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  1. Article: The Coordinated Action of Calcineurin and Cathepsin D Protects Against α-Synuclein Toxicity.

    Aufschnaiter, Andreas / Habernig, Lukas / Kohler, Verena / Diessl, Jutta / Carmona-Gutierrez, Didac / Eisenberg, Tobias / Keller, Walter / Büttner, Sabrina

    Frontiers in molecular neuroscience

    2017  Volume 10, Page(s) 207

    Abstract: The degeneration of dopaminergic neurons during Parkinson's disease (PD) is intimately linked to malfunction of α-synuclein (αSyn), the main component of the proteinaceous intracellular inclusions characteristic for this pathology. The cytotoxicity of ... ...

    Abstract The degeneration of dopaminergic neurons during Parkinson's disease (PD) is intimately linked to malfunction of α-synuclein (αSyn), the main component of the proteinaceous intracellular inclusions characteristic for this pathology. The cytotoxicity of αSyn has been attributed to disturbances in several biological processes conserved from yeast to humans, including Ca
    Language English
    Publishing date 2017-06-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2017.00207
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The propeptide of yeast cathepsin D inhibits programmed necrosis.

    Carmona-Gutiérrez, D / Bauer, M A / Ring, J / Knauer, H / Eisenberg, T / Büttner, S / Ruckenstuhl, C / Reisenbichler, A / Magnes, C / Rechberger, G N / Birner-Gruenberger, R / Jungwirth, H / Fröhlich, K-U / Sinner, F / Kroemer, G / Madeo, F

    Cell death & disease

    2011  Volume 2, Page(s) e161

    Abstract: The lysosomal endoprotease cathepsin D (CatD) is an essential player in general protein turnover ...

    Abstract The lysosomal endoprotease cathepsin D (CatD) is an essential player in general protein turnover and specific peptide processing. CatD-deficiency is associated with neurodegenerative diseases, whereas elevated CatD levels correlate with tumor malignancy and cancer cell survival. Here, we show that the CatD ortholog of the budding yeast Saccharomyces cerevisiae (Pep4p) harbors a dual cytoprotective function, composed of an anti-apoptotic part, conferred by its proteolytic capacity, and an anti-necrotic part, which resides in the protein's proteolytically inactive propeptide. Thus, deletion of PEP4 resulted in both apoptotic and necrotic cell death during chronological aging. Conversely, prolonged overexpression of Pep4p extended chronological lifespan specifically through the protein's anti-necrotic function. This function, which triggered histone hypoacetylation, was dependent on polyamine biosynthesis and was exerted via enhanced intracellular levels of putrescine, spermidine and its precursor S-adenosyl-methionine. Altogether, these data discriminate two pro-survival functions of yeast CatD and provide first insight into the physiological regulation of programmed necrosis in yeast.
    MeSH term(s) Acetylation ; Apoptosis/genetics ; Aspartic Acid Endopeptidases/biosynthesis ; Aspartic Acid Endopeptidases/deficiency ; Aspartic Acid Endopeptidases/genetics ; Biogenic Polyamines/metabolism ; Cathepsin D/genetics ; Cathepsin D/metabolism ; Cell Survival ; Cellular Senescence ; Gene Deletion ; Gene Expression ; Histones/genetics ; Histones/metabolism ; Lysosomes/genetics ; Lysosomes/metabolism ; Necrosis/genetics ; Necrosis/metabolism ; Plasmids ; Protein Engineering/methods ; Protein Precursors/genetics ; Protein Precursors/metabolism ; Protein Structure, Tertiary/genetics ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/biosynthesis ; Saccharomyces cerevisiae Proteins/genetics ; Sequence Homology, Amino Acid ; Transfection
    Chemical Substances Biogenic Polyamines ; Histones ; Protein Precursors ; Saccharomyces cerevisiae Proteins ; PEP4 protein, S cerevisiae (EC 3.4.23.) ; Aspartic Acid Endopeptidases (EC 3.4.23.-) ; Cathepsin D (EC 3.4.23.5)
    Language English
    Publishing date 2011-05-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2541626-1
    ISSN 2041-4889 ; 2041-4889
    ISSN (online) 2041-4889
    ISSN 2041-4889
    DOI 10.1038/cddis.2011.43
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  3. Article ; Online: Spermidine supplementation in rare translation-associated disorders.

    Zimmermann, Andreas / Carmona-Gutierrez, Didac / Madeo, Frank

    Cell stress

    2021  Volume 5, Issue 3, Page(s) 29–32

    Abstract: The polyamine spermidine is essential for protein translation in eukaryotes, both as a substrate for the hypusination of the translation initiation factor eIF5A as well as general translational fidelity. Dwindling spermidine levels during aging have been ...

    Abstract The polyamine spermidine is essential for protein translation in eukaryotes, both as a substrate for the hypusination of the translation initiation factor eIF5A as well as general translational fidelity. Dwindling spermidine levels during aging have been implicated in reduced immune cell function through insufficient eIF5A hypusination, which can be restored by external supplementation. Recent findings characterize a group of novel Mendelian disorders linked to
    Language English
    Publishing date 2021-03-08
    Publishing country Austria
    Document type Journal Article ; Comment
    ISSN 2523-0204
    ISSN (online) 2523-0204
    DOI 10.15698/cst2021.03.243
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The ups and downs of caloric restriction and fasting: from molecular effects to clinical application.

    Hofer, Sebastian J / Carmona-Gutierrez, Didac / Mueller, Melanie I / Madeo, Frank

    EMBO molecular medicine

    2021  Volume 14, Issue 1, Page(s) e14418

    Abstract: Age-associated diseases are rising to pandemic proportions, exposing the need for efficient and low-cost methods to tackle these maladies at symptomatic, behavioral, metabolic, and physiological levels. While nutrition and health are closely intertwined, ...

    Abstract Age-associated diseases are rising to pandemic proportions, exposing the need for efficient and low-cost methods to tackle these maladies at symptomatic, behavioral, metabolic, and physiological levels. While nutrition and health are closely intertwined, our limited understanding of how diet precisely influences disease often precludes the medical use of specific dietary interventions. Caloric restriction (CR) has approached clinical application as a powerful, yet simple, dietary modulation that extends both life- and healthspan in model organisms and ameliorates various diseases. However, due to psychological and social-behavioral limitations, CR may be challenging to implement into real life. Thus, CR-mimicking interventions have been developed, including intermittent fasting, time-restricted eating, and macronutrient modulation. Nonetheless, possible side effects of CR and alternatives thereof must be carefully considered. We summarize key concepts and differences in these dietary interventions in humans, discuss their molecular effects, and shed light on advantages and disadvantages.
    MeSH term(s) Caloric Restriction ; Diet ; Fasting/physiology ; Humans
    Language English
    Publishing date 2021-11-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2467145-9
    ISSN 1757-4684 ; 1757-4676
    ISSN (online) 1757-4684
    ISSN 1757-4676
    DOI 10.15252/emmm.202114418
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: The rise of

    Egger, Nadine B / Kainz, Katharina / Schulze, Adina / Bauer, Maria A / Madeo, Frank / Carmona-Gutierrez, Didac

    Microbial cell (Graz, Austria)

    2022  Volume 9, Issue 8, Page(s) 141–144

    Abstract: ... Candida ... ...

    Abstract Candida auris
    Language English
    Publishing date 2022-08-01
    Publishing country Austria
    Document type Editorial
    ZDB-ID 2814756-X
    ISSN 2311-2638
    ISSN 2311-2638
    DOI 10.15698/mic2022.08.782
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  6. Article: Assessing chronological aging in Saccharomyces cerevisiae.

    Schulze, Adina / Zimmermann, Andreas / Kainz, Katharina / Egger, Nadine B / Bauer, Maria A / Madeo, Frank / Carmona-Gutierrez, Didac

    Methods in cell biology

    2023  Volume 181, Page(s) 87–108

    Abstract: Chronological age represents the time that passes between birth and a given date. To understand the complex network of factors contributing to chronological lifespan, a variety of model organisms have been implemented. One of the best studied organisms ... ...

    Abstract Chronological age represents the time that passes between birth and a given date. To understand the complex network of factors contributing to chronological lifespan, a variety of model organisms have been implemented. One of the best studied organisms is the yeast Saccharomyces cerevisiae, which has greatly contributed toward identifying conserved biological mechanisms that act on longevity. Here, we discuss high- und low-throughput protocols to monitor and characterize chronological lifespan and chronological aging-associated cell death in S. cerevisiae. Included are propidium iodide staining with the possibility to quantitatively assess aging-associated cell death via flow cytometry or qualitative assessments via microscopy, cell viability assessment through plating and cell counting and cell death characterization via propidium iodide/AnnexinV staining and subsequent flow cytometric analysis or microscopy. Importantly, all of these methods combined give a clear picture of the chronological lifespan under different conditions or genetic backgrounds and represent a starting point for pharmacological or genetic interventions.
    MeSH term(s) Saccharomyces cerevisiae/metabolism ; Propidium/metabolism ; Saccharomyces cerevisiae Proteins/metabolism
    Chemical Substances Propidium (36015-30-2) ; Saccharomyces cerevisiae Proteins
    Language English
    Publishing date 2023-07-12
    Publishing country United States
    Document type Journal Article
    ISSN 0091-679X
    ISSN 0091-679X
    DOI 10.1016/bs.mcb.2022.09.006
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  7. Article: Assessing autophagic flux in yeast.

    Kainz, Katharina / Pendl, Tobias / Madeo, Frank / Carmona-Gutierrez, Didac

    Methods in cell biology

    2020  Volume 164, Page(s) 73–94

    MeSH term(s) Autophagy ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae Proteins
    Chemical Substances Saccharomyces cerevisiae Proteins
    Language English
    Publishing date 2020-11-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 0091-679X
    ISSN 0091-679X
    DOI 10.1016/bs.mcb.2020.10.014
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  8. Article: Fungal infections in humans: the silent crisis.

    Kainz, Katharina / Bauer, Maria A / Madeo, Frank / Carmona-Gutierrez, Didac

    Microbial cell (Graz, Austria)

    2020  Volume 7, Issue 6, Page(s) 143–145

    Abstract: Annually, over 150 million severe cases of fungal infections occur worldwide, resulting in approximately 1.7 million deaths per year. Alarmingly, these numbers are continuously on the rise with a number of social and medical developments during the past ... ...

    Abstract Annually, over 150 million severe cases of fungal infections occur worldwide, resulting in approximately 1.7 million deaths per year. Alarmingly, these numbers are continuously on the rise with a number of social and medical developments during the past decades that have abetted the spread of fungal infections. Additionally, the long-term therapeutic application and prophylactic use of antifungal drugs in high-risk patients have promoted the emergence of (multi)drug-resistant fungi, including the extremely virulent strain
    Keywords covid19
    Language English
    Publishing date 2020-06-01
    Publishing country Austria
    Document type Editorial
    ZDB-ID 2814756-X
    ISSN 2311-2638
    ISSN 2311-2638
    DOI 10.15698/mic2020.06.718
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  9. Article: Murals meet microbes: at the crossroads of microbiology and cultural heritage.

    Bauer, Maria A / Kainz, Katharina / Ruckenstuhl, Christoph / Madeo, Frank / Carmona-Gutierrez, Didac

    Microbial cell (Graz, Austria)

    2021  Volume 8, Issue 12, Page(s) 276–279

    Abstract: Our cultural heritage consists of manifold cultural expressions and represents a defining feature of our societies that needs to be further inherited to future generations. Even though humankind always fought a daily struggle for survival, at the same ... ...

    Abstract Our cultural heritage consists of manifold cultural expressions and represents a defining feature of our societies that needs to be further inherited to future generations. Even though humankind always fought a daily struggle for survival, at the same time, it seemed to have a spiritual need that went far beyond mere materialistic satisfaction and nowadays manifests in sometimes very ancient, yet brilliant artistic works. This fundamental legacy is endangered by several instances, including biodeterioration. Indeed, microorganisms play a significant role in the decline of all forms of tangible cultural heritage, including movable, immovable and underwater cultural heritage. Microbial colonization, biofilm formation and damaging metabolite production eventually result in critical decay. Thus, efforts to mitigate the negative impact of damaging microorganisms have been pursued with diverse physical, chemical and biological approaches. Intriguingly, recent advances have unveiled that specific microorganisms and microbial-based technologies also have the potential for cultural heritage preservation and present unique advantages. This short piece provides a quick overview on the duality of microorganisms in the conservation and restoration of cultural heritage.
    Language English
    Publishing date 2021-12-06
    Publishing country Austria
    Document type Editorial
    ZDB-ID 2814756-X
    ISSN 2311-2638
    ISSN 2311-2638
    DOI 10.15698/mic2021.12.765
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: A hundred spotlights on microbiology: how microorganisms shape our lives.

    Carmona-Gutierrez, Didac / Kainz, Katharina / Zimmermann, Andreas / Hofer, Sebastian J / Bauer, Maria A / Ruckenstuhl, Christoph / Kroemer, Guido / Madeo, Frank

    Microbial cell (Graz, Austria)

    2022  Volume 9, Issue 4, Page(s) 72–79

    Abstract: Viral, bacterial, fungal and protozoal biology is of cardinal importance for the evolutionary history of life, ecology, biotechnology and infectious diseases. Various microbiological model systems have fundamentally contributed to the understanding of ... ...

    Abstract Viral, bacterial, fungal and protozoal biology is of cardinal importance for the evolutionary history of life, ecology, biotechnology and infectious diseases. Various microbiological model systems have fundamentally contributed to the understanding of molecular and cellular processes, including the cell cycle, cell death, mitochondrial biogenesis, vesicular fusion and autophagy, among many others. Microbial interactions within the environment have profound effects on many fields of biology, from ecological diversity to the highly complex and multifaceted impact of the microbiome on human health. Also, biotechnological innovation and corresponding industrial operations strongly depend on microbial engineering. With this wide range of impact in mind, the peer-reviewed and open access journal
    Language English
    Publishing date 2022-04-04
    Publishing country Austria
    Document type Editorial
    ZDB-ID 2814756-X
    ISSN 2311-2638
    ISSN 2311-2638
    DOI 10.15698/mic2022.04.773
    Database MEDical Literature Analysis and Retrieval System OnLINE

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