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  1. Article ; Online: To fuse or to divide, that was the question.

    Chen, Elizabeth H

    Nature reviews. Molecular cell biology

    2022  Volume 24, Issue 1, Page(s) 5

    Language English
    Publishing date 2022-08-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2031313-5
    ISSN 1471-0080 ; 1471-0072
    ISSN (online) 1471-0080
    ISSN 1471-0072
    DOI 10.1038/s41580-022-00533-3
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  2. Book: Cell fusion

    Chen, Elizabeth H.

    overviews and methods

    (Methods in molecular biology ; 475)

    2008  

    Author's details ed. by Elizabeth H. Chen
    Series title Methods in molecular biology ; 475
    Collection
    Keywords Molekularbiologie ; Zellfraktionierung
    Subject Cell fractionation ; Cell sorting ; Zellseparation ; Zellsortierung ; Cell separation ; Zelltrennung ; Molekulare Biologie
    Language English
    Size XI, 421 S.
    Publisher Humana Press
    Publishing place Totowa, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT015564468
    ISBN 978-1-588-29911-6 ; 1-588-29911-2 ; 9781597452502 ; 1597452505
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2008 A 4566 order for loan Magazin

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  3. Article ; Online: Inter-organ steroid hormone signaling promotes myoblast fusion via direct transcriptional regulation of a single key effector gene.

    Ruan, Zhi-Rong / Yu, Ze / Xing, Chao / Chen, Elizabeth H

    Current biology : CB

    2024  Volume 34, Issue 7, Page(s) 1438–1452.e6

    Abstract: Steroid hormones regulate tissue development and physiology by modulating the transcription of a broad spectrum of genes. In insects, the principal steroid hormones, ecdysteroids, trigger the expression of thousands of genes through a cascade of ... ...

    Abstract Steroid hormones regulate tissue development and physiology by modulating the transcription of a broad spectrum of genes. In insects, the principal steroid hormones, ecdysteroids, trigger the expression of thousands of genes through a cascade of transcription factors (TFs) to coordinate developmental transitions such as larval molting and metamorphosis. However, whether ecdysteroid signaling can bypass transcriptional hierarchies to exert its function in individual developmental processes is unclear. Here, we report that a single non-TF effector gene mediates the transcriptional output of ecdysteroid signaling in Drosophila myoblast fusion, a critical step in muscle development and differentiation. Specifically, we show that the 20-hydroxyecdysone (commonly referred to as "ecdysone") secreted from an extraembryonic tissue, amnioserosa, acts on embryonic muscle cells to directly activate the expression of antisocial (ants), which encodes an essential scaffold protein enriched at the fusogenic synapse. Not only is ants transcription directly regulated by the heterodimeric ecdysone receptor complex composed of ecdysone receptor (EcR) and ultraspiracle (USP) via ecdysone-response elements but also more strikingly, expression of ants alone is sufficient to rescue the myoblast fusion defect in ecdysone signaling-deficient mutants. We further show that EcR/USP and a muscle-specific TF Twist synergistically activate ants expression in vitro and in vivo. Taken together, our study provides the first example of a steroid hormone directly activating the expression of a single key non-TF effector gene to regulate a developmental process via inter-organ signaling and provides a new paradigm for understanding steroid hormone signaling in other developmental and physiological processes.
    MeSH term(s) Animals ; DNA-Binding Proteins/metabolism ; Ecdysone ; Ecdysteroids ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Receptors, Steroid/genetics ; Receptors, Steroid/metabolism ; Molting/physiology ; Drosophila/physiology ; Gene Expression Regulation, Developmental
    Chemical Substances DNA-Binding Proteins ; Ecdysone (3604-87-3) ; Ecdysteroids ; Drosophila Proteins ; Receptors, Steroid
    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2024.02.056
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  4. Article ; Online: Reply to Hudaib.

    Chen, Leo / Thomas, Elizabeth H X / Fitzgerald, Paul B

    Brain stimulation

    2021  Volume 14, Issue 6, Page(s) 1587–1588

    Language English
    Publishing date 2021-10-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2394410-9
    ISSN 1876-4754 ; 1935-861X
    ISSN (online) 1876-4754
    ISSN 1935-861X
    DOI 10.1016/j.brs.2021.09.013
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  5. Article ; Online: Let curiosity lead you.

    Chen, Elizabeth H

    Molecular biology of the cell

    2018  Volume 29, Issue 22, Page(s) 2603–2605

    Abstract: It is an incredible honor to receive the Woman in Cell Biology Mid-Career Award for Excellence in Research. My lab works on cell-cell fusion, an indispensable process in the conception, development, and physiology of multicellular organisms. In this ... ...

    Abstract It is an incredible honor to receive the Woman in Cell Biology Mid-Career Award for Excellence in Research. My lab works on cell-cell fusion, an indispensable process in the conception, development, and physiology of multicellular organisms. In this essay, I reflect on my curiosity-led journey, which uncovered some unexpected mechanisms underlying cell-cell fusion.
    MeSH term(s) Animals ; Caenorhabditis elegans/cytology ; Cell Fusion ; Developmental Biology/history ; Drosophila/cytology ; History, 20th Century ; History, 21st Century
    Language English
    Publishing date 2018-11-08
    Publishing country United States
    Document type Autobiography ; Historical Article ; Journal Article ; Portrait ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1098979-1
    ISSN 1939-4586 ; 1059-1524
    ISSN (online) 1939-4586
    ISSN 1059-1524
    DOI 10.1091/mbc.E18-08-0499
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: "

    Chen, Xu / Molenda, Olivia / Brown, Christopher T / Toth, Courtney R A / Guo, Shen / Luo, Fei / Howe, Jane / Nesbø, Camilla L / He, Christine / Montabana, Elizabeth A / Cate, Jamie H D / Banfield, Jillian F / Edwards, Elizabeth A

    Applied and environmental microbiology

    2023  Volume 89, Issue 5, Page(s) e0002523

    Abstract: The Candidate Phyla Radiation (CPR), also referred to as ... ...

    Abstract The Candidate Phyla Radiation (CPR), also referred to as superphylum
    MeSH term(s) Archaea/metabolism ; Benzene/metabolism ; Phylogeny ; Biomass ; RNA, Ribosomal, 16S/genetics ; RNA, Ribosomal, 16S/metabolism ; In Situ Hybridization, Fluorescence ; Bacteria/genetics ; Euryarchaeota/metabolism
    Chemical Substances Benzene (J64922108F) ; RNA, Ribosomal, 16S
    Language English
    Publishing date 2023-04-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 223011-2
    ISSN 1098-5336 ; 0099-2240
    ISSN (online) 1098-5336
    ISSN 0099-2240
    DOI 10.1128/aem.00025-23
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  7. Article ; Online: Expansion of Abdominal Aortic Aneurysm Screening and Ultrasound Utilization and Diagnosis.

    Ho, Vy Thuy / Cabot, John H / George, Elizabeth L / Garcia-Toca, Manuel / Chen, Jonathan H / Asch, Steven M / Lee, Jason T

    JAMA surgery

    2023  Volume 158, Issue 12, Page(s) 1349–1351

    MeSH term(s) Humans ; Mass Screening ; Aortic Aneurysm, Abdominal/diagnostic imaging ; Ultrasonography
    Language English
    Publishing date 2023-10-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2023.4662
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  8. Article ; Online: Old and newly synthesized histones are asymmetrically distributed in Drosophila intestinal stem cell divisions.

    Zion, Emily H / Ringwalt, Daniel / Rinaldi, Kristina / Kahney, Elizabeth W / Li, Yingying / Chen, Xin

    EMBO reports

    2023  Volume 24, Issue 7, Page(s) e56404

    Abstract: We report that preexisting (old) and newly synthesized (new) histones H3 and H4 are asymmetrically partitioned during the division of Drosophila intestinal stem cells (ISCs). Furthermore, the inheritance patterns of old and new H3 and H4 in postmitotic ... ...

    Abstract We report that preexisting (old) and newly synthesized (new) histones H3 and H4 are asymmetrically partitioned during the division of Drosophila intestinal stem cells (ISCs). Furthermore, the inheritance patterns of old and new H3 and H4 in postmitotic cell pairs correlate with distinct expression patterns of Delta, an important cell fate gene. To understand the biological significance of this phenomenon, we expressed a mutant H3T3A to compromise asymmetric histone inheritance. Under this condition, we observe an increase in Delta-symmetric cell pairs and overpopulated ISC-like, Delta-positive cells. Single-cell RNA-seq assays further indicate that H3T3A expression compromises ISC differentiation. Together, our results indicate that asymmetric histone inheritance potentially contributes to establishing distinct cell identities in a somatic stem cell lineage, consistent with previous findings in Drosophila male germline stem cells.
    MeSH term(s) Animals ; Drosophila/metabolism ; Histones/metabolism ; Intestines ; Cell Differentiation/genetics ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Cell Division/genetics
    Chemical Substances Histones ; Drosophila Proteins
    Language English
    Publishing date 2023-05-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.15252/embr.202256404
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  9. Article: Heterogeneity in Measures of Illness among Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Is Not Explained by Clinical Practice: A Study in Seven U.S. Specialty Clinics.

    Unger, Elizabeth R / Lin, Jin-Mann S / Chen, Yang / Cornelius, Monica E / Helton, Britany / Issa, Anindita N / Bertolli, Jeanne / Klimas, Nancy G / Balbin, Elizabeth G / Bateman, Lucinda / Lapp, Charles W / Springs, Wendy / Podell, Richard N / Fitzpatrick, Trisha / Peterson, Daniel L / Gottschalk, C Gunnar / Natelson, Benjamin H / Blate, Michelle / Kogelnik, Andreas M /
    Phan, Catrina C / On Behalf Of The McAm Study Group

    Journal of clinical medicine

    2024  Volume 13, Issue 5

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-02-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13051369
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  10. Article ; Online: Use of

    Fear, Elizabeth J / Torkelsen, Frida H / Zamboni, Elisa / Chen, Kuan-Ju / Scott, Martin / Jeffery, Glenn / Baseler, Heidi / Kennerley, Aneurin J

    Aging cell

    2023  Volume 22, Issue 11, Page(s) e14005

    Abstract: Mitochondrial function declines with age, and many pathological processes in neurodegenerative diseases stem from this dysfunction when mitochondria fail to produce the necessary energy required. Photobiomodulation (PBM), long-wavelength light therapy, ... ...

    Abstract Mitochondrial function declines with age, and many pathological processes in neurodegenerative diseases stem from this dysfunction when mitochondria fail to produce the necessary energy required. Photobiomodulation (PBM), long-wavelength light therapy, has been shown to rescue mitochondrial function in animal models and improve human health, but clinical uptake is limited due to uncertainty around efficacy and the mechanisms responsible. Using
    MeSH term(s) Animals ; Humans ; Aged ; Brain ; Adenosine Triphosphate ; Magnetic Resonance Spectroscopy
    Chemical Substances Adenosine Triphosphate (8L70Q75FXE)
    Language English
    Publishing date 2023-10-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2113083-8
    ISSN 1474-9726 ; 1474-9718
    ISSN (online) 1474-9726
    ISSN 1474-9718
    DOI 10.1111/acel.14005
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