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  1. Article ; Online: Anemia and red blood cell deformability in proteinuric chronic kidney disease.

    Joles, Jaap A

    Kidney international

    2022  Volume 101, Issue 3, Page(s) 649

    MeSH term(s) Anemia/etiology ; Erythrocyte Deformability ; Erythrocytes ; Humans ; Renal Insufficiency, Chronic
    Language English
    Publishing date 2022-02-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2021.11.035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 797: Show issues Location:
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  2. Article ; Online: Tailoring cardiopulmonary bypass pump flow and mean arterial pressure to maintain renal oxygenation.

    Joles, Jaap A

    Acta physiologica (Oxford, England)

    2021  Volume 231, Issue 4, Page(s) e13619

    MeSH term(s) Arterial Pressure ; Cardiopulmonary Bypass ; Humans ; Kidney ; Oxygen Consumption ; Respiratory Physiological Phenomena
    Language English
    Publishing date 2021-02-11
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2218636-0
    ISSN 1748-1716 ; 1748-1708
    ISSN (online) 1748-1716
    ISSN 1748-1708
    DOI 10.1111/apha.13619
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  3. Article ; Online: Measuring systolic and diastolic blood pressure in rodents.

    Joles, Jaap A

    Kidney international

    2019  Volume 96, Issue 6, Page(s) 1424–1425

    MeSH term(s) Animals ; Blood Pressure ; Blood Pressure Determination ; Humans ; Male ; Mice ; Rodentia ; Systole ; Telemetry
    Language English
    Publishing date 2019-10-19
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2019.09.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 797: Show issues Location:
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  4. Article ; Online: Adjusting cardiopulmonary bypass flow or arterial pressure to maintain renal medullary oxygen.

    Joles, Jaap A

    Kidney international

    2019  Volume 95, Issue 6, Page(s) 1292–1293

    Abstract: Cardiopulmonary bypass leads to renal hypoperfusion, resulting in medullary hypoxia and acute kidney injury. In instrumented sheep subjected to cardiopulmonary bypass, Lankadeva et al. found that medullary perfusion and tissue oxygen tension ( ... ...

    Abstract Cardiopulmonary bypass leads to renal hypoperfusion, resulting in medullary hypoxia and acute kidney injury. In instrumented sheep subjected to cardiopulmonary bypass, Lankadeva et al. found that medullary perfusion and tissue oxygen tension (PO
    MeSH term(s) Acute Kidney Injury ; Animals ; Arterial Pressure ; Cardiopulmonary Bypass ; Humans ; Kidney Medulla ; Oxygen ; Sheep
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2019-05-23
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2019.02.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 797: Show issues Location:
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  5. Article ; Online: Discrepancies between transcutaneous and estimated glomerular filtration rates in rats with chronic kidney disease.

    Pieters, Tobias T / Besseling, Paul J / Bovée, Dominique M / Rookmaaker, Maarten B / Verhaar, Marianne C / Yard, Benito / Hoorn, Ewout J / Joles, Jaap A

    Kidney international

    2024  

    Abstract: Accurate assessment of the glomerular filtration rate (GFR) is crucial for researching kidney disease in rats. Although validation of methods that assess GFR is crucial, large-scale comparisons between different methods are lacking. Both transcutaneous ... ...

    Abstract Accurate assessment of the glomerular filtration rate (GFR) is crucial for researching kidney disease in rats. Although validation of methods that assess GFR is crucial, large-scale comparisons between different methods are lacking. Both transcutaneous GFR (tGFR) and a newly developed estimated GFR (eGFR) equation by our group provide a low-invasive approach enabling repeated measurements. The tGFR is a single bolus method using FITC-labeled sinistrin to measure GFR based on half-life of the transcutaneous signal, whilst the eGFR is based on urinary sinistrin clearance. Here, we retrospectively compared tGFR, using both 1- and 3- compartment models (tGFR_1c and tGFR_3c, respectively) to the eGFR in a historic cohort of 43 healthy male rats and 84 male rats with various models of chronic kidney disease. The eGFR was on average considerably lower than tGFR-1c and tGFR-3c (mean differences 855 and 216 μL/min, respectively) and only 20 and 47% of measurements were within 30% of each other, respectively. The relative difference between eGFR and tGFR was highest in rats with the lowest GFR. Possible explanations for the divergence are problems inherent to tGFR, such as technical issues with signal measurement, description of the signal kinetics, and translation of half-life to tGFR, which depends on distribution volume. The unknown impact of isoflurane anesthesia used in determining mGFR remains a limiting factor. Thus, our study shows that there is a severe disagreement between GFR measured by tGFR and eGFR, stressing the need for more rigorous validation of the tGFR and possible adjustments to the underlying technique.
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2024.02.020
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    Zs.A 797: Show issues Location:
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  6. Article ; Online: Renal injury in relation to obesity and the additive effect of hypertension in female and male obese and lean ZSF1 rats.

    Nguyen, Isabel T N / Cramer, Maarten J / Joles, Jaap A / Verhaar, Marianne C

    American journal of physiology. Renal physiology

    2023  Volume 325, Issue 1, Page(s) F73–F86

    Abstract: Heart failure with preserved ejection fraction (HFpEF) is characterized by obesity, hypertension, diabetes mellitus, and chronic kidney disease. Obese ZSF1 rats, a model of HFpEF, exhibit multiple such comorbidities that can disturb cardiac function. ... ...

    Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by obesity, hypertension, diabetes mellitus, and chronic kidney disease. Obese ZSF1 rats, a model of HFpEF, exhibit multiple such comorbidities that can disturb cardiac function. Little attention has been paid to how these comorbidities affect renal disease in ZSF1 rats. HFpEF is found predominantly in women in whom obesity and hypertension are particularly prevalent. Therefore, we characterized the renal phenotype in female and male lean and obese ZSF1 rats and investigated additional effects of worsened hypertension on disease severity. Systolic blood pressure and renal function were assessed biweekly from 12 to 26 wk. From 19 wk, rats were implanted with either a deoxycorticosterone acetate pellet and fed a high-salt diet (DS) or a placebo pellet and fed a normal-salt diet. At 26 wk of age, terminal glomerular filtration rate was assessed via inulin clearance under isoflurane. Renal sections were processed for histological analysis. Lean and obese ZSF1 rats, both female and male, were mildly hypertensive (systolic blood pressure: 140-150 mmHg). All obese ZSF1 rats showed HFpEF. In female normoglycemic ZSF1 rats, obesity associated with mild proteinuria, decreased glomerular filtration rate, and glomerular hypertrophy. DS-worsened hypertension enhanced proteinuria and triggered glomerulosclerosis. Male obese ZSF1 rats were hyperglycemic and showed proteinuria, glomerular hypertrophy and sclerosis, and tubulointerstitial damage. DS-worsened hypertension aggravated this phenotype in male ZSF1 rats. In conclusion, female obese ZSF1 rats develop mild renal dysfunction and DS-worsened hypertension compromises renal function and structure in normoglycemic female obese ZSF1 rats as in hyperglycemic male obese ZSF1 rats.
    MeSH term(s) Rats ; Female ; Male ; Animals ; Heart Failure ; Stroke Volume/physiology ; Kidney/physiology ; Obesity/complications ; Hypertension/complications ; Renal Insufficiency, Chronic ; Proteinuria ; Hypertrophy ; Disease Models, Animal
    Language English
    Publishing date 2023-05-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00286.2022
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    Uc I Zs.89: Show issues Location:
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  7. Article ; Online: Fibrates in hypertension: where do we stand?

    Gremmels, Hendrik / Joles, Jaap A

    Journal of hypertension

    2018  Volume 36, Issue 5, Page(s) 1024–1028

    MeSH term(s) Animals ; Fenofibrate ; Fibric Acids ; Hypertension ; Rats ; Rats, Inbred SHR ; Stroke
    Chemical Substances Fibric Acids ; Fenofibrate (U202363UOS)
    Language English
    Publishing date 2018-03-23
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/HJH.0000000000001711
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    Zs.A 1885: Show issues Location:
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    Zs.MO 614: Show issues

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  8. Article: Albumin is an interface between blood plasma and cell membrane, and not just a sponge.

    van de Wouw, Jens / Joles, Jaap A

    Clinical kidney journal

    2021  Volume 15, Issue 4, Page(s) 624–634

    Abstract: Albumin is the most abundant protein in blood plasma and acts as a carrier for many circulating molecules. Hypoalbuminaemia, mostly caused by either renal or liver disease or malnutrition, can perturb vascular homeostasis and is involved in the ... ...

    Abstract Albumin is the most abundant protein in blood plasma and acts as a carrier for many circulating molecules. Hypoalbuminaemia, mostly caused by either renal or liver disease or malnutrition, can perturb vascular homeostasis and is involved in the development of multiple diseases. Here we review four functions of albumin and the consequences of hypoalbuminaemia on vascular homeostasis. (i) Albumin is the main determinant of plasma colloid osmotic pressure. Hypoalbuminaemia was therefore thought to be the main mechanism for oedema in nephrotic syndrome (NS), however, experimental studies showed that intrarenal mechanisms rather than hypoalbuminaemia determine formation and, in particular, maintenance of oedema. (ii) Albumin functions as an interface between lysophosphatidylcholine (LPC) and circulating factors (lipoproteins and erythrocytes) and the endothelium. Consequently, hypoalbuminaemia results in higher LPC levels in lipoproteins and erythrocyte membrane, thereby increasing atherosclerotic properties of low-density lipoprotein and blood viscosity, respectively. Furthermore, albumin dose-dependently restores LPC-induced inhibition of vasodilation. (iii) Hypoalbuminaemia impacts on vascular nitric oxide (NO) signalling by directly increasing NO production in endothelial cells, leading to reduced NO sensitivity of vascular smooth muscle cells. (iv) Lastly, albumin binds free fatty acids (FFAs). FFAs can induce vascular smooth muscle cell apoptosis, uncouple endothelial NO synthase and decrease endothelium-dependent vasodilation. Unbound FFAs can increase the formation of reactive oxygen species by mitochondrial uncoupling in multiple cell types and induce hypertriglyceridemia in NS. In conclusion, albumin acts as an interface in the circulation and hypoalbuminaemia impairs multiple aspects of vascular function that may underlie the association of hypoalbuminaemia with adverse outcomes. However, hypoalbuminaemia is not a key to oedema in NS. These insights have therapeutic implications.
    Language English
    Publishing date 2021-10-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfab194
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    Zs.A 6587: Show issues Location:
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  9. Article ; Online: Comparative physiology and hyperuricemia as a causal factor for hypertension.

    Joles, Jaap A

    Obesity (Silver Spring, Md.)

    2014  Volume 22, Issue 3, Page(s) 623

    MeSH term(s) Animals ; Humans ; Metabolic Syndrome/physiopathology ; Physiology, Comparative/methods
    Language English
    Publishing date 2014-03
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2230457-5
    ISSN 1930-739X ; 1071-7323 ; 1930-7381
    ISSN (online) 1930-739X
    ISSN 1071-7323 ; 1930-7381
    DOI 10.1002/oby.20544
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    Zs.MG 87: Show issues

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  10. Article: Fighting Oxidative Stress with Sulfur: Hydrogen Sulfide in the Renal and Cardiovascular Systems.

    Scammahorn, Joshua J / Nguyen, Isabel T N / Bos, Eelke M / Van Goor, Harry / Joles, Jaap A

    Antioxidants (Basel, Switzerland)

    2021  Volume 10, Issue 3

    Abstract: Hydrogen sulfide ( ... ...

    Abstract Hydrogen sulfide (H
    Language English
    Publishing date 2021-03-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10030373
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