LIVIVO - Search results -

Search results

Result 1 - 10 of total 30

Search options

Article: City Avoidance in the Early Phase of Psychosis: A Neglected Domain of Assessment and a Potential Target for Recovery Strategies.

Conus, Philippe / Abrahamyan Empson, Lilith / Codeluppi, Zoé / Baumann, Philipp Sebastien / Söderström, Ola / Söderström, Dag / Golay, Philippe

Frontiers in psychiatry

2019 Volume 10, Page(s) 342

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2019-06-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2019.00342
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Cathepsins and their involvement in immune responses.

Conus, Sébastien / Simon, Hans-Uwe

Swiss medical weekly

2010 Volume 140, Page(s) w13042

Abstract: The immune system is composed of an enormous variety of cells and molecules that generate a collective and coordinated response on exposure to foreign antigens, called the immune response. Within the immune response, endo-lysosomal proteases play a key ... ...

Abstract	The immune system is composed of an enormous variety of cells and molecules that generate a collective and coordinated response on exposure to foreign antigens, called the immune response. Within the immune response, endo-lysosomal proteases play a key role. In this review we cover specific roles of cathepsins in innate and adaptive immunity, as well as their implication in the pathogenesis of several diseases.
MeSH term(s)	Adaptive Immunity/immunology ; Alzheimer Disease/immunology ; Animals ; Antigen-Presenting Cells/immunology ; Apoptosis/immunology ; Arthritis, Rheumatoid/immunology ; Asthma/immunology ; Atherosclerosis/immunology ; Cathepsins/physiology ; Cytokines/physiology ; Granzymes/physiology ; Humans ; Immunity, Cellular/immunology ; Immunity, Innate/immunology ; Immunocompetence/immunology ; Inflammation/immunology ; Lysosomes/immunology ; Mice ; Neoplasms/immunology ; Osteoarthritis/immunology ; Peptide Hydrolases/physiology
Chemical Substances	Cytokines ; Cathepsins (EC 3.4.-) ; Peptide Hydrolases (EC 3.4.-) ; Granzymes (EC 3.4.21.-)
Language	English
Publishing date	2010
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2036179-8
ISSN	1424-3997 ; 1424-7860
ISSN (online)	1424-3997
ISSN	1424-7860
DOI	10.4414/smw.2010.13042
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.152: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: General laboratory diagnostics of eosinophilic GI diseases.

Conus, Sébastien / Simon, Hans-Uwe

Best practice & research. Clinical gastroenterology

2008 Volume 22, Issue 3, Page(s) 441–453

Abstract: Eosinophils and gastrointestinal tract interact in an intimate and enigmatic relationship. Under inflammatory conditions, eosinophil infiltration in the gastrointestinal tract is a common feature of numerous eosinophilic gastrointestinal disorders (EGIDs) ...

Abstract	Eosinophils and gastrointestinal tract interact in an intimate and enigmatic relationship. Under inflammatory conditions, eosinophil infiltration in the gastrointestinal tract is a common feature of numerous eosinophilic gastrointestinal disorders (EGIDs). EGIDs are disorders, for which the diagnosis is relatively difficult. Nevertheless, some common laboratory techniques are currently used for their diagnosis and disease monitoring. Besides eosinophils, mast cells and T cells have also been suggested to play a role in the pathogenesis of these disorders. Here, we review the pathogenesis and common laboratory approaches applied for their diagnosis, in particular eosinophil and mast cell markers.
MeSH term(s)	Clinical Laboratory Techniques ; Eosinophilia/diagnosis ; Eosinophilia/etiology ; Eosinophilia/metabolism ; Gastrointestinal Diseases/diagnosis ; Gastrointestinal Diseases/etiology ; Gastrointestinal Diseases/metabolism ; Humans
Language	English
Publishing date	2008
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2048181-0
ISSN	1521-6918
ISSN	1521-6918
DOI	10.1016/j.bpg.2007.09.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Se 1098: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Cathepsins: key modulators of cell death and inflammatory responses.

Conus, Sébastien / Simon, Hans-Uwe

Biochemical pharmacology

2008 Volume 76, Issue 11, Page(s) 1374–1382

Abstract: Apoptosis is a key mechanism in the build up and maintenance of both innate and adaptive immunity as well as in the regulation of cellular homeostasis in almost every organ and tissue. Central to the apoptotic process is a family of intracellular ... ...

Abstract	Apoptosis is a key mechanism in the build up and maintenance of both innate and adaptive immunity as well as in the regulation of cellular homeostasis in almost every organ and tissue. Central to the apoptotic process is a family of intracellular cysteine proteases with aspartate-specificity, called caspases. Nevertheless, there is growing evidence that other non-caspase proteases, in particular lysosomal cathepsins, can play an important role in the regulation of apoptosis. In this review, the players and the molecular mechanisms involved in the lysosomal apoptotic pathways will be discussed as well as the importance of these pathways in the immune system and the pathogenesis of diseases.
MeSH term(s)	Animals ; Cathepsins/physiology ; Cell Death/physiology ; Humans ; Immune System/physiology ; Inflammation/physiopathology ; Mice
Chemical Substances	Cathepsins (EC 3.4.-)
Language	English
Publishing date	2008-12-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	208787-x
ISSN	1873-2968 ; 0006-2952
ISSN (online)	1873-2968
ISSN	0006-2952
DOI	10.1016/j.bcp.2008.07.041
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 19: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Living and dying for inflammation: neutrophils, eosinophils, basophils.

Geering, Barbara / Stoeckle, Christina / Conus, Sébastien / Simon, Hans-Uwe

Trends in immunology

2013 Volume 34, Issue 8, Page(s) 398–409

Abstract: Neutrophils, eosinophils, and basophils play essential roles during microbe-induced and sterile inflammation. The severity of such inflammatory processes is controlled, at least in part, by factors that regulate cell death and survival of granulocytes. ... ...

Abstract	Neutrophils, eosinophils, and basophils play essential roles during microbe-induced and sterile inflammation. The severity of such inflammatory processes is controlled, at least in part, by factors that regulate cell death and survival of granulocytes. In recent years, major progress has been made in understanding the molecular mechanisms of granulocyte cell death and in identifying novel damage- and pathogen-associated molecular patterns as well as regulatory cytokines impacting granulocyte viability. Furthermore, an increased interest in innate immunity has boosted our overall understanding of granulocyte biology. In this review, we describe and compare factors and mechanisms regulating neutrophil, eosinophil, and basophil lifespan. Because dysregulation of death pathways in granulocytes can contribute to inflammation-associated immunopathology, targeting granulocyte lifespan could be therapeutically promising.
MeSH term(s)	Animals ; Basophils/cytology ; Basophils/immunology ; Cell Death/immunology ; Eosinophils/cytology ; Eosinophils/immunology ; Humans ; Inflammation/immunology ; Neutrophils/cytology ; Neutrophils/immunology
Language	English
Publishing date	2013-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2036831-8
ISSN	1471-4981 ; 1471-4906
ISSN (online)	1471-4981
ISSN	1471-4906
DOI	10.1016/j.it.2013.04.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1601: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 2: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Cathepsins and their involvement in immune responses

Conus, Sébastien / Simon, Hans-Uwe

Swiss medical weekly

2010 Volume 140, Issue July, Page(s) 4

Language	English
Document type	Article
ZDB-ID	2036179-8
ISSN	1424-7860
Database	Current Contents Medicine

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.152: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Anti-IL-5 (mepolizumab) therapy does not alter IL-5 receptor alpha levels in patients with eosinophilic esophagitis.

Conus, Sébastien / Straumann, Alex / Simon, Hans-Uwe

The Journal of allergy and clinical immunology

2009 Volume 123, Issue 1, Page(s) 269; author reply 269–70

MeSH term(s)	Adolescent ; Adult ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized ; Cytokines/biosynthesis ; Enzyme-Linked Immunosorbent Assay ; Eosinophilia/blood ; Eosinophilia/drug therapy ; Eosinophils/drug effects ; Female ; Flow Cytometry ; Fluorescent Antibody Technique ; Humans ; Interleukin-5/antagonists & inhibitors ; Interleukin-5/blood ; Male ; Middle Aged ; Receptors, Interleukin-5/blood ; Receptors, Interleukin-5/drug effects ; T-Lymphocyte Subsets/drug effects ; T-Lymphocytes/drug effects
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Cytokines ; Interleukin-5 ; Receptors, Interleukin-5 ; mepolizumab (90Z2UF0E52)
Language	English
Publishing date	2009-01
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	121011-7
ISSN	1097-6825 ; 1085-8725 ; 0091-6749
ISSN (online)	1097-6825 ; 1085-8725
ISSN	0091-6749
DOI	10.1016/j.jaci.2008.09.031
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uh III Zs.92: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Mepolizumab does not alter levels of eosinophils, T cells, and mast cells in the duodenal mucosa in eosinophilic esophagitis.

Conus, Sébastien / Straumann, Alex / Bettler, Eva / Simon, Hans-Uwe

The Journal of allergy and clinical immunology

2010 Volume 126, Issue 1, Page(s) 175–177

MeSH term(s)	Adult ; Antibodies, Monoclonal/pharmacology ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized ; Duodenum/pathology ; Eosinophilia/drug therapy ; Eosinophilia/immunology ; Eosinophils/drug effects ; Esophagitis/drug therapy ; Esophagitis/immunology ; Female ; Humans ; Interleukin-5/antagonists & inhibitors ; Intestinal Mucosa/pathology ; Male ; Mast Cells/drug effects ; T-Lymphocytes/drug effects
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Interleukin-5 ; mepolizumab (90Z2UF0E52)
Language	English
Publishing date	2010-07
Publishing country	United States
Document type	Letter ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	121011-7
ISSN	1097-6825 ; 1085-8725 ; 0091-6749
ISSN (online)	1097-6825 ; 1085-8725
ISSN	0091-6749
DOI	10.1016/j.jaci.2010.04.029
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uh III Zs.92: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Cathepsin D primes caspase-8 activation by multiple intra-chain proteolysis.

Conus, Sébastien / Pop, Cristina / Snipas, Scott J / Salvesen, Guy S / Simon, Hans-Uwe

The Journal of biological chemistry

2012 Volume 287, Issue 25, Page(s) 21142–21151

Abstract: During the resolution of inflammatory responses, neutrophils rapidly undergo apoptosis. A direct and fast activation of caspase-8 by cathepsin D was shown to be crucial in the initial steps of neutrophil apoptosis. Nevertheless, the activation mechanism ... ...

Abstract	During the resolution of inflammatory responses, neutrophils rapidly undergo apoptosis. A direct and fast activation of caspase-8 by cathepsin D was shown to be crucial in the initial steps of neutrophil apoptosis. Nevertheless, the activation mechanism of caspase-8 remains unclear. Here, by using site-specific mutants of caspase-8, we show that both cathepsin D-mediated proteolysis and homodimerization of caspase-8 are necessary to generate an active caspase-8. At acidic pH, cathepsin D specifically cleaved caspase-8 but not the initiator caspase-9 or -10 and significantly increased caspase-8 activity in dimerizing conditions. These events were completely abolished by pepstatin A, a pharmacological inhibitor of cathepsin D. The cathepsin D intra-chain proteolysis greatly stabilized the active site of caspase-8. Moreover, the main caspase-8 fragment generated by cathepsin D cleavage could be affinity-labeled with the active site probe biotin-VAD-fluoromethyl ketone, suggesting that this fragment is enzymatically active. Importantly, in an in vitro cell-free assay, the addition of recombinant human caspase-8 protein, pre-cleaved by cathepsin D, was followed by caspase-3 activation. Our data therefore indicate that cathepsin D is able to initiate the caspase cascade by direct activation of caspase-8. As cathepsin D is ubiquitously expressed, this may represent a general mechanism to induce apoptosis in a variety of immune and nonimmune cells.
MeSH term(s)	Apoptosis/physiology ; Caspase 10/chemistry ; Caspase 10/genetics ; Caspase 10/metabolism ; Caspase 8/chemistry ; Caspase 8/genetics ; Caspase 8/metabolism ; Caspase 9/chemistry ; Caspase 9/genetics ; Caspase 9/metabolism ; Cathepsin D/chemistry ; Cathepsin D/genetics ; Cathepsin D/metabolism ; Enzyme Activation/physiology ; Female ; Humans ; Male ; Neutrophils/cytology ; Neutrophils/enzymology ; Protein Multimerization/physiology ; Proteolysis ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism
Chemical Substances	Recombinant Proteins ; CASP8 protein, human (EC 3.4.22.-) ; CASP9 protein, human (EC 3.4.22.-) ; Caspase 10 (EC 3.4.22.-) ; Caspase 8 (EC 3.4.22.-) ; Caspase 9 (EC 3.4.22.-) ; CASP10 protein, human (EC 3.4.22.63) ; CTSD protein, human (EC 3.4.23.5) ; Cathepsin D (EC 3.4.23.5)
Language	English
Publishing date	2012-04-23
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.M111.306399
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uc I Zs.108: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Inflammation-associated autophagy-related programmed necrotic death of human neutrophils characterized by organelle fusion events.

Mihalache, Cristina C / Yousefi, Shida / Conus, Sébastien / Villiger, Peter M / Schneider, E Marion / Simon, Hans-Uwe

Journal of immunology (Baltimore, Md. : 1950)

2011 Volume 186, Issue 11, Page(s) 6532–6542

Abstract: The most common form of neutrophil death, under both physiological and inflammatory conditions, is apoptosis. In this study, we report a novel form of programmed necrotic cell death, associated with cytoplasmic organelle fusion events, that occurs in ... ...

Abstract	The most common form of neutrophil death, under both physiological and inflammatory conditions, is apoptosis. In this study, we report a novel form of programmed necrotic cell death, associated with cytoplasmic organelle fusion events, that occurs in neutrophils exposed to GM-CSF and other inflammatory cytokines upon ligation of CD44. Strikingly, this type of neutrophil death requires PI3K activation, a signaling event usually involved in cellular survival pathways. In the death pathway reported in this study, PI3K is required for the generation of reactive oxygen species, which somehow trigger the generation of large cytoplasmic vacuoles, generated by the fusion of CD44-containing endosomes with autophagosomes and secondary, but not primary, granules. Neutrophils demonstrating vacuolization undergo rapid cell death that depends on receptor-interacting protein 1 kinase activity and papain family protease(s), but not caspases, that are most likely activated and released, respectively, during or as a consequence of organelle fusion. Vacuolized neutrophils are present in infectious and autoimmune diseases under in vivo conditions. Moreover, isolated neutrophils from such patients are highly sensitive toward CD44-mediated PI3K activation, reactive oxygen species production, and cell death, suggesting that the newly described autophagy-related form of programmed neutrophil necrosis plays an important role in inflammatory responses.
MeSH term(s)	Autophagy/drug effects ; Autophagy/immunology ; Cell Survival/immunology ; Cells, Cultured ; Cytokines/pharmacology ; Endosomes/immunology ; Endosomes/metabolism ; Endosomes/ultrastructure ; Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology ; Humans ; Hyaluronan Receptors/immunology ; Hyaluronan Receptors/metabolism ; Immunoblotting ; Inflammation/immunology ; Inflammation/metabolism ; Microscopy, Confocal ; Microscopy, Electron ; NADPH Oxidases/immunology ; NADPH Oxidases/metabolism ; Necrosis/immunology ; Neutrophils/drug effects ; Neutrophils/immunology ; Neutrophils/metabolism ; Organelles/immunology ; Organelles/metabolism ; Organelles/ultrastructure ; Papain/immunology ; Papain/metabolism ; Phagosomes/immunology ; Phagosomes/metabolism ; Phagosomes/ultrastructure ; Phosphatidylinositol 3-Kinases/immunology ; Phosphatidylinositol 3-Kinases/metabolism ; Reactive Oxygen Species/immunology ; Reactive Oxygen Species/metabolism ; Time Factors ; Vacuoles/immunology ; Vacuoles/metabolism ; Vacuoles/ultrastructure
Chemical Substances	Cytokines ; Hyaluronan Receptors ; Reactive Oxygen Species ; Granulocyte-Macrophage Colony-Stimulating Factor (83869-56-1) ; NADPH Oxidases (EC 1.6.3.-) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Papain (EC 3.4.22.2)
Language	English
Publishing date	2011-06-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.1004055
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ud II Zs.37: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 28: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito