Article ; Online: Genetic diversity of HLA system in two populations from San Luis Potosí, Mexico: San Luis Potosí City and rural San Luis Potosí.
2019 Volume 81, Issue 9, Page(s) 528–530
Abstract: ... in 117 Mexicans from the state of San Luis Potosí living in the city of San Luis Potosí (N = 30) and ...
| Abstract | We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 117 Mexicans from the state of San Luis Potosí living in the city of San Luis Potosí (N = 30) and rural communities (N = 87), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes in the state include 13 Native American, six European, two African and two Asian haplotypes. Admixture estimates revealed that the main genetic components are Native American (52.72 ± 0.66% by ML; 48.29% of Native American haplotypes) and European (34.62 ± 4.28% by ML; 32.48% of European haplotypes), and a relatively high African genetic component (12.66 ± 4.61% by ML; 10.26% of African haplotypes). |
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| MeSH term(s) | Alleles ; Ethnic Groups/genetics ; Gene Frequency ; Genetic Variation ; Genetics, Population ; Geography ; HLA Antigens/genetics ; Haplotypes ; Humans ; Linkage Disequilibrium ; Mexico ; Rural Population |
| Chemical Substances | HLA Antigens |
| Language | English |
| Publishing date | 2019-07-24 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 801524-7 |
| ISSN | 1879-1166 ; 0198-8859 |
| ISSN (online) | 1879-1166 |
| ISSN | 0198-8859 |
| DOI | 10.1016/j.humimm.2019.07.291 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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