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  1. Article: Antiepileptic drug therapy in brain tumor patients: a complex relationship.

    Dietrich, Jorg

    Neuro-oncology practice

    2022  Volume 9, Issue 2, Page(s) 83–84

    Language English
    Publishing date 2022-01-28
    Publishing country England
    Document type Editorial
    ZDB-ID 2768945-1
    ISSN 2054-2585 ; 2054-2577
    ISSN (online) 2054-2585
    ISSN 2054-2577
    DOI 10.1093/nop/npac010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The best matrix for the brain: advances in secondary CNS lymphoma.

    Dietrich, Jorg

    The Lancet. Haematology

    2021  Volume 8, Issue 2, Page(s) e96–e97

    MeSH term(s) Brain/diagnostic imaging ; Central Nervous System Neoplasms/drug therapy ; Hematopoietic Stem Cell Transplantation ; Humans ; Lymphoma, Large B-Cell, Diffuse ; Transplantation, Autologous
    Language English
    Publishing date 2021-01-26
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2352-3026
    ISSN (online) 2352-3026
    DOI 10.1016/S2352-3026(20)30431-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Inter-library loan at ZB MED

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  3. Book: Werkzeuge für das integrierte Flussgebietsmanagement

    Dietrich, Jörg

    Ergebnisse der Fallstudie Werra ; mit 106 Tabellen

    (Konzepte für die nachhaltige Entwicklung einer Flusslandschaft ; 7 ; Ökologie)

    2006  

    Author's details Jörg Dietrich ... (Hrsg.)
    Series title Konzepte für die nachhaltige Entwicklung einer Flusslandschaft ; 7
    Ökologie
    Collection
    Keywords Werra ; Einzugsgebiet ; Europäische Union
    Subject Einzugsbereich
    Language German
    Size XVII, 452 S. : Ill., graph. Darst., Kt.
    Publisher Weißensee-Verl
    Publishing place Berlin
    Publishing country Germany
    Document type Book
    Accompanying material 1 CD-ROM (12 cm)
    HBZ-ID HT014823372
    ISBN 3-89998-082-4 ; 978-3-89998-082-0
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    064/746 available for loan (reading room) Freihandmagazin (U1)

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  4. Article ; Online: Neurotoxicity of Cancer Therapies.

    Dietrich, Jorg

    Continuum (Minneapolis, Minn.)

    2020  Volume 26, Issue 6, Page(s) 1646–1672

    Abstract: Purpose of review: This article reviews neurologic complications associated with chemotherapy, radiation therapy, antiangiogenic therapy, and immunotherapy.: Recent findings: Cancer therapies can cause a wide range of neurologic adverse effects and ... ...

    Abstract Purpose of review: This article reviews neurologic complications associated with chemotherapy, radiation therapy, antiangiogenic therapy, and immunotherapy.
    Recent findings: Cancer therapies can cause a wide range of neurologic adverse effects and may result in significant patient morbidity and mortality. Although some treatment-associated neurologic complications manifest acutely and are often reversible and transient, others occur with delayed onset, can be progressive, and are uniquely challenging to patient management. With an increase in multimodality and combination therapies, including targeted therapies and immunotherapies, and prolonged patient survival, novel and unique patterns of neurologic complications have emerged.
    Summary: Both conventional and novel cancer therapies can adversely affect the nervous system, thereby producing a wide range of neurologic complications. Increased awareness among neurologists and early recognition of cancer therapy-induced neurotoxic syndromes is critically important to minimize patient morbidity, prevent permanent injury, and improve patient outcomes.
    MeSH term(s) Combined Modality Therapy ; Humans ; Immunotherapy/adverse effects ; Neoplasms/drug therapy ; Nervous System Diseases ; Neurotoxicity Syndromes
    Language English
    Publishing date 2020-11-13
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1538-6899
    ISSN (online) 1538-6899
    DOI 10.1212/CON.0000000000000943
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Exploring Novel Therapeutic Avenues for Chemotherapy Related Cognitive Impairment.

    Dietrich, Jorg / Parsons, Michael W / Santarnecchi, Emiliano

    Cancer research

    2024  

    Abstract: Many cancer patients are at risk of developing cognitive symptoms that often become evident during or after cancer-directed therapy and may involve difficulties with attention, concentration, multitasking, executive function, and memory. Despite recent ... ...

    Abstract Many cancer patients are at risk of developing cognitive symptoms that often become evident during or after cancer-directed therapy and may involve difficulties with attention, concentration, multitasking, executive function, and memory. Despite recent advances in identifying potential molecular and cellular mechanisms underlying cancer and chemotherapy-related cognitive impairment, there is generally a lack of effective treatment strategies, and the development of novel therapeutic interventions represents a major unmet medical need in clinical practice. A recent study by Kim and colleagues suggests that multi-sensory 40-Hz gamma entrainment using sensory stimuli (GENUS) with combined visual and auditory stimuli is associated with powerful neuroprotective effects in mouse models of cisplatin or methotrexate-induced 'chemobrain'. While the study has some limitations and successful interventions in animal models have often failed to translate into clinical practice, this non-invasive treatment modality has promise to protect brain structure and function and could be tested in cancer patients who are at risk for cognitive decline.
    Language English
    Publishing date 2024-04-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-24-1342
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.135/5: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Editorial: Cellular CNS repair strategies, technologies and therapeutic developments.

    Bruun, Tim-Henrik / Dietrich, Jorg / Klingseisen, Anna / Bogdahn, Ulrich

    Frontiers in cellular neuroscience

    2023  Volume 17, Page(s) 1200639

    Language English
    Publishing date 2023-04-28
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2023.1200639
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Investigational treatment strategies in glioblastoma: progress made and barriers to success.

    Nelson, Thomas A / Dietrich, Jorg

    Expert opinion on investigational drugs

    2023  Volume 32, Issue 10, Page(s) 921–930

    Abstract: Introduction: Glioblastoma, isocitrate dehydrogenase wildtype (IDHwt), remains an incurable disease despite considerable research effort. The current standard of care since 2005 comprises maximal safe resection followed by radiation with concurrent and ... ...

    Abstract Introduction: Glioblastoma, isocitrate dehydrogenase wildtype (IDHwt), remains an incurable disease despite considerable research effort. The current standard of care since 2005 comprises maximal safe resection followed by radiation with concurrent and adjuvant temozolomide; more recently, the addition of tumor treating fields was approved in the newly diagnosed and recurrent disease settings.
    Areas covered: Searches of PubMed, Cochrane Library, and ClinicalTrials.gov provided a foundation for this review. We first describe early research including carmustine wafers, brachytherapy, anti-angiogenesis, and immune checkpoint inhibition for glioblastoma. Next, we discuss challenges precluding the translation of preclinical successes. This is followed by a description of promising treatments such as chimeric antigen receptor T-cell therapy as well as the recent qualified successes of cancer vaccinations. Non-immunotherapy trials are also highlighted, and ongoing or pending phase 2 and 3 clinical trials are codified in study tables.
    Expert opinion: Unfortunately, hundreds of trials, including of agents effective in systemic malignancy, have not drastically changed management of glioblastoma. This may reflect unique resistance mechanisms and highlights a need for multimodality treatments beyond surgery, radiation, and conventional chemotherapy. Novel techniques, such as those in the emerging field of cancer neuroscience, may help uncover tolerable and effective regimens for this lethal malignancy.
    MeSH term(s) Humans ; Glioblastoma/pathology ; Brain Neoplasms/drug therapy ; Brain Neoplasms/pathology ; Temozolomide/therapeutic use ; Combined Modality Therapy ; Therapies, Investigational
    Chemical Substances Temozolomide (YF1K15M17Y)
    Language English
    Publishing date 2023-11-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1182884-5
    ISSN 1744-7658 ; 0967-8298 ; 1354-3784
    ISSN (online) 1744-7658
    ISSN 0967-8298 ; 1354-3784
    DOI 10.1080/13543784.2023.2267982
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3739: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: The complexities underlying epilepsy in people with glioblastoma.

    Sokolov, Elisaveta / Dietrich, Jorg / Cole, Andrew J

    The Lancet. Neurology

    2023  Volume 22, Issue 6, Page(s) 505–516

    Abstract: Seizures are among the most common clinical signs in people with glioblastoma. Advances over the past 5 years, including new clinical trial data, have increased the understanding of why some individuals with glioblastoma are susceptible to seizures, how ... ...

    Abstract Seizures are among the most common clinical signs in people with glioblastoma. Advances over the past 5 years, including new clinical trial data, have increased the understanding of why some individuals with glioblastoma are susceptible to seizures, how seizures manifest clinically, and what implications seizures have for patient management. The pathophysiology of epilepsy in people with glioblastoma relates to a combination of intrinsic epileptogenicity of tumour tissue, alterations in the tumour and peritumoural microenvironment, and the physical and functional disturbance of adjacent brain structures. Successful management of epilepsy in people with glioblastoma remains challenging; factors such as drug-drug interactions between cancer therapies and antiseizure medications, and medication side-effects, can affect seizure outcomes and quality of life. Advances in novel therapies provide some promise for people with glioblastoma; however, the effects of these therapies on seizures are yet to be fully determined. Looking forward, insights into electrical activity as a driver of tumour cell growth and the intrinsic hyperexcitability of tumour tissue might represent useful targets for treatment and disease modification. There is a pressing need for large randomised clinical trials in this field.
    MeSH term(s) Humans ; Anticonvulsants/therapeutic use ; Carbamazepine/therapeutic use ; Epilepsy, Generalized ; Glioblastoma/therapy ; Glioblastoma/drug therapy ; Epilepsies, Partial/drug therapy ; Quality of Life ; Epilepsy/drug therapy ; Epilepsy/etiology ; Seizures/drug therapy ; Tumor Microenvironment
    Chemical Substances Anticonvulsants ; Carbamazepine (33CM23913M)
    Language English
    Publishing date 2023-04-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(23)00031-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5955: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Book ; Thesis: Expressionsanalyse von Neurotransmitter-Rezeptoren und von Rezeptoren für die Wachstumsfaktoren Endothelin und vascular endothelial growth factor in Gehirntumoren

    Dietrich, Jörg

    1998  

    Author's details vorgelegt von Jörg Dietrich
    Language German
    Size 83 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Regensburg, Univ., Diss., 1998
    HBZ-ID HT009626876
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    99 D 247 order for loan Magazin

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  10. Article ; Online: Assessment and Management of Cognitive Symptoms in Patients With Brain Tumors.

    Parsons, Michael W / Dietrich, Jörg

    American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting

    2021  Volume 41, Page(s) e90–e99

    Abstract: Cognitive symptoms occur in almost all patients with brain tumors at varying points in the disease course. Deficits in neurocognitive function may be caused by the tumor itself, treatment (surgery, radiation, or chemotherapy), or other complicating ... ...

    Abstract Cognitive symptoms occur in almost all patients with brain tumors at varying points in the disease course. Deficits in neurocognitive function may be caused by the tumor itself, treatment (surgery, radiation, or chemotherapy), or other complicating factors (e.g., seizures, fatigue, mood disturbance) and can have a profound effect on functional independence and quality of life. Assessment of neurocognitive function is an important part of comprehensive care of patients with brain tumors. In the neuro-oncology clinic, assessment may include cognitive screening tools and inquiry into subjective cognitive function. Neuropsychological assessment is an important adjunct to identify cognitive symptoms and can be used as an opportunity to intervene through transformative feedback and treatment planning. Preventative measures can be taken to reduce cognitive side effects of treatment, such as awake craniotomies with intraoperative mapping during neurosurgery or prophylactic measures during radiation therapy (e.g., hippocampal avoidance, neuroprotectant treatment with memantine). Rehabilitative therapies, including cognitive rehabilitation and computerized cognitive exercise, are options for managing cognitive problems in an individualized manner. Pharmacotherapy, including use of stimulant medications and acetylcholinesterase inhibitors, has shown benefits for patients with brain tumors when tailored to an individual's cognitive profile. Identification and management of co-occurring issues, such as sleep disturbance, fatigue, and depression, can also improve neurocognitive function. There are promising therapies under development that may provide new options for treatment in the future. Integrating careful assessment and treatment of cognition throughout the disease course for patients with brain tumors can improve functional outcomes and quality of life.
    MeSH term(s) Brain Neoplasms/complications ; Brain Neoplasms/diagnosis ; Brain Neoplasms/therapy ; Cognition ; Cognition Disorders/diagnosis ; Cognition Disorders/etiology ; Cognition Disorders/therapy ; Fatigue/diagnosis ; Fatigue/epidemiology ; Fatigue/etiology ; Humans ; Quality of Life
    Language English
    Publishing date 2021-06-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2431126-1
    ISSN 1548-8756 ; 1548-8748
    ISSN (online) 1548-8756
    ISSN 1548-8748
    DOI 10.1200/EDBK_320813
    Database MEDical Literature Analysis and Retrieval System OnLINE

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