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  1. Article ; Online: Capillary rarefication as a possible cause of long-COVID syndrome.

    Osiaevi, Irina / Kümpers, Philipp / Weinmann-Menke, Julia / Pavenstädt, Hermann / Rovas, Alexandros

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2024  

    Language English
    Publishing date 2024-02-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfae026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: „Wir müssen die Heimdialyse stärken“: Der 10-Punkte-Plan der Deutschen Gesellschaft für Nephrologie (DGfN)

    Pavenstädt, Hermann / Galle, Jan C.

    Nephrologie aktuell

    2023  Volume 27, Issue 01, Page(s) 36–38

    Abstract: Die Deutsche Gesellschaft für Nephrologie e. V. (DGfN) befasst sich seit Langem mit dem Thema Heimdialyse aus medizinischer Sicht, doch in den letzten Jahren wurden Heimverfahren wegen gesellschaftlicher Entwicklungen auf besondere Weise in den Fokus der ...

    Abstract Die Deutsche Gesellschaft für Nephrologie e. V. (DGfN) befasst sich seit Langem mit dem Thema Heimdialyse aus medizinischer Sicht, doch in den letzten Jahren wurden Heimverfahren wegen gesellschaftlicher Entwicklungen auf besondere Weise in den Fokus der Nephrologie gerückt: Der Trend hin zur Individualisierung der Therapie, das wachsende Problem des Pflegemangels und Gründe des Umwelt- und Klimaschutzes sind dabei vorrangig zu nennen. Seit Veröffentlichung der Studie MAU-PD (MAU-PD: Multidimensionale Analyse der Ursachen für die niedrige Prävalenz der ambulanten Peritonealdialyse in Deutschland) und nach Anfrage aus dem Gemeinsamen Bundesausschuss (G-BA) hat sich die DGfN zur Stellungnahme entschieden und die Frage bearbeitet, wie Heimverfahren gestärkt werden können. In den Diskussionen wurde deutlich, dass die relativ geringe Rate an Heimdialysepatient*innen viele Gründe hat und dass man der Herausforderung, die Rate perspektivisch anzuheben, „ganzheitlich“ und auf vielen Ebenen begegnen muss. Mit einem 10-Punkte-Plan skizzierte die DGfN die Maßnahmen, die eine Trendwende herbeiführen könnten. Nun arbeitet sie an der Umsetzung des Plans und nutzt dazu unter anderem die Expertise ihrer Kommissionen.
    Language German
    Publishing date 2023-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 3131412-0
    ISSN 2751-9139 ; 2751-9120
    ISSN (online) 2751-9139
    ISSN 2751-9120
    DOI 10.1055/a-1989-5659
    Database Thieme publisher's database

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  3. Article ; Online: Corrigendum: Novel Therapeutic Strategies for Dyslipidemia: First Report of Inclisiran Therapy in a Kidney Transplanted Patient.

    Ueberdiek, Lars / Jehn, Ulrich / Pavenstädt, Hermann / Gebauer, Katrin / Reuter, Stefan

    Transplant international : official journal of the European Society for Organ Transplantation

    2023  Volume 36, Page(s) 11313

    Abstract: This corrects the article DOI: 10.3389/ti.2023.11104.]. ...

    Abstract [This corrects the article DOI: 10.3389/ti.2023.11104.].
    Language English
    Publishing date 2023-03-23
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.3389/ti.2023.11313
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Novel Therapeutic Strategies for Dyslipidemia: First Report of Inclisiran Therapy in a Kidney Transplanted Patient.

    Ueberdiek, Lars / Jehn, Ulrich / Pavenstädt, Hermann / Gebauer, Katrin / Reuter, Stefan

    Transplant international : official journal of the European Society for Organ Transplantation

    2023  Volume 36, Page(s) 11104

    MeSH term(s) Humans ; Dyslipidemias/drug therapy ; RNA, Small Interfering/therapeutic use ; Kidney
    Chemical Substances ALN-PCS ; RNA, Small Interfering
    Language English
    Publishing date 2023-01-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.3389/ti.2023.11104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Hydroxychloroquine-Induced Renal Phospholipidosis: Case Report and Review of Differential Diagnoses.

    Menke, Amélie Friederike / Heitplatz, Barbara / Van Marck, Veerle / Pavenstädt, Hermann / Jehn, Ulrich

    Case reports in nephrology and dialysis

    2024  Volume 14, Issue 1, Page(s) 20–29

    Abstract: Introduction: Renal phospholipidosis describes the accumulation of phospholipids in the lysosomes of kidney cells, in particular podocytes. Originally, this was described primarily in the context of the lysosomal storage disorder Fabry disease. It is ... ...

    Abstract Introduction: Renal phospholipidosis describes the accumulation of phospholipids in the lysosomes of kidney cells, in particular podocytes. Originally, this was described primarily in the context of the lysosomal storage disorder Fabry disease. It is now known that a variety of drugs can lead to the accumulation of lysosomal phospholipids.
    Case presentation: We present the case of a 69-year-old female patient suffering chronic kidney disease and systemic lupus erythematosus who underwent a kidney biopsy because of a further increase in serum creatinine levels. There was no evidence of lupus nephritis, but electron microscopy showed zebra bodies as a morphological sign of phospholipidosis. This was most likely drug-induced after 25 years of continuous medication with hydroxychloroquine. A renal biopsy 2 years and 6 months earlier, when the renal function of the patient was distinctively better, showed no signs of renal phospholipidosis. Afterward, medication with hydroxychloroquine was discontinued, and renal function parameters remained stable in the 1-year course.
    Conclusion: This case raises the question of how severely impaired renal function affects the risk of hydroxychloroquine-induced renal phospholipidosis and underlines that hydroxychloroquine should be administered with caution in patients with kidney insufficiency. Moreover, we provide a review of the causes of renal phospholipidosis, which have been described in the literature and give an overview of possible differential diagnoses in cases with histologically proven phospholipidosis in renal biopsies.
    Language English
    Publishing date 2024-02-16
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2809879-1
    ISSN 2296-9705
    ISSN 2296-9705
    DOI 10.1159/000536448
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: First Report on Successful Conversion of Long-Term Treatment of Recurrent Atypical Hemolytic Uremic Syndrome With Eculizumab to Ravulizumab in a Renal Transplant Patient.

    Jehn, Ulrich / Altuner, Ugur / Pavenstädt, Hermann / Reuter, Stefan

    Transplant international : official journal of the European Society for Organ Transplantation

    2022  Volume 35, Page(s) 10846

    MeSH term(s) Humans ; Atypical Hemolytic Uremic Syndrome/drug therapy ; Kidney Transplantation ; Antibodies, Monoclonal, Humanized/therapeutic use
    Chemical Substances ravulizumab (C3VX249T6L) ; eculizumab (A3ULP0F556) ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2022-10-03
    Publishing country Switzerland
    Document type Letter
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.3389/ti.2022.10846
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: WWC Proteins: Important Regulators of Hippo Signaling in Cancer.

    Höffken, Verena / Hermann, Anke / Pavenstädt, Hermann / Kremerskothen, Joachim

    Cancers

    2021  Volume 13, Issue 2

    Abstract: The Hippo signaling pathway is known to regulate cell differentiation, proliferation and apoptosis. Whereas activation of the Hippo signaling pathway leads to phosphorylation and cytoplasmic retention of the transcriptional coactivator YAP, decreased ... ...

    Abstract The Hippo signaling pathway is known to regulate cell differentiation, proliferation and apoptosis. Whereas activation of the Hippo signaling pathway leads to phosphorylation and cytoplasmic retention of the transcriptional coactivator YAP, decreased Hippo signaling results in nuclear import of YAP and subsequent transcription of pro-proliferative genes. Hence, a dynamic and precise regulation of the Hippo signaling pathway is crucial for organ size control and the prevention of tumor formation. The transcriptional activity of YAP is controlled by a growing number of upstream regulators including the family of WWC proteins. WWC1, WWC2 and WWC3 represent cytosolic scaffolding proteins involved in intracellular transport processes and different signal transduction pathways. Earlier in vitro experiments demonstrated that WWC proteins positively regulate the Hippo pathway via the activation of large tumor suppressor kinases 1/2 (LATS1/2) kinases and the subsequent cytoplasmic accumulation of phosphorylated YAP. Later, reduced WWC expression and subsequent high YAP activity were shown to correlate with the progression of human cancer in different organs. Although the function of WWC proteins as upstream regulators of Hippo signaling was confirmed in various studies, their important role as tumor modulators is often overlooked. This review has been designed to provide an update on the published data linking WWC1, WWC2 and WWC3 to cancer, with a focus on Hippo pathway-dependent mechanisms.
    Language English
    Publishing date 2021-01-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13020306
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Loss of S1P Lyase Expression in Human Podocytes Causes a Reduction in Nephrin Expression That Involves PKCδ Activation.

    Imeri, Faik / Stepanovska Tanturovska, Bisera / Manaila, Roxana / Pavenstädt, Hermann / Pfeilschifter, Josef / Huwiler, Andrea

    International journal of molecular sciences

    2023  Volume 24, Issue 4

    Abstract: Sphingosine 1-phosphate (S1P) lyase (SPL, ...

    Abstract Sphingosine 1-phosphate (S1P) lyase (SPL,
    MeSH term(s) Animals ; Humans ; Mice ; Interleukin-6 ; Nephrotic Syndrome ; Podocytes ; RNA, Messenger ; Protein Kinase C-delta
    Chemical Substances Interleukin-6 ; nephrin ; RNA, Messenger ; SGPL1 protein, human (EC 4.1.2.27) ; Protein Kinase C-delta (EC 2.7.11.13)
    Language English
    Publishing date 2023-02-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24043267
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  9. Article ; Online: Interleukin-6 drives endothelial glycocalyx damage in COVID-19 and bacterial sepsis.

    Drost, Carolin Christina / Rovas, Alexandros / Osiaevi, Irina / Schughart, Klaus / Lukasz, Alexander / Linke, Wolfgang A / Pavenstädt, Hermann / Kümpers, Philipp

    Angiogenesis

    2024  

    Abstract: Damage of the endothelial glycocalyx (eGC) plays a central role in the development of vascular hyperpermeability and organ damage during systemic inflammation. However, the specific signalling pathways for eGC damage remain poorly defined. Aim of this ... ...

    Abstract Damage of the endothelial glycocalyx (eGC) plays a central role in the development of vascular hyperpermeability and organ damage during systemic inflammation. However, the specific signalling pathways for eGC damage remain poorly defined. Aim of this study was to combine sublingual video-microscopy, plasma proteomics and live cell imaging to uncover further pathways of eGC damage in patients with coronavirus disease 2019 (COVID-19) or bacterial sepsis. This secondary analysis of the prospective multicenter MICROCODE study included 22 patients with COVID-19 and 43 patients with bacterial sepsis admitted to intermediate or intensive care units and 10 healthy controls. Interleukin-6 (IL-6) was strongly associated with damaged eGC and correlated both with eGC dimensions (r
    Language English
    Publishing date 2024-04-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1484717-6
    ISSN 1573-7209 ; 0969-6970
    ISSN (online) 1573-7209
    ISSN 0969-6970
    DOI 10.1007/s10456-024-09916-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5094: Show issues Location:
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  10. Article ; Online: Monocytes as Targets for Immunomodulation by Regional Citrate Anticoagulation.

    Di Marco, Giovana Seno / Chasan, Achmet Imam / Boeckel, Göran Ramin / Beul, Katrin / Pavenstädt, Hermann / Roth, Johannes / Brand, Marcus

    International journal of molecular sciences

    2024  Volume 25, Issue 5

    Abstract: Immune alterations in end-stage renal patients receiving hemodialysis are complex and predispose patients to infections. Anticoagulation may also play an immunomodulatory role in addition to the accumulation of uremic toxins and the effects of the ... ...

    Abstract Immune alterations in end-stage renal patients receiving hemodialysis are complex and predispose patients to infections. Anticoagulation may also play an immunomodulatory role in addition to the accumulation of uremic toxins and the effects of the dialysis procedure. Accordingly, it has been recently shown that the infection rate increases in patients under regional citrate anticoagulation (RCA) compared with systemic heparin anticoagulation (SHA). We hypothesized that RCA affects the immune status of hemodialysis patients by targeting monocytes. In a cohort of 38 end-stage renal patients undergoing hemodialysis, we demonstrated that whole blood monocytes of patients receiving RCA-but not SHA-failed to upregulate surface activation markers, like human leukocyte antigen class II (HLA-DR), after stressful insults, indicating a state of deactivation during and immediately after dialysis. Additionally, RNA sequencing (RNA-seq) data and gene set enrichment analysis of pre-dialysis monocytes evidenced a great and complex difference between the groups given that, in the RCA group, monocytes displayed a dramatic transcriptional change with increased expression of genes related to the cell cycle regulation, cellular metabolism, and cytokine signaling, compatible with the reprogramming of the immune response. Transcriptomic changes in pre-dialysis monocytes signalize the lasting nature of the RCA-related effects, suggesting that monocytes are affected even beyond the dialysis session. Furthermore, these findings demonstrate that RCA-but not SHA-impairs the response of monocytes to activation stimuli and alters the immune status of these patients with potential clinical implications.
    MeSH term(s) Humans ; Citric Acid/pharmacology ; Anticoagulants/pharmacology ; Monocytes ; Citrates ; Heparin ; Renal Dialysis/methods ; Immunity
    Chemical Substances Citric Acid (2968PHW8QP) ; Anticoagulants ; Citrates ; Heparin (9005-49-6)
    Language English
    Publishing date 2024-03-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25052900
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