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Article ; Online: Complexity synchronization in emergent intelligence.

Mahmoodi, Korosh / Kerick, Scott E / Franaszczuk, Piotr J / Parsons, Thomas D / Grigolini, Paolo / West, Bruce J

2024 Volume 14, Issue 1, Page(s) 6758

Abstract: In this work, we use a simple multi-agent-based-model (MABM) of a social network, implementing selfish algorithm (SA) agents, to create an adaptive environment and show, using a modified diffusion entropy analysis (DEA), that the mutual-adaptive ... ...

Abstract	In this work, we use a simple multi-agent-based-model (MABM) of a social network, implementing selfish algorithm (SA) agents, to create an adaptive environment and show, using a modified diffusion entropy analysis (DEA), that the mutual-adaptive interaction between the parts of such a network manifests complexity synchronization (CS). CS has been shown to exist by processing simultaneously measured time series from among organ-networks (ONs) of the brain (neurophysiology), lungs (respiration), and heart (cardiovascular reactivity) and to be explained theoretically as a synchronization of the multifractal dimension (MFD) scaling parameters characterizing each time series. Herein, we find the same kind of CS in the emergent intelligence of groups formed in a self-organized social interaction without macroscopic control but with biased self-interest between two groups of agents playing an anti-coordination game. This computational result strongly suggests the existence of the same CS in real-world social phenomena and in human-machine interactions as that found empirically in ONs.
MeSH term(s)	Humans ; Algorithms ; Intelligence ; Entropy
Language	English
Publishing date	2024-03-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-57384-5
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Article ; Online: Effects of Transcranial Direct Current Stimulation on Cognitive and Affective Outcomes Using Virtual Stimuli: A Systematic Review.

Asbee, Justin / Parsons, Thomas D

Cyberpsychology, behavior and social networking

2021 Volume 24, Issue 11, Page(s) 699–714

Abstract: Transcranial direct current stimulation (tDCS) is a noninvasive form of brain stimulation used to influence neural activity. While early tDCS studies primarily used static stimuli, there is growing interest in dynamic stimulus presentations using virtual ...

Abstract	Transcranial direct current stimulation (tDCS) is a noninvasive form of brain stimulation used to influence neural activity. While early tDCS studies primarily used static stimuli, there is growing interest in dynamic stimulus presentations using virtual environments (VEs). This review attempts to convey the state of the field. This is not a quantitative meta-analysis as there are not yet enough studies following consistent protocols and/or reporting adequate data. In addition to reviewing the state of the literature, this review includes an exploratory analysis of the available data. Following preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines, studies were culled from several databases. Results from this review reveal differences between online and offline stimulation. While offline stimulation did not influence affective and cognitive outcomes, online stimulation led to small changes in affect and cognition. Future studies should include randomized controlled trials with larger samples. Furthermore, greater care needs to be applied to full data reporting (e.g., means, standard deviations, and data for their nonsignificant findings) to improve our understanding of the combined effects of virtual stimuli with tDCS.
MeSH term(s)	Cognition ; Humans ; Transcranial Direct Current Stimulation
Language	English
Publishing date	2021-02-24
Publishing country	United States
Document type	Journal Article ; Systematic Review
ZDB-ID	2545735-4
ISSN	2152-2723 ; 2152-2715
ISSN (online)	2152-2723
ISSN	2152-2715
DOI	10.1089/cyber.2020.0301
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Article ; Online: Impact of Accumulating Risk Factors on the Incidence of Dislocation After Primary Reverse Total Shoulder Arthroplasty Using a Medial Glenoid Lateral Humerus Onlay Prosthesis.

Parsons, Moby / Elwell, Josie / Muh, Stephanie / Wright, Thomas / Flurin, Pierre / Zuckerman, Joseph / Roche, Christopher

Journal of shoulder and elbow surgery

2024

Abstract: Introduction: The aim of this study is to facilitate preoperative identification of patients at-risk for dislocation after reverse total shoulder arthroplasty (rTSA) using the Equinoxe rTSA prosthesis (medialized glenoid, lateralized onlay humerus with ... ...

Abstract	Introduction: The aim of this study is to facilitate preoperative identification of patients at-risk for dislocation after reverse total shoulder arthroplasty (rTSA) using the Equinoxe rTSA prosthesis (medialized glenoid, lateralized onlay humerus with a 145° neck angle) and quantify the impact of accumulating risk factors on the occurrence of dislocation. Methods: We retrospectively analyzed 10,023 primary rTSA patients from an international multi-center database of a single platform shoulder prosthesis and quantified the dislocation rate associated with multiple combinations of previously identified risk factors. To adapt our statistical results for prospective identification of patients most at-risk for dislocation, we stratified our dataset by multiple risk factor combinations and calculated the odds ratio for each cohort to quantify the impact of accumulating risk factors on dislocation. Results: 136 (52F/83M/1UNK) of 10,023 primary rTSA patients were reported to have a dislocation for a rate of 1.4%. Patients with zero risk factors were rare, where only 12.7% of patients (1,268 of 10,023) had no risk factors, and only 0.5% of these (6 of 1,268) had a report of dislocation. The dislocation rate increased in patient cohorts with an increasing number of risk factors. Specifically, the dislocation rate increased from 0.9% for a patient cohort with 1 risk factor to 1.0% for 2 risk factors, 1.6% for 3 risk factors, 2.7% for 4 risk factors, 5.3% for 5 risk factors, and 7.3% for 6 risk factors. Stratifying dislocation rate by multiple risk factor combinations identified numerous cohorts with either an elevated risk or a diminished risk for dislocation. Discussion: This 10,023 rTSA multi-center study demonstrated that 1.4% of rTSA patients experienced dislocation with one specific medialized glenoid/lateralized humerus onlay rTSA prosthesis. Stratifying patients by multiple combinations of risk factors demonstrated the impact of accumulating risk factors on incidence of dislocation. rTSA patients with the greatest risk of dislocation were: male gender, age ≤67 years at the time of surgery, patients with BMI ≥31, patients who received cemented humeral stems, patients who received glenospheres having a diameter >40mm, and/or patients who received expanded/laterally offset glenospheres. Patients with these risk factors who are considering rTSA using a medial glenoid/lateral humerus, should be made aware of their elevated dislocation risk profile.
Language	English
Publishing date	2024-02-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1170782-3
ISSN	1532-6500 ; 1058-2746
ISSN (online)	1532-6500
ISSN	1058-2746
DOI	10.1016/j.jse.2023.12.017
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Article ; Online: Development of broadly neutralizing antibodies targeting the cytomegalovirus subdominant antigen gH.

Parsons, Andrea J / Ophir, Sabrina I / Duty, J Andrew / Kraus, Thomas A / Stein, Kathryn R / Moran, Thomas M / Tortorella, Domenico

Communications biology

2022 Volume 5, Issue 1, Page(s) 387

Abstract: Human cytomegalovirus (HCMV) is a β-herpesvirus that increases morbidity and mortality in immunocompromised individuals including transplant recipients and newborns. New anti-HCMV therapies are an urgent medical need for diverse patient populations. HCMV ...

Abstract	Human cytomegalovirus (HCMV) is a β-herpesvirus that increases morbidity and mortality in immunocompromised individuals including transplant recipients and newborns. New anti-HCMV therapies are an urgent medical need for diverse patient populations. HCMV infection of a broad range of host tissues is dependent on the gH/gL/gO trimer and gH/gL/UL28/UL130/UL131A pentamer complexes on the viral envelope. We sought to develop safe and effective therapeutics against HCMV by generating broadly-neutralizing, human monoclonal antibodies (mAbs) from VelocImmune® mice immunized with gH/gL cDNA. Following high-throughput binding and neutralization screening assays, 11 neutralizing antibodies were identified with unique CDR3 regions and a high-affinity (K
MeSH term(s)	Animals ; Antibodies, Monoclonal ; Antibodies, Neutralizing ; Antigens, Viral ; Broadly Neutralizing Antibodies ; Cytomegalovirus/genetics ; Humans ; Infant, Newborn ; Mice ; Viral Envelope Proteins/genetics
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Neutralizing ; Antigens, Viral ; Broadly Neutralizing Antibodies ; Viral Envelope Proteins
Language	English
Publishing date	2022-04-25
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-022-03294-z
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Article ; Online: Development of broadly neutralizing antibodies targeting the cytomegalovirus subdominant antigen gH

Andrea J. Parsons / Sabrina I. Ophir / J. Andrew Duty / Thomas A. Kraus / Kathryn R. Stein / Thomas M. Moran / Domenico Tortorella

Communications Biology, Vol 5, Iss 1, Pp 1-

2022 Volume 15

Abstract: A panel of neutralizing human monoclonal antibodies targeting human cytomegalovirus offers a combination approach geared toward virus entry and replication to prevent viral dissemination. ...

Abstract	A panel of neutralizing human monoclonal antibodies targeting human cytomegalovirus offers a combination approach geared toward virus entry and replication to prevent viral dissemination.
Keywords	Biology (General) ; QH301-705.5
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
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Article: Comparison of Traditional and Virtual Reality-Based Episodic Memory Performance in Clinical and Non-Clinical Cohorts.

Barnett, Michael D / Chek, Carmen J W / Shorter, Sydni S / Parsons, Thomas D

Brain sciences

2022 Volume 12, Issue 8

Abstract: The California Verbal Learning Test, Second Edition (CVLT-II) and the Virtual Environment Grocery Store (VEGS) use list learning and recognition tasks to assess episodic memory. This study aims to: (1) Replicate prior construct validity results among a ... ...

Abstract	The California Verbal Learning Test, Second Edition (CVLT-II) and the Virtual Environment Grocery Store (VEGS) use list learning and recognition tasks to assess episodic memory. This study aims to: (1) Replicate prior construct validity results among a new sample of young adults and healthy older adults; (2) Extend this work to a clinical sample of older adults with a neurocognitive diagnosis; (3) Compare CVLT-II and VEGS performance among these groups; and (4) Validate the independence of CVLT and VEGS episodic memory performance measures from executive functioning performance measures. Typically developing young adults (
Language	English
Publishing date	2022-07-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci12081019
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Article ; Online: Critical gaps in understanding treatment outcomes in adolescents and young adults with lymphoma: A review of current data.

Pophali, Priyanka A / Morton, Lindsay M / Parsons, Susan K / Hodgson, David / Thanarajasingam, Gita / Thompson, Carrie / Habermann, Thomas M / Savage, Kerry J

EJHaem

2023 Volume 4, Issue 4, Page(s) 927–933

Abstract: Adolescents and young adults (AYA) with lymphoma experience treatment-related effects in the short and long term that impact their quality of life and survivorship experience. The effort to improve outcomes for AYA lymphoma survivors requires ... ...

Abstract	Adolescents and young adults (AYA) with lymphoma experience treatment-related effects in the short and long term that impact their quality of life and survivorship experience. The effort to improve outcomes for AYA lymphoma survivors requires understanding the available literature, identifying current knowledge deficits, designing better clinical trials incorporating the patient perspective, using novel tools to bridge data gaps and building survivorship guidelines that translate research to clinical practice. This review article summarizes the current state of lymphoma treatment-related outcomes in AYAs and provides future direction.
Language	English
Publishing date	2023-08-25
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2688-6146
ISSN (online)	2688-6146
DOI	10.1002/jha2.778
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Article ; Online: Quantifying success after reverse total shoulder arthroplasty: the substantial clinically important percentage of maximal possible improvement.

Nieboer, Micah J / Hao, Kevin A / Tams, Carl / King, Joseph J / Wright, Thomas W / Parsons, Moby / Schoch, Bradley S / Simovitch, Ryan W

Journal of shoulder and elbow surgery

2023 Volume 32, Issue 12, Page(s) 2501–2507

Abstract: Background: Changes in preoperative to postoperative outcome scores are often used to quantify success after reverse total shoulder arthroplasty (rTSA). However, ceiling effects associated with many outcome scores limit the ability to differentiate ... ...

Abstract	Background: Changes in preoperative to postoperative outcome scores are often used to quantify success after reverse total shoulder arthroplasty (rTSA). However, ceiling effects associated with many outcome scores limit the ability to differentiate success among high-functioning patients. The percentage of maximal possible improvement (%MPI) was introduced to simplify and better stratify patient success. The primary purpose of this study was to define the %MPI thresholds associated with substantial clinical improvement following primary rTSA and compare the rates of success as defined by those achieving the substantial clinical benefit (SCB) compared to the 30% MPI for different outcome scores. Methods: A retrospective review was performed of an international shoulder arthroplasty database between 2003 and 2020. All primary rTSAs performed using a single implant system with a minimum 2-year follow-up were reviewed. Preoperative and postoperative outcome scores were evaluated for all patients to calculate improvement. Six outcome scores were assessed: the Simple Shoulder Test (SST), Constant, American Shoulder and Elbow Surgeons (ASES), University of California Los Angeles (UCLA), Shoulder Pain and Disability Index (SPADI), and Shoulder Arthroplasty Smart (SAS) scores. The proportion of patients achieving the SCB and 30% MPI was determined for each outcome score. Thresholds for the substantial clinically important %MPI (SCI-%MPI) were calculated using an anchor-based method for each outcome score and stratified by age and sex. Results: Of total, 2573 shoulders with a mean follow-up of 47 months were included. Outcome scores with known ceiling effects (SST, ASES, UCLA, SPADI) had higher rates of patients achieving the 30% MPI compared to scores without ceiling effects (Constant, SAS). However, scores without ceiling effects had higher rates of patients achieving the SCB. The SCI-%MPI differed among outcome scores, and mean values were 47% for the SST, 35% for the Constant score, 50% for the ASES score, 52% for the UCLA score, 47% for the SPADI score, and 45% for the SAS score. The SCI-%MPI increased in patients older than 60 years (P < .001) except for the SAS and Constant scores. SCI-%MPI was greater in females for all scores assessed except the Constant and SPADI scores (P < .001 for all). The higher SCI-%MPI thresholds in these populations mean that these patients required a greater fraction of the MPI to have substantial improvement. Conclusion: The %MPI judged relative to patient-reported substantial clinical improvement offers an alternative method to quickly assess improvements across patient outcome scores. Given considerable variation in the %MPI corresponding to substantial clinical improvement, we recommend utilizing score-specific estimates of the SCI-%MPI to gauge success when evaluating patients undergoing primary rTSA.
MeSH term(s)	Female ; Humans ; Male ; Arthroplasty, Replacement, Shoulder/methods ; Shoulder Joint/surgery ; Treatment Outcome ; Prostheses and Implants ; Shoulder Pain/surgery ; Retrospective Studies ; Range of Motion, Articular
Language	English
Publishing date	2023-06-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1170782-3
ISSN	1532-6500 ; 1058-2746
ISSN (online)	1532-6500
ISSN	1058-2746
DOI	10.1016/j.jse.2023.05.004
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Article ; Online: Quantifying success after anatomic total shoulder arthroplasty: the minimal clinically important percentage of maximal possible improvement.

Hao, Kevin A / Tams, Carl / Nieboer, Micah J / King, Joseph J / Wright, Thomas W / Simovitch, Ryan W / Parsons, Moby / Schoch, Bradley S

Journal of shoulder and elbow surgery

2023 Volume 32, Issue 4, Page(s) 688–694

Abstract: Introduction: Changes in pre- to postoperative outcome scores are often used to quantify success after anatomic total shoulder arthroplasty (aTSA). However, ceiling effects associated with many outcome scores limit the ability to differentiate success ... ...

Abstract	Introduction: Changes in pre- to postoperative outcome scores are often used to quantify success after anatomic total shoulder arthroplasty (aTSA). However, ceiling effects associated with many outcome scores limit the ability to differentiate success among high-functioning patients. The percentage maximal possible improvement (%MPI) was introduced to better stratify patient success; however, it is unclear if the 30% threshold first proposed correlates with perceived patient success across all outcome scores. The purpose of this study was to compare the proportion of patients that achieved the minimal clinically important difference (MCID) and %MPI for different outcome scores and to define the %MPI thresholds associated with patient satisfaction following primary aTSA. Methods: A retrospective review was performed of an international shoulder arthroplasty database between 2003 and 2020. All primary aTSAs performed using a single implant system with minimum 2-year follow-up were reviewed. Pre- and postoperative outcome scores were evaluated for all patients to calculate improvement. The proportion of patients achieving the MCID and 30% MPI were determined for each outcome score. Thresholds for the minimal clinically important %MPI (MCI-%MPI) were calculated using an anchor-based method for each outcome score and stratified by age and sex. Results: 1593 shoulders with a mean follow-up of 59.3 months were included. Outcome scores with known ceiling effects (Simple Shoulder Test [SST], American Shoulder and Elbow Surgeons Standardized Shoulder Assessment Form [ASES], University of California-Los Angeles shoulder score [UCLA]) had higher rates of patients achieving the 30% MPI but not the previously reported MCID. Inversely, outcome scores without significant ceiling effects (Constant and Shoulder Arthroplasty Smart [SAS] scores) had higher rates of patients achieving the MCID but not the 30% MPI. The MCI-%MPI differed among outcome scores, and mean values were as follows: 33% for the SST, 24% for the Constant score, 32% for the ASES score, 38% for the UCLA score, 30% for the Shoulder Pain and Disability Index score, and 33% for the SAS score. The MCI-%MPI increased with greater age (P < .003) and females had thresholds greater than or equal to males for all scores assessed, meaning that patients with higher thresholds required a greater fraction of the possible improvement for a given score to be satisfied. Conclusion: The %MPI offers a simple method to quickly assess improvements across patient outcome scores. However, the %MPI that represents patient improvement after surgery is not uniformly the previously established 30% threshold. Surgeons should use score-specific estimates of the MCI-%MPI to gauge success when evaluating patients undergoing primary aTSA.
MeSH term(s)	Male ; Female ; Humans ; Arthroplasty, Replacement, Shoulder/methods ; Shoulder Joint/surgery ; Treatment Outcome ; Patient Satisfaction ; Prostheses and Implants ; Retrospective Studies
Language	English
Publishing date	2023-01-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	1170782-3
ISSN	1532-6500 ; 1058-2746
ISSN (online)	1532-6500
ISSN	1058-2746
DOI	10.1016/j.jse.2022.12.012
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Article ; Online: Quantifying success after reverse total shoulder arthroplasty: the minimal clinically important percentage of maximal possible improvement.

Nieboer, Micah J / Hao, Kevin A / Tams, Carl / King, Joseph J / Wright, Thomas W / Simovitch, Ryan W / Parsons, Moby / Schoch, Bradley S

Journal of shoulder and elbow surgery

2023 Volume 32, Issue 11, Page(s) 2296–2302

Abstract: Background: In high functioning patients, the ceiling effect associated with many patient-reported outcome measures (PROMs) limits the ability to appropriately stratify success. The percentage maximal possible improvement (%MPI) was introduced as ... ...

Abstract	Background: In high functioning patients, the ceiling effect associated with many patient-reported outcome measures (PROMs) limits the ability to appropriately stratify success. The percentage maximal possible improvement (%MPI) was introduced as another evaluation tool, with a proposed threshold of success at 30%. It remains unclear if this threshold correlates with perceived patient success following shoulder arthroplasty. The purpose of this study was to compare the proportion of patients that achieved the minimal clinically important difference (MCID) and %MPI for different outcome scores and to define the %MPI thresholds associated with patient satisfaction following primary reverse total shoulder arthroplasty (rTSA). Methods: A retrospective review was performed of an international shoulder arthroplasty database between 2003 and 2020. All primary rTSAs performed using a single implant system with minimum 2-year follow-up were reviewed. Pre- and postoperative outcome scores were evaluated for all patients to determine the raw improvement and %MPI. The proportion of patients achieving the MCID and 30% MPI were determined for each outcome score. Thresholds for the minimal clinically important %MPI (MCI-%MPI) were calculated using an anchor-based method for each outcome score and stratified by age and sex. Results: A total of 2573 shoulders with a mean follow-up of 47 months were included. Outcome scores with known ceiling effects (Simple Shoulder Test [SST], Shoulder Pain and Disability Index [SPADI], University of California-Los Angeles shoulder score [UCLA]) had higher rates of patients achieving the 30% MPI but not the previously reported MCID. Inversely, outcome scores without significant ceiling effects (Constant and Shoulder Arthroplasty Smart [SAS] scores) had higher rates of patients achieving the MCID, but not the 30% MPI. The MCI-%MPI differed among outcome scores and mean values were as follows: 33% for the SST, 27% for the Constant score, 35% for the American Shoulder and Elbow Surgeons Standardized Shoulder Assessment Form (ASES) score, 43% for the UCLA score, 34% for the SPADI score, and 30% for the SAS score. The MCI-%MPI increased with greater age for SPADI (P < .04) and SAS (P < .01) scores, meaning that patients with higher thresholds required a greater fraction of the possible improvement for a given score to be satisfied but did not reach statistical significance for other scores. Females had a greater MCI-%MPI for the SAS and ASES scores and a lower MCI-MPI% for the SPADI score. Conclusion: The %MPI offers a simple method to quickly assess improvements across patient outcome scores. However, the %MPI that represents patient improvement after surgery is not uniformly the previously established 30% threshold. Surgeons should use score-specific estimates of the MCI-%MPI to gauge success when evaluating patients undergoing primary rTSA.
Language	English
Publishing date	2023-05-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	1170782-3
ISSN	1532-6500 ; 1058-2746
ISSN (online)	1532-6500
ISSN	1058-2746
DOI	10.1016/j.jse.2023.04.011
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