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Article ; Online: Functional Effects of Receptor-Binding Domain Mutations of SARS-CoV-2 B.1.351 and P.1 Variants.

Bayarri-Olmos, Rafael / Jarlhelt, Ida / Johnsen, Laust Bruun / Hansen, Cecilie Bo / Helgstrand, Charlotte / Rose Bjelke, Jais / Matthiesen, Finn / Nielsen, Susanne Dam / Iversen, Kasper Karmark / Ostrowski, Sisse Rye / Bundgaard, Henning / Frikke-Schmidt, Ruth / Garred, Peter / Skjoedt, Mikkel-Ole

Frontiers in immunology

2021 Volume 12, Page(s) 757197

Abstract: The recent identification and rise to dominance of the P.1 and B.1.351 SARS-CoV-2 variants have ... immune evasive consequences of the P.1 and B.1.351 RBD mutations. E484K and N501Y result in gain-of-function ... the two different 417 substitutions severely impair the RBD/ACE-2 affinity, but in the combined P.1 and B ...

Abstract	The recent identification and rise to dominance of the P.1 and B.1.351 SARS-CoV-2 variants have brought international concern because they may confer fitness advantages. The same three positions in the receptor-binding domain (RBD) are affected in both variants, but where the 417 substitution differs, the E484K/N501Y have co-evolved by convergent evolution. Here we characterize the functional and immune evasive consequences of the P.1 and B.1.351 RBD mutations. E484K and N501Y result in gain-of-function with two different outcomes: The N501Y confers a ten-fold affinity increase towards ACE-2, but a modest antibody evasion potential of plasma from convalescent or vaccinated individuals, whereas the E484K displays a significant antibody evasion capacity without a major impact on affinity. On the other hand, the two different 417 substitutions severely impair the RBD/ACE-2 affinity, but in the combined P.1 and B.1.351 RBD variants, this effect is partly counterbalanced by the effect of the E484K and N501Y. Our results suggest that the combination of these three mutations is a two-step forward and one step back in terms of viral fitness.
MeSH term(s)	Adult ; Amino Acid Substitution ; Angiotensin-Converting Enzyme 2/immunology ; Antibodies, Viral/immunology ; BNT162 Vaccine ; COVID-19 Vaccines/administration & dosage ; COVID-19 Vaccines/immunology ; Female ; Humans ; Male ; Mutation, Missense ; Protein Domains ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/immunology ; Vaccination
Chemical Substances	Antibodies, Viral ; COVID-19 Vaccines ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; BNT162 Vaccine (N38TVC63NU)
Language	English
Publishing date	2021-10-07
Publishing country	Switzerland
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.757197
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Three pauses and three P waves: what is the mechanism?

Wright, Matthew / Knecht, Sébastien / Matsuo, Seiichiro / Lim, Kang-Teng / Hocini, Mélèze / Jaïs, Pierre / Haïssaguerre, Michel

Journal of cardiovascular electrophysiology

2008 Volume 19, Issue 5, Page(s) 562–564

MeSH term(s)	Atrial Fibrillation/complications ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/surgery ; Atrial Flutter/complications ; Atrial Flutter/diagnosis ; Atrial Flutter/surgery ; Diagnosis, Differential ; Electrocardiography/methods ; Humans ; Male ; Middle Aged
Language	English
Publishing date	2008-05
Publishing country	United States
Document type	Case Reports ; Clinical Conference ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1025989-2
ISSN	1540-8167 ; 1045-3873
ISSN (online)	1540-8167
ISSN	1045-3873
DOI	10.1111/j.1540-8167.2007.01090.x
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Zs.A 2863: Show issues

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Article ; Online: Description of a large family with autosomal dominant hypercholesterolemia associated with the APOE p.Leu167del mutation.

Human mutation

2012 Volume 34, Issue 1, Page(s) 83–87

Abstract: ... and whole exome sequencing, we identified a mutation in the APOE gene, c.500_502delTCC/p.Leu167del ... the involvement of the APOE p.Leu167del in ADH, with (1) a predicted destabilization of an alpha-helix ...

Abstract	Apolipoprotein (apo) E mutants are associated with type III hyperlipoproteinemia characterized by high cholesterol and triglycerides levels. Autosomal dominant hypercholesterolemia (ADH), due to the mutations in the LDLR, APOB, or PCSK9 genes, is characterized by an isolated elevation of cholesterol due to the high levels of low-density lipoproteins (LDLs). We now report an exceptionally large family including 14 members with ADH. Through genome-wide mapping, analysis of regional/functional candidate genes, and whole exome sequencing, we identified a mutation in the APOE gene, c.500_502delTCC/p.Leu167del, previously reported associated with sea-blue histiocytosis and familial combined hyperlipidemia. We confirmed the involvement of the APOE p.Leu167del in ADH, with (1) a predicted destabilization of an alpha-helix in the binding domain, (2) a decreased apo E level in LDLs, and (3) a decreased catabolism of LDLs. Our results show that mutations in the APOE gene can be associated with bona fide ADH.
MeSH term(s)	Adolescent ; Adult ; Apolipoproteins E/chemistry ; Apolipoproteins E/genetics ; Apolipoproteins E/metabolism ; Child ; Cholesterol/metabolism ; Cholesterol, HDL/metabolism ; Cholesterol, LDL/metabolism ; Chromosomes, Human, Pair 19/genetics ; Family Health ; Female ; Gene Deletion ; Genetic Predisposition to Disease/genetics ; Haplotypes ; Humans ; Hyperlipoproteinemia Type II/genetics ; Male ; Middle Aged ; Models, Molecular ; Mutation ; Pedigree ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Triglycerides/metabolism ; Young Adult
Chemical Substances	Apolipoproteins E ; Cholesterol, HDL ; Cholesterol, LDL ; Triglycerides ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2012-10-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1126646-6
ISSN	1098-1004 ; 1059-7794
ISSN (online)	1098-1004
ISSN	1059-7794
DOI	10.1002/humu.22215
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Zs.A 3586: Show issues

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Article: Morphological characteristics of P waves during selective pulmonary vein pacing.

Yamane, T / Shah, D C / Peng, J T / Jaïs, P / Hocini, M / Deisenhofer, I / Choi, K J / Macle, L / Clémenty, J / Haïssaguerre, M

Journal of the American College of Cardiology

2001 Volume 38, Issue 5, Page(s) 1505–1510

Abstract: Objectives: We sought to assess the value of 12-lead electrocardiogram (ECG) P-wave morphology ... In 30 patients P-wave configurations were studied during sinus rhythm and during pacing at six sites ... from the four PVs: top and bottom of each superior PV and both inferior PVs. The P-wave amplitude, duration and ...

Abstract	Objectives: We sought to assess the value of 12-lead electrocardiogram (ECG) P-wave morphology to recognize the paced pulmonary vein (PV). Background: Prediction of arrhythmogenic PVs producing ectopy or initiating atrial fibrillation (AF) using 12-lead ECG may facilitate curative ablation. Methods: In 30 patients P-wave configurations were studied during sinus rhythm and during pacing at six sites from the four PVs: top and bottom of each superior PV and both inferior PVs. The P-wave amplitude, duration and morphology were assessed, and predictive accuracies were calculated for the most significant parameters. An algorithm predicting the paced PV was developed and prospectively evaluated in a different population of 20 patients. RESULTS; Three criteria were used to distinguish right from left PV: 1) a positive P-wave in lead aVL and the amplitude of P-wave in lead I > or =50 microV indicated right PV origin (specificity 100% and 97%, respectively); 2) a notched P-wave in lead II was a predictor of left PV origin (specificity 95%); and 3) the amplitude ratio of lead III/II and the duration of positivity in lead V(1) were also helpful in distinguishing left versus right PV origin. In addition, superior PVs could be distinguished from inferior according to the amplitude in lead II (> or =100 microV). In prospective evaluation, an algorithm based on the above four criteria identified 93% of left versus right PV and totally 79% of the specific PVs paced. Conclusions: Pacing from the different PVs produced a P-wave with distinctive characteristics that could be used as criteria in an algorithm to identify the PV of origin with an accuracy of 79%.
MeSH term(s)	Aged ; Algorithms ; Analysis of Variance ; Atrial Fibrillation/etiology ; Cardiac Complexes, Premature/complications ; Cardiac Complexes, Premature/diagnosis ; Cardiac Complexes, Premature/surgery ; Cardiac Pacing, Artificial/methods ; Cardiac Pacing, Artificial/standards ; Catheter Ablation ; Chi-Square Distribution ; Diagnosis, Differential ; Electrocardiography/instrumentation ; Electrocardiography/methods ; Electrocardiography/standards ; Electrophysiology ; Female ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Prospective Studies ; Pulmonary Veins ; Tachycardia, Ectopic Junctional/etiology ; Tachycardia, Paroxysmal/etiology
Language	English
Publishing date	2001-11-01
Publishing country	United States
Document type	Journal Article ; Validation Studies
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/s0735-1097(01)01578-9
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Zs.A 1846: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 196: Show issues

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Article ; Online: Advances in understanding atrial arrhythmogenesis: Insights from sophisticated mapping techniques and histopathological correlations.

Vlachos, Konstantinos / Jais, Pierre

Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese

2023 Volume 75, Page(s) 96–98

MeSH term(s)	Humans ; Atrial Fibrillation ; Heart Atria
Language	English
Publishing date	2023-09-23
Publishing country	Netherlands
Document type	Editorial
ZDB-ID	2215027-4
ISSN	2241-5955 ; 1109-9666
ISSN (online)	2241-5955
ISSN	1109-9666
DOI	10.1016/j.hjc.2023.09.014
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Zs.A 6187: Show issues

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Article ; Online: A Posterior Wall Resistant to Electroporation Finally Blocked With Vein of Marshall Ethanol Infusion.

Ascione, Ciro / Kowalewski, Christopher / Pambrun, Thomas / Derval, Nicolas / Jaïs, Pierre

JACC. Clinical electrophysiology

2023 Volume 9, Issue 5, Page(s) 729–732

MeSH term(s)	Humans ; Electroporation Therapies ; Electroporation
Language	English
Publishing date	2023-02-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2846739-5
ISSN	2405-5018 ; 2405-500X ; 2405-500X
ISSN (online)	2405-5018 ; 2405-500X
ISSN	2405-500X
DOI	10.1016/j.jacep.2022.12.018
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Article ; Online: A Bigger Thermal Footprint: A Step Forward for Catheter Ablation?

Jaïs, Pierre / Ramirez, F Daniel

JACC. Clinical electrophysiology

2020 Volume 6, Issue 5, Page(s) 520–522

MeSH term(s)	Atrial Fibrillation/surgery ; Catheter Ablation ; Humans ; Pulmonary Veins/surgery ; Temperature
Language	English
Publishing date	2020-06-08
Publishing country	United States
Document type	Editorial ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	2846739-5
ISSN	2405-5018 ; 2405-500X ; 2405-500X
ISSN (online)	2405-5018 ; 2405-500X
ISSN	2405-500X
DOI	10.1016/j.jacep.2020.02.001
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Article ; Online: A diabetic foot wound healing assessment tool: A scoping review

Jais, Suriadi / Pratama, Kharisma

Heliyon. 2023 May, v. 9, no. 5 p.e15736-

2023

Abstract: Indonesia faces a challenge in controlling the burden of diabetic foot ulcers, which necessitates a nursing care management approach to optimize the healing of complications by accurately monitoring wound healing progress using wound assessment tools. ... ...

Abstract	Indonesia faces a challenge in controlling the burden of diabetic foot ulcers, which necessitates a nursing care management approach to optimize the healing of complications by accurately monitoring wound healing progress using wound assessment tools. This literature review, which is part of a scoping study framework, searched electronic databases including PubMed, ScienceDirect, EBSCOhost, and Google Scholar to find papers relevant to the Indonesian context. Five papers were chosen from a total of 463 papers discovered. The diabetic foot ulcer wound assessment tools DFUAS (diabetic foot ulcer assessment scale), DMIST (deep, maceration, infection, size, and tunneling), and MUNGS (maceration, undermining, necrotic, granulation, and symptoms/signs) were identified in the literature review. For leg ulcers, LUMT (leg ulcer measurement tool) and RESVECH 2.0 (Results Expected from Chronic Wound Healing Assessment) were used. DMIST, DFUAS, and MUNGS are used to predict healed and non-healing wounds. LUMT determines the evaluation and documentation of leg ulcers, and RESVECH 2.0 is designed to shorten the duration of chronic wound occurrence. The psychometric properties of the DMIST scale were identified, including reliability, validity, and responsiveness. Five tools for assessing chronic wounds were identified. The predictive validity and responsiveness of the DMIST tool were supported by a sufficient rating based on evidence quality. This scoping review provides an overview of the measurement properties of available assessment tools for diabetic foot ulcers.
Keywords	diabetic foot ; maceration ; Indonesia ; Diabetic ulcer ; Assessment ; Reliability ; Validity ; Wound healing ; DFU = ; DFUAS = ; LUMT = ; MUNGS = ; DMIST = ; DEPA = ; PWAT = ; CHS = ; NERDS = ; STONES = ; IWGDF = ; PEDIS = ; CSSC = ; DFIWS = ; RESVECH = ; PRISMA-ScR = ; BWAT = ; PUSH = ; ICC = ; RCT = ; KMO = ; IRR =
Language	English
Dates of publication	2023-05
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e15736
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Belimumab corticosteroid-sparing treatment in systemic lupus erythematosus: a real-life observational study (BESST study).

Jaïs, Marie / Roblot, Pascal / Maillot, François / Hamidou, Mohamed / Enfrein, Antoine / Lescoat, Alain / Puyade, Mathieu / Martin, Mickaël / Perier, Amandine

Rheumatology international

2024

Abstract: ... signed-rank test. The threshold for statistical significance was set at p < 0.05. Thirty patients were ... observed at month 6 (10 [7-20] vs 6.75 [2-9] mg, p < 0.0001), continued until month 12 (10 [7-20] mg vs 5 ... 0-7.12] mg, p < 0.001) and was sustained until month 24. The proportion of patients with very low ...

Abstract	Data about the impact of Belimumab on corticosteroid sparing in real life are scarce. To assess the corticosteroid-sparing effect among patients with systemic lupus erythematosus (SLE) treated with Belimumab in real-life settings. Multicentric observational retrospective study including patients with SLE and having received Belimumab for at least 6 months between 2011 and 2020, in eight French hospitals. "Low dose" referred to patients receiving up to 7.5 mg of prednisone a day and "Very low dose" to those receiving strictly ≤ 5 mg prednisone a day The primary endpoint was the reduction of daily prednisone dose after six months of Belimumab. The secondary endpoint was a change in the proportion of patients with low or very low dose of prednisone as well as those without prednisone during the Belimumab course. Censoring occurred for patients who stopped Belimumab. Bivariate analyses were performed using the Wilcoxon signed-rank test. The threshold for statistical significance was set at p < 0.05. Thirty patients were included. All were female with a median age of 38 years. A significant reduction in prednisone dose was observed at month 6 (10 [7-20] vs 6.75 [2-9] mg, p < 0.0001), continued until month 12 (10 [7-20] mg vs 5 [0-7.12] mg, p < 0.001) and was sustained until month 24. The proportion of patients with very low dose of prednisone and those without prednisone progressively increased during the Belimumab course. Introducing Belimumab in patients with SLE, in real-life conditions, is associated with early and sustained corticosteroid-sparing effect.
Language	English
Publishing date	2024-04-30
Publishing country	Germany
Document type	Journal Article
ZDB-ID	8286-7
ISSN	1437-160X ; 0172-8172
ISSN (online)	1437-160X
ISSN	0172-8172
DOI	10.1007/s00296-024-05589-2
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Zs.A 1639: Show issues

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Article: Negative lead I P waves during anteroseptal accessory pathway orthodromic reciprocating tachycardia.

Shah, D C / Jaïs, P / Haïssaguerre, M / Takahashi, A / Clémenty, J

The American journal of cardiology

1997 Volume 80, Issue 2, Page(s) 227–229

Abstract: Although a negative retrograde P wave in lead I during orthodromic reciprocating tachycardia is ... thought to indicate a left free wall accessory pathway, we describe similar negative P waves in lead ...

Abstract	Although a negative retrograde P wave in lead I during orthodromic reciprocating tachycardia is thought to indicate a left free wall accessory pathway, we describe similar negative P waves in lead I during orthodromic reciprocating tachycardia through anteroseptally situated accessory pathways.
MeSH term(s)	Adult ; Catheter Ablation ; Diagnosis, Differential ; Electrocardiography ; Female ; Humans ; Male ; Tachycardia, Atrioventricular Nodal Reentry/diagnosis ; Tachycardia, Paroxysmal/diagnosis ; Tachycardia, Paroxysmal/physiopathology ; Tachycardia, Paroxysmal/surgery
Language	English
Publishing date	1997-07-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/s0002-9149(97)00329-9
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