	10.1016/j.compbiolchem.2018.11.007
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Article ; Online: Association of Clinical Events With Everolimus Exposure in Kidney Transplant Patients Receiving Low Doses of Tacrolimus.

Shihab, F / Qazi, Y / Mulgaonkar, S / McCague, K / Patel, D / Peddi, V R / Shaffer, D

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

2017 Volume 17, Issue 9, Page(s) 2363–2371

Abstract: A key objective in the use of immunosuppression after kidney transplantation is to attain the optimal balance between efficacy and safety. In a phase 3b, multicenter, randomized, open-label, noninferiority study, the incidences of clinical events, renal ... ...

Abstract	A key objective in the use of immunosuppression after kidney transplantation is to attain the optimal balance between efficacy and safety. In a phase 3b, multicenter, randomized, open-label, noninferiority study, the incidences of clinical events, renal dysfunction, and adverse events (AEs) were analyzed at 12 months in 309 de novo renal transplant recipients receiving everolimus (EVR), low-dose tacrolimus (LTac), and prednisone. Cox proportional hazard regression modeling was used to estimate the probability of clinical events at specified combinations of time-normalized EVR and Tac trough concentrations. At 12 months, the highest incidence of treated biopsy-proven acute rejection (tBPAR) and graft loss occurred most often in patients with EVR trough concentration <3 ng/mL (64.7% and 10.5%, respectively). At 1 month and 12 months, increasing EVR levels were associated with fewer tBPAR events (both p < 0.0001). Low estimated glomerular filtration rate (eGFR) and decreased eGFR occurred more often in patients with lower EVR and higher Tac levels. AEs were most often observed in patients with EVR levels <3 ng/mL. This study supports maintaining an EVR trough concentration of 3-8 ng/mL, when combined with LTac, to achieve balanced efficacy and safety in renal transplant recipients. Trial registration: NCT01025817.
MeSH term(s)	Adolescent ; Adult ; Aged ; Everolimus/therapeutic use ; Female ; Follow-Up Studies ; Glomerular Filtration Rate ; Graft Rejection/drug therapy ; Graft Rejection/epidemiology ; Graft Survival/drug effects ; Humans ; Immunosuppressive Agents/therapeutic use ; Kidney Failure, Chronic/surgery ; Kidney Function Tests ; Kidney Transplantation ; Male ; Middle Aged ; Postoperative Complications ; Prognosis ; Risk Factors ; Tacrolimus/therapeutic use ; Transplant Recipients ; Young Adult
Chemical Substances	Immunosuppressive Agents ; Everolimus (9HW64Q8G6G) ; Tacrolimus (WM0HAQ4WNM)
Language	English
Publishing date	2017-03-04
Publishing country	United States
Document type	Clinical Trial, Phase III ; Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	2060594-8
ISSN	1600-6143 ; 1600-6135
ISSN (online)	1600-6143
ISSN	1600-6135
DOI	10.1111/ajt.14215
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Zs.A 5542: Show issues

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Article ; Online: One-pot synthesis, biological evaluation and molecular docking studies of fused thiazolo[2,3-b]pyrimidinone-pyrazolylcoumarin hybrids.

Gondru, Ramesh / Peddi, Saikiran Reddy / Manga, Vijjulatha / Khanapur, Manjulatha / Gali, Rajitha / Sirassu, Narsimha / Bavantula, Rajitha

Molecular diversity

2018 Volume 22, Issue 4, Page(s) 943–956

Abstract: As a part of our endeavor toward the synthesis of a new class of biologically potent heterocyclic hybrids, a series of newly fused thiazolo[2,3-b]pyrimidinones bearing a pyrazolylcoumarin moiety (6a-p) were synthesized in acceptable yields. Anticipated ... ...

Abstract	As a part of our endeavor toward the synthesis of a new class of biologically potent heterocyclic hybrids, a series of newly fused thiazolo[2,3-b]pyrimidinones bearing a pyrazolylcoumarin moiety (6a-p) were synthesized in acceptable yields. Anticipated structures of all titled compounds were in agreement with spectral and analytical (C, H and N) analyses. The compounds were screened for in vitro antibacterial activity against both G
MeSH term(s)	Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/metabolism ; Anti-Bacterial Agents/pharmacology ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Escherichia coli Proteins/antagonists & inhibitors ; Escherichia coli Proteins/chemistry ; Escherichia coli Proteins/metabolism ; Humans ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Protein Conformation ; Pyrimidinones/chemical synthesis ; Pyrimidinones/chemistry ; Pyrimidinones/metabolism ; Pyrimidinones/pharmacology ; Structure-Activity Relationship
Chemical Substances	Anti-Bacterial Agents ; Antineoplastic Agents ; Escherichia coli Proteins ; Pyrimidinones
Language	English
Publishing date	2018-07-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1376507-3
ISSN	1573-501X ; 1381-1991
ISSN (online)	1573-501X
ISSN	1381-1991
DOI	10.1007/s11030-018-9845-0
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Zs.A 4946: Show issues

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Article ; Online: Antimicrobial Efficacy of Lipopeptide Antibiotic, Lantibiotic and Cationic Bisbiguanide against Enterococcus faecalis Biofilm

Goliya Sneha / Uday Kumar Chowdary Birapu / Ravindar Puppala / Balaji Kethineni / Praveenkanth Reddy / Ravigna Peddi

Journal of Clinical and Diagnostic Research, Vol 13, Iss 6, Pp ZC32-ZC

An In-vitro Study

2019 Volume 35

Abstract: ... III: N1-Nisin at 25 mg, Group IV: N2-Nisin at 50 mg, Group V: CHX- 2% Chlorhexidine, Group VI: NaOCl ...

Abstract	Introduction: Cyclic lipopeptides, lantibiotics are newer antimicrobials showing promising efficacy against various grampositive micro-organisms. Daptomycin is a cyclic lipopeptide antibiotic with potent bactericidal activity against most grampositive organisms. Nisin is a naturally occurring antimicrobial peptide produced by strains of Lactococcus lactis. Aim: To compare the antimicrobial efficacy of cyclic lipopeptide antibiotics with beta-lactamase inhibitors (Daptomycin-Ceftaroline) at 40 µg and 80 µg, lantibiotics (Nisin) at 25 mg and 50 mg, bisbiguanide (2% Chlorhexidine) and 3% Sodium hypochlorite against E. faecalis biofilm when used as irrigating solutions. Materials and Methods: Forty-five primary teeth were decoronated, sectioned along the midsagittal plane and each half was used as a sample. E. faecalis, biofilm which was grown on the tooth surface for three weeks, was removed by vortexing and an emulsion was prepared by adding 1.5 mL of saline. The samples were distributed into six groups (n=15, each group), Group I: D1-Daptomycin mixed with ceftaroline at 80 µg, Group II: D2-Daptomycin mixed with ceftaroline at 40 µg, Group III: N1-Nisin at 25 mg, Group IV: N2-Nisin at 50 mg, Group V: CHX- 2% Chlorhexidine, Group VI: NaOCl -3% Sodium hypochlorite. The disks of medicaments were prepared and placed in the petri dishes and zone of inhibition was assessed. Data obtained were analysed by One-way Analysis of Variance test and Post-Hoc multiple comparisons test and paired t-test. Results: Intragroup comparison showed no statistical significance when the mean zone of inhibition was observed after two days and seven days in all the groups except for NaOCl group (p-value=0.023.) When intergroup comparison was done, D2 showed highest inhibition of bacteria followed by D1>N2>CHX>N1>NaOCl at 2nd day. At 7th day D2 had highest zone of inhibition followed by CHX>D1>N2>N1>NaOCl. Conclusion: Daptomycin mixed with ceftaroline at 80 µg showed better antibacterial effect than all the tested ...
Keywords	chlorhexidine ; canal disinfection ; daptomycin ; nisin ; primary teeth ; Medicine ; R
Subject code	630
Language	English
Publishing date	2019-06-01T00:00:00Z
Publisher	JCDR Research and Publications Private Limited
Document type	Article ; Online
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