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  1. Article ; Online: Neuroscience-Based Nomenclature (NbN): the Portuguese version of the new classification for psychopharmacological drugs.

    Galduroz, José Carlos Fernandes / Zampronio, Aleksander Roberto / Vital, Maria Aparecida Barbato Frazão / Sallet, Paulo Clemente / Zohar, Joseph / Andreatini, Roberto

    Trends in psychiatry and psychotherapy

    2024  

    Abstract: Neuroscience-Based Nomenclature (NbN) is a proposal to provide a nomenclature based on neuroscience and pharmacology instead of the old disease-based classification. NbN is based on the mechanism of action and pharmacological target and aims to assist in ...

    Abstract Neuroscience-Based Nomenclature (NbN) is a proposal to provide a nomenclature based on neuroscience and pharmacology instead of the old disease-based classification. NbN is based on the mechanism of action and pharmacological target and aims to assist in rational prescription, reduce stigma, and increase treatment adherence. Currently, NbN is endorsed by many psychiatric associations, adopted by several relevant journals, and included in major psychiatry textbooks. Therefore, it is important that NbN is known to psychiatrists.
    Language English
    Publishing date 2024-01-18
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2708374-3
    ISSN 2238-0019 ; 2238-0019
    ISSN (online) 2238-0019
    ISSN 2238-0019
    DOI 10.47626/2237-6089-2023-0771
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Persistent ocular mpox infection in an immunocompetent individual.

    Raccagni, Angelo Roberto / Clemente, Tommaso / Ranzenigo, Martina / Cicinelli, Maria Vittoria / Castagna, Antonella / Nozza, Silvia

    The Lancet. Infectious diseases

    2023  Volume 23, Issue 6, Page(s) 652–653

    MeSH term(s) Humans ; Mpox (monkeypox) ; Face
    Language English
    Publishing date 2023-04-21
    Publishing country United States
    Document type Letter
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(23)00266-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5743: Show issues Location:
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  3. Article ; Online: Undergraduate Education in Transplantation.

    Cobos, Marisa / Lausada, Natalia / Tanús, Roberto / Raimondi, J Clemente

    Transplantation proceedings

    2023  Volume 55, Issue 6, Page(s) 1466–1468

    Abstract: Introduction: Training in the transplants of organs, tissues, and cells as a therapeutic modality of multiple pathologies is essential in undergraduate education. The medical aspects typical of the theme are associated with ethical, legal, religious, ... ...

    Abstract Introduction: Training in the transplants of organs, tissues, and cells as a therapeutic modality of multiple pathologies is essential in undergraduate education. The medical aspects typical of the theme are associated with ethical, legal, religious, and philosophical concerns, giving a holistic view of the process. We present a teaching model of the donation-transplant process with 15 years of experience.
    Methods: The subject of Organ, Tissue, and Cell Transplants began its activities in 2008. It is an elective, annual subject included in the last year of the medical career. Since its inception, it has established a continuous teaching methodology with a global approach to the donation and transplantation process.
    Results: During the last 15 years and until the moment of the presentation, 1057 students have registered for the subject, 80.6% (852) completed the requirements of approval of the course, 79.9% of the students presented for the final evaluation (681), and 96.4% (654) of the students passed the final assessment. The average final grade calculated was equal to 6.53 ± 2.9 points out of 10; 205 students (19.4%) still need to comply with the final evaluative instance.
    Conclusion: The available literature has different training modalities, but none resembles the model presented. It is concluded that, during these 15 years, the pedagogic expectations in the training of human resources have been exceeded.
    MeSH term(s) Humans ; Curriculum ; Education, Medical, Undergraduate ; Students, Medical
    Language English
    Publishing date 2023-05-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2023.03.078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 835: Show issues Location:
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  4. Article ; Online: Factors associated with discordant immuno-viral response in HIV-positive Peruvian adult people treated between 2005 and 2017

    Roberto Carrasco Navarro / Raúl Montalvo Otivo / Johana Clemente Lazo

    HIV & AIDS Review. International Journal of HIV-Related Problems, Vol 21, Iss 2, Pp 164-

    2022  Volume 168

    Keywords hiv ; haart ; developing countries ; Medicine ; R
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher Termedia Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Characterization of human CD4

    Pulvirenti, Nadia / Silvetri, Ylenia / Clemente, Francesca / Bosotti, Roberto / Carelli, Elena / Moschetti, Giorgia / Gruarin, Paola / Vasco, Chiara / Crosti, Maria Cristina / Sarnicola, Maria Lucia / Valenti, Luca / Prati, Daniele / Abrignani, Sergio / Geginat, Jens

    European journal of immunology

    2024  Volume 54, Issue 4, Page(s) e2350675

    Abstract: ... Human ... ...

    Abstract Human CD4
    MeSH term(s) Humans ; Interleukin-10 ; T-Lymphocyte Subsets ; T-Lymphocytes, Regulatory ; CD4-Positive T-Lymphocytes ; Th1 Cells ; Cell Differentiation ; T-Box Domain Proteins/genetics
    Chemical Substances Interleukin-10 (130068-27-8) ; EOMES protein, human ; T-Box Domain Proteins
    Language English
    Publishing date 2024-02-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202350675
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 489: Show issues Location:
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    Zs.MG 85: Show issues

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  6. Article: The Management of Phaeochromocytomas and Paragangliomas in the Era of Precision Medicine: Where Are We Now? Evidence-Based Systemic Treatment Options and Future Cluster Oriented Perspectives.

    Bracigliano, Alessandra / Marretta, Antonella Lucia / Guerrera, Luigi Pio / Simioli, Roberto / Clemente, Ottavia / Granata, Vincenza / Minopoli, Anita / Della Vittoria Scarpati, Giuseppina / Picozzi, Fernanda / Cannella, Lucia / Pizzolorusso, Antonio / Di Gennaro, Francesca / Tafuto, Roberto / Sarno, Maria Rosaria / Cavalcanti, Ernesta / Ribera, Dario / Tafuto, Salvatore

    Pharmaceuticals (Basel, Switzerland)

    2024  Volume 17, Issue 3

    Abstract: Pheochromocytomas (PCCs) and Paragangliomas (PGLs), commonly known as PPGLs to include both entities, are rare neuroendocrine tumors that may arise in the context of hereditary syndromes or be sporadic. However, even among sporadic PPGLs, identifiable ... ...

    Abstract Pheochromocytomas (PCCs) and Paragangliomas (PGLs), commonly known as PPGLs to include both entities, are rare neuroendocrine tumors that may arise in the context of hereditary syndromes or be sporadic. However, even among sporadic PPGLs, identifiable somatic alterations in at least one of the known susceptibility genes can be detected. Therefore, about 3/4 of all PPGL patients can be assigned to one of the three molecular clusters that have been identified in the last years with difference in the underlying pathogenetic mechanisms, biochemical phenotype, metastatic potential, and prognosis. While surgery represents the mainstay of treatment for localized PPGLs, several therapeutic options are available in advanced and/or metastatic setting. However, only few of them hinge upon prospective data and a cluster-oriented approach has not yet been established. In order to render management even more personalized and improve the prognosis of this molecularly complex disease, it is undoubtable that genetic testing for germline mutations as well as genome profiling for somatic mutations, where available, must be improved and become standard practice. This review summarizes the current evidence regarding diagnosis and treatment of PPGLs, supporting the need of a more cluster-specific approach in clinical practice.
    Language English
    Publishing date 2024-03-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph17030354
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Real-practice management and treatment of idiopathic multicentric Castleman disease with siltuximab: a collection of clinical experiences.

    Rossini, Bernardo / Cecchi, Nicola / Clemente, Felice / De Paolis, Maria Rosaria / Hohaus, Stefan / Innao, Vanessa / Lucignano, Mariano / Massaiu, Roberto / Palumbo, Giovanna / Rigolin, Gian Matteo / Rossi, Francesca Gaia / Verga, Luisa / Guarini, Attilio

    Drugs in context

    2024  Volume 13

    Abstract: Castleman disease (CD) is a group of lymphoproliferative disorders that share common histopathological features yet have widely different aetiologies, clinical features and grades of severity as well as treatments and outcomes. Siltuximab is currently ... ...

    Abstract Castleman disease (CD) is a group of lymphoproliferative disorders that share common histopathological features yet have widely different aetiologies, clinical features and grades of severity as well as treatments and outcomes. Siltuximab is currently the only therapy approved by the FDA and EMA for idiopathic multicentric CD and is recommended as first-line therapy in treatment guidelines. Despite the extensive characterization of siltuximab treatment in clinical trials, available evidence from real-world practice is still scant. This collection of clinical experiences focuses on patients treated with siltuximab therapy, particularly regarding the idiopathic multicentric CD diagnostic work-up, and on treatment administration in patients with complex disease entering differential diagnosis with CD or concomitant diseases. Thus, these data help further characterize and improve the use of siltuximab in real practice in terms of effectiveness and safety of long-term administration as well as consequences of treatment interruption.
    Language English
    Publishing date 2024-03-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2719560-0
    ISSN 1740-4398 ; 1745-1981
    ISSN (online) 1740-4398
    ISSN 1745-1981
    DOI 10.7573/dic.2023-9-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Improving the Quantification of Colorimetric Signals in Paper-Based Immunosensors with an Open-Source Reader.

    Russell, Steven M / Alba-Patiño, Alejandra / Vaquer, Andreu / Clemente, Antonio / de la Rica, Roberto

    Sensors (Basel, Switzerland)

    2022  Volume 22, Issue 5

    Abstract: Measuring the colorimetric signals produced by the biospecific accumulation of colorimetric probes and recording the results is a key feature for next-generation paper-based rapid tests. Manual processing of these tests is time-consuming and prone to a ... ...

    Abstract Measuring the colorimetric signals produced by the biospecific accumulation of colorimetric probes and recording the results is a key feature for next-generation paper-based rapid tests. Manual processing of these tests is time-consuming and prone to a loss of accuracy when interpreting faint and patchy signals. Proprietary, closed-source readers and software companies offering automated smartphone-based assay readings have both been criticized for interoperability issues. Here, we introduce a minimal reader prototype composed of open-source hardware and open-source software that has the benefits of automatic assay quantification while avoiding the interoperability issues associated with closed-source readers. An image-processing algorithm was developed to automate the selection of an optimal region of interest and measure the average pixel intensity. When used to quantify signals produced by lateral flow immunoassays for detecting antibodies against SARS-CoV-2, results obtained with the proposed algorithm were comparable to those obtained with a manual method but with the advantage of improving the precision and accuracy when quantifying small spots or faint and patchy signals.
    MeSH term(s) Biosensing Techniques ; COVID-19/diagnosis ; Colorimetry/methods ; Humans ; Immunoassay/methods ; SARS-CoV-2
    Language English
    Publishing date 2022-02-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s22051880
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Affective state estimation based on Russell's model and physiological measurements.

    Cittadini, Roberto / Tamantini, Christian / Scotto di Luzio, Francesco / Lauretti, Clemente / Zollo, Loredana / Cordella, Francesca

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 9786

    Abstract: Affective states are psycho-physiological constructs connecting mental and physiological processes. They can be represented in terms of arousal and valence according to the Russel's model and can be extracted from physiological changes in human body. ... ...

    Abstract Affective states are psycho-physiological constructs connecting mental and physiological processes. They can be represented in terms of arousal and valence according to the Russel's model and can be extracted from physiological changes in human body. However, a well-established optimal feature set and a classification method effective in terms of accuracy and estimation time are not present in the literature. This paper aims at defining a reliable and efficient approach for real-time affective state estimation. To obtain this, the optimal physiological feature set and the most effective machine learning algorithm, to cope with binary as well as multi-class classification problems, were identified. ReliefF feature selection algorithm was implemented to define a reduced optimal feature set. Supervised learning algorithms, such as K-Nearest Neighbors (KNN), cubic and gaussian Support Vector Machine, and Linear Discriminant Analysis, were implemented to compare their effectiveness in affective state estimation. The developed approach was tested on physiological signals acquired on 20 healthy volunteers during the administration of images, belonging to the International Affective Picture System, conceived for inducing different affective states. ReliefF algorithm reduced the number of physiological features from 23 to 13. The performances of machine learning algorithms were compared and the experimental results showed that both accuracy and estimation time benefited from the optimal feature set use. Furthermore, the KNN algorithm resulted to be the most suitable for affective state estimation. The results of the assessment of arousal and valence states on 20 participants indicate that KNN classifier, adopted with the 13 identified optimal features, is the most effective approach for real-time affective state estimation.
    MeSH term(s) Humans ; Emotions ; Algorithms ; Machine Learning ; Support Vector Machine
    Language English
    Publishing date 2023-06-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-36915-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Vitamin D Status in an Italian Pediatric Cohort: Is There a Role for Tobacco Smoking Exposure?

    Clemente, Maria Grazia / Argiolas, Dario / Bassu, Stefania / Bitti, Angela / Locci, Cristian / Argiolas, Mauro / Argiolas, Lino / Saderi, Laura / Puci, Mariangela V / Sotgiu, Giovanni / Blue, Mary E / Antonucci, Roberto

    Journal of clinical research in pediatric endocrinology

    2024  

    Abstract: Introduction: Vitamin D deficiency is a common public health issue worldwide. The purpose of this study was to investigate the vitamin D status and its potential determinants in children residing in Sardinia (40°N), Italy.: Methods: A total of 182 ... ...

    Abstract Introduction: Vitamin D deficiency is a common public health issue worldwide. The purpose of this study was to investigate the vitamin D status and its potential determinants in children residing in Sardinia (40°N), Italy.
    Methods: A total of 182 children (males: 51.7%; median age: 9 years) were enrolled over a 12-month period. Serum 25(OH)D was measured by an immune-chemiluminescence assay. A questionnaire was used to gather information on other variables, including passive smoke exposure.
    Results: Mean (SD) serum 25(OH)D was 25.2 (8.3) ng/mL for the whole group. The majority (n=123, 67.6%) of children had vitamin D sufficient values >20 ng/mL, while about 1/3 had vitamin D insufficient/deficient values (≤20 ng/mL (n=59, 32.4%). Among the variables investigated, passive smoke exposure was significantly associated with insufficient 25(OH)D levels (p<0.0001).
    Conclusion: Our results further prove that hypovitaminosis D is common in the Italian children and documented that passive smoke exposure is a significant risk factor for hypovitaminosis D.
    Language English
    Publishing date 2024-03-25
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2641608-6
    ISSN 1308-5735 ; 1308-5727
    ISSN (online) 1308-5735
    ISSN 1308-5727
    DOI 10.4274/jcrpe.galenos.2024.2023-11-16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6942: Show issues Location:
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