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  1. Book ; Thesis: Die Reaktivierung des Zellzyklus sensibilisiert Podozyten für Folgeschäden

    Hagen, Manuel

    2018  

    Author's details vorgelegt von Manuel Johannes Hagen
    Language German ; English
    Size 33 Seiten, Illustrationen, Diagramme, 21 cm
    Publishing place Erlangen ; Nürnberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Friedrich-Alexander-Universität Erlangen-Nürnberg, 2018
    Note Enthält 1 Sonderabdruck aus Zeitschrift in englischer Sprache
    HBZ-ID HT019789390
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2018 D 836 order for loan Magazin

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  2. Article: A Retrospective Analysis of Temporal Lobe Gliosis after Middle Fossa Resection of Small Vestibular Schwannomas.

    Scheich, Matthias / Bürklein, Miriam / Stöth, Manuel / Bison, Brigitte / Hagen, Rudolf / Hackenberg, Stephan / Vogt, Marius L

    Brain sciences

    2024  Volume 14, Issue 3

    Abstract: Introduction: The middle cranial fossa (MCF) approach is a well-established procedure in surgery of the internal auditory canal, as well as with the retrosigmoid and translabyrinthine approaches. It is commonly used in the hearing-preserving ... ...

    Abstract Introduction: The middle cranial fossa (MCF) approach is a well-established procedure in surgery of the internal auditory canal, as well as with the retrosigmoid and translabyrinthine approaches. It is commonly used in the hearing-preserving microsurgery of small vestibular schwannomas (VS). The debate about the "best" approach for the microsurgery of small VS without contact to the brainstem is controversial. It has been stated that the MCF approach leads to irreversible damage to the temporal lobe, which may be evident in follow-up magnet resonance imaging (MRI) as gliosis in up to 70% of patients.
    Materials and methods: This study represents a retrospective chart analysis conducted at a tertiary university hospital. Here, 76 postoperative MRIs were re-evaluated by an experienced neuroradiologist and compared with the preoperative images. Temporal lobe gliosis was classified on an ordinal scale as absent, slight, moderate or severe. Occurrence of gliosis was matched to the clinical predictors (tumor stage, tumor volume, sex, age, and side).
    Results: No case of severe or moderate gliosis was found in the patient group. Slight gliosis of the temporal lobe was rare and was only detected in four patients (5%). There was no relation between clinical predictors and the incidence of gliosis.
    Conclusions: In our cohort, postoperative MR imaging did not reveal relevant damage to the temporal lobe parenchyma. This confirms the safe concept of microsurgery of small tumors via the middle fossa approach. The severe glioses described in other studies may be caused by a forced insertion of the retractor or by more extended approaches. However, further prospective neurocognitive studies seem to be necessary in order to assess functional changes in the temporal lobe.
    Language English
    Publishing date 2024-03-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci14030295
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Discontinuation of anti‑programmed cell death protein 1 immune checkpoint inhibition after complete remission in head and neck squamous cell carcinoma: A case report and literature review.

    Stöth, Manuel / Meyer, Till / Gehrke, Thomas / Hagen, Rudolf / Scheich, Matthias / Hackenberg, Stephan / Scherzad, Agmal

    Oncology letters

    2023  Volume 26, Issue 5, Page(s) 489

    Abstract: Programmed cell death protein 1 (PD-1) inhibition plays a central role in the current treatment of recurrent or metastatic head and neck squamous cell carcinoma (R/M-HNSCC). Some patients achieve a durable response, and even complete remission (CR) is ... ...

    Abstract Programmed cell death protein 1 (PD-1) inhibition plays a central role in the current treatment of recurrent or metastatic head and neck squamous cell carcinoma (R/M-HNSCC). Some patients achieve a durable response, and even complete remission (CR) is possible, though it occurs rarely. In cases of durable CR, there are no guidelines regarding a possible discontinuation of immunotherapy. Since clinical experience on this issue is limited, the present study reported on a case of a durable CR following discontinuation of PD-1 inhibition in R/M-HNSCC and additionally presented an overview on the current literature. The present study reported on a case of CR of recurrent oropharyngeal cancer after four cycles of PD-1 monotherapy with Nivolumab. The therapy was discontinued after overall 46 cycles. Even after 3 more years of follow-up, there was no sign of tumor recurrence. Overall, according to reports from the literature, CR seems to be an indicator for durable disease control after therapy discontinuation. Since data on therapy termination is rare, decisions about when to stop successful immunotherapy in R/M-HNSCC have to be made individually for each patient.
    Language English
    Publishing date 2023-09-27
    Publishing country Greece
    Document type Case Reports
    ZDB-ID 2573196-8
    ISSN 1792-1082 ; 1792-1074
    ISSN (online) 1792-1082
    ISSN 1792-1074
    DOI 10.3892/ol.2023.14076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Conference proceedings: Die Versorgung von tracheopharyngealen und tracheoösophagealen Fisteln nach Laryngektomie mit individuellen Pharynxprothesen

    Meyer, Till / Stöth, Manuel / Kaulitz, Stefan / Gehrke, Thomas / Hagen, Rudolf / Hackenberg, Stephan / Scherzad, Agmal

    Laryngo-Rhino-Otologie

    2023  Volume 102, Issue S 02

    Event/congress 94. Jahresversammlung Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn, Congress Center Leipzig, 2023-05-17
    Language German
    Publishing date 2023-05-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/s-0043-1766431
    Database Thieme publisher's database

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  5. Article ; Conference proceedings: The treatment of tracheopharyngeal and tracheoesophageal fistulas after laryngectomy by individual pharyngeal prostheses

    Meyer, Till / Stöth, Manuel / Kaulitz, Stefan / Gehrke, Thomas / Hagen, Rudolf / Hackenberg, Stephan / Scherzad, Agmal

    Laryngo-Rhino-Otologie

    2023  Volume 102, Issue S 02

    Event/congress 94th Annual Meeting German Society of Oto-Rhino-Laryngology, Head and Neck Surgery e.V., Bonn, Congress Center Leipzig, 2023-05-17
    Language English
    Publishing date 2023-05-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/s-0043-1767018
    Database Thieme publisher's database

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  6. Article ; Conference proceedings: Etablierung eines 3D-Modells aus primären Tumor-assoziierten Fibroblasten und Kopf-Hals-Plattenepithelkarzinom-Zellen

    Stöth, Manuel / Meyer, Till / Hagen, Rudolf / Hackenberg, Stephan / Scherzad, Agmal

    Laryngo-Rhino-Otologie

    (Abstract- und Posterband)

    2022  Volume 101, Issue S 02

    Event/congress Abstract- und Posterband - 93. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn Interface - Fokus Mensch im Zeitalter der technisierten Medizin, Deutsche Messe Hannover, 2022-05-25
    Series title Abstract- und Posterband
    Language German
    Publishing date 2022-05-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/s-0042-1747239
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  7. Article ; Conference proceedings: Establishment of a 3D model of primary tumor-associated fibroblasts and head and neck squamous cell carcinoma cells

    Stöth, Manuel / Meyer, Till / Hagen, Rudolf / Hackenberg, Stephan / Scherzad, Agmal

    Laryngo-Rhino-Otologie

    (Abstract- und Posterband)

    2022  Volume 101, Issue S 02

    Event/congress Abstract- und Posterband - 93. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn Interface - Fokus Mensch im Zeitalter der technisierten Medizin, Deutsche Messe Hannover, 2022-05-25
    Series title Abstract- und Posterband
    Language English
    Publishing date 2022-05-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/s-0042-1746605
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  8. Article ; Online: [

    Zhi, Yingjun / Higuchi, Takahiro / Hackenberg, Stephan / Hagen, Rudolf / Stöth, Manuel / Scherzad, Agmal / Buck, Andreas K / Werner, Rudolf A / Serfling, Sebastian E

    Endocrine

    2023  

    Abstract: Background: In patients with iodine-negative thyroid cancer (TC), current guidelines endorse an [: Methods: 42 consecutive patients with negative findings on [: Results: We observed no alterations of the treatment plan in 9/42 (21.4%) subjects ( ... ...

    Abstract Background: In patients with iodine-negative thyroid cancer (TC), current guidelines endorse an [
    Methods: 42 consecutive patients with negative findings on [
    Results: We observed no alterations of the treatment plan in 9/42 (21.4%) subjects (active surveillance in 9/9 [100%]). Oncological management was changed in the remaining 33/42 (78.6%; systemic treatment in 9/33 [27.3%] and non-systemic treatment in 24/33 [72.7%]). Among patients receiving non-systemic therapy, the following changes were noted: surgery in 20/24 (83.3%) and radiation therapy in 4/24 (16.7%). In the systemic group, tyrosine kinase inhibitor (TKI) was prescribed in 8/9 (88.9%), while radioiodine therapy based on a TKI-mediated redifferentiation approach was conducted in 1/9 (11.1%). In 26 subjects with available follow-up, rate of CD was 22/26 (84.6%) and among those, 15/22 (68.1%) had experienced previous management changes based on PET/CT findings.
    Conclusions: In subjects with iodine-negative TC, [
    Language English
    Publishing date 2023-12-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1194484-5
    ISSN 1559-0100 ; 1355-008X ; 0969-711X
    ISSN (online) 1559-0100
    ISSN 1355-008X ; 0969-711X
    DOI 10.1007/s12020-023-03645-8
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  9. Article: Ag- but Not ZnO-Nanoparticles Disturb the Airway Epithelial Barrier at Subtoxic Concentrations.

    Moratin, Helena / Thöle, Anna / Lang, Josephine / Ehret Kasemo, Totta / Stöth, Manuel / Hagen, Rudolf / Scherzad, Agmal / Hackenberg, Stephan

    Pharmaceutics

    2023  Volume 15, Issue 10

    Abstract: Inhalation is considered to be the most relevant source of human exposure to nanoparticles (NPs); however, only a few investigations have addressed the influence of exposing the respiratory mucosal barrier to subcytotoxic doses. In the nasal respiratory ... ...

    Abstract Inhalation is considered to be the most relevant source of human exposure to nanoparticles (NPs); however, only a few investigations have addressed the influence of exposing the respiratory mucosal barrier to subcytotoxic doses. In the nasal respiratory epithelium, cells of the mucosa represent one of the first contact points of the human organism with airborne NPs. Disruption of the epithelial barrier by harmful materials can lead to inflammation in addition to potential intrinsic toxicity of the particles. The aim of this study was to investigate whether subtoxic concentrations of zinc oxide (ZnO)- and silver (Ag)-NPs have an influence on upper airway barrier integrity. Nasal epithelial cells from 17 donors were cultured at the air-liquid interface and exposed to ZnO- and Ag-NPs. Barrier function, quantified by transepithelial electrical resistance (TEER), decreased after treatment with 10 µg/mL Ag-NPs, but FITC-dextran permeability remained stable and no change in mRNA levels of tight junction proteins and E-cadherin was detected by real-time quantitative PCR (RT-qPCR). The results indicate that subtoxic concentrations of Ag-NPs may already induce damage of the upper airway epithelial barrier in vitro. The lack of similar disruption by ZnO-NPs of similar size suggests a specific effect by Ag-NPs.
    Language English
    Publishing date 2023-10-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15102506
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Cerebral lipogranuloma: A penetrating traumatic brain injury.

    Hagen, Manuel / Coras, Roland / Engelhorn, Tobias / Schwab, Stefan / Seifert, Frank

    Neurology

    2020  Volume 95, Issue 22, Page(s) 1019–1020

    MeSH term(s) Brain Injuries, Traumatic/complications ; Granuloma, Foreign-Body/diagnostic imaging ; Granuloma, Foreign-Body/etiology ; Head Injuries, Penetrating/complications ; Humans ; Male ; Meningoencephalitis/diagnostic imaging ; Meningoencephalitis/etiology ; Middle Aged ; Seizures/etiology
    Language English
    Publishing date 2020-10-14
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000011071
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