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Article ; Online: Association of adiposity with morbidity in Finnish adults: A register-based follow-up study.

Mäki, Päivi / Harald, Kennet / Lindström, Jaana / Männistö, Satu / Laatikainen, Tiina

2023 , Page(s) 14034948221148053

Language	English
Publishing date	2023-03-14
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	1475054-5
ISSN	1651-1905 ; 1403-4948
ISSN (online)	1651-1905
ISSN	1403-4948
DOI	10.1177/14034948221148053
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Book ; Online: A systematic literature review of capstone courses in software engineering

Tenhunen, Saara / Männistö, Tomi / Luukkainen, Matti / Ihantola, Petri

2023

Abstract: Tertiary education institutions aim to prepare their computer science and software engineering students for working life. While much of the technical principles are covered in lower-level courses, team-based capstone projects are a common way to provide ... ...

Abstract	Tertiary education institutions aim to prepare their computer science and software engineering students for working life. While much of the technical principles are covered in lower-level courses, team-based capstone projects are a common way to provide students with hands-on experience and teach soft skills. This paper explores the characteristics of software engineering capstone courses presented in the literature. The goal of this work is to understand the pros and cons of different approaches by synthesising the various aspects of software engineering capstone courses and related experiences. In a systematic literature review for 2007-2022, we identified 127 primary studies. These studies were analysed based on their presented course characteristics and the reported course outcomes. The characteristics were synthesised into a taxonomy consisting of duration, team sizes, client and project sources, project implementation, and student assessment. We found out that capstone courses generally last one semester and divide students into groups of 4-5 where they work on a project for a client. For a slight majority of courses, the clients are external to the course staff and students are often expected to produce a proof-of-concept level software product as the main end deliverable. The courses also offer versatile assessments for students throughout the project. This paper provides researchers and educators with a classification of characteristics of software engineering capstone courses based on previous research. We further synthesise insights on the reported outcomes of capstone courses. Our review study aims to help educators to identify various ways of organising capstones and effectively plan and deliver their own capstone courses. The characterisation also helps researchers to conduct further studies on software engineering capstones.
Keywords	Computer Science - Software Engineering ; Computer Science - Computers and Society ; K.3.2 ; D.2
Subject code	028
Publishing date	2023-01-09
Publishing country	us
Document type	Book ; Online
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Article ; Online: Attribution of diabetes to the development of severe liver disease in the general population.

Vuorinen, Miika / Männistö, Ville T / Salomaa, Veikko / Britton, Annie / Jula, Antti / Männistö, Satu / Lundqvist, Annamari / Perola, Markus / Åberg, Fredrik

Liver international : official journal of the International Association for the Study of the Liver

2022 Volume 42, Issue 10, Page(s) 2186–2194

Abstract: ... in both the FINRISK (HR, 1.92; p < .001) and Whitehall II (HR, 2.37; p < .001) cohorts, and this remained significant ... increased the risk of liver-related outcomes in the FINRISK (HR, 1.43; p = .044) and Whitehall II (HR, 2.04 ... p = .051) cohorts.: Conclusion: Approximately 12%-14% of severe liver-related outcomes are ...

Abstract	Background and aims: Diabetes is associated with advanced liver disease and predicts mortality regardless of the primary aetiology of the liver disease. Even a family history of diabetes has been linked to advanced liver fibrosis in non-alcoholic fatty liver disease (NAFLD). However, the fraction of liver-related outcomes in the general population that are attributable to diabetes remains unclear. Methods: The population attributable fraction (PAF) of diabetes for liver disease as a time-dependent exposure was estimated in the Finnish FINRISK study (n = 28 787) and the British Whitehall II study (n = 7855). We also assessed the predictive ability of a family history of diabetes for liver-related outcomes. Incident diabetes data were from drug purchase/reimbursement and healthcare registries (FINRISK) or follow-up examinations (Whitehall II). Incident severe liver outcomes were identified through linkage with national healthcare registries. Results: Diabetes was associated with a two-fold risk of liver-related outcomes in both the FINRISK (HR, 1.92; p < .001) and Whitehall II (HR, 2.37; p < .001) cohorts, and this remained significant after adjusting for multiple confounders. PAF analyses demonstrated that diabetes explained 12-14% of the risk for severe liver-related outcomes after 10 and 20 years of follow-up. Also, maternal diabetes increased the risk of liver-related outcomes in the FINRISK (HR, 1.43; p = .044) and Whitehall II (HR, 2.04; p = .051) cohorts. Conclusion: Approximately 12%-14% of severe liver-related outcomes are attributable to diabetes at the population level. The association between maternal diabetes and liver disease might suggest a mitochondrial genetic mechanism.
MeSH term(s)	Diabetes Mellitus/epidemiology ; Humans ; Liver Cirrhosis ; Non-alcoholic Fatty Liver Disease/epidemiology ; Risk Factors
Language	English
Publishing date	2022-05-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2102783-3
ISSN	1478-3231 ; 1478-3223
ISSN (online)	1478-3231
ISSN	1478-3223
DOI	10.1111/liv.15296
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Book ; Online: Software startup within a university -- producing industry-ready graduates

Tenhunen, Saara / Männistö, Tomi / Ihantola, Petri / Kousa, Jami / Luukkainen, Matti

2023

Abstract: Previous research has demonstrated that preparing students for life in software engineering is not a trivial task. Authentic learning experiences are challenging to provide, and there are gaps between what students have done at the university and what ... ...

Abstract	Previous research has demonstrated that preparing students for life in software engineering is not a trivial task. Authentic learning experiences are challenging to provide, and there are gaps between what students have done at the university and what they are expected to master when getting into the industry after graduation. To address this challenge, we present a novel way of teaching industry-relevant skills in a university-led internal software startup called Software Development Academy (SDA). In addition to describing the SDA concept in detail, we have investigated what educational aspects characterise SDA and how it compares to capstone projects. The questions are answered based on 15 semi-structured interviews with alumni of SDA. Working with production-quality software and having a wide range of responsibilities were perceived as the most integral aspects of SDA and provided students with a comprehensive skill set for the future. Comment: Accepted for publication at the 45th IEEE/ACM International Conference on Software Engineering, Software Engineering Education and Training track (ICSE SEET 2023)
Keywords	Computer Science - Software Engineering ; K.3.2 ; D.2
Subject code	028
Publishing date	2023-01-17
Publishing country	us
Document type	Book ; Online
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Article ; Online: Effects of partial replacement of red and processed meat with non-soya legumes on bone and mineral metabolism and amino acid intakes in BeanMan randomised clinical trial.

Itkonen, Suvi T / Karhu, Piia / Pellinen, Tiina / Lehtovirta, Mikko / Kaartinen, Niina E / Männistö, Satu / Päivärinta, Essi / Pajari, Anne-Maria

The British journal of nutrition

2023 Volume 131, Issue 1, Page(s) 82–91

Abstract: The transition towards more plant-based diets may pose risks for bone health such as low vitamin D and Ca intakes. Findings for the contribution of animal and plant proteins and their amino acids (AA) to bone health are contradictory. This 6-week ... ...

Abstract	The transition towards more plant-based diets may pose risks for bone health such as low vitamin D and Ca intakes. Findings for the contribution of animal and plant proteins and their amino acids (AA) to bone health are contradictory. This 6-week clinical trial aimed to investigate whether partial replacement of red and processed meat (RPM) with non-soya legumes affects AA intakes and bone turnover and mineral metabolism in 102 healthy 20-65-year-old men. Participants were randomly assigned to diet groups controlled for RPM and legume intake (designed total protein intake (TPI) 18 E%): the meat group consumed 760 g RPM per week (25 % TPI) and the legume group consumed non-soya legume-based products (20 % TPI) and 200 g RPM per week, the upper limit of the Planetary Health Diet (5 % TPI). No differences in bone (bone-specific alkaline phosphatase; tartrate-resistant acid phosphatase 5b) or mineral metabolism (25-hydroxyvitamin D; parathyroid hormone; fibroblast growth factor 23; phosphate and Ca) markers or Ca and vitamin D intakes were observed between the groups (
MeSH term(s)	Male ; Animals ; Humans ; Young Adult ; Adult ; Middle Aged ; Aged ; Fabaceae ; Diet ; Meat ; Vegetables ; Vitamin D ; Amino Acids ; Minerals
Chemical Substances	Vitamin D (1406-16-2) ; Amino Acids ; Minerals
Language	English
Publishing date	2023-07-10
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	280396-3
ISSN	1475-2662 ; 0007-1145
ISSN (online)	1475-2662
ISSN	0007-1145
DOI	10.1017/S0007114523001514
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Article ; Online: Long-Term Outcome and Treatment in Persistent and Transient Congenital Hyperinsulinism: A Finnish Population-Based Study.

Männistö, Jonna M E / Jääskeläinen, Jarmo / Otonkoski, Timo / Huopio, Hanna

The Journal of clinical endocrinology and metabolism

2021 Volume 106, Issue 4, Page(s) e1542–e1551

Abstract: ... to 2015.: Patients: 106 patients with P-CHI and 132 patients with T-CHI (in total, 42 diagnosed ... n = 69) was 1:13 500 and of T-CHI (n = 127) 1:7400 live births. In the 21st century P-CHI group ... in the P-CHI and T-CHI groups. However, the 21st century P-CHI patients had significantly more frequent ...

Abstract	Context: The management of congenital hyperinsulinism (CHI) has improved. Objective: To examine the treatment and long-term outcome of Finnish patients with persistent and transient CHI (P-CHI and T-CHI). Design: A population-based retrospective study of CHI patients treated from 1972 to 2015. Patients: 106 patients with P-CHI and 132 patients with T-CHI (in total, 42 diagnosed before and 196 after year 2000) with median follow-up durations of 12.5 and 6.2 years, respectively. Main outcome measures: Recovery, diabetes, pancreatic exocrine dysfunction, neurodevelopment. Results: The overall incidence of CHI (n = 238) was 1:11 300 live births (1972-2015). From 2000 to 2015, the incidence of P-CHI (n = 69) was 1:13 500 and of T-CHI (n = 127) 1:7400 live births. In the 21st century P-CHI group, hyperinsulinemic medication was initiated and normoglycemia achieved faster relative to earlier. Of the 74 medically treated P-CHI patients, 68% had discontinued medication. Thirteen (12%) P-CHI patients had partial pancreatic resection and 19 (18%) underwent near-total pancreatectomy. Of these, 0% and 84% developed diabetes and 23% and 58% had clinical pancreatic exocrine dysfunction, respectively. Mild neurological difficulties (21% vs 16%, respectively) and intellectual disability (9% vs 5%, respectively) were as common in the P-CHI and T-CHI groups. However, the 21st century P-CHI patients had significantly more frequent normal neurodevelopment and significantly more infrequent diabetes and pancreatic exocrine dysfunction compared with those diagnosed earlier. Conclusions: Our results demonstrated improved treatment and long-term outcome in the 21st century P-CHI patients relative to earlier.
MeSH term(s)	Adolescent ; Adult ; Child ; Child, Preschool ; Congenital Hyperinsulinism/epidemiology ; Congenital Hyperinsulinism/therapy ; Female ; Finland ; Gestational Age ; Humans ; Infant ; Male ; Retrospective Studies ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2021-01-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgab024
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Article ; Online: Poor health status before the COVID-19 pandemic is associated with unfavourable changes in health-related lifestyle.

Jääskeläinen, Tuija / Sääksjärvi, Katri / Pietilä, Arto / Männistö, Satu / Kaartinen, Niina E / Lundqvist, Annamari / Koskinen, Seppo / Koponen, Päivikki

Scandinavian journal of public health

2023 Volume 51, Issue 5, Page(s) 792–796

MeSH term(s)	Adult ; Male ; Humans ; Female ; Pandemics ; Follow-Up Studies ; COVID-19/epidemiology ; Life Style ; Health Status
Language	English
Publishing date	2023-04-12
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	1475054-5
ISSN	1651-1905 ; 1403-4948
ISSN (online)	1651-1905
ISSN	1403-4948
DOI	10.1177/14034948231163960
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Article ; Online: Association between arterial hypertension and liver outcomes using polygenic risk scores: a population-based study.

Åberg, Fredrik / Kantojärvi, Katri / Männistö, Ville / But, Anna / Salomaa, Veikko / Niiranen, Teemu / Färkkilä, Martti / Luukkonen, Panu / Männistö, Satu / Lundqvist, Annamari / Perola, Markus / Jula, Antti

Scientific reports

2022 Volume 12, Issue 1, Page(s) 15581

Abstract: Arterial hypertension (HTA) is associated with liver disease, but causality remains unclear. We investigated whether genetic predisposition to HTA is associated with liver disease in the population, and if antihypertensive medication modifies this ... ...

Abstract	Arterial hypertension (HTA) is associated with liver disease, but causality remains unclear. We investigated whether genetic predisposition to HTA is associated with liver disease in the population, and if antihypertensive medication modifies this association. Participants of the Finnish health-examination surveys, FINRISK 1992-2012 and Health 2000 (n = 33,770), were linked with national electronic healthcare registers for liver-related outcomes (K70-K77, C22.0) and with the drug reimbursement registry for new initiation of antihypertensive medication during follow-up. Genetic predisposition to HTA was defined by polygenic risk scores (PRSs). During a median 12.9-year follow-up (409,268.9 person-years), 441 liver-related outcomes occurred. In the fully-adjusted Cox-regression models, both measured systolic blood pressure and clinically defined HTA were associated with liver-related outcomes. PRSs for systolic and diastolic blood pressure were significantly associated with liver-related outcomes (HR/SD 1.19, 95% CI 1.01-1.24, and 1.12, 95% CI 1.01-1.25, respectively). In the highest quintile of the systolic blood pressure PRS, new initiation of antihypertensive medication was associated with reduced rates of liver-related outcomes (HR 0.55, 95% CI 0.31-0.97). HTA and a genetic predisposition for HTA are associated with liver-related outcomes in the population. New initiation of antihypertensive medication attenuates this association in persons with high genetic risk for HTA.
MeSH term(s)	Antihypertensive Agents/therapeutic use ; Genetic Predisposition to Disease ; Humans ; Hypertension/drug therapy ; Hypertension/epidemiology ; Hypertension/genetics ; Liver ; Risk Factors
Chemical Substances	Antihypertensive Agents
Language	English
Publishing date	2022-09-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-20084-z
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Article ; Online: Joint effects of alcohol use, smoking and body mass index as an explanation for the alcohol harm paradox: causal mediation analysis of eight cohort studies.

Peña, Sebastián / Mäkelä, Pia / Laatikainen, Tiina / Härkänen, Tommi / Männistö, Satu / Heliövaara, Markku / Koskinen, Seppo

Addiction (Abingdon, England)

2021 Volume 116, Issue 8, Page(s) 2220–2230

Abstract: Background and aims: Lower socio-economic status (SES) is associated with higher alcohol-related harm despite lower levels of alcohol use. Differential vulnerability due to joint effects of behavioural risk factors is one potential explanation for this ' ...

Abstract	Background and aims: Lower socio-economic status (SES) is associated with higher alcohol-related harm despite lower levels of alcohol use. Differential vulnerability due to joint effects of behavioural risk factors is one potential explanation for this 'alcohol harm paradox'. We analysed to what extent socio-economic inequalities in alcohol-mortality are mediated by alcohol, smoking and body mass index (BMI), and their joint effects with each other and with SES. Design: Cohort study of eight health examination surveys (1978-2007) linked to mortality data. Setting: Finland. Participants: A total of 53 632 Finnish residents aged 25+ years. Measurements: The primary outcome was alcohol-attributable mortality. We used income as an indicator of SES. We assessed the joint effects between income and mediators (alcohol use, smoking and BMI) and between the mediators, adjusting for socio-demographic indicators. We used causal mediation analysis to calculate the total, direct, indirect and mediated interactive effects using Aalen's additive hazards models. Findings: During 1 085 839 person-years of follow-up, we identified 865 alcohol-attributable deaths. We found joint effects for income and alcohol use and income and smoking, resulting in 46.8 and 11.4 extra deaths due to the interaction per 10 000 person-years. No interactions were observed for income and BMI or between alcohol and other mediators. The lowest compared with the highest income quintile was associated with 5.5 additional alcohol deaths per 10 000 person-years (95% confidence interval = 3.7, 7.3) after adjusting for confounders. The proportion mediated by alcohol use was negative (-69.3%), consistent with the alcohol harm paradox. The proportion mediated by smoking and BMI and their additive interactions with income explained 18.1% of the total effect of income on alcohol-attributable mortality. Conclusions: People of lower socio-economic status appear to be more vulnerable to the effects of alcohol use and smoking on alcohol-attributable mortality. Behavioural risk factors and their joint effects with income may explain part of the alcohol harm paradox.
MeSH term(s)	Alcohol Drinking/epidemiology ; Body Mass Index ; Cohort Studies ; Humans ; Mediation Analysis ; Smoking ; Socioeconomic Factors
Language	English
Publishing date	2021-01-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1141051-6
ISSN	1360-0443 ; 0965-2140
ISSN (online)	1360-0443
ISSN	0965-2140
DOI	10.1111/add.15395
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Article ; Online: Association between social jet lag, quality of diet and obesity by diurnal preference in Finnish adult population.

Suikki, Tiina / Maukonen, Mirkka / Partonen, Timo / Jousilahti, Pekka / Kanerva, Noora / Männistö, Satu

Chronobiology international

2021 Volume 38, Issue 5, Page(s) 720–731

Abstract: The evening type has been associated with unhealthy behaviors and adverse health outcomes, such as unhealthy dietary habits and obesity. Misalignment between biological and social rhythms, referred to as social jet lag (SJL), has been considered to ... ...

Abstract	The evening type has been associated with unhealthy behaviors and adverse health outcomes, such as unhealthy dietary habits and obesity. Misalignment between biological and social rhythms, referred to as social jet lag (SJL), has been considered to explain these outcomes, because evening types are more prone to SJL. However, the existing evidence has been inconsistent and SJL by diurnal preference has hardly been examined. We examined the associations between SJL, the quality of the diet, and the prevalence of obesity by diurnal preference. This dataset included 6779 Finns (55% women, aged 25-74 years) from the National FINRISK 2012 and DILGOM 2014 studies. Diurnal preference was assessed with a shortened version of the Morningness-Eveningness Questionnaire (MEQ). SJL was calculated with the sleep-corrected formula (SJL
MeSH term(s)	Adult ; Circadian Rhythm ; Diet ; Female ; Finland ; Humans ; Jet Lag Syndrome ; Male ; Obesity ; Sleep ; Surveys and Questionnaires
Language	English
Publishing date	2021-02-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	998996-1
ISSN	1525-6073 ; 0742-0528
ISSN (online)	1525-6073
ISSN	0742-0528
DOI	10.1080/07420528.2021.1876721
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