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Article: Indolamin 2,3-dioxygenáza v onkologii a psychiatrii.

Vonka, Vladimír / Horáček, Jiří

2015 Volume 154, Issue 1, Page(s) 3–10

Abstract: In the last years an attention has been paid to the indoleamine 2,3-dioxygenase (IDO), an enzyme catabolising L-tryptophan to kynurenine. Growing evidence has been accumulated that kynurenine and other metabolites of tryptophan play an important role in ... ...

Title translation	Indoleamine 2,3-dioxygenase in oncology and psychiatry.
Abstract	In the last years an attention has been paid to the indoleamine 2,3-dioxygenase (IDO), an enzyme catabolising L-tryptophan to kynurenine. Growing evidence has been accumulated that kynurenine and other metabolites of tryptophan play an important role in the pathogenesis of malignant tumours and some neurological and psychiatric disorders. The gradual recognition of mechanisms operative in their development may help to identify etiological factors involved and becomes prerequisite for the progress in their diagnostics and therapy. In oncology, great effort is directed to the development and testing of substances inhibiting IDO activity. It is expected that some of them will be utilized in the immunotherapy of cancer. In the field of psychiatric disorders, namely in schizophrenia and depression, the role of IDO is linked to immune dysregulation. In those diseases, IDO represents a potential mediator between immunological reactivity and alterations of the brain function. Changes in the IDO activity may also mediate interaction between the genetic predisposition and environmental factors.
MeSH term(s)	Brain/metabolism ; Humans ; Indoleamine-Pyrrole 2,3,-Dioxygenase/physiology ; Interferon-gamma/metabolism ; Kynurenine/metabolism ; Mental Disorders/diagnosis ; Mental Disorders/physiopathology ; Mental Disorders/therapy ; Neoplasms/diagnosis ; Neoplasms/physiopathology ; Neoplasms/therapy ; Tryptophan/metabolism
Chemical Substances	Indoleamine-Pyrrole 2,3,-Dioxygenase ; Kynurenine (343-65-7) ; Interferon-gamma (82115-62-6) ; Tryptophan (8DUH1N11BX)
Language	Czech
Publishing date	2015
Publishing country	Czech Republic
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	413441-2
ISSN	1805-4420 ; 0008-7335
ISSN (online)	1805-4420
ISSN	0008-7335
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Article: Genová terapie v Ceské republice.

Vonka, V

Casopis lekaru ceskych

2003 Volume 142, Issue 9, Page(s) 515–518

Abstract: Gene therapy represents one of the most promising applications of molecular biology and genetic engineering in medicine. At present its introduction meets series of problems which are of technical, methodological and ethical nature. Although the research ...

Title translation	Gene therapy in the Czech Republic.
Abstract	Gene therapy represents one of the most promising applications of molecular biology and genetic engineering in medicine. At present its introduction meets series of problems which are of technical, methodological and ethical nature. Although the research in the field of gene therapy in the Czech Republic is on a good level, there is little hope that its achievements will be tested in clinical trials in the near future. In the Czech Republic a law enabling the use of preparations based on the newest biotechnologies in human medicine is missing. Similarly, a production unit capable of preparing the new gene-based drugs according to the Good Manufactory Praxis is not available and the State Institute for Control of Drugs has not any working group fully qualified for their control. The paper proposes actions aimed at solving the present unfavourable situation. The fact that the interest of clinicians in gene therapy is rapidly growing, and that there are signs of increasing interest of public in its achievements, gives good prospects for the introduction of gene therapy into medical praxis in this country in the not very distant future.
MeSH term(s)	Biomedical Research ; Czech Republic ; Genetic Therapy ; Humans
Language	Czech
Publishing date	2003
Publishing country	Czech Republic
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	413441-2
ISSN	1805-4420 ; 0008-7335
ISSN (online)	1805-4420
ISSN	0008-7335
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Article: K problému kauzality v medicínĕ. Prípad virů a nádorů--cást 1. Obecné zásady kauzálních studií v medicínĕ.

Vonka, V

Casopis lekaru ceskych

2004 Volume 143, Issue 6, Page(s) 409–413

Abstract: Clarification of the aetiology of chronic human diseases such as atherosclerosis or cancer is one of the dominant topics in the contemporary medical research. It is believed that identification of the causal factors will enable more efficient prevention ... ...

Title translation	To the problems of causality in medicine: the case of viruses and tumors--I. General principles of causal studies in medicine.
Abstract	Clarification of the aetiology of chronic human diseases such as atherosclerosis or cancer is one of the dominant topics in the contemporary medical research. It is believed that identification of the causal factors will enable more efficient prevention and diagnosis of these diseases and, in some instances, also permit more effective therapy. The task is difficult because of the multistep and multifactorial origin of these diseases. In this paper the author attempts to review the present methodological approaches to aetiological studies of chronic diseases and discusses the role of criteria for identifying causal relationships.
MeSH term(s)	Causality ; Disease/etiology ; Humans ; Logic ; Neoplasms/etiology ; Virus Diseases/etiology
Language	Czech
Publishing date	2004
Publishing country	Czech Republic
Document type	English Abstract ; Journal Article
ZDB-ID	413441-2
ISSN	1805-4420 ; 0008-7335
ISSN (online)	1805-4420
ISSN	0008-7335
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Article: K problému kauzality v medicínĕ. Prípad virů a nádorů--Cást 2. Viry a lidské zhoubné nádory.

Vonka, V

Casopis lekaru ceskych

2004 Volume 143, Issue 7, Page(s) 485–489

Abstract: A special case in contemporary etiological studies is definition of the role of viruses in the pathogenesis of human cancer. Virus-associated cancer develops only in a small minority of infected subjects, which implies that, if the virus does play a role ...

Title translation	Problems of causality in medicine: The case of viruses and tumors--Part 2. Viruses and human malignant tumors.
Abstract	A special case in contemporary etiological studies is definition of the role of viruses in the pathogenesis of human cancer. Virus-associated cancer develops only in a small minority of infected subjects, which implies that, if the virus does play a role in the pathogenesis of the malignancy, other factors must be also involved. The author summarises the general properties of human tumour viruses, reviews the development of causal thinking in microbiology and proposes guidelines that might help to determine the role of viruses in human cancer.
MeSH term(s)	Humans ; Neoplasms/diagnosis ; Neoplasms/virology ; Virus Diseases/complications
Language	Czech
Publishing date	2004
Publishing country	Czech Republic
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	413441-2
ISSN	1805-4420 ; 0008-7335
ISSN (online)	1805-4420
ISSN	0008-7335
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Article: Prophylactic vaccines against cancers of non-infectious origin: a dream or a real possibility?

Vonka, Vladimír / Hirsch, Ivan

Central European journal of public health

2022 Volume 29, Issue 4, Page(s) 247–258

Abstract: The dramatic progress in tumour biology and immunology in the past several years has opened new avenues for the treatment and prevention of cancer. One of the great contributions of the immunotherapeutic approaches is an increasing understanding of the ... ...

Abstract	The dramatic progress in tumour biology and immunology in the past several years has opened new avenues for the treatment and prevention of cancer. One of the great contributions of the immunotherapeutic approaches is an increasing understanding of the immunology of cancer, which is, gradually creating conditions for the development of prophylactic anti-cancer vaccines. Efficient vaccines have been developed and employed for the prophylaxis of two frequent cancers of viral origin, namely cervical cancer and liver cancer. The new knowledge on the interactions between the immune system and the malignant tumors seems to provide means for the development of prophylactic vaccines against cancers developing due to the mutations in the proto-oncogenes converting their products into oncoproteins. According to the present estimates, these cancers form a great majority of human malignancies. Recent evidence has indicated that the immune system recognizes such mutated proteins, and that the development of cancer is due to the failure of the immune system to eliminate neoplastic cells. Followingly, it can be expected that inducing immunity against the mutated epitopes will increase the capacity of the body to deal with the initiated precancerous cells. In the present paper this hypothesis is primarily discussed in the relationship with colorectal cancer (CRC), which seems to be a well-fitting candidate for prophylactic vaccination. CRC is the third most frequent malignancy and the fourth most common cause of cancer mortality. Mutations of two proto-oncogenes, namely RAS and RAF, are involved in the majority of CRC cases and, in addition, they are shared with other human malignancies. Therefore, the strategy to be used for prophylaxis of CRC is discussed together with several other frequent human cancers, namely lung cancer, pancreatic duct cancer and melanoma. The prophylactic vaccines proposed are aimed at the reduction of the incidence of these and, to a lesser extent, some other cancers.
MeSH term(s)	Female ; Humans ; Melanoma ; Pancreatic Neoplasms ; Papillomavirus Infections ; Papillomavirus Vaccines ; Uterine Cervical Neoplasms ; Vaccination ; Vaccines
Chemical Substances	Papillomavirus Vaccines ; Vaccines
Language	English
Publishing date	2022-01-13
Publishing country	Czech Republic
Document type	Journal Article
ZDB-ID	1176053-9
ISSN	1803-1048 ; 1210-7778 ; 0022-1732
ISSN (online)	1803-1048
ISSN	1210-7778 ; 0022-1732
DOI	10.21101/cejph.a7219
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Article ; Online: Overview of Current Findings about the Role of Oestrogen Receptor α in Cancer Cell Signalling Pathways

Voňka, P / Hrstka, R

Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti

2019 Volume 32, Issue Suppl 3, Page(s) 34–38

Abstract: Background: Oestrogen receptor α is a key biomarker for breast cancer, and the presence or absence of oestrogen receptor α in breast cancer influences the treatment regimens and patients’ prognosis. Oestrogen receptors α are activated after ligand ... ...

Title translation	Souhrn aktuálních poznatků o úloze estrogenového receptoru α v nádorové buněčné signalizaci.
Abstract	Background: Oestrogen receptor α is a key biomarker for breast cancer, and the presence or absence of oestrogen receptor α in breast cancer influences the treatment regimens and patients’ prognosis. Oestrogen receptors α are activated after ligand binding, then translocate into the nucleus and activate the transcription of specific genes. This process is called the genomic effect of oestrogen receptor α. Oestrogen receptor α also has nongenomic effects that are exerted mainly in cytoplasm. Due to the important involvement of oestrogen receptor α in cell signalling, these receptors represent a key target for anticancer therapy. Purpose: Although oestrogen receptor α was discovered 60 years ago, the corresponding signalling pathways have not yet been fully described due to their complexity. With respect to the considerable extent of oestrogen receptor α signalling, covering all related information is beyond the scope of this review, which is focused mainly on recently discovered aspects of oestrogen receptor α function.
MeSH term(s)	Antineoplastic Agents/therapeutic use ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Proliferation ; Estrogen Receptor alpha/antagonists & inhibitors ; Estrogen Receptor alpha/metabolism ; Female ; Humans ; Prognosis ; Signal Transduction
Chemical Substances	Antineoplastic Agents ; ESR1 protein, human ; Estrogen Receptor alpha
Language	English
Publishing date	2019-10-03
Publishing country	Czech Republic
Document type	Journal Article ; Review
ZDB-ID	1217739-8
ISSN	1802-5307 ; 0862-495X
ISSN (online)	1802-5307
ISSN	0862-495X
DOI	10.14735/amko20193S
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Zánĕtlivá stromální reakce v epiteliálních neoplaziích dĕlozního hrdla v korelaci s infekcí HPV.

Tichý, M / Tichá, V / Kolár, Z / Brychtová, S / Bystron, J / Kotrsová, L / Hamsíková, E / Dusek, J / Vonka, V

Ceskoslovenska patologie

1998 Volume 34, Issue 4, Page(s) 142–148

Abstract: 260 cases of women with epithelial neoplasias of the uterine cervix were studied: HPV infection was detected by DNA in situ hybridization and serology, simultaneously structure and intensity of stromal inflammatory reaction (SR) were evaluated ( ... ...

Title translation	Inflammatory stromal reaction in epithelial neoplasia of the uterine cervix in correlation with HPV infection.
Abstract	260 cases of women with epithelial neoplasias of the uterine cervix were studied: HPV infection was detected by DNA in situ hybridization and serology, simultaneously structure and intensity of stromal inflammatory reaction (SR) were evaluated (semiquantitatively) as well as standard clinical immunological parametres investigated by serology. Results proved the same character of SR in intraepithelial lesions and invasive carcinomas and the intensity of SR increasing in relation to the gravity of epithelial dysplasia. There was not found any significant difference in SR between cases with detected HPV infection and cases lacking it. Summarized immunological parametres were in limits of normal reference range.
MeSH term(s)	Cervical Intraepithelial Neoplasia/complications ; Cervical Intraepithelial Neoplasia/pathology ; Female ; Humans ; Papillomaviridae ; Papillomavirus Infections/complications ; Tumor Virus Infections/complications ; Uterine Cervical Neoplasms/complications ; Uterine Cervical Neoplasms/pathology
Language	Czech
Publishing date	1998-11
Publishing country	Czech Republic
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	138273-1
ISSN	1210-7875 ; 0009-0611 ; 0371-1854
ISSN	1210-7875 ; 0009-0611 ; 0371-1854
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Article: Prítomnost lidských papilomavirů v nádorech zenského genitálu.

Krcmár, M / Hirsch, I / Kanka, J / Johannes, R / Vonka, V

Casopis lekaru ceskych

1988 Volume 127, Issue 22, Page(s) 689–693

Title translation	Incidence of human papillomaviruses in tumors of the female genitalia.
MeSH term(s)	Condylomata Acuminata/microbiology ; DNA, Viral/analysis ; Female ; Genital Neoplasms, Female/microbiology ; Humans ; Papillomaviridae/genetics ; Papillomaviridae/isolation & purification ; Uterine Cervical Neoplasms/microbiology
Chemical Substances	DNA, Viral
Language	Czech
Publishing date	1988-05-27
Publishing country	Czech Republic
Document type	English Abstract ; Journal Article
ZDB-ID	413441-2
ISSN	1805-4420 ; 0008-7335
ISSN (online)	1805-4420
ISSN	0008-7335
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Article ; Online: Electrochemical biosensors for analysis of DNA point mutations in cancer research

Ondraskova, Katerina / Sebuyoya, Ravery / Moranova, Ludmila / Holcakova, Jitka / Voňka, Petr / Hrstka, Roman / Bartosik, Martin

Anal Bioanal Chem. 2023 Mar., v. 415, no. 6 p.1065-1085

2023

Abstract: Cancer is a genetic disease induced by mutations in DNA, in particular point mutations in important driver genes that lead to protein malfunctioning and ultimately to tumorigenesis. Screening for the most common DNA point mutations, especially in such ... ...

Abstract	Cancer is a genetic disease induced by mutations in DNA, in particular point mutations in important driver genes that lead to protein malfunctioning and ultimately to tumorigenesis. Screening for the most common DNA point mutations, especially in such genes as TP53, BRCA1 and BRCA2, EGFR, KRAS, or BRAF, is crucial to determine predisposition risk for cancer or to predict response to therapy. In this review, we briefly depict how these genes are involved in cancer, followed by a description of the most common techniques routinely applied for their analysis, including high-throughput next-generation sequencing technology and less expensive low-throughput options, such as real-time PCR, restriction fragment length polymorphism, or high resolution melting analysis. We then introduce benefits of electrochemical biosensors as interesting alternatives to the standard methods in terms of cost, speed, and simplicity. We describe most common strategies involved in electrochemical biosensing of point mutations, relying mostly on PCR or isothermal amplification techniques, and critically discuss major challenges and obstacles that, until now, prevented their more widespread application in clinical settings.
Keywords	DNA ; biosensors ; carcinogenesis ; electrochemistry ; genetic disorders ; quantitative polymerase chain reaction ; restriction fragment length polymorphism ; risk ; therapeutics ; tumor suppressor proteins
Language	English
Dates of publication	2023-03
Size	p. 1065-1085.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
Note	Review
ISSN	1618-2642
DOI	10.1007/s00216-022-04388-7
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Comments on therapeutic cancer vaccines.

Vonka, Vladimír

Immunotherapy

2012 Volume 4, Issue 2, Page(s) 133–135

MeSH term(s)	Animals ; Antigens, Neoplasm/immunology ; Cancer Vaccines/therapeutic use ; Dendritic Cells/immunology ; Dendritic Cells/transplantation ; Genetic Vectors ; Humans ; Immunotherapy ; Models, Animal ; Neoplasms/pathology ; Neoplasms/therapy ; Peptide Fragments/immunology ; Precision Medicine ; Vaccines, DNA
Chemical Substances	Antigens, Neoplasm ; Cancer Vaccines ; Peptide Fragments ; Vaccines, DNA
Language	English
Publishing date	2012-02
Publishing country	England
Document type	Editorial ; Research Support, Non-U.S. Gov't
ISSN	1750-7448
ISSN (online)	1750-7448
DOI	10.2217/imt.11.173
Database	MEDical Literature Analysis and Retrieval System OnLINE

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