LIVIVO - Search results -

Search results

Result 1 - 10 of total 1348

Search options

Article ; Online: Impact of nitrogen fertilizer timing on nitrate loss and crop production in northwest Iowa [Erratum: Jan. 2023, 52(1), p. 224]

Waring, Emily Rose / Sawyer, John / Pederson, Carl / Helmers, Matt

Journal of Environmental Quality. 2022 July, v. 51, no. 4, p. 696-707

2022 , Page(s) 696–707

Abstract: In the U.S. Midwest, nitrate in subsurface tile drainage from corn (Zea mays L.)–soybean [Glycine max (L.) Merr.] systems is detrimental to water quality at local and national scales. The objective of this replicated plot study in northwest Iowa, ... ...

Abstract	In the U.S. Midwest, nitrate in subsurface tile drainage from corn (Zea mays L.)–soybean [Glycine max (L.) Merr.] systems is detrimental to water quality at local and national scales. The objective of this replicated plot study in northwest Iowa, performed in 2015–2020, was to investigate the influence of nitrogen (N) fertilizer timing on crop production and NO₃ load in subsurface (tile) drainage discharge. Four treatments applied to corn included fall anhydrous ammonia with a nitrification inhibitor (F), spring anhydrous ammonia (S), split‐banded urea at planting and mid‐vegetative growth (SS), and no N fertilizer (0N). Across crops and years, NO₃–N concentration in subsurface drainage discharge was the same at 11.7 mg L–¹ for F and S applied anhydrous ammonia (AA). The NO₃–N concentration was statistically lower with SS urea (10 mg L–¹) than F and S, and 0N was lower than SS at 8.3 mg L–¹. Average annual NO₃–N loads were not different between any treatments due to plot variability in drainage discharge. Corn responded to N application, with overall mean yield the same for F, S, and SS. There were no agronomic or water quality benefits for applying AA in spring compared with fall, where the F included a nitrification inhibitor and was applied to cold soils. Split‐applied urea had a small positive water quality impact but no crop yield enhancement. This study shows that there were improvements to NO₃–N concentration in subsurface drainage discharge, but more nutrient reduction practices are needed than fertilizer N management alone to reduce nitrate load to surface water systems.
Keywords	Glycine max ; Zea mays ; anhydrous ammonia ; cold ; corn ; crop yield ; nitrates ; nitrification inhibitors ; nitrogen ; nitrogen fertilizers ; spring ; subsurface drainage ; surface water ; tile drainage ; urea ; water quality ; Iowa
Language	English
Dates of publication	2022-07
Size	p. 696-707
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	120525-0
ISSN	1537-2537 ; 0047-2425
ISSN (online)	1537-2537
ISSN	0047-2425
DOI	10.1002/jeq2.20366
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 2687: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: (with research data) The role of hybridization during ecological divergence of southwestern white pine (Pinus strobiformis) and limber pine (P. flexilis).

Menon, Mitra / Bagley, Justin C / Friedline, Christopher J / Whipple, Amy V / Schoettle, Anna W / Leal-Sàenz, Alejandro / Wehenkel, Christian / Molina-Freaner, Francisco / Flores-Rentería, Lluvia / Gonzalez-Elizondo, M Socorro / Sniezko, Richard A / Cushman, Samuel A / Waring, Kristen M / Eckert, Andrew J

Molecular ecology

2018 Volume 27, Issue 5, Page(s) 1245–1260

Abstract: Interactions between extrinsic factors, such as disruptive selection and intrinsic factors, such as genetic incompatibilities among loci, often contribute to the maintenance of species boundaries. The relative roles of these factors in the establishment ... ...

Abstract	Interactions between extrinsic factors, such as disruptive selection and intrinsic factors, such as genetic incompatibilities among loci, often contribute to the maintenance of species boundaries. The relative roles of these factors in the establishment of reproductive isolation can be examined using species pairs characterized by gene flow throughout their divergence history. We investigated the process of speciation and the maintenance of species boundaries between Pinus strobiformis and Pinus flexilis. Utilizing ecological niche modelling, demographic modelling and genomic cline analyses, we illustrated a divergence history with continuous gene flow. Our results supported an abundance of advanced generation hybrids and a lack of loci exhibiting steep transition in allele frequency across the hybrid zone. Additionally, we found evidence for climate-associated variation in the hybrid index and niche divergence between parental species and the hybrid zone. These results are consistent with extrinsic factors, such as climate, being an important isolating mechanism. A build-up of intrinsic incompatibilities and of coadapted gene complexes is also apparent, although these appear to be in the earliest stages of development. This supports previous work in coniferous species demonstrating the importance of extrinsic factors in facilitating speciation. Overall, our findings lend support to the hypothesis that varying strength and direction of selection pressures across the long lifespans of conifers, in combination with their other life history traits, delays the evolution of strong intrinsic incompatibilities.
MeSH term(s)	Gene Flow ; Gene Frequency ; Hybridization, Genetic ; Models, Theoretical ; Pinus/genetics ; Pinus/physiology ; Reproductive Isolation ; Species Specificity
Language	English
Publishing date	2018-03-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1126687-9
ISSN	1365-294X ; 0962-1083
ISSN (online)	1365-294X
ISSN	0962-1083
DOI	10.1111/mec.14505
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Bonn / Germany

Z 2005/723: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Comparative Association Mapping Reveals Conservation of Major Gene Resistance to White Pine Blister Rust in Southwestern White Pine (Pinus strobiformis) and Limber Pine (P. flexilis)

Liu, Jun-Jun / Schoettle, Anna W. / Sniezko, Richard A. / Waring, Kristen M. / Williams, Holly / Zamany, Arezoo / Johnson, Jeremy S. / Kegley, Angelia

Phytopathology. 2022 May, v. 112, no. 5

2022

Abstract: ... resistance (MGR) present in two species, southwestern white pine (Pinus strobiformis) Cr3 and limber pine (P ... single nucleotide polymorphism (SNP) assays designed with Cr4-linked polymorphic genes. We found that ∼70% of P. flexilis SNPs ... were transferable to P. strobiformis. Furthermore, several Cr4-linked SNPs were significantly ...

Abstract	All native North American white pines are highly susceptible to white pine blister rust (WPBR) caused by Cronartium ribicola. Understanding genomic diversity and molecular mechanisms underlying genetic resistance to WPBR remains one of the great challenges in improvement of white pines. To compare major gene resistance (MGR) present in two species, southwestern white pine (Pinus strobiformis) Cr3 and limber pine (P. flexilis) Cr4, we performed association analyses of Cr3-controlled resistant traits using single nucleotide polymorphism (SNP) assays designed with Cr4-linked polymorphic genes. We found that ∼70% of P. flexilis SNPs were transferable to P. strobiformis. Furthermore, several Cr4-linked SNPs were significantly associated with the Cr3-controlled traits in P. strobiformis families. The most significantly associated SNP (M326511_1126R) almost colocalized with Cr4 on the Pinus consensus linkage group 8, suggesting that Cr3 and Cr4 might be the same R locus, or have localizations very close to each other in the syntenic region of the P. strobiformis and P. flexilis genomes. M326511_1126R was identified as a nonsynonymous SNP, causing amino acid change (Val₃₇₆Ile) in a putative pectin acetylesterase, with coding sequences identical between the two species. Moreover, top Cr3-associated SNPs were further developed as TaqMan genotyping assays, suggesting their usefulness as marker-assisted selection (MAS) tools to distinguish genotypes between quantitative resistance and MGR. This work demonstrates the successful transferability of SNP markers between two closely related white pine species in the hybrid zone, and the possibility for deployment of MAS tools to facilitate long-term WPBR management in P. strobiformis breeding and conservation.
Keywords	Cronartium ribicola ; Pinus flexilis ; Pinus strobiformis ; amino acids ; genetic resistance ; genetic variation ; genotyping ; hybrids ; linkage groups ; loci ; major genes ; marker-assisted selection ; pectins ; plant pathology ; single nucleotide polymorphism ; white pine blister rust
Language	English
Dates of publication	2022-05
Size	p. 1093-1102.
Publishing place	The American Phytopathological Society
Document type	Article
ZDB-ID	208889-7
ISSN	1943-7684 ; 0031-949X
ISSN (online)	1943-7684
ISSN	0031-949X
DOI	10.1094/PHYTO-09-21-0382-R
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 71/717: Show issues
Z 2505: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article: (with research data) The role of hybridization during ecological divergence of southwestern white pine (Pinus strobiformis) and limber pine (P. flexilis)

Menon, Mitra / Bagley, Justin C / Cushman, Samuel A / Eckert, Andrew J / Flores‐Rentería, Lluvia / Friedline, Christopher J / Gonzalez‐Elizondo, M. Socorro / Leal‐Sàenz, Alejandro / Molina‐Freaner, Francisco / Schoettle, Anna W / Sniezko, Richard A / Waring, Kristen M / Wehenkel, Christian / Whipple, Amy V

Molecular ecology. 2018 Mar., v. 27, no. 5

2018

Abstract	Interactions between extrinsic factors, such as disruptive selection and intrinsic factors, such as genetic incompatibilities among loci, often contribute to the maintenance of species boundaries. The relative roles of these factors in the establishment of reproductive isolation can be examined using species pairs characterized by gene flow throughout their divergence history. We investigated the process of speciation and the maintenance of species boundaries between Pinus strobiformis and Pinus flexilis. Utilizing ecological niche modelling, demographic modelling and genomic cline analyses, we illustrated a divergence history with continuous gene flow. Our results supported an abundance of advanced generation hybrids and a lack of loci exhibiting steep transition in allele frequency across the hybrid zone. Additionally, we found evidence for climate‐associated variation in the hybrid index and niche divergence between parental species and the hybrid zone. These results are consistent with extrinsic factors, such as climate, being an important isolating mechanism. A build‐up of intrinsic incompatibilities and of coadapted gene complexes is also apparent, although these appear to be in the earliest stages of development. This supports previous work in coniferous species demonstrating the importance of extrinsic factors in facilitating speciation. Overall, our findings lend support to the hypothesis that varying strength and direction of selection pressures across the long lifespans of conifers, in combination with their other life history traits, delays the evolution of strong intrinsic incompatibilities.
Keywords	climate ; conifers ; developmental stages ; gene flow ; gene frequency ; genes ; genomics ; hybridization ; hybrids ; intrinsic factors ; life history ; loci ; models ; niches ; Pinus flexilis ; Pinus strobiformis ; reproductive isolation
Language	English
Dates of publication	2018-03
Size	p. 1245-1260.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	1126687-9
ISSN	1365-294X ; 0962-1083
ISSN (online)	1365-294X
ISSN	0962-1083
DOI	10.1111/mec.14505
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 2005/723: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Roles of arginine and lysine residues in the translocation of a cell-penetrating peptide from (13)C, (31)P, and (19)F solid-state NMR.

Su, Yongchao / Doherty, Tim / Waring, Alan J / Ruchala, Piotr / Hong, Mei

Biochemistry

2009 Volume 48, Issue 21, Page(s) 4587–4595

Abstract: ... Low-temperature (13)C-(31)P distances between the peptide and the lipid phosphates indicate that both the Arg(10 ... guanidinium Czeta atom and the Lys(13) Cepsilon atom are close to the lipid (31)P (4.0-4.2 A), proving ...

Abstract	Cell-penetrating peptides (CPPs) are small cationic peptides that cross the cell membrane while carrying macromolecular cargoes. We use solid-state NMR to investigate the structure and lipid interaction of two cationic residues, Arg(10) and Lys(13), in the CPP penetratin. (13)C chemical shifts indicate that Arg(10) adopts a rigid beta-strand conformation in the liquid-crystalline state of anionic lipid membranes. This behavior contrasts with all other residues observed so far in this peptide, which adopt a dynamic beta-turn conformation with coil-like chemical shifts at physiological temperature. Low-temperature (13)C-(31)P distances between the peptide and the lipid phosphates indicate that both the Arg(10) guanidinium Czeta atom and the Lys(13) Cepsilon atom are close to the lipid (31)P (4.0-4.2 A), proving the existence of charge-charge interaction for both Arg(10) and Lys(13) in the gel-phase membrane. However, since lysine substitution in CPPs is known to weaken their translocation ability, we propose that the low temperature stabilizes interactions of both lysine and arginine with the phosphates, whereas at high temperatures, the lysine-phosphate interaction is much weaker than the arginine-phosphate interaction. This is supported by the unusually high rigidity of the Arg(10) side chain and its beta-strand conformation at high temperatures. The latter is proposed to be important for ion pair formation by allowing close approach of the lipid headgroups to guanidinium side chains. (19)F and (13)C spin diffusion experiments indicate that penetratin is oligomerized into beta-sheets in gel-phase membranes. These solid-state NMR data indicate that guanidinium-phosphate interactions exist in penetratin, and guanidinium groups play a stronger structural role than ammonium groups in the lipid-assisted translocation of CPPs across liquid-crystalline cell membranes.
MeSH term(s)	Amino Acid Sequence ; Arginine ; Carrier Proteins/chemistry ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Cell Membrane/metabolism ; Cell-Penetrating Peptides ; Hydrophobic and Hydrophilic Interactions ; Lipid Metabolism ; Lipids/chemistry ; Lysine ; Magnetic Resonance Spectroscopy ; Molecular Sequence Data ; Mutation ; Protein Multimerization ; Protein Structure, Quaternary ; Protein Transport ; Temperature
Chemical Substances	Carrier Proteins ; Cell-Penetrating Peptides ; Lipids ; Arginine (94ZLA3W45F) ; penetratin (A2AQZ20TEK) ; Lysine (K3Z4F929H6)
Language	English
Publishing date	2009-04-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1108-3
ISSN	1520-4995 ; 0006-2960
ISSN (online)	1520-4995
ISSN	0006-2960
DOI	10.1021/bi900080d
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 217: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Evolution and sustainability: gathering the strands for an Anthropocene synthesis.

Søgaard Jørgensen, Peter / Weinberger, Vanessa P / Waring, Timothy M

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

2023 Volume 379, Issue 1893, Page(s) 20220251

Abstract: How did human societies evolve to become a major force of global change? What dynamics can lead societies on a trajectory of global sustainability? The astonishing growth in human population, economic activity and environmental impact has brought these ... ...

Abstract	How did human societies evolve to become a major force of global change? What dynamics can lead societies on a trajectory of global sustainability? The astonishing growth in human population, economic activity and environmental impact has brought these questions to the fore. This theme issue pulls together a variety of traditions that seek to address these questions using different theories and methods. In this Introduction, we review and organize the major strands of work on how the Anthropocene evolved, how evolutionary dynamics are influencing sustainability efforts today, and what principles, strategies and capacities will be important to guide us towards global sustainability in the future. We present a set of synthetic insights and highlight frontiers for future research efforts which could contribute to a consolidated synthesis. This article is part of the theme issue 'Evolution and sustainability: gathering the strands for an Anthropocene synthesis'.
MeSH term(s)	Humans ; Environment ; Anthropogenic Effects
Language	English
Publishing date	2023-11-13
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	208382-6
ISSN	1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
ISSN (online)	1471-2970
ISSN	0080-4622 ; 0264-3839 ; 0962-8436
DOI	10.1098/rstb.2022.0251
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Einzelsignatur: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Cytochrome P450: genotype to phenotype.

Waring, Rosemary H

Xenobiotica; the fate of foreign compounds in biological systems

2019 Volume 50, Issue 1, Page(s) 9–18

Abstract: The cytochromes P450 comprise a family of enzymes that are responsible for around three-quarters of all drug metabolism reactions that occur in human populations. Many isoforms of cytochrome P450 exist but most reactions are undertaken by CYP2C9, CYP2C19, ...

Abstract	The cytochromes P450 comprise a family of enzymes that are responsible for around three-quarters of all drug metabolism reactions that occur in human populations. Many isoforms of cytochrome P450 exist but most reactions are undertaken by CYP2C9, CYP2C19, CYP2D6 and CYP3A4. This brief review focusses on the first three isozymes which exhibit polymorphism of phenotype.If there is a wide variation in drug metabolising capacity within the population, this may precipitate clinical consequences and influence the drug treatment of patients. Such problems range from a lack of efficacy to unanticipated toxicity. In order to minimise untoward events and "personalise" a patient's treatment, efforts have been made to discover an individual's drug metabolism status. This requires knowledge of the subject's phenotype at the time of clinical treatment. Since such testing is difficult, time-consuming and costly, the simpler approach of genotyping has been advocated.However, the correlation between genotype and phenotype is not good, with values of up to 50% misprediction being reported. Genotype-assisted forecasts cannot therefore be used with confidence to replace actual phenotype measurements. Obfuscating factors discussed include gene splicing, single nucleotide polymorphisms, epigenetics and microRNA, transcription regulation and multiple gene copies.
MeSH term(s)	Cytochrome P-450 CYP2C19 ; Cytochrome P-450 CYP2C9 ; Cytochrome P-450 CYP2D6 ; Cytochrome P-450 CYP3A ; Cytochrome P-450 Enzyme System/metabolism ; Genotype ; Humans ; Inactivation, Metabolic ; Phenotype ; Polymorphism, Single Nucleotide
Chemical Substances	Cytochrome P-450 Enzyme System (9035-51-2) ; Cytochrome P-450 CYP2C9 (EC 1.14.13.-) ; CYP2C19 protein, human (EC 1.14.14.1) ; Cytochrome P-450 CYP2C19 (EC 1.14.14.1) ; Cytochrome P-450 CYP2D6 (EC 1.14.14.1) ; Cytochrome P-450 CYP3A (EC 1.14.14.1)
Language	English
Publishing date	2019-08-14
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	120287-x
ISSN	1366-5928 ; 0049-8254
ISSN (online)	1366-5928
ISSN	0049-8254
DOI	10.1080/00498254.2019.1648911
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 782: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Quantity of cigarettes smoked when co-used with alcohol and cannabis: Consideration of different definitions of co-use based on daily diary data.

Waring, Joseph J C / Nguyen, Nhung / Ling, Pamela M / Thrul, Johannes

Drug and alcohol dependence

2024 Volume 258, Page(s) 111264

Abstract: ... t=10.8, p<.001) and cannabis (b=0.822, SE=0.209, t=3.9, p<.001). There were no significant ...

Abstract	Introduction: Cigarettes are frequently co-used with alcohol and cannabis. However, definitions of co-use vary and the extent to which cigarette use changes on days with different patterns of co-use is unclear. We compared the number of cigarettes smoked on different days based on co-use patterns of cigarettes and alcohol or cannabis. Methods: This study analyzed 2408 smoking days collected in a 30-day smartphone-based daily diary study among 146 young adults (aged 18-26) with an oversample from sexual minority groups. Two separate multilevel models were estimated: one for cigarette and alcohol co-use and the other for cigarette and cannabis co-use. Both models examined day-level associations between the number of cigarettes smoked and 3 different types of days (smoking-only days, same-occasion co-use days, different-occasion co-use days), controlling for demographic characteristics. Results: More cigarettes were smoked on same-occasion co-use days compared to cigarette-smoking-only days for both alcohol (b=1.474, SE=0.136, t=10.8, p<.001) and cannabis (b=0.822, SE=0.209, t=3.9, p<.001). There were no significant differences in cigarettes smoked on days with co-use on the same day, but on different occasions, compared to days with smoking only. Conclusions: Compared to days with cigarette smoking only, more cigarettes are smoked on days when cigarettes are co-used with alcohol or cannabis on the same occasion, while the same is not true for days with co-use on different occasions. Conflating different definitions of co-use may impact findings on associations between co-use and smoking behavior.
Language	English
Publishing date	2024-03-12
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	519918-9
ISSN	1879-0046 ; 0376-8716
ISSN (online)	1879-0046
ISSN	0376-8716
DOI	10.1016/j.drugalcdep.2024.111264
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1310: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Hydroxylation of 1-bromopentane involving cytochrome P-450.

Grasse, F R / James, S P / Waring, R H

The Biochemical journal

1970 Volume 119, Issue 5, Page(s) 51P–52P

MeSH term(s)	Animals ; Bromine ; Cytochromes/metabolism ; Hydrocarbons, Halogenated/metabolism ; Hydrocarbons, Halogenated/urine ; Lactates/metabolism ; Microsomes, Liver/enzymology ; Propionates/metabolism ; Rats ; Sulfhydryl Compounds/metabolism
Chemical Substances	Cytochromes ; Hydrocarbons, Halogenated ; Lactates ; Propionates ; Sulfhydryl Compounds ; Bromine (SBV4XY874G)
Language	English
Publishing date	1970-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2969-5
ISSN	1470-8728 ; 0264-6021 ; 0006-2936 ; 0306-3275
ISSN (online)	1470-8728
ISSN	0264-6021 ; 0006-2936 ; 0306-3275
DOI	10.1042/bj1190051pb
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uc I Zs.110: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Associations between olfactory dysfunction and cognition: a scoping review.

Jacobson, Patricia T / Vilarello, Brandon J / Tervo, Jeremy P / Waring, Nicholas A / Gudis, David A / Goldberg, Terry E / Devanand, D P / Overdevest, Jonathan B

Journal of neurology

2024 Volume 271, Issue 3, Page(s) 1170–1203

Abstract: Introduction: Strong evidence suggests that olfactory dysfunction (OD) can predict additional neurocognitive decline in neurodegenerative conditions such as Alzheimer's and Parkinson's diseases. However, research exploring olfaction and cognition in ... ...

Abstract	Introduction: Strong evidence suggests that olfactory dysfunction (OD) can predict additional neurocognitive decline in neurodegenerative conditions such as Alzheimer's and Parkinson's diseases. However, research exploring olfaction and cognition in younger populations is limited. The aim of this review is to evaluate cognitive changes among non-elderly adults with non-COVID-19-related OD. Methods: We performed a structured comprehensive literature search of PubMed, Ovid Embase, Web of Science, and Cochrane Library in developing this scoping review. The primary outcome of interest was the association between OD and cognitive functioning in adults less than 60 years of age. Results: We identified 2878 studies for title and abstract review, with 167 undergoing full text review, and 54 selected for data extraction. Of these, 34 studies reported on populations of individuals restricted to the ages of 18-60, whereas the remaining 20 studies included a more heterogeneous population with the majority of individuals in this target age range in addition to some above the age of 60. The etiologies for smell loss among the included studies were neuropsychiatric disorders (37%), idiopathic cause (25%), type 2 diabetes (7%), trauma (5%), infection (4%), intellectual disability (4%), and other (18%). Some studies reported numerous associations and at times mixed, resulting in a total number of associations greater than the included number of 54 studies. Overall, 21/54 studies demonstrated a positive association between olfaction and cognition, 7/54 demonstrated no association, 25/54 reported mixed results, and only 1/54 demonstrated a negative association. Conclusion: Most studies demonstrate a positive correlation between OD and cognition, but the data are mixed with associations less robust in this young adult population compared to elderly adults. Despite the heterogeneity in study populations and outcomes, this scoping review serves as a starting point for further investigation on this topic. Notably, as many studies in this review involved disorders that may have confounding effects on both olfaction and cognition, future research should control for these confounders and incorporate non-elderly individuals with non-psychiatric causes of smell loss.
MeSH term(s)	Aged ; Humans ; Middle Aged ; Young Adult ; Anosmia/complications ; Cognition ; Diabetes Mellitus, Type 2/complications ; Olfaction Disorders/epidemiology ; Olfaction Disorders/etiology ; Smell ; Adult
Language	English
Publishing date	2024-01-13
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	187050-6
ISSN	1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
ISSN (online)	1432-1459
ISSN	0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
DOI	10.1007/s00415-023-12057-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui II Zs.40: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito