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Article ; Online: Feasibility of Telehealth and Innovative Technologies to Limit Excessive Gestational Weight Gain.

Mattson, Rebecca / Barger, Mary K

2023 Volume 28, Issue 1, Page(s) 30–40

Abstract: ... between 12 and 27 weeks' gestation, with a prepregnancy body mass index of ≥30 kg/m: Methods ... than those who did not receive nutritional counseling (p = .523), there was no significant difference between ... the intervention group and historical control individuals (p = .716).: Conclusion: Incorporating telehealth ...

Abstract	Objective: To test the feasibility of using telehealth to deliver nutritional counseling by tracking gestational weight gain remotely using Bluetooth weight scales. Design: Quasi-experimental feasibility study. Setting: One-on-one nutritional counseling was conducted remotely via a telehealth platform using a registered dietitian. Participants: Twenty-nine pregnant individuals ages 18 years or older, between 12 and 27 weeks' gestation, with a prepregnancy body mass index of ≥30 kg/m Methods: This study tested the feasibility of using telehealth to deliver nutritional counseling for 30 minutes, once a week, for 6 weeks. Self-weighing was tracked through a preconfigured Bluetooth scale given to study participants that enabled weight data to be automatically uploaded each time the scale was used. Results: Among the 11 study participants receiving Bluetooth scales, adherence to self-weighing was high (81%). All five participants randomized to nutritional counseling found that telehealth visits with a registered dietitian were easy to use and helpful. Although participants who received nutritional counseling gained 2.5 lb less than those who did not receive nutritional counseling (p = .523), there was no significant difference between the intervention group and historical control individuals (p = .716). Conclusion: Incorporating telehealth for nutrition counseling and accurate remote weight data collection may be part of a comprehensive strategy to address gestational weight gain in high-risk pregnant populations. Further research with larger samples is needed.
MeSH term(s)	Female ; Humans ; Pregnancy ; Counseling ; Feasibility Studies ; Gestational Weight Gain ; Obesity ; Prenatal Care ; Telemedicine ; Weight Gain ; Adolescent ; Adult
Language	English
Publishing date	2023-11-18
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2275619-X
ISSN	1751-486X ; 1751-4851
ISSN (online)	1751-486X
ISSN	1751-4851
DOI	10.1016/j.nwh.2023.08.002
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Zs.A 4732: Show issues

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Article ; Online: NADPH and Mitochondrial Quality Control as Targets for a Circadian-Based Fasting and Exercise Therapy for the Treatment of Parkinson's Disease.

Curtis, William M / Seeds, William A / Mattson, Mark P / Bradshaw, Patrick C

Cells

2022 Volume 11, Issue 15

Abstract: Dysfunctional mitochondrial quality control (MQC) is implicated in the pathogenesis of Parkinson's disease (PD). The improper selection of mitochondria for mitophagy increases reactive oxygen species (ROS) levels and lowers ATP levels. The downstream ... ...

Abstract	Dysfunctional mitochondrial quality control (MQC) is implicated in the pathogenesis of Parkinson's disease (PD). The improper selection of mitochondria for mitophagy increases reactive oxygen species (ROS) levels and lowers ATP levels. The downstream effects include oxidative damage, failure to maintain proteostasis and ion gradients, and decreased NAD
MeSH term(s)	Exercise Therapy ; Fasting ; Humans ; Mitochondria/metabolism ; NAD/metabolism ; NADP/metabolism ; Parkinson Disease/metabolism ; Peroxynitrous Acid/metabolism ; Superoxides/metabolism
Chemical Substances	NAD (0U46U6E8UK) ; Superoxides (11062-77-4) ; Peroxynitrous Acid (14691-52-2) ; NADP (53-59-8)
Language	English
Publishing date	2022-08-04
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11152416
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Article ; Online: Common and divergent molecular mechanisms of fasting and ketogenic diets.

Paoli, Antonio / Tinsley, Grant M / Mattson, Mark P / De Vivo, Immaculata / Dhawan, Ravi / Moro, Tatiana

Trends in endocrinology and metabolism: TEM

2023 Volume 35, Issue 2, Page(s) 125–141

Abstract: Intermittent short-term fasting (ISTF) and ketogenic diets (KDs) exert overlapping but not identical effects on cell metabolism, function, and resilience. Whereas health benefits of KD are largely mediated by the ketone bodies (KBs), ISTF engages ... ...

Abstract	Intermittent short-term fasting (ISTF) and ketogenic diets (KDs) exert overlapping but not identical effects on cell metabolism, function, and resilience. Whereas health benefits of KD are largely mediated by the ketone bodies (KBs), ISTF engages additional adaptive physiological responses. KDs act mainly through inhibition of histone deacetylases (HDACs), reduction of oxidative stress, improvement of mitochondria efficiency, and control of inflammation. Mechanisms of action of ISTF include stimulation of autophagy, increased insulin and leptin sensitivity, activation of AMP-activated protein kinase (AMPK), inhibition of the mechanistic target of rapamycin (mTOR) pathway, bolstering mitochondrial resilience, and suppression of oxidative stress and inflammation. Frequent switching between ketogenic and nonketogenic states may optimize health by increasing stress resistance, while also enhancing cell plasticity and functionality.
MeSH term(s)	Humans ; Diet, Ketogenic ; Ketone Bodies/metabolism ; Fasting ; Oxidative Stress/physiology ; Inflammation
Chemical Substances	Ketone Bodies
Language	English
Publishing date	2023-10-28
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1042384-9
ISSN	1879-3061 ; 1043-2760
ISSN (online)	1879-3061
ISSN	1043-2760
DOI	10.1016/j.tem.2023.10.001
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Zs.A 2999: Show issues

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Article ; Online: Preclinical cardiac perforation reduction in leadless pacing: An update to the Micra leadless pacemaker delivery system.

Roberts, Paul R / Garweg, Christophe / Yue, Arthur M / Mattson, Alexander R / Raghupathy, Ramesh / Piccini, Jonathan P

Pacing and clinical electrophysiology : PACE

2023 Volume 46, Issue 9, Page(s) 1085–1091

Abstract: Background: Leadless pacemakers have been developed to avoid some of the complications that are associated transvenous pacemakers. Pericardial effusion is a rare complication of leadless pacemaker implantation, which may result from perforation of the ... ...

Abstract	Background: Leadless pacemakers have been developed to avoid some of the complications that are associated transvenous pacemakers. Pericardial effusion is a rare complication of leadless pacemaker implantation, which may result from perforation of the delivery catheter. In this study, we describe preclinical perforation performance of an updated Micra delivery catheter. Methods: To assess preclinical perforation performance of the updated delivery catheter, three analyses were performed. First, Finite Element Analysis (FEA) computational modeling was performed to estimate the target tissue stress during Micra delivery catheter tenting. Second, benchtop perforation forces of ovine tissue were recorded for the original and updated delivery catheters. Finally, a Monte-Carlo simulation combining human cadaveric Micra implant forces and human ventricular tissue perforation properties was performed to estimate clinical perforation performance. Results: FEA modeling demonstrated a 66% reduction in target tissue stress when using the updated Micra delivery catheter (6.2 vs. 2.2 psi, Original vs. Updated Micra delivery catheter). Updated Micra delivery catheters required 20% more force to perforate porcine ventricular tissues in benchtop testing (μ Conclusions: This study, using computer modelling and benchtop experimentation, has indicated that increased surface area and rounding of the updated Micra catheter tip significantly improves preclinical perforation performance. It will be important to evaluate the impact of these catheter design changes with robust registry data.
MeSH term(s)	Humans ; Animals ; Sheep ; Swine ; Treatment Outcome ; Equipment Design ; Pacemaker, Artificial ; Heart Ventricles ; Cadaver
Language	English
Publishing date	2023-07-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	424437-0
ISSN	1540-8159 ; 0147-8389
ISSN (online)	1540-8159
ISSN	0147-8389
DOI	10.1111/pace.14776
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Zs.A 1466: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Predictive factors for prolonged sick leave in breast cancer patients treated with adjuvant therapies: a retrospective registry study.

Leskelä, Riikka-Leena / Haavisto, Ira / Pennanen, Paula / Lahelma, Mari / Mattson, Johanna / Poikonen-Saksela, Paula

Acta oncologica (Stockholm, Sweden)

2023 Volume 62, Issue 10, Page(s) 1331–1337

Abstract: Background: Being able to work during and after breast cancer treatments is important for patients to have a sense of normalcy, financial security, and improved quality of life, and for society due to the economic burden of sick leave. Factors ... ...

Abstract	Background: Being able to work during and after breast cancer treatments is important for patients to have a sense of normalcy, financial security, and improved quality of life, and for society due to the economic burden of sick leave. Factors influencing the length of sick leave can be sociodemographic factors, workplace adaptations, recurrences, symptoms, and type of treatment. The aim of this study is to analyse factors associated with prolonged sick leave after adjuvant breast cancer treatments. Methods: The population of this registry study consists of 1333 early breast cancer patients diagnosed and treated in Helsinki University Hospital between 2016 and 2018. Data on patient demographics, disease characteristics, treatment, and healthcare resource utilization were obtained from Helsinki University Hospital and data on income level and sick leave were obtained from Kela sickness benefits registry. Prolonged sick leave was determined as the patient accumulating 30 or more reimbursed sick leave days during a 60-day follow-up period after the end of active oncological treatment. Univariate analysis and multivariate analysis were conducted. Results: A total of 26% of the patients in this study were on sick leave for 30 or more days after the active treatments ended. Study findings show that chemotherapy, triple-negative breast cancer, reconstructive surgery, amount of outpatient visits, and income are associated with prolonged sick leave. Independent predictors of prolonged sick leave were treatment line, number of outpatient contacts, reconstruction, and triple-negative breast cancer. Conclusions: Our study shows that prolonged sick leave affects a substantial number of working-age women with early breast cancer. Independent predictors for prolonged sick leave were all treatment-related. Targeted support for treatment-related side-effects already during the treatment period could lead to better recovery and earlier return to work.
MeSH term(s)	Humans ; Female ; Retrospective Studies ; Sick Leave ; Triple Negative Breast Neoplasms ; Quality of Life ; Registries
Language	English
Publishing date	2023-09-12
Publishing country	England
Document type	Journal Article
ZDB-ID	896449-x
ISSN	1651-226X ; 0349-652X ; 0284-186X ; 1100-1704
ISSN (online)	1651-226X
ISSN	0349-652X ; 0284-186X ; 1100-1704
DOI	10.1080/0284186X.2023.2254483
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Zs.A 6348: Show issues

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Article ; Online: Lars R Holsti (1926-2023), Big name in Finnish and Nordic oncology.

Mäntylä, Matti / Elomaa, Inkeri / Mattson, Johanna / Lindroos, Pia / Killander, Dick / Littbrand, Bo / Overgaard, Jens / Tenhunen, Mikko

Acta oncologica (Stockholm, Sweden)

2024 Volume 63, Page(s) 229

MeSH term(s)	Finland ; Medical Oncology/history ; History, 20th Century ; History, 21st Century ; Humans ; Scandinavian and Nordic Countries ; Neoplasms
Language	English
Publishing date	2024-04-29
Publishing country	Sweden
Document type	Historical Article ; Biography ; Journal Article ; Portrait
ZDB-ID	896449-x
ISSN	1651-226X ; 0349-652X ; 0284-186X ; 1100-1704
ISSN (online)	1651-226X
ISSN	0349-652X ; 0284-186X ; 1100-1704
DOI	10.2340/1651-226X.2024.40168
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Article ; Online: Contribution of Th17 cells to tissue injury in hypertension.

Basile, David P / Abais-Battad, Justine M / Mattson, David L

Current opinion in nephrology and hypertension

2021 Volume 30, Issue 2, Page(s) 151–158

Abstract: Purpose of review: Hypertension has been demonstrated to be a chief contributor to morbidity and mortality throughout the world. Although the cause of hypertension is multifactorial, emerging evidence, obtained in experimental studies, as well as ... ...

Abstract	Purpose of review: Hypertension has been demonstrated to be a chief contributor to morbidity and mortality throughout the world. Although the cause of hypertension is multifactorial, emerging evidence, obtained in experimental studies, as well as observational studies in humans, points to the role of inflammation and immunity. Many aspects of immune function have now been implicated in hypertension and end-organ injury; this review will focus upon the recently-described role of Th17 cells in this pathophysiological response. Recent findings: Studies in animal models and human genetic studies point to a role in the adaptive immune system as playing a contributory role in hypertension and renal tissue damage. Th17 cells, which produce the cytokine IL17, are strongly pro-inflammatory cells, which may contribute to tissue damage if expressed in chronic disease conditions. The activity of these cells may be enhanced by physiological factors associated with hypertension such as dietary salt or Ang II. This activity may culminate in the increased sodium retaining activity and exacerbation of inflammation and renal fibrosis via multiple cellular mechanisms. Summary: Th17 cells are a distinct component of the adaptive immune system that may strongly enhance pathways leading to increased sodium reabsorption, elevated vascular tone and end-organ damage. Moreover, this pathway may lend itself towards specific targeting for treatment of kidney disease and hypertension.
MeSH term(s)	Animals ; Humans ; Hypertension ; Kidney ; Kidney Diseases ; Sodium Chloride, Dietary ; Th17 Cells
Chemical Substances	Sodium Chloride, Dietary
Language	English
Publishing date	2021-01-04
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	1151092-4
ISSN	1473-6543 ; 1535-3842 ; 1062-4813 ; 1062-4821
ISSN (online)	1473-6543 ; 1535-3842
ISSN	1062-4813 ; 1062-4821
DOI	10.1097/MNH.0000000000000680
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Zs.A 3686: Show issues

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Article ; Online: Public Health Interventions and Overdose-Related Outcomes Among Persons With Opioid Use Disorder.

Nataraj, Nisha / Rikard, S Michaela / Zhang, Kun / Jiang, Xinyi / Guy, Gery P / Rice, Ketra / Mattson, Christine L / Gladden, R Matthew / Mustaquim, Desiree M / Illg, Zachary N / Seth, Puja / Noonan, Rita K / Losby, Jan L

JAMA network open

2024 Volume 7, Issue 4, Page(s) e244617

Abstract: Importance: Given the high number of opioid overdose deaths in the US and the complex epidemiology of opioid use disorder (OUD), systems models can serve as a tool to identify opportunities for public health interventions.: Objective: To estimate the ...

Abstract	Importance: Given the high number of opioid overdose deaths in the US and the complex epidemiology of opioid use disorder (OUD), systems models can serve as a tool to identify opportunities for public health interventions. Objective: To estimate the projected 3-year association between public health interventions and opioid overdose-related outcomes among persons with OUD. Design, setting, and participants: This decision analytical model used a simulation model of the estimated US population aged 12 years and older with OUD that was developed and analyzed between January 2019 and December 2023. The model was parameterized and calibrated using 2019 to 2020 data and used to estimate the relative change in outcomes associated with simulated public health interventions implemented between 2021 and 2023. Main outcomes and measures: Projected OUD and medications for OUD (MOUD) prevalence in 2023 and number of nonfatal and fatal opioid-involved overdoses among persons with OUD between 2021 and 2023. Results: In a baseline scenario assuming parameters calibrated using 2019 to 2020 data remained constant, the model projected more than 16 million persons with OUD not receiving MOUD treatment and nearly 1.7 million persons receiving MOUD treatment in 2023. Additionally, the model projected over 5 million nonfatal and over 145 000 fatal opioid-involved overdoses among persons with OUD between 2021 and 2023. When simulating combinations of interventions that involved reducing overdose rates by 50%, the model projected decreases of up to 35.2% in nonfatal and 36.6% in fatal opioid-involved overdoses among persons with OUD. Interventions specific to persons with OUD not currently receiving MOUD treatment demonstrated the greatest reduction in numbers of nonfatal and fatal overdoses. Combinations of interventions that increased MOUD initiation and decreased OUD recurrence were projected to reduce OUD prevalence by up to 23.4%, increase MOUD prevalence by up to 137.1%, and reduce nonfatal and fatal opioid-involved overdoses among persons with OUD by 6.7% and 3.5%, respectively. Conclusions and relevance: In this decision analytical model study of persons with OUD, findings suggested that expansion of evidence-based interventions that directly reduce the risk of overdose fatality among persons with OUD, such as through harm reduction efforts, could engender the highest reductions in fatal overdoses in the short-term. Interventions aimed at increasing MOUD initiation and retention of persons in treatment projected considerable improvement in MOUD and OUD prevalence but could require a longer time horizon for substantial reductions in opioid-involved overdoses.
MeSH term(s)	Humans ; Opiate Overdose/epidemiology ; Public Health ; Analgesics, Opioid/therapeutic use ; Drug Overdose/epidemiology ; Opioid-Related Disorders/epidemiology
Chemical Substances	Analgesics, Opioid
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2024.4617
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Article: Response of Common Ice Plant (Mesembryanthemum crystallinum L.) to Sodium Chloride Concentration in Hydroponic Nutrient Solution

Xia, Jiaqi / Mattson, Neil

HortScience. 2022 July, v. 57, no. 7

2022

Abstract: ... week, and given five NaCl treatments [0 M (control), 0.05 M, 0.10 M, 0.20 M, 0.40 M NaCl]. Sequential ... destructive harvests to determine plant growth occurred at day 7, 14, and 21 after NaCl treatment. The 0.05 M ... shoot FW by 193% compared with the control plants. The 0.10 M NaCl also had stimulating effect ...

Abstract	Common ice plant (Mesembryanthemum crystallinum L.) is a novel edible succulent plant with savory flavor. It has epidermal bladder cells (EBCs) that store water and sodium chloride (NaCl) located on the epidermis of the leaves and stems. Ice plant is an obligatory halophyte that requires NaCl for optimum growth. The objective of this study was to determine the impact of NaCl on growth of ice plant for hydroponic production as an edible leafy green and to quantify the ability of ice plant to take up NaCl from the environment. Four-week-old seedlings of ice plant were transplanted into hydroponic systems, established for 1 week, and given five NaCl treatments [0 M (control), 0.05 M, 0.10 M, 0.20 M, 0.40 M NaCl]. Sequential destructive harvests to determine plant growth occurred at day 7, 14, and 21 after NaCl treatment. The 0.05 M NaCl had the greatest stimulating effect on biomass, increasing total fresh weight (FW) by 173% and shoot FW by 193% compared with the control plants. The 0.10 M NaCl also had stimulating effect as compared with 0 M, but plants were not as large as those receiving 0.05 M NaCl. The 0.20 M NaCl had little effect on plant growth compared with the control. The 0.40 M NaCl had a strong stunting effect on plant growth. All plants treated with NaCl had less root weight than the control, and higher NaCl concentration resulted in greater reduction in root weight. However, for the 0.05 and 0.10 M treatment, the gain in shoot weight exceeded the loss in root weight. Plants gained or lost water in a faster rate than dry mass, which resulted in larger differences among treatments in FW than in dry weight (DW). Plants treated with higher NaCl concentrations developed fewer, smaller, and thicker leaves but contained more EBCs per unit leaf surface area. There was high Na and Cl accumulation in leaf tissues of all salt-treated plants (e.g., 180,507 mg·kg⁻¹ Na and 125,084 mg·kg⁻¹ Cl in the 0.05 M treatment vs. 13,558 mg·kg⁻¹ Na and 12,991 mg·kg⁻¹ Cl in the 0 M treatment). This indicated potential for bioremediation of saline soil or hydroponic water. Concentrations of macronutrients such as nitrogen (N), phosphorus (P), calcium (Ca), magnesium (Mg), and sulfur (S) were reduced when plants received increasing NaCl treatments. In general, this study showed that growth of ice plant benefited from 0.05 and 0.10 M NaCl additions to the hydroponic nutrient solution. Ice plant deserves further work on its ability to reduce Na and Cl from accumulating in recirculating hydroponic nutrient solution.
Keywords	Mesembryanthemum crystallinum ; biomass ; bioremediation ; bladder ; cacti and succulents ; calcium ; flavor ; green leafy vegetables ; halophytes ; hydroponics ; leaves ; magnesium ; nitrogen ; nutrient solutions ; phosphorus ; plant growth ; saline soils ; sodium chloride ; sulfur ; surface area
Language	English
Dates of publication	2022-07
Size	p. 750-756.
Publishing place	American Society for Horticultural Science
Document type	Article
ISSN	2327-9834
DOI	10.21273/HORTSCI16246-22
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Intermittent and periodic fasting, longevity and disease.

Longo, Valter D / Di Tano, Maira / Mattson, Mark P / Guidi, Novella

Nature aging

2021 Volume 1, Issue 1, Page(s) 47–59

Abstract: Intermittent and periodic fasting (IF and PF, respectively) are emerging as safe strategies to affect longevity and healthspan by acting on cellular aging and disease risk factors, while causing no or minor side effects. IF lasting from 12 to 48 hours ... ...

Abstract	Intermittent and periodic fasting (IF and PF, respectively) are emerging as safe strategies to affect longevity and healthspan by acting on cellular aging and disease risk factors, while causing no or minor side effects. IF lasting from 12 to 48 hours and repeated every 1 to 7 days and PF lasting 2 to 7 days and repeated once per month or less have the potential to prevent and treat disease, but their effect on cellular aging and the molecular mechanisms involved are only beginning to be unraveled. Here, we describe the different fasting methods and their effect on longevity in organisms ranging from yeast to humans, linking them to the major nutrient-sensing signaling pathways and focusing on the benefits of the fasting and the refeeding periods. We also discuss both the therapeutic potential and side effects of IF and PF with a focus on cancer, autoimmunity, neurodegeneration and metabolic and cardiovascular disease.
MeSH term(s)	Humans ; Longevity ; Caloric Restriction ; Fasting ; Cardiovascular Diseases ; Saccharomyces cerevisiae
Language	English
Publishing date	2021-01-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2662-8465
ISSN (online)	2662-8465
DOI	10.1038/s43587-020-00013-3
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