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  1. Book ; Conference proceedings: Essentials of mucosal immunology

    Kagnoff, Martin F.

    1996  

    Title variant Mucosal immunology
    Event/congress International Congress on Mucosal Immunology (8, 1995, SanDiegoCalif.)
    Author's details [8th International Congress of Mucosal Immunology ... 1995, San Diego, California]. Ed. by Martin F. Kagnoff
    Keywords Mucous Membrane / immunology / congresses ; Schleimhaut ; Immunologie
    Subject Klinische Immunologie ; Mucosa
    Language English
    Size XXXIV, 597 S. : Ill., graph. Darst.
    Publisher Acad. Press
    Publishing place San Diego u.a.
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT007370725
    ISBN 0-12-394330-2 ; 978-0-12-394330-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1996 A 6506 order for loan Magazin

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  2. Article ; Online: The intestinal epithelium is an integral component of a communications network.

    Kagnoff, Martin F

    The Journal of clinical investigation

    2014  Volume 124, Issue 7, Page(s) 2841–2843

    Abstract: The epithelial lining of the intestine forms a barrier that separates the intestinal lumen from the host's internal milieu and is critical for fluid and electrolyte secretion and nutrient absorption. In the early 1990s, my laboratory discovered that ... ...

    Abstract The epithelial lining of the intestine forms a barrier that separates the intestinal lumen from the host's internal milieu and is critical for fluid and electrolyte secretion and nutrient absorption. In the early 1990s, my laboratory discovered that intestinal epithelial cells could alter their phenotype and produce proinflammatory chemokines and cytokines when stimulated by pathogenic enteric luminal microbes or proinflammatory agonists produced by cells in the underlying mucosa. It is now well accepted that intestinal epithelial cells can be induced to express and secrete specific arrays of cytokines, chemokines, and antimicrobial defense molecules. The coordinated release of molecules by intestinal epithelial cells is crucial for activating intestinal mucosal inflammatory responses as well as mucosal innate and adaptive immune responses. More recent studies have focused on the intestinal epithelial signaling pathways that culminate in immune activation as well as the role of these pathways in host defense, mucosal injury, mucosal wound healing, and tumorigenesis. The emerging picture indicates that intestinal epithelial cells represent an integral component of a highly regulated communications network that can transmit essential signals to cells in the underlying intestinal mucosa, and that intestinal epithelial cells, in turn, serve as targets of mucosal mediators. These signals are essential for maintaining intestinal mucosal defense and homeostasis.
    MeSH term(s) Animals ; Cytokines/biosynthesis ; Homeostasis ; Host-Pathogen Interactions/immunology ; Humans ; Immunity, Mucosal ; Intestinal Mucosa/cytology ; Intestinal Mucosa/immunology ; Intestinal Mucosa/microbiology ; Models, Immunological ; Signal Transduction/immunology
    Chemical Substances Cytokines
    Language English
    Publishing date 2014-07-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI75225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Conference proceedings: 8th International Congress of Mucosal Immunology

    Kagnoff, Martin F.

    San Diego, California, Monday, July 17 to Thursday, July 20, 1995

    (Clinical immunology and immunopathology ; 76,1, Pt. 2)

    1995  

    Event/congress International Congress on Mucosal Immunology (8, 1995, SanDiegoCalif.)
    Author's details guest ed.: Martin F. Kagnoff
    Series title Clinical immunology and immunopathology ; 76,1, Pt. 2
    Collection
    Keywords Mucous Membrane / immunology / congresses ; Immunkrankheit
    Subject Immunopathie ; Immunologische Krankheit ; Immunologische Erkrankung
    Language English
    Size S144 S. : graph. Darst.
    Publisher Acad. Press
    Publishing place San Diego u.a.
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT006703325
    Database Catalogue ZB MED Medicine, Health

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    Zs A 880 -76,1,Pt.2- not available for loan Zeitschriften-Lesesaal

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  4. Article ; Online: Introduction: celiac disease.

    Kagnoff, Martin F

    Seminars in immunopathology

    2012  Volume 34, Issue 4, Page(s) 471–472

    Abstract: This is the introduction for the Special Issue on Celiac Disease. ...

    Abstract This is the introduction for the Special Issue on Celiac Disease.
    MeSH term(s) Celiac Disease/diagnosis ; Celiac Disease/etiology ; Celiac Disease/therapy ; Humans
    Language English
    Publishing date 2012-07
    Publishing country Germany
    Document type Introductory Journal Article
    ZDB-ID 2316828-6
    ISSN 1863-2300 ; 1863-2297
    ISSN (online) 1863-2300
    ISSN 1863-2297
    DOI 10.1007/s00281-012-0326-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book: Gut and intestinal immunology

    Kagnoff, Martin F.

    (Immunology and allergy clinics of North America ; 8,3)

    1988  

    Author's details Martin F. Kagnoff, guest ed
    Series title Immunology and allergy clinics of North America ; 8,3
    Collection
    Keywords Gastrointestinal System / immunology
    Size XII S., S. 349 - 584 : Ill., graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT003279669
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Se 710 -8,3- verfügbar in Königswinter Königswinter

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  6. Article: 2007 William K. Warren, Jr., prize for excellence in celiac disease research awarded to professor Ludvig M. Sollid of Oslo, Norway.

    Kagnoff, Martin F

    Gastroenterology

    2007  Volume 133, Issue 1, Page(s) 9–10

    MeSH term(s) Awards and Prizes ; Celiac Disease ; Gastroenterology/history ; History, 21st Century ; Humans ; Norway
    Language English
    Publishing date 2007-07
    Publishing country United States
    Document type Historical Article ; Journal Article
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2007.04.074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 572: Show issues

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  7. Article: Mucosal inflammation in celiac disease: interleukin-15 meets transforming growth factor beta-1.

    Kagnoff, Martin F

    Gastroenterology

    2007  Volume 132, Issue 3, Page(s) 1174–1176

    MeSH term(s) Celiac Disease/immunology ; Celiac Disease/metabolism ; Humans ; Immunity, Innate ; Immunity, Mucosal ; Interleukin-15/metabolism ; Intestinal Mucosa/immunology ; Intestinal Mucosa/metabolism ; Signal Transduction ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Transforming Growth Factor beta1/metabolism
    Chemical Substances Interleukin-15 ; Transforming Growth Factor beta1
    Language English
    Publishing date 2007-03
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2007.01.062
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Celiac disease: pathogenesis of a model immunogenetic disease.

    Kagnoff, Martin F

    The Journal of clinical investigation

    2007  Volume 117, Issue 1, Page(s) 41–49

    Abstract: Celiac disease is characterized by small-intestinal mucosal injury and nutrient malabsorption in genetically susceptible individuals in response to the dietary ingestion of wheat gluten and similar proteins in barley and rye. Disease pathogenesis ... ...

    Abstract Celiac disease is characterized by small-intestinal mucosal injury and nutrient malabsorption in genetically susceptible individuals in response to the dietary ingestion of wheat gluten and similar proteins in barley and rye. Disease pathogenesis involves interactions among environmental, genetic, and immunological factors. Although celiac disease is predicted by screening studies to affect approximately 1% of the population of the United States and is seen both in children and in adults, 10%-15% or fewer of these individuals have been diagnosed and treated. This article focuses on the role of adaptive and innate immune mechanisms in the pathogenesis of celiac disease and how current concepts of immunopathogenesis might provide alternative approaches for treating celiac disease.
    MeSH term(s) Celiac Disease/genetics ; Celiac Disease/immunology ; Celiac Disease/pathology ; HLA Antigens/genetics ; Humans ; Intestinal Mucosa ; Lymphocyte Activation ; Models, Genetic ; Models, Immunological ; T-Lymphocytes/immunology
    Chemical Substances HLA Antigens
    Language English
    Publishing date 2007-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI30253
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  9. Article: Microbial-epithelial cell crosstalk during inflammation: the host response.

    Kagnoff, Martin F

    Annals of the New York Academy of Sciences

    2006  Volume 1072, Page(s) 313–320

    Abstract: The intestinal epithelium forms a single cell barrier that separates the host's internal milieu from luminal contents. This article examines the role of the intestinal epithelium as a critical component of a communications network that is essential for ... ...

    Abstract The intestinal epithelium forms a single cell barrier that separates the host's internal milieu from luminal contents. This article examines the role of the intestinal epithelium as a critical component of a communications network that is essential for transmitting signals generated in response to infection with microbial pathogens to cells of the innate and acquired immune systems in the underlying intestinal mucosa. It further highlights the importance of intestinal epithelium in mediating host antimicrobial defense through the production of antimicrobial peptides of the defensin and cathelicidin families.
    MeSH term(s) Animals ; Humans ; Immunity, Mucosal ; Inflammation/immunology ; Inflammation/microbiology ; Inflammatory Bowel Diseases/immunology ; Inflammatory Bowel Diseases/microbiology ; Inflammatory Bowel Diseases/prevention & control ; Intestinal Mucosa/immunology ; Intestinal Mucosa/microbiology
    Language English
    Publishing date 2006-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 211003-9
    ISSN 1749-6632 ; 0077-8923
    ISSN (online) 1749-6632
    ISSN 0077-8923
    DOI 10.1196/annals.1326.038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Overview and pathogenesis of celiac disease.

    Kagnoff, Martin F

    Gastroenterology

    2005  Volume 128, Issue 4 Suppl 1, Page(s) S10–8

    MeSH term(s) Celiac Disease/genetics ; Celiac Disease/physiopathology ; Genetic Predisposition to Disease ; Glutens/metabolism ; Glutens/pharmacology ; Humans ; Intestinal Mucosa/pathology ; Intestine, Small/pathology
    Chemical Substances Glutens (8002-80-0)
    Language English
    Publishing date 2005-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2005.02.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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