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Article: Long-term follow-up in preschool children after radiofrequency catheter ablation of arrhythmias.

Svintsova, Liliya I / Krivolapov, Sergey N / Dzhaffarova, Olga Y / Plotnikova, Irina V

2023 Volume 39, Issue 3, Page(s) 405–411

Abstract: Background: Radiofrequency ablation (RFA) is the standard method of treatment for tachyarrhythmias in school children, and it leads to complete recovery in children without structural heart disease. However, RFA in young children is limited by the risk ... ...

Abstract	Background: Radiofrequency ablation (RFA) is the standard method of treatment for tachyarrhythmias in school children, and it leads to complete recovery in children without structural heart disease. However, RFA in young children is limited by the risk of complications and unstudied remote effects of radiofrequency lesions. Objective: To present the experience of RFA of arrhythmias and the results of follow-up of younger children. Materials and methods: RFA procedures ( Results: The overall effectiveness of RFA, considering the repeated procedures performed due to the primary ineffectiveness and recurrencies, was 94.7%. There was no mortality associated with RFA in patients, including young patients. All cases of "major" complications are associated with RFA of the left-sided accessory pathway and tachycardia foci and are represented by the mitral valve damage in three patients (1.4%). Tachycardia and preexcitation recurred in 44 (21%) patients. There was a correlation between recurrences and parameters of RFA (odds ratio 0.894; 95% confidence interval: 0.804-0.994; Conclusion: The use of the minimum effective parameters of RFA in children reduces the risk of complications, but increases arrhythmia recurrence rate.
Language	English
Publishing date	2023-03-10
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2696593-8
ISSN	1883-2148 ; 1880-4276
ISSN (online)	1883-2148
ISSN	1880-4276
DOI	10.1002/joa3.12827
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Cardiac Strangulation in Children: Asymptomatic Complication of Epicardial Pacing.

Dzhaffarova, Olga Yu / Svintsova, Liliya I / Kartofeleva, Elena O / Krivolapov, Sergey N / Svyazov, Evgeny A / Plotnikova, Irina V / Popov, Sergey V

JACC. Case reports

2022 Volume 4, Issue 14, Page(s) 857–861

Abstract: Cardiac strangulation is a rare but potentially life-threatening mechanical complication associated with epicardial pacemaker implantation in growing children. This article presents 2 case reports of left ventricular strangulation in 4- and 3-year-old ... ...

Abstract	Cardiac strangulation is a rare but potentially life-threatening mechanical complication associated with epicardial pacemaker implantation in growing children. This article presents 2 case reports of left ventricular strangulation in 4- and 3-year-old children who had an epicardial pacemaker system implanted at an early age. (
Language	English
Publishing date	2022-06-22
Publishing country	Netherlands
Document type	Case Reports
ISSN	2666-0849
ISSN (online)	2666-0849
DOI	10.1016/j.jaccas.2022.05.014
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Thiocarbonyl Derivatives of Natural Chlorins: Synthesis Using Lawesson's Reagent and a Study of Their Properties.

Pogorilyy, Viktor / Ostroverkhov, Petr / Efimova, Valeria / Plotnikova, Ekaterina / Bezborodova, Olga / Diachkova, Ekaterina / Vasil'ev, Yuriy / Pankratov, Andrei / Grin, Mikhail

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 10

Abstract: The development of sulfur-containing pharmaceutical compounds is important in the advancement of medicinal chemistry. Photosensitizers (PS) that acquire new properties upon incorporation of sulfur-containing groups or individual sulfur atoms into their ... ...

Abstract	The development of sulfur-containing pharmaceutical compounds is important in the advancement of medicinal chemistry. Photosensitizers (PS) that acquire new properties upon incorporation of sulfur-containing groups or individual sulfur atoms into their structure are not neglected, either. In this work, a synthesis of sulfur-containing derivatives of natural chlorophyll
MeSH term(s)	Chlorophyll A ; Organothiophosphorus Compounds/chemistry ; Sulfur
Chemical Substances	2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide (A4125MQ8RX) ; chlorin (2683-84-3) ; Chlorophyll A (YF5Q9EJC8Y) ; Organothiophosphorus Compounds ; Sulfur (70FD1KFU70)
Language	English
Publishing date	2023-05-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28104215
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Article: Does Proteomic Mirror Reflect Clinical Characteristics of Obesity?

Kiseleva, Olga I / Arzumanian, Viktoriia A / Poverennaya, Ekaterina V / Pyatnitskiy, Mikhail A / Ilgisonis, Ekaterina V / Zgoda, Victor G / Plotnikova, Oksana A / Sharafetdinov, Khaider K / Lisitsa, Andrey V / Tutelyan, Victor A / Nikityuk, Dmitry B / Archakov, Alexander I / Ponomarenko, Elena A

Journal of personalized medicine

2021 Volume 11, Issue 2

Abstract: Obesity is a frightening chronic disease, which has tripled since 1975. It is not expected to slow down staying one of the leading cases of preventable death and resulting in an increased clinical and economic burden. Poor lifestyle choices and excessive ...

Abstract	Obesity is a frightening chronic disease, which has tripled since 1975. It is not expected to slow down staying one of the leading cases of preventable death and resulting in an increased clinical and economic burden. Poor lifestyle choices and excessive intake of "cheap calories" are major contributors to obesity, triggering type 2 diabetes, cardiovascular diseases, and other comorbidities. Understanding the molecular mechanisms responsible for development of obesity is essential as it might result in the introducing of anti-obesity targets and early-stage obesity biomarkers, allowing the distinction between metabolic syndromes. The complex nature of this disease, coupled with the phenomenon of metabolically healthy obesity, inspired us to perform data-centric, hypothesis-generating pilot research, aimed to find correlations between parameters of classic clinical blood tests and proteomic profiles of 104 lean and obese subjects. As the result, we assembled patterns of proteins, which presence or absence allows predicting the weight of the patient fairly well. We believe that such proteomic patterns with high prediction power should facilitate the translation of potential candidates into biomarkers of clinical use for early-stage stratification of obesity therapy.
Language	English
Publishing date	2021-01-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm11020064
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Article: Draft genome sequences of strains

Olsson, Björn E / Korsakova, Ekaterina S / Anan'ina, Lyudmila N / Pyankova, Anna A / Mavrodi, Olga V / Plotnikova, Elena G / Mavrodi, Dmitri V

Standards in genomic sciences

2017 Volume 12, Page(s) 39

Abstract: Halomonads are moderately halophilic bacteria that are studied as models of prokaryotic osmoadaptation and sources of enzymes and chemicals for biotechnological applications. Despite the progress in understanding the diversity of these organisms, our ... ...

Abstract	Halomonads are moderately halophilic bacteria that are studied as models of prokaryotic osmoadaptation and sources of enzymes and chemicals for biotechnological applications. Despite the progress in understanding the diversity of these organisms, our ability to explain ecological, metabolic, and biochemical traits of halomonads at the genomic sequence level remains limited. This study addresses this gap by presenting draft genomes of
Language	English
Publishing date	2017-07-19
Publishing country	England
Document type	Case Reports
ZDB-ID	2586662-X
ISSN	1944-3277
ISSN	1944-3277
DOI	10.1186/s40793-017-0251-5
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Article ; Online: Does Proteomic Mirror Reflect Clinical Characteristics of Obesity?

Olga I. Kiseleva / Viktoriia A. Arzumanian / Ekaterina V. Poverennaya / Mikhail A. Pyatnitskiy / Ekaterina V. Ilgisonis / Victor G. Zgoda / Oksana A. Plotnikova / Khaider K. Sharafetdinov / Andrey V. Lisitsa / Victor A. Tutelyan / Dmitry B. Nikityuk / Alexander I. Archakov / Elena A. Ponomarenko

Journal of Personalized Medicine, Vol 11, Iss 2, p

2021 Volume 64

Abstract	Obesity is a frightening chronic disease, which has tripled since 1975. It is not expected to slow down staying one of the leading cases of preventable death and resulting in an increased clinical and economic burden. Poor lifestyle choices and excessive intake of “cheap calories” are major contributors to obesity, triggering type 2 diabetes, cardiovascular diseases, and other comorbidities. Understanding the molecular mechanisms responsible for development of obesity is essential as it might result in the introducing of anti-obesity targets and early-stage obesity biomarkers, allowing the distinction between metabolic syndromes. The complex nature of this disease, coupled with the phenomenon of metabolically healthy obesity, inspired us to perform data-centric, hypothesis-generating pilot research, aimed to find correlations between parameters of classic clinical blood tests and proteomic profiles of 104 lean and obese subjects. As the result, we assembled patterns of proteins, which presence or absence allows predicting the weight of the patient fairly well. We believe that such proteomic patterns with high prediction power should facilitate the translation of potential candidates into biomarkers of clinical use for early-stage stratification of obesity therapy.
Keywords	obesity ; BMI ; blood tests ; proteomics ; mass spectrometry ; Medicine ; R
Subject code	610 ; 616
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Innovative computer technologies as an implementer of active methods of training

Efremova Oksana N. / Ivanova Tatyana O. / Plotnikova Inna V. / Chaykovskaya Olga N.

SHS Web of Conferences, Vol 28, p

2016 Volume 01031

Abstract: Introduction of computer means in high schools is dictated by innovative processes in education.One of the latest innovations is Moodle, an open source web-based platform that provides a virtual learningenvironment. The article describes the arrangement ... ...

Abstract	Introduction of computer means in high schools is dictated by innovative processes in education.One of the latest innovations is Moodle, an open source web-based platform that provides a virtual learningenvironment. The article describes the arrangement of students' learning at the technical university with thehelp of didactic materials placed on the Moodle platform. The experimental work has shown that theorganization of learning by means of the virtual learning environment had a positive effect on the level oftraining of first-year students. The survey conducted after the experiment completion allowed us to revealthe difficulties that students experienced during the work in the electronic environment, and, therefore, toplan the ways of their elimination.
Keywords	Social Sciences ; H
Language	English
Publishing date	2016-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Aurora A kinase activity influences calcium signaling in kidney cells.

Plotnikova, Olga V / Pugacheva, Elena N / Golemis, Erica A

The Journal of cell biology

2011 Volume 193, Issue 6, Page(s) 1021–1032

Abstract: Most studies of Aurora A (AurA) describe it as a mitotic centrosomal kinase. However, we and others have recently identified AurA functions as diverse as control of ciliary resorption, cell differentiation, and cell polarity control in interphase cells. ... ...

Abstract	Most studies of Aurora A (AurA) describe it as a mitotic centrosomal kinase. However, we and others have recently identified AurA functions as diverse as control of ciliary resorption, cell differentiation, and cell polarity control in interphase cells. In these activities, AurA is transiently activated by noncanonical signals, including Ca(2+)-dependent calmodulin binding. These and other observations suggested that AurA might be involved in pathological conditions, such as polycystic kidney disease (PKD). In this paper, we show that AurA is abundant in normal kidney tissue but is also abnormally expressed and activated in cells lining PKD-associated renal cysts. PKD arises from mutations in the PKD1 or PKD2 genes, encoding polycystins 1 and 2 (PC1 and PC2). AurA binds, phosphorylates, and reduces the activity of PC2, a Ca(2+)-permeable nonselective cation channel and, thus, limits the amplitude of Ca(2+) release from the endoplasmic reticulum. These and other findings suggest AurA may be a relevant new biomarker or target in the therapy of PKD.
MeSH term(s)	Animals ; Aurora Kinase A ; Aurora Kinases ; Calcium/metabolism ; Calcium Signaling/physiology ; HEK293 Cells ; Humans ; Kidney/cytology ; Kidney/metabolism ; Kidney/pathology ; Mice ; Polycystic Kidney Diseases/genetics ; Polycystic Kidney Diseases/metabolism ; Polycystic Kidney Diseases/pathology ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; TRPP Cation Channels/genetics ; TRPP Cation Channels/metabolism
Chemical Substances	TRPP Cation Channels ; polycystic kidney disease 1 protein ; polycystic kidney disease 2 protein ; Aurka protein, mouse (EC 2.7.11.1) ; Aurora Kinase A (EC 2.7.11.1) ; Aurora Kinases (EC 2.7.11.1) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2011-06-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	218154-x
ISSN	1540-8140 ; 0021-9525
ISSN (online)	1540-8140
ISSN	0021-9525
DOI	10.1083/jcb.201012061
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Article: Influence of Lipid Composition of Cationic Liposomes 2X3-DOPE on mRNA Delivery into Eukaryotic Cells.

Vysochinskaya, Vera / Shishlyannikov, Sergey / Zabrodskaya, Yana / Shmendel, Elena / Klotchenko, Sergey / Dobrovolskaya, Olga / Gavrilova, Nina / Makarova, Darya / Plotnikova, Marina / Elpaeva, Ekaterina / Gorshkov, Andrey / Moshkoff, Dmitry / Maslov, Mikhail / Vasin, Andrey

Pharmaceutics

2022 Volume 15, Issue 1

Abstract: The design of cationic liposomes for efficient mRNA delivery can significantly improve mRNA-based therapies. Lipoplexes based on polycationic lipid 1,26-bis(cholest-5-en-3β-yloxycarbonylamino)-7,11,16,20-tetraazahexacosane tetrahydrochloride (2X3) and ... ...

Abstract	The design of cationic liposomes for efficient mRNA delivery can significantly improve mRNA-based therapies. Lipoplexes based on polycationic lipid 1,26-bis(cholest-5-en-3β-yloxycarbonylamino)-7,11,16,20-tetraazahexacosane tetrahydrochloride (2X3) and helper lipid 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) were formulated in different molar ratios (1:1, 1:2, 1:3) to efficiently deliver model mRNAs to BHK-21 and A549. The objective of this study was to examine the effect of 2X3-DOPE composition as well as lipid-to-mRNA ratio (amino-to-phosphate group ratio, N/P) on mRNA transfection. We found that lipoplex-mediated transfection efficiency depends on both liposome composition and the N/P ratio. Lipoplexes with an N/P ratio of 10/1 showed nanometric hydrodynamic size, positive ζ potential, maximum loading, and transfection efficiency. Liposomes 2X3-DOPE (1:3) provided the superior delivery of both mRNA coding firefly luciferase and mRNA-eGFP into BHK-21 cells and A549 cells, compared with commercial Lipofectamine MessengerMax.
Language	English
Publishing date	2022-12-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics15010008
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Article: Primary cilia and the cell cycle.

Plotnikova, Olga V / Pugacheva, Elena N / Golemis, Erica A

Methods in cell biology

2009 Volume 94, Page(s) 137–160

Abstract: Cilia are microtubule-based structures that protrude from the cell surface and function as sensors for mechanical and chemical environmental cues that regulate cellular differentiation or division. In metazoans, ciliary signaling is important during ... ...

Abstract	Cilia are microtubule-based structures that protrude from the cell surface and function as sensors for mechanical and chemical environmental cues that regulate cellular differentiation or division. In metazoans, ciliary signaling is important during organismal development and in the homeostasis controls of adult tissues, with receptors for the Hedgehog, platelet derived growth factor (PDGF), Wnt, and other signaling cascades arrayed and active along the ciliary membrane. In normal cells, cilia are dynamically regulated during cell cycle progression: present in G0 and G1 cells, and usually in S/G2 cells, but almost invariably resorbed before mitotic entry, to reappear post-cytokinesis. This periodic resorption and reassembly of cilia, specified by the intrinsic cell cycle the intrinsic cell cycle machinery, influences the susceptibility of cells to the influence of extrinsic signals with cilia-associated receptors. Pathogenic conditions of mammals associated with loss of or defects in ciliary integrity include a number of developmental disorders, cystic syndromes in adults, and some cancers. With the continuing expansion of the list of human diseases associated with ciliary abnormalities, the identification of the cellular mechanisms regulating ciliary growth and disassembly has become a topic of intense research interest. Although these mechanisms are far from being understood, a number of recent studies have begun to identify key regulatory factors that may begin to offer insight into disease pathogenesis and treatment. In this chapter we will discuss the current state of knowledge regarding cell cycle control of ciliary dynamics, and provide general methods that can be applied to investigate cell cycle-dependent ciliary growth and disassembly.
MeSH term(s)	Animals ; Cell Cycle/physiology ; Cell Cycle Proteins/metabolism ; Cell Fractionation/methods ; Cells, Cultured ; Cilia/metabolism ; Cilia/ultrastructure ; Glycogen Synthase Kinase 3/metabolism ; Humans ; Signal Transduction/physiology ; Von Hippel-Lindau Tumor Suppressor Protein/metabolism
Chemical Substances	Cell Cycle Proteins ; Von Hippel-Lindau Tumor Suppressor Protein (EC 2.3.2.27) ; Glycogen Synthase Kinase 3 (EC 2.7.11.26)
Language	English
Publishing date	2009-12-23
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	0091-679X
ISSN	0091-679X
DOI	10.1016/S0091-679X(08)94007-3
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