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Article ; Online: Celiac crisis, a rare and profound presentation of celiac disease: a case report.

Forrest, Elizabeth Ann / Wong, Mark / Nama, Srinivasa / Sharma, Siddharth

2018 Volume 18, Issue 1, Page(s) 59

Abstract: Background: Celiac crisis is a life-threatening manifestation of celiac disease and is rare in adults, with only a handful of cases documented worldwide and mostly in children.: Case presentation: A profoundly emaciated 43-year-old female presented ... ...

Abstract	Background: Celiac crisis is a life-threatening manifestation of celiac disease and is rare in adults, with only a handful of cases documented worldwide and mostly in children. Case presentation: A profoundly emaciated 43-year-old female presented with profuse diarrhoea, shortness of breath, left leg swelling with ulceration and immobility (Body Mass Index (BMI) = 14.7 kg/m Conclusions: Celiac crisis is a rare and potentially life-threatening presentation of celiac disease, often a diagnosis of exclusion. Subacute combined degeneration of the spinal cord should be considered in patients with chronic Vitamin B12 deficiency presenting with neurological symptoms.
MeSH term(s)	Acidosis/etiology ; Adult ; Celiac Disease/complications ; Celiac Disease/diagnosis ; Diarrhea/etiology ; Dyspnea/etiology ; Edema/etiology ; Female ; Humans ; Hypoalbuminemia/etiology ; Leg ; Muscle Weakness/etiology ; Pulmonary Embolism/etiology ; Skin Ulcer/etiology ; Spinal Cord/pathology ; Venous Thrombosis/etiology ; Vitamin B 12 Deficiency/complications ; Vitamin B 12 Deficiency/etiology
Language	English
Publishing date	2018-05-02
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2041351-8
ISSN	1471-230X ; 1471-230X
ISSN (online)	1471-230X
ISSN	1471-230X
DOI	10.1186/s12876-018-0784-0
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Article: Risk factors and clinical indicators for the development of biliary strictures post liver transplant: Significance of bilirubin.

Forrest, Elizabeth Ann / Reiling, Janske / Lipka, Geraldine / Fawcett, Jonathan

World journal of transplantation

2017 Volume 7, Issue 6, Page(s) 349–358

Abstract: Aim: To identify risk factors associated with the formation of biliary strictures post liver transplantation over a period of 10-year in Queensland.: Methods: Data on liver donors and recipients in Queensland between 2005 and 2014 was obtained from ... ...

Abstract	Aim: To identify risk factors associated with the formation of biliary strictures post liver transplantation over a period of 10-year in Queensland. Methods: Data on liver donors and recipients in Queensland between 2005 and 2014 was obtained from an electronic patient data system. In addition, intra-operative and post-operative characteristics were collected and a logistical regression analysis was performed to evaluate their association with the development of biliary strictures. Results: Of 296 liver transplants performed, 285 (96.3%) were from brain dead donors. Biliary strictures developed in 45 (15.2%) recipients. Anastomotic stricture formation ( Conclusion: In addition to known risk factors, bilirubin levels in the early post-operative period could be used as a clinical indicator for biliary stricture formation.
Language	English
Publishing date	2017-12-18
Publishing country	United States
Document type	Journal Article
ISSN	2220-3230
ISSN	2220-3230
DOI	10.5500/wjt.v7.i6.349
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Article: Beyond ecosystem modeling: A roadmap to community cyberinfrastructure for ecological data‐model integration

Fer, Istem / Gardella, Anthony K / Shiklomanov, Alexey N / Campbell, Eleanor E / Cowdery, Elizabeth M / De Kauwe, Martin G / Desai, Ankur / Duveneck, Matthew J / Fisher, Joshua B / Haynes, Katherine D / Hoffman, Forrest M / Johnston, Miriam R / Kooper, Rob / LeBauer, David S / Mantooth, Joshua / Parton, William J / Poulter, Benjamin / Quaife, Tristan / Raiho, Ann /

Schaefer, Kevin / Serbin, Shawn P / Simkins, James / Wilcox, Kevin R / Viskari, Toni / Dietze, Michael C

Global change biology. 2021 Jan., v. 27, no. 1

2021

Abstract: In an era of rapid global change, our ability to understand and predict Earth's natural systems is lagging behind our ability to monitor and measure changes in the biosphere. Bottlenecks to informing models with observations have reduced our capacity to ... ...

Abstract	In an era of rapid global change, our ability to understand and predict Earth's natural systems is lagging behind our ability to monitor and measure changes in the biosphere. Bottlenecks to informing models with observations have reduced our capacity to fully exploit the growing volume and variety of available data. Here, we take a critical look at the information infrastructure that connects ecosystem modeling and measurement efforts, and propose a roadmap to community cyberinfrastructure development that can reduce the divisions between empirical research and modeling and accelerate the pace of discovery. A new era of data‐model integration requires investment in accessible, scalable, and transparent tools that integrate the expertise of the whole community, including both modelers and empiricists. This roadmap focuses on five key opportunities for community tools: the underlying foundations of community cyberinfrastructure; data ingest; calibration of models to data; model‐data benchmarking; and data assimilation and ecological forecasting. This community‐driven approach is a key to meeting the pressing needs of science and society in the 21st century.
Keywords	Biological Sciences ; biosphere ; ecosystems ; empirical research ; global change ; infrastructure
Language	English
Dates of publication	2021-01
Size	p. 13-26.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	NAL-AP-2-clean ; JOURNAL ARTICLE
ZDB-ID	1281439-8
ISSN	1365-2486 ; 1354-1013
ISSN (online)	1365-2486
ISSN	1354-1013
DOI	10.1111/gcb.15409
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Article ; Online: Beyond ecosystem modeling: A roadmap to community cyberinfrastructure for ecological data-model integration.

Schaefer, Kevin / Serbin, Shawn P / Simkins, James / Wilcox, Kevin R / Viskari, Toni / Dietze, Michael C

Global change biology

2020 Volume 27, Issue 1, Page(s) 13–26

Abstract	In an era of rapid global change, our ability to understand and predict Earth's natural systems is lagging behind our ability to monitor and measure changes in the biosphere. Bottlenecks to informing models with observations have reduced our capacity to fully exploit the growing volume and variety of available data. Here, we take a critical look at the information infrastructure that connects ecosystem modeling and measurement efforts, and propose a roadmap to community cyberinfrastructure development that can reduce the divisions between empirical research and modeling and accelerate the pace of discovery. A new era of data-model integration requires investment in accessible, scalable, and transparent tools that integrate the expertise of the whole community, including both modelers and empiricists. This roadmap focuses on five key opportunities for community tools: the underlying foundations of community cyberinfrastructure; data ingest; calibration of models to data; model-data benchmarking; and data assimilation and ecological forecasting. This community-driven approach is a key to meeting the pressing needs of science and society in the 21st century.
MeSH term(s)	Ecosystem ; Forecasting ; Models, Theoretical
Language	English
Publishing date	2020-11-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1281439-8
ISSN	1365-2486 ; 1354-1013
ISSN (online)	1365-2486
ISSN	1354-1013
DOI	10.1111/gcb.15409
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Article ; Online: Presentation abstracts.

Rice, Laura / Sung, JongHun / Keane, Kathleen / Peterson, Elizabeth / Sosnoff, Jacob / Farkas, Gary / Swartz, Ann / Strath, Scott / Gorgey, Ashraf / Berg, Arthur / Gater, David / Dyson-Hudson, Trevor / Malanga, Gerard / Cherian, Chris / Michalec, Monica / Kirshblum, Steven / Miller, Carrie / Garlanger, Kristin / Kortes, Sam /

Schnorenberg, Alyssa / Slavens, Brooke / Lee, Kenneth / Potter-Baker, Kelsey / Frost, Frederick / Plow, Ela / Solinsky, Ryan / Wilson, Catherine / Henry, Carrie Ann / Lombard, Alexander / Maher, Matthew / Weir, Joseph / Saeed, Sana / Cirnigliaro, Christopher / Specht, Adam / Garbarini, Erica / Augustine, Jonathan / Forrest, Gail / Bauman, William / Wecht, Jill / Hearn, Jasmine / Razvi, Imaduddin S / Sikka, Seema / Callender, Librada / Bennett, Monica / Robertson, Keston / Driver, Simon / Kline-Quiroz, Cristina / Donovan, Jayne / Botticello, Amanda / Arnold, Dannae / Latham, Nancy / Houlihan, Bethlyn / Bickmore, Timothy / Trinh, Ha / Shamekhi, Ameneh / Ellis, Teresa / LaVela, Sherri L / Burkhart, Elizabeth / Kale, Ibuola / Bombardier, Charles / Snoxell, Ellen / Knezevic, Steven / Hong, EunKyoung / Asselin, Pierre / Kornfeld, Stephen / Gorman, Peter / Spungen, Ann / Castillo, Camilo / Cleveland, Christine / Gabet, Joelle / Harrington, Amanda / Arenth, Patricia / Dolbow, David / Luther, Stephen / Finch, Dezon / Bouayad, Lina / Kopp, Marcel / Watzlawick, Ralf / Martus, Peter / Failli, Vieri / Finkenstaedt, Felix / Chen, Yuying / DeVivo, Michael / Dirnagl, Ulrich / Schwab, Jan / LiMonta, James / Santiago, Tiffany / Wu, Yu-Kuang / Harel, Noam / Monden, Kimberley / Trost, Zina / Nguyen, Nguyen / Morse, Leslie / Boals, Adriel / Wenzel, Lisa / Silveira, Stephanie / Hughes, Rosemary / Nosek, Margaret / LeDoux, Tracey / Taylor, Heather / Diaz, Lauren / Robinson-Whelen, Susan / Garshick, Eric / Betz, Kendra / Krause, James / Cao, Yue / Li, Chao / Hon, Beverly / Khong, Cria-May / Dirlikov, Ben / Shem, Kazuko / Charlifue, Susan / Song, Shawn / Burns, Stephen

The journal of spinal cord medicine

2018 Volume 41, Issue 5, Page(s) 599–622

Language	English
Publishing date	2018-08-17
Publishing country	England
Document type	Journal Article
ZDB-ID	1223949-5
ISSN	2045-7723 ; 1079-0268
ISSN (online)	2045-7723
ISSN	1079-0268
DOI	10.1080/10790268.2018.1498262
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Article ; Online: Obesity not associated with severity among hospitalized adults with seasonal influenza virus infection.

Braun, Elise S / Crawford, Forrest W / Desai, Mayur M / Meek, James / Kirley, Pam Daily / Miller, Lisa / Anderson, Evan J / Oni, Oluwakemi / Ryan, Patricia / Lynfield, Ruth / Bargsten, Marisa / Bennett, Nancy M / Lung, Krista L / Thomas, Ann / Mermel, Elizabeth / Lindegren, Mary Lou / Schaffner, William / Price, Andrea / Chaves, Sandra S

Infection

2015 Volume 43, Issue 5, Page(s) 569–575

Abstract: We examined seasonal influenza severity [artificial ventilation, intensive care unit (ICU) admission, and radiographic-confirmed pneumonia] by weight category among adults hospitalized with laboratory-confirmed influenza. Using multivariate logistic ... ...

Abstract	We examined seasonal influenza severity [artificial ventilation, intensive care unit (ICU) admission, and radiographic-confirmed pneumonia] by weight category among adults hospitalized with laboratory-confirmed influenza. Using multivariate logistic regression models, we found no association between obesity or severe obesity and artificial ventilation or ICU admission; however, overweight and obese patients had decreased risk of pneumonia. Underweight was associated with pneumonia (adjusted odds ratio 1.31; 95 % confidence interval 1.04, 1.64).
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Critical Care ; Female ; Hospitalization ; Humans ; Influenza, Human/complications ; Influenza, Human/pathology ; Male ; Middle Aged ; Obesity/complications ; Pneumonia/pathology ; Respiration, Artificial ; Young Adult
Language	English
Publishing date	2015-10
Publishing country	Germany
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	185104-4
ISSN	1439-0973 ; 0300-8126 ; 0173-2129
ISSN (online)	1439-0973
ISSN	0300-8126 ; 0173-2129
DOI	10.1007/s15010-015-0802-x
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Article ; Online: Stakeholder engagement infrastructure to support multicenter research networks: Advances from the clinical research networks participating in PCORnet.

Cope, Elizabeth L / McTigue, Kathleen M / Forrest, Christopher B / Carton, Thomas W / Fair, Alecia M / Goytia, Crispin / Harrington, Joseph M / Lowe, Susan / Merritt, J Greg / Shenkman, Elizabeth A / Stephens, William J / Templeton, Anna / Williams, Neely A / Zemon, Nadine / Millender, Sarah / Angove, Rebekah S M

Learning health systems

2022 Volume 7, Issue 1, Page(s) e10313

Abstract: Background: The evidence based on the inclusion of patients and other stakeholders as partners in the clinical research process has grown substantially. However, little has been reported on how stakeholders are engaged in the governance of large-scale ... ...

Abstract	Background: The evidence based on the inclusion of patients and other stakeholders as partners in the clinical research process has grown substantially. However, little has been reported on how stakeholders are engaged in the governance of large-scale clinical research networks and the infrastructure used by research networks to support engagement in network-affiliated activities. Objectives: The objective was to document engagement activities and practices emerging from Clinical Research Networks (CRNs) participating in PCORnet, the National Patient-Centered Clinical Research Network, specifically regarding governance and engagement infrastructure. Methods: We conducted an environmental scan of PCORnet CRN engagement structures, assets, and services, focusing on network oversight structures for policy development and strategic decision-making. The scan included assets and services for supporting patient/stakeholder engagement. Data were collected by searching web-based literature and tool repositories, review of CRN Engagement Plans, analysis of previously collected key informant interviews, and CRN-based iterative review of structured worksheets. Results: We identified 87 discrete engagement structures, assets, and services across nine CRNs. All CRNs engage patients/stakeholders in their governance, maintain workgroups and/or staff dedicated to overseeing engagement strategies, and offer one or more services to non-CRN researchers to enhance conducting engaged clinical research. Conclusions: This work provides an important resource for the research community to explore engagement across peers, reflect on progress, consider opportunities to leverage existing infrastructure, and identify new collaborators. It also serves to highlight PCORnet as a resource for non-CRN researchers seeking to efficiently conduct engaged clinical research and a venue for advancing the science of engagement.
Language	English
Publishing date	2022-05-12
Publishing country	United States
Document type	Journal Article
ISSN	2379-6146
ISSN (online)	2379-6146
DOI	10.1002/lrh2.10313
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Article ; Online: Population Pharmacokinetic Analyses for Ertapenem in Subjects with a Wide Range of Body Sizes.

Lakota, Elizabeth A / Landersdorfer, Cornelia B / Zhang, Li / Nafziger, Anne N / Bertino, Joseph S / Bhavnani, Sujata M / Forrest, Alan

Antimicrobial agents and chemotherapy

2018 Volume 62, Issue 10

Abstract: Despite a number of studies reporting that ertapenem pharmacokinetic parameters differ considerably in obese patients from those in healthy volunteers, functions describing the relationships between this agent's pharmacokinetics and indicators of body ... ...

Abstract	Despite a number of studies reporting that ertapenem pharmacokinetic parameters differ considerably in obese patients from those in healthy volunteers, functions describing the relationships between this agent's pharmacokinetics and indicators of body size have not been developed. The aim of this analysis was to develop an ertapenem population pharmacokinetic model using data from a previously described study in normal-weight, obese, and morbidly obese healthy volunteers. A single ertapenem 1-g dose administered intravenously was evaluated in 30 subjects within different body mass index (BMI) categories. The population pharmacokinetic model was developed using the first-order conditional estimation method with interaction (FOCE-I) algorithm within NONMEM. The ability of age, sex, renal function, and various body size measures (total body weight, height, body mass index, ideal body weight, fat-free mass, and body surface area [BSA]) to explain a portion of the interindividual variability on select pharmacokinetic parameters was explored using stepwise forward selection (α = 0.01) and backward elimination (α = 0.001). The data were best described using a linear three-compartment model with total body weight as a covariate on clearance (CL = 1.79 · [weight/95.90]
MeSH term(s)	Adult ; Algorithms ; Body Mass Index ; Body Size ; Body Weight/physiology ; Carbapenems/blood ; Carbapenems/pharmacokinetics ; Ertapenem/blood ; Ertapenem/pharmacokinetics ; Female ; Humans ; Male ; Pharmacokinetics
Chemical Substances	Carbapenems ; Ertapenem (G32F6EID2H)
Language	English
Publishing date	2018-09-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/AAC.00784-18
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Article ; Online: Design of the Healthcare Worker Exposure Response and Outcomes (HERO) research platform.

Friedland, Anne / Hernandez, Adrian F / Anstrom, Kevin J / Chen-Lim, Mei Lin / Cohen, Lauren W / Currier, Judith S / Forrest, Christopher B / Fraser, Ryan / Fraulo, Elizabeth / George, Anoop / Handberg, Eileen / Jackman, Jennifer / Koellhoffer, Jayne / Lawrence, Daryl / Leverty, Renee / McAdams, Patty / McCourt, Brian / Mickley, Brenda / Naqvi, Syed Hasan /

O'Brien, Emily C / Olson, Rachel / Prater, Clyde / Rothman, Russell L / Shenkman, Elizabeth / Shostak, Jack / Turner, Kisha Batey / Webb, Laura / Woods, Chris / Naggie, Susanna

Contemporary clinical trials

2021 Volume 109, Page(s) 106525

Abstract: Background: The SARS CoV-2 virus has caused one of the deadliest pandemics in recent history, resulting in over 170 million deaths and global economic disruption. There remains an urgent need for clinical trials to test therapies for treatment and ... ...

Abstract	Background: The SARS CoV-2 virus has caused one of the deadliest pandemics in recent history, resulting in over 170 million deaths and global economic disruption. There remains an urgent need for clinical trials to test therapies for treatment and prevention. Design: An online research platform was created to support a registry community of healthcare workers (HCWs) to understand their experiences and conduct clinical studies to address their concerns. The first study, HERO-HCQ, was a double-blind, multicenter, randomized, pragmatic trial to evaluate the superiority of hydroxychloroquine (HCQ) vs placebo for pre-exposure prophylaxis (PrEP) of COVID-19 clinical infection in HCWs. Secondary objectives were to assess the efficacy of HCQ in preventing viral shedding of COVID-19 among HCWs and to assess the safety and tolerability of HCQ. Methods: HCWs joined the Registry and were pre-screened for trial interest and eligibility. Trial participants were randomized 1:1 to receive HCQ or placebo. On-site baseline assessment included a COVID-19 nasopharyngeal PCR and blood serology test. Weekly follow-up was done via an online portal and included screening for symptoms of COVID-19, self-reported testing, adverse events, and quality of life assessments. The on-site visit was repeated at Day 30. Discussion: The HERO research platform offers an approach to rapidly engage, screen, invite and enroll into clinical studies using a novel participant-facing online portal interface and remote data collection, enabling limited onsite procedures for conduct of a pragmatic clinical trial. This platform may be an example for future clinical trials of common conditions to enable more rapid evidence generation.
MeSH term(s)	COVID-19 ; Health Personnel ; Humans ; Quality of Life ; SARS-CoV-2 ; Treatment Outcome
Language	English
Publishing date	2021-08-08
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2182176-8
ISSN	1559-2030 ; 1551-7144
ISSN (online)	1559-2030
ISSN	1551-7144
DOI	10.1016/j.cct.2021.106525
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Article: Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3.

Journal of medicinal chemistry

2005 Volume 48, Issue 20, Page(s) 6169–6173

Abstract: A class of 3,5-diphenyl-1,2,4-oxadiazole based compounds have been identified as potent sphingosine-1-phosphate-1 (S1P1) receptor agonists with minimal affinity for the S1P2 and S1P3 receptor subtypes. Analogue 26 (S1P1 IC50 = 0.6 nM) has an excellent ... ...

Abstract	A class of 3,5-diphenyl-1,2,4-oxadiazole based compounds have been identified as potent sphingosine-1-phosphate-1 (S1P1) receptor agonists with minimal affinity for the S1P2 and S1P3 receptor subtypes. Analogue 26 (S1P1 IC50 = 0.6 nM) has an excellent pharmacokinetics profile in the rat and dog and is efficacious in a rat skin transplant model, indicating that S1P3 receptor agonism is not a component of immunosuppressive efficacy.
MeSH term(s)	Animals ; CHO Cells ; Cricetinae ; Cricetulus ; Dogs ; Graft Survival ; Immunosuppressive Agents/chemical synthesis ; Immunosuppressive Agents/pharmacokinetics ; Immunosuppressive Agents/pharmacology ; Lymphocyte Count ; Oxadiazoles/chemical synthesis ; Oxadiazoles/pharmacokinetics ; Oxadiazoles/pharmacology ; Radioligand Assay ; Rats ; Rats, Inbred Lew ; Rats, Sprague-Dawley ; Receptors, Lysosphingolipid/agonists ; Skin Transplantation ; Structure-Activity Relationship
Chemical Substances	Immunosuppressive Agents ; Oxadiazoles ; Receptors, Lysosphingolipid
Language	English
Publishing date	2005-10-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/jm0503244
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