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  1. Article ; Online: Characterization of CD11c

    Bossuyt, Xavier

    The Journal of allergy and clinical immunology

    2023  Volume 153, Issue 1, Page(s) 354

    MeSH term(s) Humans ; B-Lymphocytes ; Longitudinal Studies ; CD11c Antigen
    Chemical Substances CD11c Antigen
    Language English
    Publishing date 2023-10-20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2023.09.033
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  2. Article ; Online: DFS70 Autoantibodies: Clinical Utility in Antinuclear Antibody Testing.

    Bossuyt, Xavier

    Clinical chemistry

    2023  Volume 70, Issue 2, Page(s) 374–381

    Abstract: Background: Screening for antinuclear antibodies (ANA) by indirect immunofluorescence (IIF) on HEp-2 cells is helpful for the diagnosis and classification of ANA-associated rheumatic diseases, including systemic lupus erythematosus, Sjögren syndrome, ... ...

    Abstract Background: Screening for antinuclear antibodies (ANA) by indirect immunofluorescence (IIF) on HEp-2 cells is helpful for the diagnosis and classification of ANA-associated rheumatic diseases, including systemic lupus erythematosus, Sjögren syndrome, mixed connective tissue disease, systemic sclerosis, and inflammatory myopathies. The dense fine speckled (DFS) pattern is a special HEp-2 IIF pattern (produced by anti-DFS70 antibodies) because it is not associated with a specific medical condition and therefore can obfuscate interpretation.
    Content: In this paper, detection methods for and clinical associations of anti-DFS70 antibodies are reviewed.
    Summary: The target antigen of the antibodies that cause the DFS pattern is a 70 kDa protein (DFS70). Commercial methods that detect antibodies to full-length or truncated DFS70 are available for use in clinical laboratories (ELISA, chemiluminescence, dot/line blot). Anti-DFS70 can be found in (apparently) healthy individuals (with a higher frequency in young individuals and in females), in several (inflammatory) conditions and in malignancy. There is no clinical association that is well-established. Special attention (and critical reflection) is given to the observation that monospecific anti-DFS70 (i.e., in the absence of antibodies that are linked to ANA-associated rheumatic diseases) is rarely found in ANA-associated rheumatic diseases.
    MeSH term(s) Female ; Humans ; Antibodies, Antinuclear ; Autoantibodies ; Autoimmune Diseases/diagnosis ; Enzyme-Linked Immunosorbent Assay ; Rheumatic Diseases/diagnosis ; Transcription Factors ; Male
    Chemical Substances Antibodies, Antinuclear ; Autoantibodies ; Transcription Factors
    Language English
    Publishing date 2023-12-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1093/clinchem/hvad181
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  3. Article ; Online: Reporting Likelihood Ratio in Autoimmune Serology: Just a Theory or Feasible in Practice?

    Bossuyt, Xavier / Van Hoovels, Lieve

    Clinical chemistry

    2024  Volume 70, Issue 3, Page(s) 482–485

    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1093/clinchem/hvad222
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  4. Article ; Online: The added value of reporting likelihood ratios to laboratory test results in allergy and clinical immunology.

    Bossuyt, Xavier / Frans, Glynis

    The journal of allergy and clinical immunology. In practice

    2022  Volume 10, Issue 6, Page(s) 1667

    MeSH term(s) Allergy and Immunology ; Humans ; Hypersensitivity/diagnosis
    Language English
    Publishing date 2022-02-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2022.02.041
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  5. Article ; Online: Anticitrullinated protein antibodies: taking into account antibody levels improves interpretation.

    Bossuyt, Xavier

    Annals of the rheumatic diseases

    2017  Volume 76, Issue 9, Page(s) e33

    MeSH term(s) Citrulline ; Rheumatoid Factor ; Sweden
    Chemical Substances Citrulline (29VT07BGDA) ; Rheumatoid Factor (9009-79-4)
    Language English
    Publishing date 2017-01-24
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2016-211039
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  6. Article ; Online: Likelihood Ratio Approach and Clinical Interpretation of Laboratory Tests.

    Fierz, Walter / Bossuyt, Xavier

    Frontiers in immunology

    2021  Volume 12, Page(s) 655262

    MeSH term(s) Area Under Curve ; Clinical Laboratory Techniques/methods ; Clinical Laboratory Techniques/standards ; Diagnostic Tests, Routine/methods ; Diagnostic Tests, Routine/standards ; Humans ; ROC Curve
    Language English
    Publishing date 2021-04-16
    Publishing country Switzerland
    Document type Letter
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.655262
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  7. Article ; Online: From autoantibody test results to decision making: Incorporating likelihood ratios within medical practice.

    Deane, Kevin D / Van Hoovels, Lieve / Joy, Veena E / Olschowka, Nina / Bossuyt, Xavier

    Autoimmunity reviews

    2024  Volume 23, Issue 5, Page(s) 103537

    Abstract: Autoantibodies are important laboratory markers to support diagnosis of autoimmune diseases. Interpretation of autoantibodies is classically done in a dichotomous way (positive versus negative). Yet, interpretation of autoantibody test results can be ... ...

    Abstract Autoantibodies are important laboratory markers to support diagnosis of autoimmune diseases. Interpretation of autoantibodies is classically done in a dichotomous way (positive versus negative). Yet, interpretation of autoantibody test results can be improved by reporting likelihood ratios. Likelihood ratios convey information on how much more/less likely a test result is in individuals with the disease compared to individuals without the disease. It incorporates information on the antibody level (the higher the antibody level, the higher the association with the disease), which is helpful for (differential) diagnosis. Likelihood ratios are unit-independent and allow users to harmonize test result interpretation. When the likelihood ratio is combined with information on the pre-test probability, post-test probability can be appraised. In this review, the applicability of likelihood ratio in autoimmune diagnostics will be reviewed from the perspective of the clinician, the laboratory professional and the in vitro diagnostic industry.
    Language English
    Publishing date 2024-03-31
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2144145-5
    ISSN 1873-0183 ; 1568-9972
    ISSN (online) 1873-0183
    ISSN 1568-9972
    DOI 10.1016/j.autrev.2024.103537
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  8. Article ; Online: Clinical, immunologic, and genetic characteristics of children with ALPS: A single-center experience.

    Vanhye, Lotte / Bossuyt, Xavier / Meyts, Isabelle / Bucciol, Giorgia

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2022  Volume 34, Issue 2, Page(s) e13924

    MeSH term(s) Humans ; Child ; Mutation ; Lymphoproliferative Disorders ; Autoimmune Diseases/genetics
    Language English
    Publishing date 2022-11-22
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/pai.13924
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    Zs.A 3096: Show issues Location:
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  9. Article ; Online: Classification of rheumatoid arthritis: is it time to revise the criteria?

    Steiner, Guenter / Verschueren, Patrick / Van Hoovels, Lieve / Studenic, Paul / Bossuyt, Xavier

    RMD open

    2024  Volume 10, Issue 2

    Abstract: Classification criteria have been developed for rheumatoid arthritis (RA) and other rheumatic diseases in order to gather a homogeneous patient population for clinical studies and facilitate the timely implementation of therapeutic measures. Although ... ...

    Abstract Classification criteria have been developed for rheumatoid arthritis (RA) and other rheumatic diseases in order to gather a homogeneous patient population for clinical studies and facilitate the timely implementation of therapeutic measures. Although classification criteria are not intended to be used for diagnosis, they are frequently used to support the diagnostic process in clinical practice, including clinical decision-making. The 2010 American College of Rheumatology (ACR)/European Alliance of Associations for Rheumatology (EULAR) classification criteria for RA are capable of identifying the majority of symptomatic patients with RA already in the earliest stages of the disease who are not yet showing radiographic changes. These patients will also profit from the early implementation of therapy with disease-modifying antirheumatic drugs (DMARDs). However, the risk of misclassification is higher as compared with the former 1987 ACR criteria, which were considerably less sensitive to the recognition of patients with early RA. Of note, the presence of rheumatoid factors (RFs) and anticitrullinated protein antibodies (ACPAs) has been attributed equal weight in the 2010 ACR/EULAR criteria and may contribute up to 50% of the score needed for being classified as RA. However, while ACPAs have been proven to be the most specific serological markers of RA, the specificity of RF is moderate, especially at lower titres. This may lead to the misclassification of RF-positive patients and, consequently, the unjustified implementation of DMARD therapy. Therefore, issues arise on how comprehensive the criteria should be and whether they should be updated and adapted to findings from the past two decades that might increase both their specificity and sensitivity.
    MeSH term(s) Humans ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/drug therapy ; Aminosalicylic Acids/therapeutic use ; Rheumatoid Factor ; Rheumatic Diseases
    Chemical Substances acetyl 4-aminosalicylic acid (102338-89-6) ; Aminosalicylic Acids ; Rheumatoid Factor (9009-79-4)
    Language English
    Publishing date 2024-04-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2812592-7
    ISSN 2056-5933 ; 2056-5933
    ISSN (online) 2056-5933
    ISSN 2056-5933
    DOI 10.1136/rmdopen-2023-003851
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  10. Article ; Online: Two Novel Biallelic RASGRP1 Mutations Presenting with Immunodeficiency, Hodgkin's Lymphoma, and Autoimmunity.

    Momenilandi, Mana / Pourvali, Ali / Shahrooei, Mohammad / Bossuyt, Xavier

    Journal of clinical immunology

    2022  Volume 42, Issue 6, Page(s) 1160–1163

    MeSH term(s) Autoimmunity/genetics ; DNA-Binding Proteins ; Guanine Nucleotide Exchange Factors/genetics ; Hodgkin Disease/diagnosis ; Hodgkin Disease/genetics ; Humans ; Immunologic Deficiency Syndromes/diagnosis ; Immunologic Deficiency Syndromes/genetics ; Mutation/genetics
    Chemical Substances DNA-Binding Proteins ; Guanine Nucleotide Exchange Factors ; RASGRP1 protein, human
    Language English
    Publishing date 2022-05-20
    Publishing country Netherlands
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 779361-3
    ISSN 1573-2592 ; 0271-9142
    ISSN (online) 1573-2592
    ISSN 0271-9142
    DOI 10.1007/s10875-022-01281-x
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