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Article ; Online: Bronchial Artery Embolization in Management of Hemoptysis in a Developing Country

Puneet Garg / Ayush Khandelwal / Krishna Bhardwaj / Pranav Ish / Rajat Khurana / Amita Malik

The Arab Journal of Interventional Radiology, Vol 07, Iss 01, Pp 026-

An Initial Experience

2023 Volume 030

Abstract: Objectives This article evaluates the immediate success, recurrence rate, complications, and the culprit vessel of bronchial artery embolization (BAE) in patients presenting with hemoptysis. Materials and Methods All patients who underwent BAE from July ... ...

Abstract	Objectives This article evaluates the immediate success, recurrence rate, complications, and the culprit vessel of bronchial artery embolization (BAE) in patients presenting with hemoptysis. Materials and Methods All patients who underwent BAE from July 1, 2018 to August 31, 2021 were included. BAE was done for moderate to severe hemoptysis or for mild hemoptysis which was recurrent and not controlled by medical management. Patients referred for surgical intervention and hemoptysis controlled on medical management were excluded. Results One hundred and thirty patients underwent BAE in the study period. Mean age was 41.5 years and majority (73.1%) was male. Forty-three (33.1%) patients had mild, 46 (35.4%) had moderate, and 41 (31.5%) with the duration of symptoms ranging from 3 days to 25 years. Most common culprit vessel was posterior intercostal artery closely followed by the intercostobronchial artery. Hypervascularity was the most common angiographic abnormality encountered. On an average, 2.75 vessels were embolized per BAE with a wide range of 1 to 8 vessels. Hemoptysis control was seen in 96.1% patients immediately, 90.7 % at 1 month, 82.3 % at 3 months, and 66.9 % at 6 months. Overall recurrence was seen in 43 patients (33.1%). Chest pain was the most common minor side effect occurring in 77.1% cases. Conclusion BAE is a safe and effective procedure that can be performed routinely in patients presenting with moderate to massive hemoptysis or with mild hemoptysis refractory to medical management.
Keywords	bronchial artery embolization ; hemoptysis ; recurrence ; pva ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Bronchial Artery Embolization in Management of Hemoptysis in a Developing Country: An Initial Experience

Garg, Puneet / Khandelwal, Ayush / Bhardwaj, Krishna / Ish, Pranav / Khurana, Rajat / Malik, Amita

The Arab Journal of Interventional Radiology

2023 Volume 07, Issue 01, Page(s) 26–30

Abstract: Objectives: This article evaluates the immediate success, recurrence rate, complications, and the culprit vessel of bronchial artery embolization (BAE) in patients presenting with hemoptysis.: Materials and Methods: All patients who underwent BAE ... ...

Abstract	Objectives: This article evaluates the immediate success, recurrence rate, complications, and the culprit vessel of bronchial artery embolization (BAE) in patients presenting with hemoptysis. Materials and Methods: All patients who underwent BAE from July 1, 2018 to August 31, 2021 were included. BAE was done for moderate to severe hemoptysis or for mild hemoptysis which was recurrent and not controlled by medical management. Patients referred for surgical intervention and hemoptysis controlled on medical management were excluded. Results: One hundred and thirty patients underwent BAE in the study period. Mean age was 41.5 years and majority (73.1%) was male. Forty-three (33.1%) patients had mild, 46 (35.4%) had moderate, and 41 (31.5%) with the duration of symptoms ranging from 3 days to 25 years. Most common culprit vessel was posterior intercostal artery closely followed by the intercostobronchial artery. Hypervascularity was the most common angiographic abnormality encountered. On an average, 2.75 vessels were embolized per BAE with a wide range of 1 to 8 vessels. Hemoptysis control was seen in 96.1% patients immediately, 90.7 % at 1 month, 82.3 % at 3 months, and 66.9 % at 6 months. Overall recurrence was seen in 43 patients (33.1%). Chest pain was the most common minor side effect occurring in 77.1% cases. Conclusion: BAE is a safe and effective procedure that can be performed routinely in patients presenting with moderate to massive hemoptysis or with mild hemoptysis refractory to medical management.
Keywords	bronchial artery embolization ; hemoptysis ; recurrence ; PVA
Language	English
Publishing date	2023-01-01
Publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
Publishing place	Stuttgart ; New York
Document type	Article
ISSN	2542-7083 ; 2542-7075
ISSN (online)	2542-7083
ISSN	2542-7075
DOI	10.1055/s-0043-1763496
Database	Thieme publisher's database

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Article ; Online: Fluorescent metal quantum clusters: an updated overview of the synthesis, properties, and biological applications.

Khandelwal, Puneet / Poddar, Pankaj

Journal of materials chemistry. B

2017 Volume 5, Issue 46, Page(s) 9055–9084

Abstract: Metal quantum clusters are evolving as excellent systems for a wide range of biological applications due to their small size (∼2 nm), tunable optical properties, including optical absorption, photoluminescence (UV to NIR), nonlinear optical properties ( ... ...

Abstract	Metal quantum clusters are evolving as excellent systems for a wide range of biological applications due to their small size (∼2 nm), tunable optical properties, including optical absorption, photoluminescence (UV to NIR), nonlinear optical properties (two-photon absorption, two-photon fluorescence, and second/third harmonic generation), ultrafast dynamics (relaxation kinetics, electron-phonon coupling, and radiative emission), and magnetism. These excellent properties have resulted in their use in a broad range of applications, including the sensing of ions (heavy metal ions, anions), biomolecules (proteins, DNA, miRNA, and enzymes), biological cells, diagnosis, and therapy. This article presents an introduction to metal quantum clusters, including a brief history of research in this system and an overview of the existing theories to understand their properties. We also discuss the synthesis methods, the various properties of quantum clusters and present a broad and updated overview of the applications of metal quantum clusters in biology.
Language	English
Publishing date	2017-11-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/c7tb02320k
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mullerianosis of urinary bladder: The great impersonator.

Sancheti, Sankalp / Somal, Puneet Kaur / Chaudhary, Debashish / Khandelwal, Sachin

Indian journal of pathology & microbiology

2020 Volume 63, Issue 4, Page(s) 627–629

Abstract: Müllerianosis of the urinary bladder is a rare entity with less than 30 cases reported. It encompasses a mixture of different types of Mullerian lesions like endometriosis, endocervicosis, and endosalpingiosis. It typically affects the women of ... ...

Abstract	Müllerianosis of the urinary bladder is a rare entity with less than 30 cases reported. It encompasses a mixture of different types of Mullerian lesions like endometriosis, endocervicosis, and endosalpingiosis. It typically affects the women of reproductive age group. The symptoms vary from hematuria and dysuria, to pelvic pain, which may be associated with menstruation. It can mimic a malignant tumor clinically and radiologically; hence, it is important that a correct diagnosis is rendered in these cases to avoid unnecessary radical procedures. Herein we report a case of mullerianosis of the urinary bladder in a young female and discuss the important differential diagnosis and various treatment modalities.
MeSH term(s)	Adult ; Diagnosis, Differential ; Endometriosis/pathology ; Female ; Histological Techniques ; Humans ; Mullerian Ducts ; Tomography, X-Ray Computed ; Urinary Bladder/diagnostic imaging ; Urinary Bladder/pathology
Language	English
Publishing date	2020-11-23
Publishing country	India
Document type	Case Reports ; Journal Article
ZDB-ID	197621-7
ISSN	0974-5130 ; 0377-4929
ISSN (online)	0974-5130
ISSN	0377-4929
DOI	10.4103/IJPM.IJPM_726_19
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Article: Fluorescent metal quantum clusters: an updated overview of the synthesis, properties, and biological applications

Khandelwal, Puneet / Poddar, Pankaj

Journal of materials chemistry B. 2017 Nov. 29, v. 5, no. 46

2017

Abstract	Metal quantum clusters are evolving as excellent systems for a wide range of biological applications due to their small size (∼2 nm), tunable optical properties, including optical absorption, photoluminescence (UV to NIR), nonlinear optical properties (two-photon absorption, two-photon fluorescence, and second/third harmonic generation), ultrafast dynamics (relaxation kinetics, electron–phonon coupling, and radiative emission), and magnetism. These excellent properties have resulted in their use in a broad range of applications, including the sensing of ions (heavy metal ions, anions), biomolecules (proteins, DNA, miRNA, and enzymes), biological cells, diagnosis, and therapy. This article presents an introduction to metal quantum clusters, including a brief history of research in this system and an overview of the existing theories to understand their properties. We also discuss the synthesis methods, the various properties of quantum clusters and present a broad and updated overview of the applications of metal quantum clusters in biology.
Keywords	DNA ; absorption ; anions ; enzymes ; fluorescence ; heavy metals ; magnetism ; metal ions ; microRNA ; optical properties ; photoluminescence ; proteins ; therapeutics
Language	English
Dates of publication	2017-1129
Size	p. 9055-9084.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/c7tb02320k
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Correction to: Development and Utility of an ELISA Method for Sensitive and Specific Detection of IgE Antidrug Antibodies.

Jiang, Lynn L / Khandelwal, Puneet / Clarke, Adam W / Bakhtiar, Ray / Zou, Linglong / Zhong, Zhandong Don

The AAPS journal

2020 Volume 22, Issue 3, Page(s) 57

Abstract: During the production process, the author order of Zhandong Don Zhong and Lynn L. Jiang were inadvertently placed. Lynn L. Jiang is the first author of this manuscript; Zhandong Don Zhong is the last author. ...

Abstract	During the production process, the author order of Zhandong Don Zhong and Lynn L. Jiang were inadvertently placed. Lynn L. Jiang is the first author of this manuscript; Zhandong Don Zhong is the last author.
Language	English
Publishing date	2020-03-16
Publishing country	United States
Document type	Journal Article ; Published Erratum
ISSN	1550-7416
ISSN (online)	1550-7416
DOI	10.1208/s12248-020-00439-y
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Article ; Online: A surfactant polymer wound dressing protects human keratinocytes from inducible necroptosis.

Khandelwal, Puneet / Das, Amitava / Sen, Chandan K / Srinivas, Sangly P / Roy, Sashwati / Khanna, Savita

Scientific reports

2021 Volume 11, Issue 1, Page(s) 4357

Abstract: Chronic wounds show necroptosis from which keratinocytes must be protected to enable appropriate wound re-epithelialization and closure. Poloxamers, a class of synthetic triblock copolymers, are known to be effective against plasma membrane damage (PMD). ...

Abstract	Chronic wounds show necroptosis from which keratinocytes must be protected to enable appropriate wound re-epithelialization and closure. Poloxamers, a class of synthetic triblock copolymers, are known to be effective against plasma membrane damage (PMD). The purpose of this study is to evaluate the efficacy of a specific poloxamer, surfactant polymer dressing (SPD), which is currently used clinically as wound care dressing, against PMD in keratinocytes. Triton X-100 (TX100) at sub-lytic concentrations caused PMD as demonstrated by the efflux of calcein and by the influx of propidium iodide and FM1-43. TX100, an inducer of necroptosis, led to mitochondrial fragmentation, depletion of nuclear HMGB1, and activation of signaling complex associated with necroptosis (i.e., activation of RIP3 and phosphorylation of MLKL). All responses following exposure of human keratinocytes to TX100 were attenuated by pre- or co-treatment with SPD (100 mg/ml). The activation and translocation of phospho-MLKL to the plasma membrane, taken together with depletion of nuclear HMGB1, characterized the observed cell death as necroptosis. Thus, our findings show that TX100-induced plasma membrane damage and death by necroptosis were both attenuated by SPD, allowing keratinocyte survival. The significance of such protective effects of SPD on keratinocytes in wound re-epithelialization and closure warrant further studies.
MeSH term(s)	Bandages, Hydrocolloid ; Cell Membrane/metabolism ; Cells, Cultured ; HMGB1 Protein/metabolism ; HaCaT Cells ; Humans ; Mitochondria/metabolism ; Necroptosis ; Protein Kinases/metabolism ; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism ; Surface-Active Agents/chemistry ; Wound Healing
Chemical Substances	HMGB1 Protein ; HMGB1 protein, human ; Surface-Active Agents ; MLKL protein, human (EC 2.7.-) ; Protein Kinases (EC 2.7.-) ; RIPK3 protein, human (EC 2.7.11.1) ; Receptor-Interacting Protein Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2021-02-23
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-82260-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A surfactant polymer wound dressing protects human keratinocytes from inducible necroptosis

Puneet Khandelwal / Amitava Das / Chandan K. Sen / Sangly P. Srinivas / Sashwati Roy / Savita Khanna

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 15

Abstract: Abstract Chronic wounds show necroptosis from which keratinocytes must be protected to enable appropriate wound re-epithelialization and closure. Poloxamers, a class of synthetic triblock copolymers, are known to be effective against plasma membrane ... ...

Abstract	Abstract Chronic wounds show necroptosis from which keratinocytes must be protected to enable appropriate wound re-epithelialization and closure. Poloxamers, a class of synthetic triblock copolymers, are known to be effective against plasma membrane damage (PMD). The purpose of this study is to evaluate the efficacy of a specific poloxamer, surfactant polymer dressing (SPD), which is currently used clinically as wound care dressing, against PMD in keratinocytes. Triton X-100 (TX100) at sub-lytic concentrations caused PMD as demonstrated by the efflux of calcein and by the influx of propidium iodide and FM1-43. TX100, an inducer of necroptosis, led to mitochondrial fragmentation, depletion of nuclear HMGB1, and activation of signaling complex associated with necroptosis (i.e., activation of RIP3 and phosphorylation of MLKL). All responses following exposure of human keratinocytes to TX100 were attenuated by pre- or co-treatment with SPD (100 mg/ml). The activation and translocation of phospho-MLKL to the plasma membrane, taken together with depletion of nuclear HMGB1, characterized the observed cell death as necroptosis. Thus, our findings show that TX100-induced plasma membrane damage and death by necroptosis were both attenuated by SPD, allowing keratinocyte survival. The significance of such protective effects of SPD on keratinocytes in wound re-epithelialization and closure warrant further studies.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Adequacy of Histopathology Reports Representing Oncologic Resection Specimens: An Experience of Reporting Practice in Rural India.

Bansal, Saloni / Sali, Akash Pramod / Sancheti, Sankalp / Somal, Puneet Kaur / Khandelwal, Sachin / Goel, Alok Kumar / Kapoor, Rakesh

Archives of pathology & laboratory medicine

2022 Volume 146, Issue 11, Page(s) 1378–1386

Abstract: Context.—: The histopathology reporting practice in rural areas is largely variable. To ensure the adequacy of histopathology reports (HPRs), the College of American Pathologists (CAP) has developed cancer reporting checklists.: Objective.—: To ... ...

Abstract	Context.—: The histopathology reporting practice in rural areas is largely variable. To ensure the adequacy of histopathology reports (HPRs), the College of American Pathologists (CAP) has developed cancer reporting checklists. Objective.—: To assess the adequacy of resection specimen HPRs received from outside centers for a second opinion. Further, the adequacy of breast resection HPRs from these centers was compared with that of our center. Additionally, the reports representing endometrial carcinoma were assessed for impact on the treatment decision. Design.—: This was a retrospective study conducted from June 2015 to December 2019. HPRs from outside centers and our institute were analyzed for mandatory reporting elements as per CAP 2013 checklists. Results.—: A total of 730 HPRs (558 outside HPRs and 172 in-house breast HPRs) were reviewed for completeness. The outside HPRs were complete in 42 of 558 cases (7.5%). Only 11 of 143 reports (7.7%) from the academic centers were complete. Seventeen of 249 outside breast HPRs (6.8%) were complete, whereas predominant (n = 123 of 172; 71.5%) in-house breast HPRs were adequate. Most outside endometrial carcinoma reports (60.8%; n = 28 of 46) were inadequate with potential impact on the adjuvant treatment, whereas 10 of 46 reports (21.7%) were inadequate and had an actual impact on the adjuvant treatment decision. Conclusions.—: Minimal data set reporting using checklists is not yet widely operational in most rural laboratories. We call for continuous education and sensitization of the practicing pathologists, oncopathology education of the trainees, and regulatory standards for signing out an oncopathology report.
MeSH term(s)	Humans ; Female ; Retrospective Studies ; Research Report ; Checklist ; India ; Endometrial Neoplasms/surgery
Language	English
Publishing date	2022-02-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	194119-7
ISSN	1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
ISSN (online)	1543-2165
ISSN	0363-0153 ; 0096-8528 ; 0003-9985
DOI	10.5858/arpa.2021-0237-OA
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Article ; Online: Retention of Anticancer Activity of Curcumin after Conjugation with Fluorescent Gold Quantum Clusters

Puneet Khandelwal / Aftab Alam / Arpankumar Choksi / Samit Chattopadhyay / Pankaj Poddar

ACS Omega, Vol 3, Iss 5, Pp 4776-

An in Vitro and in Vivo Xenograft Study

2018 Volume 4785

Keywords	Chemistry ; QD1-999
Language	English
Publishing date	2018-05-01T00:00:00Z
Publisher	American Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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