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Article ; Online: The triplet puzzle theory indicates extensive formation of heteromers between opioid and chemokine receptor subtypes.

Tarakanov, Alexander O / Fuxe, Kjell

Journal of neural transmission (Vienna, Austria : 1996)

2015 Volume 122, Issue 11, Page(s) 1509–1514

Abstract: Biochemical studies had previously demonstrated examples of heteromerization between opioid and chemokine receptors. Based on the triplet puzzle theory, it has been discovered that opioid receptors are structurally more closely related to chemokine ... ...

Abstract	Biochemical studies had previously demonstrated examples of heteromerization between opioid and chemokine receptors. Based on the triplet puzzle theory, it has been discovered that opioid receptors are structurally more closely related to chemokine receptors than to other class A G-protein-coupled receptors. Their similarity is established in terms of the number of triplet homologies Asn-Leu-Ala, Thr-Leu-Pro, and Tyr-Ala-Phe in the amino acid code of extensive numbers of members of these two receptor groups. Such widespread similarities probably mean that many opioid and chemokine receptor subtypes utilize some of these mutual triplets to form heteromers. The findings underline that heteromerization among these two receptor groups can represent a major general mechanism for significant interactions between opioid peptides and chemokines in pain and neuroinflammation within the neural-glial networks of the CNS including immune cells.
MeSH term(s)	Amino Acid Sequence ; Humans ; Models, Molecular ; Receptors, Chemokine/genetics ; Receptors, Chemokine/metabolism ; Receptors, Opioid/genetics ; Receptors, Opioid/metabolism
Chemical Substances	Receptors, Chemokine ; Receptors, Opioid
Language	English
Publishing date	2015-11
Publishing country	Austria
Document type	Journal Article
ZDB-ID	184163-4
ISSN	1435-1463 ; 0300-9564
ISSN (online)	1435-1463
ISSN	0300-9564
DOI	10.1007/s00702-015-1421-5
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Article: Glutamate heteroreceptor complexes in the brain.

Borroto-Escuela, Dasiel O / Tarakanov, Alexander O / Brito, Ismel / Fuxe, Kjell

Pharmacological reports : PR

2018 Volume 70, Issue 5, Page(s) 936–950

Abstract: The existence of mGluR, NMDAR, AMPAR and putative KAR heteroreceptor complexes in synaptic and extrasynaptic regions of brain glutamate synapses represents a major integrative mechanism. Our aim in the current article is to analyze if the formation of ... ...

Abstract	The existence of mGluR, NMDAR, AMPAR and putative KAR heteroreceptor complexes in synaptic and extrasynaptic regions of brain glutamate synapses represents a major integrative mechanism. Our aim in the current article is to analyze if the formation of the different types glutamate hetereceptor complexes involves the contribution of triplet amino acid homologies (protriplets) in a postulated receptor interface based on the triplet puzzle theory. Seven main sets (lists) of receptor pairs in databases were used containing various sets (lists) of human receptor heteromers and nonheteromers obtained from the available scientific publications including the publically available GPCR-hetnet database. Brain mGluR1-mGluR5 and mGluR2-mGluR4 isoreceptor complexes were demonstrated with a predominant extrasynaptic localization at a post- and prejunctional localization. The existence of putative mGluR4-mGluR7 heteroreceptor complexes in the basal ganglia is proposed. Metabotropic glutamate receptor subtypes also participated in the formation of a large number of heteroreceptor complexes like mGluR1-A1R, mGluR5-A2AR, mGluR5-D2R and D2R-A2AR-mGluR5, located in relation to glutamate synapses, especially in the basal ganglia. A putative mGluR1-GABAB1/2 heterocomplex may also exist. NMDAR heteroreceptor complexes were also demonstrated as a fundamental integrative mechanism in the glutamate synapse and its extrasynaptic membranes. It represented fundamental work on inter alia NMDAR-mGluR5, NMDAR-D1R and NMDAR-D2R heteroreceptor complexes involving both antagonistic and facilitatory allosteric receptor-receptor interactions. As to AMPA receptors, a heterocomplex was found for the interaction between IFNgR1 and the AMPAR mediated via the subunit GluA1 which may be of relevance for neuroinflammation. AMPAR-D2R heteroreceptor complexes were also demonstrated. Besides glutamate heteroreceptor complexes and their allosteric receptor-receptor interactions, a significant mechanism for the functional crosstalk can also be phosphorylation and/or reorganization of adapter proteins with dynamic binding to the two receptors modulating the allosteric receptor mechanism.
MeSH term(s)	Animals ; Brain/metabolism ; Humans ; Multiprotein Complexes/metabolism ; Protein Isoforms/metabolism ; Receptors, Glutamate/metabolism ; Sequence Homology, Amino Acid
Chemical Substances	Multiprotein Complexes ; Protein Isoforms ; Receptors, Glutamate
Language	English
Publishing date	2018-04-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2186248-5
ISSN	1734-1140
ISSN	1734-1140
DOI	10.1016/j.pharep.2018.04.002
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Zs.A 861: Show issues

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Article: IL1R2, CCR2, and CXCR4 May Form Heteroreceptor Complexes with NMDAR and D2R: Relevance for Schizophrenia.

Borroto-Escuela, Dasiel O / Tarakanov, Alexander O / Bechter, Karl / Fuxe, Kjell

Frontiers in psychiatry

2017 Volume 8, Page(s) 24

Abstract: The mild neuroinflammation hypothesis of schizophrenia was introduced by Bechter in 2001. It has been hypothesized that a hypofunction of glutamatergic ... ...

Abstract	The mild neuroinflammation hypothesis of schizophrenia was introduced by Bechter in 2001. It has been hypothesized that a hypofunction of glutamatergic signaling
Language	English
Publishing date	2017-02-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2017.00024
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Article ; Online: FGFR1-5-HT1A Heteroreceptor Complexes: Implications for Understanding and Treating Major Depression.

Borroto-Escuela, Dasiel O / Tarakanov, Alexander O / Fuxe, Kjell

Trends in neurosciences

2016 Volume 39, Issue 1, Page(s) 5–15

Abstract: The serotonin and neurotrophic factor hypotheses of depression are well known. The discovery of brain fibroblast growth factor receptor 1 (FGFR1)-5 hydroxytryptamine receptor 1A (5-HT1A) heteroreceptor complexes, and their enhancement of neuroplasticity, ...

Abstract	The serotonin and neurotrophic factor hypotheses of depression are well known. The discovery of brain fibroblast growth factor receptor 1 (FGFR1)-5 hydroxytryptamine receptor 1A (5-HT1A) heteroreceptor complexes, and their enhancement of neuroplasticity, offers an integration of these hypotheses at the molecular level. They were first described in the hippocampus and later in midbrain 5-HT neurons, where these heterocomplexes are enriched in 5-HT1A autoreceptors. Combined FGF2 and 5-HT1A agonist treatment increased the formation of these heterocomplexes and the facilitatory allosteric receptor-receptor interactions within them led to the enhancement of FGFR1 signaling and was associated with the development of antidepressant effects. We discuss these findings with regard to a theory of motifs critically involved in these interactions and suggest that these complexes represent novel targets for antidepressants.
MeSH term(s)	Animals ; Depressive Disorder, Major/drug therapy ; Depressive Disorder, Major/metabolism ; Humans ; Neurosciences/trends ; Receptor, Fibroblast Growth Factor, Type 1/metabolism ; Receptor, Serotonin, 5-HT1A/metabolism
Chemical Substances	Receptor, Serotonin, 5-HT1A (112692-38-3) ; Receptor, Fibroblast Growth Factor, Type 1 (EC 2.7.10.1)
Language	English
Publishing date	2016-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	282488-7
ISSN	1878-108X ; 0378-5912 ; 0166-2236
ISSN (online)	1878-108X
ISSN	0378-5912 ; 0166-2236
DOI	10.1016/j.tins.2015.11.003
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Zs.A 1442: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Integrin triplets of marine sponges in the murine and human MHCI-CD8 interface and in the interface of human neural receptor heteromers and subunits.

Tarakanov, Alexander O / Fuxe, Kjell G

SpringerPlus

2013 Volume 2, Issue 1, Page(s) 128

Abstract: Based on our theory, main triplets of amino acid residues have been discovered in cell-adhesion receptors (integrins) of marine sponges, which participate as homologies in the interface between two major immune molecules, MHC class I (MHCI) and CD8αβ. ... ...

Abstract	Based on our theory, main triplets of amino acid residues have been discovered in cell-adhesion receptors (integrins) of marine sponges, which participate as homologies in the interface between two major immune molecules, MHC class I (MHCI) and CD8αβ. They appear as homologies also in several human neural receptor heteromers and subunits. The obtained results probably mean that neural and immune receptors also utilize these structural integrin triplets to form heteromers and ion channels, which are required for a tuned and integrated intracellular and intercellular communication and a communication between cells and the extracellular matrix with an origin in sponges, the oldest multicellular animals.
Language	English
Publishing date	2013-03-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661116-8
ISSN	2193-1801
ISSN	2193-1801
DOI	10.1186/2193-1801-2-128
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Article ; Online: The triplet puzzle of homologies in receptor heteromers exists also in other types of protein-protein interactions.

Tarakanov, Alexander O / Fuxe, Kjell G

Journal of molecular neuroscience : MN

2011 Volume 44, Issue 3, Page(s) 173–177

Abstract: Based on our theory, we point out main triplets of amino acid residues in the GABAB1 receptor, found in the central and peripheral nervous system, which seem to be critical for both receptor heterodimerization and chemokine binding. The obtained results ... ...

Abstract	Based on our theory, we point out main triplets of amino acid residues in the GABAB1 receptor, found in the central and peripheral nervous system, which seem to be critical for both receptor heterodimerization and chemokine binding. The obtained results suggest that these triplets may "guide-and-clasp" protein-protein interactions playing a role, e.g., in neuroinflammation disorders.
MeSH term(s)	Amino Acid Motifs ; Animals ; Humans ; Models, Molecular ; Molecular Sequence Data ; Protein Binding ; Protein Interaction Domains and Motifs/genetics ; Protein Isoforms/chemistry ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Protein Multimerization ; Receptors, GABA-B/chemistry ; Receptors, GABA-B/genetics ; Receptors, GABA-B/metabolism ; Sequence Alignment
Chemical Substances	Protein Isoforms ; Receptors, GABA-B
Language	English
Publishing date	2011-03-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	1043392-2
ISSN	1559-1166 ; 0895-8696
ISSN (online)	1559-1166
ISSN	0895-8696
DOI	10.1007/s12031-011-9511-9
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Article ; Online: Carbon nanotubes towards medicinal biochips.

Tarakanov, Alexander O / Goncharova, Larisa B / Tarakanov, Yury A

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

2010 Volume 2, Issue 1, Page(s) 1–10

Abstract: This overview focuses on the recent advances in carbon nanotube (CNT)-based biochips and tries to clarify their potential for modern molecular medicine. ...

Abstract	This overview focuses on the recent advances in carbon nanotube (CNT)-based biochips and tries to clarify their potential for modern molecular medicine.
MeSH term(s)	Animals ; Biomedical Technology/methods ; Drug Delivery Systems/methods ; Humans ; Microchip Analytical Procedures/methods ; Nanotubes, Carbon
Chemical Substances	Nanotubes, Carbon
Language	English
Publishing date	2010-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2502698-7
ISSN	1939-0041 ; 1939-5116
ISSN (online)	1939-0041
ISSN	1939-5116
DOI	10.1002/wnan.69
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Zs.A 6781: Show issues

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Article ; Online: Passive microwave radiometry in biomedical studies.

Goryanin, Igor / Karbainov, Sergey / Shevelev, Oleg / Tarakanov, Alexander / Redpath, Keith / Vesnin, Sergey / Ivanov, Yuri

Drug discovery today

2020 Volume 25, Issue 4, Page(s) 757–763

Abstract: Passive microwave radiometry (MWR) measures natural emissions in the range 1-10GHz from proteins, cells, organs and the whole human body. The intensity of intrinsic emission is determined by biochemical and biophysical processes. The nature of this ... ...

Abstract	Passive microwave radiometry (MWR) measures natural emissions in the range 1-10GHz from proteins, cells, organs and the whole human body. The intensity of intrinsic emission is determined by biochemical and biophysical processes. The nature of this process is still not very well known. Infrared thermography (IRT) can detect emission several microns deep (skin temperature), whereas MWR allows detection of thermal abnormalities down to several centimeters (internal or deep temperature). MWR is noninvasive and inexpensive. It requires neither fluorescent nor radioactive labels, nor ionizing or other radiation. MWR can be used in early drug discovery as well as preclinical and clinical studies.
MeSH term(s)	Animals ; Body Temperature/physiology ; Clinical Trials as Topic/methods ; Drug Discovery/methods ; Drug Evaluation, Preclinical/methods ; Humans ; Microwaves ; Radiometry/methods ; Thermography/methods
Language	English
Publishing date	2020-01-28
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1324988-5
ISSN	1878-5832 ; 1359-6446
ISSN (online)	1878-5832
ISSN	1359-6446
DOI	10.1016/j.drudis.2020.01.016
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Article ; Online: Cell-cell nanotubes: Tunneling through several types of synapses.

Tarakanov, Alexander O / Goncharova, Larisa B

Communicative & integrative biology

2009 Volume 2, Issue 4, Page(s) 359–361

Abstract: Nanotube can be generally seen as a nanoscale cylindrical structure. Membrane (or tunneling) nanotube (TNT) is a cytoplasmic tunnel between two cells. Such direct cell-cell channel is used for a physical transport of biochemical cargo, whereas ... ...

Abstract	Nanotube can be generally seen as a nanoscale cylindrical structure. Membrane (or tunneling) nanotube (TNT) is a cytoplasmic tunnel between two cells. Such direct cell-cell channel is used for a physical transport of biochemical cargo, whereas nanotubular networks between cells may be a novel principle of communicative and integrative biology. Recently, TNTs and their networks were discovered in plant cells and then they were reported also in animal cells. Just the reverse, a notion of plant synapse has been also proposed only recently, long after the corresponding notion of neuronal synapse in animals. However, both TNTs and synapses seem to be closely related and evolutionary conserved structures through different types of cells. Accordingly, this mini-review aims to demonstrate that TNTs may represent one of the deep functional similarities between neuronal, immune, viral and plant synapses.
Language	English
Publishing date	2009-08-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2451097-X
ISSN	1942-0889 ; 1942-0889
ISSN (online)	1942-0889
ISSN	1942-0889
DOI	10.4161/cib.2.4.8289
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Article ; Online: Triplet puzzle: homologies of receptor heteromers.

Tarakanov, Alexander O / Fuxe, Kjell G

Journal of molecular neuroscience : MN

2009 Volume 41, Issue 2, Page(s) 294–303

Abstract: Based on a mathematical approach, we deduce a set of triplet homologies that may be responsible for receptor-receptor interactions. We show how such triplets of amino acid residues and their 'teams' may be utilized to construct a kind of code that ... ...

Abstract	Based on a mathematical approach, we deduce a set of triplet homologies that may be responsible for receptor-receptor interactions. We show how such triplets of amino acid residues and their 'teams' may be utilized to construct a kind of code that determines (and/or predicts) which receptors should or should not form heterodimers. Based on the obtained results, we propose a 'guide-and-clasp' manner for receptor-receptor interactions where 'adhesive guides' might be the triplet homologies. We also demonstrate their relevance to protein-protein interactions and mention possible implications for novel pharmacological targets and strategies for treatment of diseases, e.g. neuroinflammatory diseases.
MeSH term(s)	Amino Acid Sequence ; Membrane Proteins/chemistry ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Models, Molecular ; Models, Theoretical ; Molecular Sequence Data ; Protein Multimerization ; Protein Structure, Quaternary
Chemical Substances	Membrane Proteins
Language	English
Publishing date	2009-12-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1043392-2
ISSN	1559-1166 ; 0895-8696
ISSN (online)	1559-1166
ISSN	0895-8696
DOI	10.1007/s12031-009-9313-5
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