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  1. Book ; Online ; E-Book: 2024 Nelson's Pediatric Antimicrobial Therapy

    Bradley, John S. / Nelson, John D. / Elizabeth, Barnett / Cantey, Joseph B. / Kimberlin, David W. / Palumbo, Paul E. / Sauberan, Jason / Smart, J. Howard / Steinbach, William J.

    2024  

    Abstract: Completely updated and revised, the 30th edition of this best-selling reference provides instant access to the latest recommendations for treatment of infectious diseases in children. For each disease, the authors provide a commentary to help select ... ...

    Abstract Completely updated and revised, the 30th edition of this best-selling reference provides instant access to the latest recommendations for treatment of infectious diseases in children. For each disease, the authors provide a commentary to help select the best of all antimicrobial choices. Drug descriptions cover all antimicrobial agents available today and include complete information about dosing regimens. Free updates available at aap.org/Nelsons.
    Language English
    Size 1 online resource (403 pages)
    Edition 30th ed.
    Publisher American Academy of Pediatrics
    Publishing place Elk Grove Village
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-61002-697-7 ; 9781610026963 ; 978-1-61002-697-0 ; 1610026969
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Nelson's neonatal antimicrobial therapy

    Cantey, Joseph B. / Nelson, John D. / Elizabeth, Barnett / Bradley, John S. / Kimberlin, David W. / Palumbo, Paul E. / Smart, J. Howard / Steinbach, William J. / Sauberan, Jason

    2024  

    Abstract: Completely updated and revised, Nelson's Neonatal Antimicrobial Therapy, 2nd Edition, provides the most current, practical, and evidence-based recommendations for health care professionals treating neonates. Developed by leading experts in antimicrobial ... ...

    Title variant Neonatal antimicrobial therapy
    Institution American Academy of Pediatrics
    Author's details Joseph B. Cantey, MD, MPH, Jason Sauberan, PharmD Editors in Chief, John D. Nelson, Emeritus
    Abstract Completely updated and revised, Nelson's Neonatal Antimicrobial Therapy, 2nd Edition, provides the most current, practical, and evidence-based recommendations for health care professionals treating neonates. Developed by leading experts in antimicrobial therapy, this resource aims to help clinicians select the right drug, dose, and duration for the treatment of bacterial, viral, fungal, and parasitic infections in neonates.

    Front Matter -- 1. Choosing an Antibiotic for the Neonate -- 2. Antimicrobial Drug Therapy for Neonates -- 3. Bacterial Infections in Neonates -- 4. Viral Infections in Neonates -- 5. Fungal Infections in Neonates -- 6. Parasitic Infections in Neonates -- 7. Antimicrobial Stewardship in the Nursery -- Index.
    Subject code 618.9201
    Language English
    Size 1 Online-Ressource (x, 92 Seiten)
    Edition Second edition
    Publisher American Academy of Pediatrics
    Publishing place Elk Grove Village
    Publishing country United States
    Document type Book ; Online ; E-Book
    Note Description based on publisher supplied metadata and other sources
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030696544
    ISBN 978-1-61002-699-4 ; 9781610026987 ; 1-61002-699-3 ; 1610026985
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Programs Promoting Virtual Social Connections and Friendships for Youth with Disabilities: A Scoping Review.

    Smart, Eric / Li, Joelle / Becerra, Maria / King, Gillian

    Physical & occupational therapy in pediatrics

    2023  Volume 43, Issue 6, Page(s) 780–805

    Abstract: ... friendships in their personal social networks. Data extraction involved program characteristics (e.g ... Each approach was grounded in the principles of fostering privacy and independence (i.e., socializing with peers ... without relying on caregivers), safety and self-expression (i.e., communicating authentically), plus confidence ...

    Abstract Aims: This scoping review explores what is known about programs that support youth with physical and developmental disabilities to create virtual social connections as a means toward friendships.
    Methods: Peer-reviewed studies were searched in six electronic databases: CINAHL, EMBASE, ERIC, MEDLINE, PsycINFO, and Scopus. Two reviewers screened articles that described programs in which participants, ages 8-20, interacted with others online, and reported outcomes related to virtual social connections and friendships in their personal social networks. Data extraction involved program characteristics (e.g., duration, group members, online platform) plus qualitative description outlining access and participation experiences.
    Results: After screening 12,605 articles, 9 were determined eligible. Programs followed two approaches: (1) training youth to use the internet and technology to access virtual spaces independently; and (2) designing virtual opportunities and activities that encourage youth interaction and collaboration. Each approach was grounded in the principles of fostering privacy and independence (i.e., socializing with peers without relying on caregivers), safety and self-expression (i.e., communicating authentically), plus confidence and capability (i.e., trying new skills).
    Conclusions: This scoping review provides guidance on enhancing access and participation of youth with disabilities in virtual spaces where they can develop social connections that increase chances for friendships.
    MeSH term(s) Adolescent ; Humans ; Caregivers ; Disabled Persons ; Friends
    Language English
    Publishing date 2023-04-30
    Publishing country England
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 783998-4
    ISSN 1541-3144 ; 0194-2638
    ISSN (online) 1541-3144
    ISSN 0194-2638
    DOI 10.1080/01942638.2023.2199827
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2678: Show issues Location:
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  4. Article ; Online: Artificial intelligence as a diagnostic aid in cross-sectional radiological imaging of surgical pathology in the abdominopelvic cavity: a systematic review.

    Fowler, George E / Blencowe, Natalie S / Hardacre, Conor / Callaway, Mark P / Smart, Neil J / Macefield, Rhiannon

    BMJ open

    2023  Volume 13, Issue 3, Page(s) e064739

    Abstract: Objectives: There is emerging use of artificial intelligence (AI) models to aid diagnostic imaging. This review examined and critically appraised the application of AI models to identify surgical pathology from radiological images of the abdominopelvic ... ...

    Abstract Objectives: There is emerging use of artificial intelligence (AI) models to aid diagnostic imaging. This review examined and critically appraised the application of AI models to identify surgical pathology from radiological images of the abdominopelvic cavity, to identify current limitations and inform future research.
    Design: Systematic review.
    Data sources: Systematic database searches (Medline, EMBASE, Cochrane Central Register of Controlled Trials) were performed. Date limitations (January 2012 to July 2021) were applied.
    Eligibility criteria: Primary research studies were considered for eligibility using the PIRT (participants, index test(s), reference standard and target condition) framework. Only publications in the English language were eligible for inclusion in the review.
    Data extraction and synthesis: Study characteristics, descriptions of AI models and outcomes assessing diagnostic performance were extracted by independent reviewers. A narrative synthesis was performed in accordance with the Synthesis Without Meta-analysis guidelines. Risk of bias was assessed (Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2)).
    Results: Fifteen retrospective studies were included. Studies were diverse in surgical specialty, the intention of the AI applications and the models used. AI training and test sets comprised a median of 130 (range: 5-2440) and 37 (range: 10-1045) patients, respectively. Diagnostic performance of models varied (range: 70%-95% sensitivity, 53%-98% specificity). Only four studies compared the AI model with human performance. Reporting of studies was unstandardised and often lacking in detail. Most studies (n=14) were judged as having overall high risk of bias with concerns regarding applicability.
    Conclusions: AI application in this field is diverse. Adherence to reporting guidelines is warranted. With finite healthcare resources, future endeavours may benefit from targeting areas where radiological expertise is in high demand to provide greater efficiency in clinical care. Translation to clinical practice and adoption of a multidisciplinary approach should be of high priority.
    Prospero registration number: CRD42021237249.
    MeSH term(s) Humans ; Pathology, Surgical ; Artificial Intelligence ; Cross-Sectional Studies ; Retrospective Studies ; Radiography
    Language English
    Publishing date 2023-03-06
    Publishing country England
    Document type Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2022-064739
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  5. Article: A Comparative Study of Uterine Artery Doppler Parameters and Endometrial Characteristics in Women with Unexplained Infertility and Fertile Women at a Nigerian Teaching Hospital.

    Smart, A E / Obajimi, G O / Adekanmi, A J / Obajimi, M O

    West African journal of medicine

    2022  Volume 39, Issue 5, Page(s) 451–458

    Abstract: Objectives: To investigate the uterine artery Doppler parameters and endometrial characteristics in women with unexplained infertility.: Methods: A prospective case-control study of 42 women with unexplained infertility and 42 fertile controls. Their ...

    Abstract Objectives: To investigate the uterine artery Doppler parameters and endometrial characteristics in women with unexplained infertility.
    Methods: A prospective case-control study of 42 women with unexplained infertility and 42 fertile controls. Their mid-luteal phase transvaginal Doppler parameters of both uterine arteries and endometrial characteristics (endometrial blood flow, thickness and volume) were investigated and analysed. P values < 0.05 was statistically significant.
    Results: The mean uterine artery pulsatility index (PI) and resistivity index (RI) of the cases (women with unexplained infertility) were significantly higher compared to the values in the fertile controls (PI = 2.81±0.61 vs 2.15±0.65; p=0.001) (RI= 0.87±0.08 vs 0.82±0.07; p=0.003). In addition, the end-diastolic volume (EDV) (6.12±4.17 vs 9.37±5.14; p=0.007) and endometrial-subendometrial blood flow (p=0.036) were significantly lower in the cases compared to the controls. Multivariate logistics analysis showed that PI was independently associated with infertile status (p=0.006). There was no significant difference in the mean PSV (48.69±10.9 vs 50.58±11.30; p=0.602), endometrial thickness (10.30+3.13 vs 10.72+3.10; p=0.544), endometrial volume (7.82+1.56 vs 8.23+1.71; p=0.323), mean age (32.28±4.062 vs 31.91±3.58 years; p=0.502), body mass index (26.15±2.71kg/m2 vs 25.24±2.85 kg/m2; p=0.18) menstrual bleeding days (4.07±0.89 days vs 4.02±0.95 days; p=0.481) duration of menstrual cycle (28.02±1.09 days vs 27.64±1.36 days; p= 0.162), smoking history (p=0.909) and alcohol intake (p=0.507) of the infertile women compared with the fertile controls, respectively.
    Conclusion: Women with unexplained infertility have increased uterine artery Doppler PI and RI and reduced endometrial-subendometrial perfusion compared with fertile controls.
    MeSH term(s) Adult ; Case-Control Studies ; Female ; Hospitals, Teaching ; Humans ; Infertility, Female/diagnostic imaging ; Nigeria/epidemiology ; Uterine Artery/diagnostic imaging ; Uterus/diagnostic imaging
    Language English
    Publishing date 2022-05-21
    Publishing country Nigeria
    Document type Journal Article
    ZDB-ID 1132088-6
    ISSN 0189-160X
    ISSN 0189-160X
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3527: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Gut enterotype-dependent modulation of gut microbiota and their metabolism in response to xanthohumol supplementation in healthy adults.

    Jamieson, Paige E / Smart, Eli B / Bouranis, John A / Choi, Jaewoo / Danczak, Robert E / Wong, Carmen P / Paraiso, Ines L / Maier, Claudia S / Ho, Emily / Sharpton, Thomas J / Metz, Thomas O / Bradley, Ryan / Stevens, Jan F

    Gut microbes

    2024  Volume 16, Issue 1, Page(s) 2315633

    Abstract: Xanthohumol (XN), a polyphenol found in the hop plant ( ...

    Abstract Xanthohumol (XN), a polyphenol found in the hop plant (
    MeSH term(s) Adult ; Humans ; Gastrointestinal Microbiome ; RNA, Ribosomal, 16S/genetics ; Flavonoids/pharmacology ; Prebiotics ; Propiophenones
    Chemical Substances xanthohumol (T4467YT1NT) ; RNA, Ribosomal, 16S ; Flavonoids ; Prebiotics ; Propiophenones
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2575755-6
    ISSN 1949-0984 ; 1949-0984
    ISSN (online) 1949-0984
    ISSN 1949-0984
    DOI 10.1080/19490976.2024.2315633
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  7. Article ; Online: Low recruitment drives the decline of red porgy (Pagrus pagrus) along the southeast USA Atlantic coast: Inferences from fishery-independent trap and video monitoring.

    Bacheler, Nathan M / Klibansky, Nikolai / Bubley, Walter J / Smart, Tracey I

    PloS one

    2023  Volume 18, Issue 7, Page(s) e0286078

    Abstract: ... Highest red porgy relative abundance from traps and video occurred in deep areas (i.e., 60-100 m) between ... habitats (i.e., pavement). We confirmed recent low recruitment of red porgy in the region based ...

    Abstract Red porgy (Pagrus pagrus) is a reef-associated, economically-important, winter-spawning, protogynous Sparidae species that appears to have declined in abundance in recent years along the southeast United States Atlantic coast. We used spatially-explicit generalized additive models built with fishery-independent chevron trap (1990-2021) and video data (2011-2021) to quantify the ways in which red porgy relative abundance and mean size varied across temporal, spatial, environmental, and habitat variables. Mean red porgy relative abundance from traps declined by 77% between 1992 and 2021, and declines were similarly large (69%) on video between 2011 and 2021. The largest two-year decline in relative abundance occurred early in the COVID-19 pandemic (2019-2021)- 32% in traps and 45% on video-despite already low abundance. Highest red porgy relative abundance from traps and video occurred in deep areas (i.e., 60-100 m) between southern North Carolina and north Georgia, and red porgy preferred low relief but continuous hardbottom habitats (i.e., pavement). We confirmed recent low recruitment of red porgy in the region based on the large increase in mean length (29%) and severe (~99%) declines of juvenile red porgy caught over the 32-year trap survey. Evidence suggests that recruitment failure is partially or mostly responsible for red porgy abundance declines, and, moreover, the regulation of harvest is unlikely to achieve sustainable management goals until recruitment increases.
    MeSH term(s) Animals ; Humans ; Fisheries ; Pandemics ; COVID-19 ; Perciformes/physiology ; North Carolina
    Language English
    Publishing date 2023-07-05
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0286078
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  8. Book ; Online: Polytope

    Leuridan, Mathilde / Hawkes, James / Smart, Simon / Danovaro, Emanuele / Quintino, Tiago

    An Algorithm for Efficient Feature Extraction on Hypercubes

    2023  

    Abstract: Data extraction algorithms on data hypercubes, or datacubes, are traditionally only capable of cutting boxes of data along the datacube axes. For many use cases however, this is not a sufficient approach and returns more data than users might actually ... ...

    Abstract Data extraction algorithms on data hypercubes, or datacubes, are traditionally only capable of cutting boxes of data along the datacube axes. For many use cases however, this is not a sufficient approach and returns more data than users might actually need. This not only forces users to apply post-processing after extraction, but more importantly this consumes more I/O resources than is necessary. When considering very large datacubes from which users only want to extract small non-rectangular subsets, the box approach does not scale well. Indeed, with this traditional approach, I/O systems quickly reach capacity, trying to read and return unwanted data to users. In this paper, we propose a novel technique, based on computational geometry concepts, which instead carefully pre-selects the precise bytes of data which the user needs in order to then only read those from the datacube. As we discuss later on, this novel extraction method will considerably help scale access to large petabyte size data hypercubes in a variety of scientific fields.

    Comment: 10 pages, 13 figures
    Keywords Computer Science - Information Retrieval ; Computer Science - Computational Geometry ; 68P20 ; E.1 ; H.3.1 ; H.3.3 ; F.2.2 ; G.4 ; J.2 ; J.3
    Subject code 006
    Publishing date 2023-06-20
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Cell Adhesion Molecules in Plasticity and Metastasis.

    Smart, Jessica A / Oleksak, Julia E / Hartsough, Edward J

    Molecular cancer research : MCR

    2020  Volume 19, Issue 1, Page(s) 25–37

    Abstract: Prior to metastasis, modern therapeutics and surgical intervention can provide a favorable long-term survival for patients diagnosed with many types of cancers. However, prognosis is poor for patients with metastasized disease. Melanoma is the deadliest ... ...

    Abstract Prior to metastasis, modern therapeutics and surgical intervention can provide a favorable long-term survival for patients diagnosed with many types of cancers. However, prognosis is poor for patients with metastasized disease. Melanoma is the deadliest form of skin cancer, yet i
    MeSH term(s) Cell Adhesion Molecules/metabolism ; Disease Progression ; Humans ; Neoplasm Metastasis ; Prognosis
    Chemical Substances Cell Adhesion Molecules
    Language English
    Publishing date 2020-10-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2098788-2
    ISSN 1557-3125 ; 1541-7786
    ISSN (online) 1557-3125
    ISSN 1541-7786
    DOI 10.1158/1541-7786.MCR-20-0595
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5744: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Fertilization using manure minimizes the trade-offs between biodiversity and forage production in agri-environment scheme grasslands.

    Villa-Galaviz, Edith / Smart, Simon M / Ward, Susan E / Fraser, Mariecia D / Memmott, Jane

    PloS one

    2023  Volume 18, Issue 10, Page(s) e0290843

    Abstract: A common practice used to restore and maintain biodiversity in grasslands is to stop or decrease the use of fertilizers as they are a major cause of biodiversity loss. This practice is problematic for farmers who need fertilizers to increase forage and ... ...

    Abstract A common practice used to restore and maintain biodiversity in grasslands is to stop or decrease the use of fertilizers as they are a major cause of biodiversity loss. This practice is problematic for farmers who need fertilizers to increase forage and meet the nutritional needs of livestock. Evidence is needed that helps identify optimal fertilizer regimes that could benefit biodiversity and livestock production simultaneously over the long-term. Here, we evaluated the impact of different fertilizer regimes on indicators related to both biodiversity (plant, pollinator, leaf miners and parasitoid Shannon-Weiner diversity, bumblebee abundance, nectar productivity and forb species richness), and forage production (ash, crude protein, ruminant metabolizable energy and dry matter). To this end, we used data from a grassland restoration experiment managed under four nutrient inputs schemes for 27 years: farmyard manure (FYM; 72 kg N ha-1 yr-1), artificial nitrogen-phosphorus and potassium (NPK; 25 kg N ha-1 yr-1), FYM + NPK (97 kg N ha-1 yr-1) and no-fertilizer. Results showed strong trade-offs between biodiversity and forage production under all treatments even in applications lower than the critical load in the EU. Overall, farmyard manure was the fertilizer that optimized production and biodiversity while 97 kg N ha-1 yr-1 of fertilizer addition (FYM+NPK) had the most negative impact on biodiversity. Finally, forage from places where no fertilizer has been added for 27 years did not meet the nutritional requirements of cattle, but it did for sheep. Rethinking typical approaches of nutrient addition could lead to land management solutions suitable for biological conservation and agriculture.
    MeSH term(s) Cattle ; Animals ; Sheep ; Grassland ; Manure ; Fertilizers ; Agriculture/methods ; Biodiversity ; Nitrogen/metabolism ; Livestock/metabolism ; Fertilization ; Soil
    Chemical Substances Manure ; Fertilizers ; Nitrogen (N762921K75) ; Soil
    Language English
    Publishing date 2023-10-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0290843
    Database MEDical Literature Analysis and Retrieval System OnLINE

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