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  1. Article ; Online: Demonstration of k-vector selective microscopy for nanoscale mapping of higher order spin wave modes.

    Träger, Nick / Gruszecki, Paweł / Lisiecki, Filip / Groß, Felix / Förster, Johannes / Weigand, Markus / Głowiński, Hubert / Kuświk, Piotr / Dubowik, Janusz / Krawczyk, Maciej / Gräfe, Joachim

    Nanoscale

    2020  Volume 12, Issue 33, Page(s) 17238–17244

    Abstract: ... resolution. Additionally, we demonstrate an approach for k-vector selective imaging to deconvolute ... transmission systems and demonstrate a general technique for k-specific microscopy that can also be used ...

    Abstract As a potential route towards beyond CMOS computing magnonic waveguides show outstanding properties regarding fundamental wave physics and data transmission. Here, we use time resolved scanning transmission X-ray microscopy to directly observe spin waves in magnonic permalloy waveguides with nanoscale resolution. Additionally, we demonstrate an approach for k-vector selective imaging to deconvolute overlapping modes in real space measurements. Thereby, we observe efficient excitation of symmetric and antisymmetric modes. The profiles of higher order modes that arise from sub-micron confinement are precisely mapped out and compared to analytical models. Thus, we lay a basis for the design of multimode spin wave transmission systems and demonstrate a general technique for k-specific microscopy that can also be used beyond the field of magnonics.
    Language English
    Publishing date 2020-06-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d0nr02132f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Thesis: Untersuchungen zur Bedeutung der Stickstoffmonoxid- und Eikosanoidsynthese im Endotoxinschock des Schweines für regionale Perfusion, Sauerstofftransport und Stoffwechsel im Hepatosplanchnikusgebiet

    Träger, Karl

    2001  

    Author's details vorgelegt von Karl Träger
    Language German ; English
    Size IV, 27, [77] Bl., Ill., graph. Darst., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Ulm, Univ., Habil.-Schr., 2001
    Note Enth. außerdem 9 Sonderabdr. aus verschiedenen Zeitschr. - Beitr. teilw. dt., teilw. engl.
    HBZ-ID HT013391985
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2002 E 2843 order to use in reading room Magazin

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  3. Book ; Thesis: Methodische Grundlagen und Einsatzmöglichkeiten der Stabile-Isotopen-Technik zur Quantifizierung von Organstoffwechselleistungen

    Träger, Karl

    Bestimmung der hepatischen Glucoseproduktionsrate und der Harnstoffproduktionsrate während der Infusion von Adrenalin unter Verwendung von 6,6-D 2 -Glucose und 15 N 2 -Harnstoff

    1992  

    Author's details vorgelegt von Karl Träger
    Size III Bl., 83 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Erlangen-Nürnberg, Univ., Diss., 1992
    HBZ-ID HT004454377
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    93 D 959 order for loan Magazin

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  4. Article ; Online: Protein-Rich Rafts in Hybrid Polymer/Lipid Giant Unilamellar Vesicles.

    Otrin, Nika / Otrin, Lado / Bednarz, Claudia / Träger, Toni K / Hamdi, Farzad / Kastritis, Panagiotis L / Ivanov, Ivan / Sundmacher, Kai

    Biomacromolecules

    2024  Volume 25, Issue 2, Page(s) 778–791

    Abstract: Considerable attention has been dedicated to lipid rafts due to their importance in numerous cell functions such as membrane trafficking, polarization, and signaling. Next to studies in living cells, artificial micrometer-sized vesicles with a minimal ... ...

    Abstract Considerable attention has been dedicated to lipid rafts due to their importance in numerous cell functions such as membrane trafficking, polarization, and signaling. Next to studies in living cells, artificial micrometer-sized vesicles with a minimal set of components are established as a major tool to understand the phase separation dynamics and their intimate interplay with membrane proteins. In parallel, mixtures of phospholipids and certain amphiphilic polymers simultaneously offer an interface for proteins and mimic this segregation behavior, presenting a tangible synthetic alternative for fundamental studies and bottom-up design of cellular mimics. However, the simultaneous insertion of complex and sensitive membrane proteins is experimentally challenging and thus far has been largely limited to natural lipids. Here, we present the co-reconstitution of the proton pump
    MeSH term(s) Unilamellar Liposomes ; Polymers ; Phospholipids ; Membrane Proteins ; Membrane Microdomains/metabolism ; Adenosine Triphosphate
    Chemical Substances Unilamellar Liposomes ; Polymers ; Phospholipids ; Membrane Proteins ; Adenosine Triphosphate (8L70Q75FXE)
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article
    ISSN 1526-4602
    ISSN (online) 1526-4602
    DOI 10.1021/acs.biomac.3c00972
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Intramolecular autoinhibition regulates the selectivity of PRPF40A tandem WW domains for proline-rich motifs.

    Martínez-Lumbreras, Santiago / Träger, Lena K / Mulorz, Miriam M / Payr, Marco / Dikaya, Varvara / Hipp, Clara / König, Julian / Sattler, Michael

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 3888

    Abstract: PRPF40A plays an important role in the regulation of pre-mRNA splicing by mediating protein-protein interactions in the early steps of spliceosome assembly. By binding to proteins at the 5´ and 3´ splice sites, PRPF40A promotes spliceosome assembly by ... ...

    Abstract PRPF40A plays an important role in the regulation of pre-mRNA splicing by mediating protein-protein interactions in the early steps of spliceosome assembly. By binding to proteins at the 5´ and 3´ splice sites, PRPF40A promotes spliceosome assembly by bridging the recognition of the splices. The PRPF40A WW domains are expected to recognize proline-rich sequences in SF1 and SF3A1 in the early spliceosome complexes E and A, respectively. Here, we combine NMR, SAXS and ITC to determine the structure of the PRPF40A tandem WW domains in solution and characterize the binding specificity and mechanism for proline-rich motifs recognition. Our structure of the PRPF40A WW tandem in complex with a high-affinity SF1 peptide reveals contributions of both WW domains, which also enables tryptophan sandwiching by two proline residues in the ligand. Unexpectedly, a proline-rich motif in the N-terminal region of PRPF40A mediates intramolecular interactions with the WW tandem. Using NMR, ITC, mutational analysis in vitro, and immunoprecipitation experiments in cells, we show that the intramolecular interaction acts as an autoinhibitory filter for proof-reading of high-affinity proline-rich motifs in bona fide PRPF40A binding partners. We propose that similar autoinhibitory mechanisms are present in most WW tandem-containing proteins to enhance binding selectivity and regulation of WW/proline-rich peptide interaction networks.
    MeSH term(s) Humans ; Amino Acid Motifs ; Models, Molecular ; Proline/metabolism ; Proline/chemistry ; Protein Binding ; RNA Splicing ; RNA Splicing Factors/metabolism ; RNA Splicing Factors/chemistry ; RNA Splicing Factors/genetics ; Scattering, Small Angle ; Spliceosomes/metabolism ; WW Domains ; X-Ray Diffraction
    Chemical Substances Proline (9DLQ4CIU6V) ; RNA Splicing Factors ; PRPF40A protein, human
    Language English
    Publishing date 2024-05-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-48004-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Part 1: Management of Antithrombotic Medications in Dermatologic Surgery.

    Trager, Megan H / Gordon, Emily R / Humphreys, Tatyana R / Samie, Faramarz H

    Journal of the American Academy of Dermatology

    2024  

    Abstract: ... Specifically, we focus on vitamin K antagonist (VKA) (warfarin), direct-acting oral anticoagulants (DOAC ...

    Abstract Perioperative management of antithrombotic agents requires practical and medical considerations. Discontinuing antithrombotic therapies increases the risk of thrombotic adverse events including cerebrovascular accidents, myocardial infarction, pulmonary embolism, deep vein thrombosis, and retinal artery occlusion. Conversely, continuation of antithrombotic therapy during surgical procedures has associated bleeding risks. Currently, no guidelines exist regarding management of antithrombotic agents in the perioperative period for cutaneous surgeries and practice differs by surgeon. Here, we review the data on antithrombotic medications in patients undergoing cutaneous surgery including medication-specific surgical and postoperative bleeding risk if the medications are continued, and thromboembolic risk if the medications are interrupted. Specifically, we focus on vitamin K antagonist (VKA) (warfarin), direct-acting oral anticoagulants (DOAC) (rivaroxaban, apixaban, edoxaban, dabigatran), antiplatelet medications (aspirin, clopidogrel, prasugrel, ticagrelor, dipyridamole), unfractionated heparin, low molecular weight heparin (enoxaparin and dalteparin), fondaparinux, bruton tyrosine kinase inhibitors (BTKi) (ibrutinib, acalabrutinib), and dietary supplements (i.e., garlic, ginger, gingko).
    Language English
    Publishing date 2024-05-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2024.01.096
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Conference proceedings: PenSor – explorativer Funktionstest eines Photoplethysmographie-Sensors zur Analyse der erektilen Funktion an gesunden Männern

    Träger, Max / von Bargen, M. / Somerlik-Fuchs, K. / Gratzke, C. / Schlager, D.

    2023  , Page(s) V11.7

    Event/congress 63. Jahrestagung der Südwestdeutschen Gesellschaft für Urologie e.V.; Reutlingen; Südwestdeutsche Gesellschaft für Urologie e.V.; 2023
    Keywords Medizin, Gesundheit
    Publishing date 2023-06-20
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23swdgu106
    Database German Medical Science

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  8. Article: Extracorporeal membrane oxygenation and cytokine adsorption.

    Datzmann, Thomas / Träger, Karl

    Journal of thoracic disease

    2018  Volume 10, Issue Suppl 5, Page(s) S653–S660

    Abstract: Extracorporeal membrane oxygenation (ECMO) is an increasingly used technology for mechanical support of respiratory and cardio-circulatory failure. Excessive systemic inflammatory response is observed during sepsis and after cardiopulmonary bypass (CPB) ... ...

    Abstract Extracorporeal membrane oxygenation (ECMO) is an increasingly used technology for mechanical support of respiratory and cardio-circulatory failure. Excessive systemic inflammatory response is observed during sepsis and after cardiopulmonary bypass (CPB) with similar clinical features. The overwhelming inflammatory response is characterized by highly elevated pro- and anti-inflammatory cytokine levels. The excessive cytokine release during the overwhelming inflammatory response may result in multiple organ damage and failure. During ECMO therapy activation of complement and contact systems occur which may be followed by cytokine release. Controlling excessively increased cytokines may be considered as a valuable treatment option. Hemoadsorption therapy may be used to decrease cytokine levels in case of excessive inflammatory response and due to its unspecific adsorptive characteristics also substances like myoglobin, free hemoglobin or bilirubin. Controlling pro-inflammatory response with hemoadsorption may have positive impact on the endothelial glycocalix and also may be advantageous for maintenance of the vascular barrier function which plays a pivotal role in the development of tissue edema and oxygen mismatch. Hemoadsorption therapy seems to offer a promising new option for the treatment of patients with overwhelming inflammatory response leading to faster hemodynamic and metabolic stabilization finally resulting in preserved organ functions.
    Language English
    Publishing date 2018-04-26
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd.2017.10.128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: What about prognostic outcome parameters in patients with acute respiratory distress syndrome (ARDS) treated with veno-venous extracorporeal membrane oxygenation (VV-ECMO)?

    Datzmann, Thomas / Träger, Karl

    Journal of thoracic disease

    2018  Volume 10, Issue Suppl 17, Page(s) S2057–S2061

    Language English
    Publishing date 2018-07-12
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd.2018.05.172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Sacral Giant Cell Tumor Presenting as Low Back Pain in the Chiropractic Office: A Case Report.

    Chu, Eric C / Trager, Robert J / Shum, John S / Ng, Kenny K

    Cureus

    2023  Volume 15, Issue 1, Page(s) e33262

    Abstract: Sacral giant cell tumors are a rare cause of low back pain and may be challenging to identify via routine clinical examination and radiography. A 47-year-old woman presented to a chiropractor with a one-month history of worsening low back pain with ... ...

    Abstract Sacral giant cell tumors are a rare cause of low back pain and may be challenging to identify via routine clinical examination and radiography. A 47-year-old woman presented to a chiropractor with a one-month history of worsening low back pain with radiation to the posterior thighs, worsened with ambulation, and used a cane to walk. She previously saw an orthopedic surgeon and was diagnosed with lumbar spondylosis, having tried anti-inflammatory medications, exercises, and acupuncture without success. The chiropractor ordered lumbar magnetic resonance imaging which revealed an aggressive sacral lesion and referred the patient to an oncologist. The oncologist performed positron emission tomography/computed tomography and biopsy, confirming a sacral giant cell tumor. A surgical team recommended tumor resection, lumbosacral fusion, radiotherapy, and zoledronic acid infusion. Sacral giant cell tumors are rare and may be challenging to identify via routine radiography. These tumors are an important differential to consider for patients with unexplained lumbosacral symptoms unresponsive to care.
    Language English
    Publishing date 2023-01-02
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.33262
    Database MEDical Literature Analysis and Retrieval System OnLINE

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