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Article ; Online: Corrigendum to "Time-course evaluation of the quantitative antigen test for severe acute respiratory syndrome coronavirus 2: The potential contribution to alleviating isolation of COVID-19 patients" [27 (2021) 1669-1673].

Nomoto, Hidetoshi / Yamamoto, K

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

2021 Volume 28, Issue 2, Page(s) 361

Language	English
Publishing date	2021-10-30
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	1355399-9
ISSN	1437-7780 ; 1341-321X
ISSN (online)	1437-7780
ISSN	1341-321X
DOI	10.1016/j.jiac.2021.10.025
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Article ; Online: Impact of prioritized vaccinations for the elderly on the COVID-19 pandemic in Japan.

Nomoto, Hidetoshi / Hayakawa, Kayoko / Ohmagari, Norio

Global health & medicine

2022 Volume 4, Issue 2, Page(s) 129–132

Abstract: The Japanese government implemented a large-scale vaccination policy against the coronavirus disease 2019 (COVID-19) pandemic, primarily using messenger RNA vaccines in 2021. Its hallmark was prioritized vaccination for the elderly after healthcare ... ...

Abstract	The Japanese government implemented a large-scale vaccination policy against the coronavirus disease 2019 (COVID-19) pandemic, primarily using messenger RNA vaccines in 2021. Its hallmark was prioritized vaccination for the elderly after healthcare workers in a short period of time. Vaccination for the elderly, vulnerable to infection and severe disease, was carried out rapidly in approximately 4 months since April 2021. We evaluated the impact of Japan's vaccination policy against COVID-19 during the pandemic, with a particular focus on how prioritized vaccination for the elderly affected the pandemic. We observed a remarkable decrease in the number of infections, cluster events in long-term care facilities, and severe disease among the elderly during the fifth wave (August 2021) despite rising incidence of infections in the overall population. In conclusion, we think that prioritized vaccination for the elderly was efficacious in preventing infections and severe COVID-19 among the elderly during the fifth wave in Japan.
Language	English
Publishing date	2022-05-04
Publishing country	Japan
Document type	Journal Article
ISSN	2434-9194
ISSN (online)	2434-9194
DOI	10.35772/ghm.2022.01015
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Article ; Online: Global Outbreak Alert and Response Network (GOARN) focal point engagement meeting with partners in Japan.

Iwasaki, Haruka / Salmon, Sharon / Matsuzawa, Yukimasa / Lee, Sangnim / Takagi, Kanae / Nomoto, Hidetoshi / Ishikane, Masahiro / Ujiie, Mugen / Ohmagari, Norio

Western Pacific surveillance and response journal : WPSAR

2024 Volume 15, Issue 5 Spec edition, Page(s) 1–3

MeSH term(s)	Humans ; Japan/epidemiology ; Disease Outbreaks/prevention & control ; Global Health
Language	English
Publishing date	2024-01-30
Publishing country	Philippines
Document type	Journal Article
ZDB-ID	2592503-9
ISSN	2094-7313 ; 2094-7313
ISSN (online)	2094-7313
ISSN	2094-7313
DOI	10.5365/wpsar.2024.15.5.1100
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Article ; Online: Mansonella perstans infection in a Gabonese immigrant in Japan: an illustrative case of a clinical conundrum and management dilemma.

Kawashima, Akira / Nomoto, Hidetoshi / Takagi, Hidekazu / Hayakawa, Kayoko / Komaki-Yasuda, Kanako / Kano, Shigeyuki / Ohmagari, Norio

Journal of travel medicine

2023 Volume 30, Issue 7

MeSH term(s)	Humans ; Japan ; Mansonelliasis/diagnosis ; Mansonelliasis/drug therapy ; Emigrants and Immigrants ; Gabon ; Anti-Bacterial Agents/therapeutic use
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-10-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1212504-0
ISSN	1708-8305 ; 1195-1982
ISSN (online)	1708-8305
ISSN	1195-1982
DOI	10.1093/jtm/taad126
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Article ; Online: Autopsy of tetanus with foot gangrene as portal of entry.

Wakatsuki, Miyu / Yamamoto, Kei / Kawashima, Akira / Sakurai, Ayana / Kurokawa, Masami / Mizushima, Ryo / Okumura, Nobumasa / Yamada, Gen / Nomoto, Hidetoshi / Ohmagari, Norio

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

2023 Volume 30, Issue 5, Page(s) 450–453

Abstract: Non-traumatic chronic skin lesions are the second most common cause of tetanus. Herein, we describe an 85-year-old woman who presented with a chronically infected skin lesion. She developed tetanus while in hospital and died of respiratory failure, after ...

Abstract	Non-traumatic chronic skin lesions are the second most common cause of tetanus. Herein, we describe an 85-year-old woman who presented with a chronically infected skin lesion. She developed tetanus while in hospital and died of respiratory failure, after refusing mechanical ventilation. Routine immunization against tetanus began in Japan during 1968; hence many people born before 1968 are unvaccinated. Mortality due to tetanus is high and the proportion with protective antibodies is low in older adults. Therefore, we recommend tetanus vaccination for older persons in Japan who have chronic skin lesions and have never been vaccinated.
MeSH term(s)	Female ; Humans ; Aged ; Aged, 80 and over ; Tetanus/prevention & control ; Gangrene ; Vaccination ; Tetanus Toxoid ; Autopsy
Chemical Substances	Tetanus Toxoid
Language	English
Publishing date	2023-11-07
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	1355399-9
ISSN	1437-7780 ; 1341-321X
ISSN (online)	1437-7780
ISSN	1341-321X
DOI	10.1016/j.jiac.2023.11.004
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Article ; Online: Successful management of persistent COVID-19 using combination antiviral therapy (nirmatrelvir/ritonavir and remdesivir) and intravenous immunoglobulin transfusion in an immunocompromised host who had received CD20 depleting therapy for follicular lymphoma.

Maruki, Taketomo / Nomoto, Hidetoshi / Iwamoto, Noriko / Yamamoto, Kei / Kurokawa, Masami / Iwatsuki-Horimoto, Kiyoko / Yamayoshi, Seiya / Suzuki, Yutaka / Kawaoka, Yoshihiro / Ohmagari, Norio

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

2024

Abstract: The management of persistent symptomatic coronavirus disease 2019 (COVID-19) infections in immunocompromised patients remains unclear. Here, we present the first case of successful antiviral therapy (nirmatrelvir/ritonavir and remdesivir) in combination ... ...

Abstract	The management of persistent symptomatic coronavirus disease 2019 (COVID-19) infections in immunocompromised patients remains unclear. Here, we present the first case of successful antiviral therapy (nirmatrelvir/ritonavir and remdesivir) in combination with intravenous immunoglobulin (IVIg) in a patient who had received CD20 depleting therapy for follicular lymphoma and experienced recurrent COVID-19 relapses. After the patient received IVIg treatment, the viral load decreased without recurrence. Subsequently, it was found that the anti-spike antibody titer in the administered immunoglobulin was high at 9528.0 binding antibody units/mL. Our case highlights the potential of combination therapy with selective IVIg and antiviral drugs for relapsed immunocompromised COVID-19 patients who have received CD20 depleting therapy.
Language	English
Publishing date	2024-01-17
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	1355399-9
ISSN	1437-7780 ; 1341-321X
ISSN (online)	1437-7780
ISSN	1341-321X
DOI	10.1016/j.jiac.2024.01.008
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Article ; Online: Ventricular Assist Device-Induced Ventricular Septal Perforation.

Hoki, Ryogo / Kikuchi, Noriko / Nomoto, Michiru / Hattori, Hidetoshi / Ichihara, Yuki / Yamada, Yukiko / Saito, Satoshi / Nunoda, Shinichi / Hagiwara, Nobuhisa / Niinami, Hiroshi

Circulation journal : official journal of the Japanese Circulation Society

2022 Volume 86, Issue 8, Page(s) 1307

MeSH term(s)	Heart-Assist Devices/adverse effects ; Humans ; Treatment Outcome ; Ventricular Septal Rupture/diagnostic imaging ; Ventricular Septal Rupture/etiology ; Ventricular Septal Rupture/surgery
Language	English
Publishing date	2022-02-16
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2068090-9
ISSN	1347-4820 ; 1346-9843
ISSN (online)	1347-4820
ISSN	1346-9843
DOI	10.1253/circj.CJ-21-0742
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Ui IV Zs.74: Show issues

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Article ; Online: Octupole-driven magnetoresistance in an antiferromagnetic tunnel junction.

Chen, Xianzhe / Higo, Tomoya / Tanaka, Katsuhiro / Nomoto, Takuya / Tsai, Hanshen / Idzuchi, Hiroshi / Shiga, Masanobu / Sakamoto, Shoya / Ando, Ryoya / Kosaki, Hidetoshi / Matsuo, Takumi / Nishio-Hamane, Daisuke / Arita, Ryotaro / Miwa, Shinji / Nakatsuji, Satoru

Nature

2023 Volume 613, Issue 7944, Page(s) 490–495

Abstract: The tunnelling electric current passing through a magnetic tunnel junction (MTJ) is strongly dependent on the relative orientation of magnetizations in ferromagnetic electrodes sandwiching an insulating barrier, rendering efficient readout of spintronics ...

Abstract	The tunnelling electric current passing through a magnetic tunnel junction (MTJ) is strongly dependent on the relative orientation of magnetizations in ferromagnetic electrodes sandwiching an insulating barrier, rendering efficient readout of spintronics devices
Language	English
Publishing date	2023-01-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-022-05463-w
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Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 9: Show issues
Zs.MO 244: Show issues

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Article: Imported severe Plasmodium falciparum infection in the first trimester of pregnancy complicated by post-artemisinin delayed hemolysis and intrauterine fetal death, a case report.

Kamegai, Kohei / Hayakawa, Kayoko / Yamamoto, Kei / Nomoto, Hidetoshi / Komaki-Yasuda, Kanako / Kano, Shigeyuki / Ohmagari, Norio

Tropical medicine and health

2023 Volume 51, Issue 1, Page(s) 25

Abstract: Background: Post-artemisinin delayed hemolysis (PADH) is a serious complication in patients who recover from severe malaria after receiving artemisinin-based combined therapy (ACT), including artemether-lumefantrine. In Japan, among the antimalarial ... ...

Abstract	Background: Post-artemisinin delayed hemolysis (PADH) is a serious complication in patients who recover from severe malaria after receiving artemisinin-based combined therapy (ACT), including artemether-lumefantrine. In Japan, among the antimalarial drugs recommended by the World Health Organization (WHO) guideline for severe malaria, intravenous quinine gluconate is available only in 29 designated hospitals, and intravenous artesunate is unavailable. Therefore, oral artemether-lumefantrine is occasionally administered as an alternative, even though it may be a suboptimal treatment. In non-endemic settings like Japan, a lack of knowledge of malaria and the side effects, such as post-artemisinin delayed hemolysis caused by the ACT, can have critical consequences. Like our patient, being a primigravida in the early stages of pregnancy is a serious risk factor for severe malaria and must be carefully monitored. Case presentation: This report describes a severe case of imported Plasmodium falciparum malaria complicated by fetal loss and prolonged anemia, requiring frequent blood transfusions. The patient was a previously healthy pregnant Japanese female in her 30 s. She developed a high fever 2 days after returning from Nigeria. The patient fulfilled the severe malaria criteria by WHO. On arrival, an abdominal ultrasound incidentally revealed a fetus of 5 week gestational age with a heartbeat in the uterus. Given her pregnancy and the severity of the disease, she was administered intravenous quinine 16 mg/kg as a loading dose. However, the second dose of quinine was not administered due to frequent vomiting and QTc prolongation. We initiated treatment with oral artemether-lumefantrine, and clearance of parasitemia was confirmed by microscopic observation on day 4. Miscarriage was noted on day 6 after admission. Moreover, the patient became feverish again up to 39 °C, and from days 14 to 22, the patient required multiple blood transfusions due to PADH. On day 40, follow-up was discontinued as the hemoglobin level exceeded 10 g/dL. Conclusions: In patients who recover from severe malaria after ACT treatment, monitoring the hemoglobin level for at least a month is strongly recommended for prompt identification of PADH. Travelers to malaria-endemic countries, especially primigravida women, should be provided with adequate information on the risk and prevention of infection.
Language	English
Publishing date	2023-05-12
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2209835-5
ISSN	1349-4147 ; 1348-8945
ISSN (online)	1349-4147
ISSN	1348-8945
DOI	10.1186/s41182-023-00510-2
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Article ; Online: Clinical outcomes and epidemiological characteristics of bacteremia in the older Japanese population.

Nakamura, Keiji / Hayakawa, Kayoko / Tsuzuki, Shinya / Ide, Satoshi / Nomoto, Hidetoshi / Nakamoto, Takato / Yamada, Gen / Yamamoto, Kei / Ohmagari, Norio

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

2023 Volume 29, Issue 10, Page(s) 971–977

Abstract: Background: The characteristics and clinical consequences of bacteremia in older people, who are highly susceptible to infections, need to be clarified. This study aimed to determine the epidemiological characteristics, prognosis, and predictors of 7- ... ...

Abstract	Background: The characteristics and clinical consequences of bacteremia in older people, who are highly susceptible to infections, need to be clarified. This study aimed to determine the epidemiological characteristics, prognosis, and predictors of 7-day mortality in patients with community-acquired (CA), healthcare-associated (HCA), and hospital-onset (HO) bacteremia in older adults aged ≥65 years. Methods: Patients aged ≥65 years with positive blood cultures between April 1, 2015, and March 31, 2018, were divided into three groups: pre-old (65-74 years), old (75-89 years), and super-old (≥90 years). Characteristics based on medical exposure, including CA, HCA, and HO, were also compared and factors related to mortality were identified. Results: Overall, 1716 episodes of bacteremia were identified in 1415 patients. Of the 1211 episodes without contamination, 32.8%, 54.3%, and 12.9% occurred in pre-old, old, and super-old patients. Central line-associated bloodstream infections were more common in pre-old patients and urinary tract infections in the old and super-old. The 7-day mortality rates in the pre-old, old, and super-old groups were 7.4%, 5.8%, and 14.2% (P = 0.002), respectively. Multivariable logistic regression showed that super-old age (adjusted odds ratio, aOR: 2.09 [1.13-3.88], P = 0.019) and HO bacteremia (aOR: 1.97 [1.18-3.28], P = 0.010) were independent risk factors for 7-day mortality. Infectious disease consultation had a protective effect on 7-day mortality (aOR: 0.59 [0.35-0.99], P = 0.047). Conclusions: The epidemiology of bacteremia differs among older people; thus, they should not be treated as a single entity. A careful approach is needed for the optimal management of bacteremia in these vulnerable patients.
MeSH term(s)	Aged ; Humans ; Bacteremia/drug therapy ; Bacteremia/epidemiology ; Bacteremia/etiology ; Bacteremia/mortality ; Community-Acquired Infections/drug therapy ; Community-Acquired Infections/epidemiology ; Community-Acquired Infections/mortality ; East Asian People ; Prognosis ; Retrospective Studies ; Risk Factors ; Cross Infection/drug therapy ; Cross Infection/epidemiology ; Cross Infection/mortality ; Aged, 80 and over ; Japan/epidemiology
Language	English
Publishing date	2023-06-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1355399-9
ISSN	1437-7780 ; 1341-321X
ISSN (online)	1437-7780
ISSN	1341-321X
DOI	10.1016/j.jiac.2023.06.015
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