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  1. Article ; Online: An African loss-of-function CACNA1C variant p.T1787M associated with a risk of ventricular fibrillation.

    Blancard, Malorie / Debbiche, Amal / Kato, Koichi / Cardin, Christelle / Sabrina, Guichard / Gandjbakhch, Estelle / Probst, Vincent / Haissaguerre, Michel / Extramiana, Fabrice / Hocini, Mélèze / Olivier, Geoffroy / Leenhardt, Antoine / Guicheney, Pascale / Rougier, Jean-Sébastien

    Scientific reports

    2018  Volume 8, Issue 1, Page(s) 14619

    Abstract: Calcium regulation plays a central role in cardiac function. Several variants in the calcium channel ... ...

    Abstract Calcium regulation plays a central role in cardiac function. Several variants in the calcium channel Ca
    MeSH term(s) Adult ; African Continental Ancestry Group ; Arrhythmias, Cardiac/diagnosis ; Arrhythmias, Cardiac/ethnology ; Arrhythmias, Cardiac/genetics ; Arrhythmias, Cardiac/physiopathology ; Barium/metabolism ; Brugada Syndrome/diagnosis ; Brugada Syndrome/ethnology ; Brugada Syndrome/genetics ; Brugada Syndrome/physiopathology ; Calcium/metabolism ; Calcium Channels/genetics ; Calcium Channels/metabolism ; Calcium Channels, L-Type/genetics ; Calcium Channels, L-Type/metabolism ; Cations, Divalent ; Cohort Studies ; European Continental Ancestry Group ; Female ; Gene Expression ; Genetic Predisposition to Disease ; Heart Arrest/diagnosis ; Heart Arrest/ethnology ; Heart Arrest/genetics ; Heart Arrest/physiopathology ; Humans ; Ion Transport ; Male ; Middle Aged ; Mutation, Missense ; Patch-Clamp Techniques ; Pedigree ; Risk Factors ; Ventricular Fibrillation/diagnosis ; Ventricular Fibrillation/ethnology ; Ventricular Fibrillation/genetics ; Ventricular Fibrillation/physiopathology
    Chemical Substances CACNA1C protein, human ; CACNA2D1 protein, human ; CACNB2 protein, human ; Calcium Channels ; Calcium Channels, L-Type ; Cations, Divalent ; Barium (24GP945V5T) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2018-10-02
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-018-32867-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: GILOTTE Sophie et VOGUET Élise (dir), Terroirs d’al-Andalus et du Maghreb (viiie-xve siècle). Peuplements, ressources et sainteté. Éditions Bouchène, Paris, 2015, 251 p

    Pierre Guichard

    Revue des Mondes Musulmans et de la Méditerranée, Vol 144, p vol

    2018  Volume 144

    Keywords History of Africa ; DT1-3415 ; Social sciences (General) ; H1-99
    Language English
    Publishing date 2018-12-01T00:00:00Z
    Publisher Université de Provence
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: GILOTTE Sophie et VOGUET Élise (dir), Terroirs d’al-Andalus et du Maghreb (viiie-xve siècle). Peuplements, ressources et sainteté. Éditions Bouchène, Paris, 2015, 251 p

    Pierre Guichard

    Revue des Mondes Musulmans et de la Méditerranée, Vol 144, p vol

    2018  Volume 144

    Keywords History of Africa ; DT1-3415 ; Social sciences (General) ; H1-99
    Language English
    Publishing date 2018-12-01T00:00:00Z
    Publisher Université de Provence
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Almoubaker Mohamed et Pouillon François (dir.), Pratiquer les sciences sociales au Maghreb. Textes pour Driss Mansouri, avec un choix de ses articles, Fondation du Roi Abdul-Aziz Al-Saoud, Casablanca, 2014, 595 p. de texte en français et en anglais + 114 p. en arabe ; disponible en ligne sur le site du CJB (Rabat)

    Pierre Guichard

    Revue des Mondes Musulmans et de la Méditerranée, Vol 139, Pp 228-

    Maktabat al-Maghreb (http://books.openedition.org/cjb/)

    2016  Volume 229

    Keywords History of Africa ; DT1-3415 ; Social sciences (General) ; H1-99
    Language English
    Publishing date 2016-06-01T00:00:00Z
    Publisher Université de Provence
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Almoubaker Mohamed et Pouillon François (dir.), Pratiquer les sciences sociales au Maghreb. Textes pour Driss Mansouri, avec un choix de ses articles, Fondation du Roi Abdul-Aziz Al-Saoud, Casablanca, 2014, 595 p. de texte en français et en anglais + 114 p. en arabe ; disponible en ligne sur le site du CJB (Rabat)

    Pierre Guichard

    Revue des Mondes Musulmans et de la Méditerranée, Vol 139, Pp 228-

    Maktabat al-Maghreb (http://books.openedition.org/cjb/)

    2016  Volume 229

    Keywords History of Africa ; DT1-3415 ; Social sciences (General) ; H1-99
    Language English
    Publishing date 2016-06-01T00:00:00Z
    Publisher Université de Provence
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: An African loss-of-function CACNA1C variant p.T1787M associated with a risk of ventricular fibrillation

    Malorie Blancard / Amal Debbiche / Koichi Kato / Christelle Cardin / Guichard Sabrina / Estelle Gandjbakhch / Vincent Probst / Michel Haissaguerre / Fabrice Extramiana / Mélèze Hocini / Geoffroy Olivier / Antoine Leenhardt / Pascale Guicheney / Jean-Sébastien Rougier

    Scientific Reports, Vol 8, Iss 1, Pp 1-

    2018  Volume 13

    Abstract: Abstract Calcium regulation plays a central role in cardiac function. Several variants in the calcium channel Cav1.2 have been implicated in arrhythmic syndromes. We screened patients with Brugada syndrome, short QT syndrome, early repolarisation ... ...

    Abstract Abstract Calcium regulation plays a central role in cardiac function. Several variants in the calcium channel Cav1.2 have been implicated in arrhythmic syndromes. We screened patients with Brugada syndrome, short QT syndrome, early repolarisation syndrome, and idiopathic ventricular fibrillation to determine the frequency and pathogenicity of Cav1.2 variants. Cav1.2 related genes, CACNA1C, CACNB2 and CACNA2D1, were screened in 65 probands. Missense variants were introduced in the Cav1.2 alpha subunit plasmid by mutagenesis to assess their pathogenicity using patch clamp approaches. Six missense variants were identified in CACNA1C in five individuals. Five of them, A1648T, A1689T, G1795R, R1973Q, C1992F, showed no major alterations of the channel function. The sixth C-terminal variant, Cavα1c-T1787M, present mostly in the African population, was identified in two patients with resuscitated cardiac arrest. The first patient originated from Cameroon and the second was an inhabitant of La Reunion Island with idiopathic ventricular fibrillation originating from Purkinje tissues. Patch-clamp analysis revealed that Cavα1c-T1787M reduces the calcium and barium currents by increasing the auto-inhibition mediated by the C-terminal part and increases the voltage-dependent inhibition. We identified a loss-of-function variant, Cavα1c-T1787M, present in 0.8% of the African population, as a new risk factor for ventricular arrhythmia.
    Keywords Medicine ; R ; Science ; Q
    Subject code 572 ; 610
    Language English
    Publishing date 2018-10-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Evaluation of the efficacy, in terms of pain and disability, of a functional restoration programme in patients with chronic low back pain according to the presence of Modic 1 discopathy.

    Jaume Guichard, Pauline / Guichard, Elie / Fouquet, Bernard

    Joint bone spine

    2023  Volume 90, Issue 5, Page(s) 105567

    Abstract: Objectives: Modic type 1 disc disease (MD1) appears to be related to severe Chronic Low Back Pain (CLBP). Functional Restoration Programmes (FRP) recommended in CLBP may not be suitable for patients with MD1. The main objective was to evaluate the ... ...

    Abstract Objectives: Modic type 1 disc disease (MD1) appears to be related to severe Chronic Low Back Pain (CLBP). Functional Restoration Programmes (FRP) recommended in CLBP may not be suitable for patients with MD1. The main objective was to evaluate the effectiveness of a FRP, on the perceived incapacity and the pain intensity, in patients with non-specific CLBP according to the presence of MD1.
    Methods: We performed a single-centre retrospective cohort study in which 271 patients were included. After one month in the FRP, this programme was considered "successful" if the pain visual analog scale had decreased by at least 20/100 millimetres and if the score of the French version of the Roland-Morris disability questionnaire had decreased by at least 4/24 points.
    Results: The 271 patients had an average age of 43.2 (8.0) years and 58.3% were women. Out of our entire population, 128 (47.2%) patients were considered successful, and 51 (18.8%) patients had MD1. In patients without MD1, there was 49.1% success while this rate was 39.2% in those with MD1, but this difference was not statistically significant.
    Conclusions: We found no significant difference in the combination of pain and perceived disability after one month of a FRP in patients with CLBP without MD1 compared to those with CLBP with MD1. It therefore seems legitimate to offer FRP-type rehabilitation in patients with non-specific CLBP with MD1.
    MeSH term(s) Humans ; Female ; Adult ; Male ; Low Back Pain/diagnosis ; Low Back Pain/therapy ; Retrospective Studies ; Disability Evaluation ; Physical Therapy Modalities ; Spinal Diseases ; Chronic Pain/diagnosis ; Chronic Pain/therapy
    Language English
    Publishing date 2023-03-22
    Publishing country France
    Document type Journal Article
    ZDB-ID 2020487-5
    ISSN 1778-7254 ; 1297-319X
    ISSN (online) 1778-7254
    ISSN 1297-319X
    DOI 10.1016/j.jbspin.2023.105567
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    Zs.A 4590: Show issues Location:
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  8. Article: Solid-State ³¹P NMR, a Relevant Method to Evaluate the Distribution of Phosphates in Semi-hard Cheeses

    Gobet, Mallory / Buchin, Solange / Rondeau-Mouro, Corinne / Mietton, Bernard / Guichard, Elisabeth / Moreau, Céline / Le Quéré, Jean-Luc

    Food analytical methods. 2013 Dec., v. 6, no. 6

    2013  

    Abstract: ... of various compositions were studied, and three fractions of phosphates (P) were distinguished according ... to their mobility: (1) mobile soluble P (ca. 10� % of total P), (2) mobile insoluble P (70� %) and (3) immobile ... insoluble P (20� %). In accordance with chemical composition and buffering capacities of the cheeses ...

    Abstract The potentiality of solid-state ³¹P nuclear magnetic resonance (NMR) to determine in a non-destructive way the different states of phosphates in cheeses was examined. Sixteen semi-hard cheeses of various compositions were studied, and three fractions of phosphates (P) were distinguished according to their mobility: (1) mobile soluble P (ca. 10� % of total P), (2) mobile insoluble P (70� %) and (3) immobile insoluble P (20� %). In accordance with chemical composition and buffering capacities of the cheeses, these fractions could represent respectively (1) soluble inorganic P, (2) inorganic colloidal calcium P and phosphorylated serine residues (Pser) involved in a loose structure and (3) Pser involved in a tight environment. This method was shown to be of sufficient accuracy to evidence the effect of ripening on the different P fractions. It was thus demonstrated that solid-state NMR is an appropriate method to observe the distribution of phosphates in cheese matrix and their evolution during cheese-making.
    Keywords calcium ; chemical composition ; nuclear magnetic resonance spectroscopy ; phosphates ; semisoft cheeses ; serine
    Language English
    Dates of publication 2013-12
    Size p. 1544-1550.
    Publishing place Springer-Verlag
    Document type Article
    ZDB-ID 2429656-9
    ISSN 1936-976X ; 1936-9751
    ISSN (online) 1936-976X
    ISSN 1936-9751
    DOI 10.1007/s12161-013-9571-2
    Database NAL-Catalogue (AGRICOLA)

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    Z 7787: Show issues

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  9. Article: The transmembrane domain enhances granular targeting of P-selectin.

    Fleming, J C / Berger, G / Guichard, J / Cramer, E M / Wagner, D D

    European journal of cell biology

    1998  Volume 75, Issue 4, Page(s) 331–343

    Abstract: P-selectin is an integral membrane glycoprotein that is stored in granules of endothelial cells and ... platelets. The cytoplasmic domain of P-selectin is known to contain at least part of the signal that directs ... the protein to storage granules. In order to more fully understand how P-selectin is targeted to the regulated ...

    Abstract P-selectin is an integral membrane glycoprotein that is stored in granules of endothelial cells and platelets. The cytoplasmic domain of P-selectin is known to contain at least part of the signal that directs the protein to storage granules. In order to more fully understand how P-selectin is targeted to the regulated secretory pathway, we have expressed chimeric constructs between P- and E-selectin, a protein which is expressed on the cell surface, in a rat insulinoma cell line. Immunofluorescence studies indicated that replacing the cytoplasmic domain of E-selectin with that of P-selectin resulted in low-level granular expression. In contrast, when both the transmembrane and cytoplasmic domains of E-selectin were replaced with the analogous domains of P-selectin, the granular localization appeared greatly increased. This was confirmed by immunoelectron microscopy which demonstrated a three- to fourfold improvement in granular targeting, i.e. similar to wild-type P-selectin. The transmembrane domain had to be in the context of the P-selectin cytoplasmic domain as this membrane-spanning region could not induce granular targeting on its own. These results describe a novel function for the transmembrane domain of P-selectin in enhancing the efficiency of granular targeting and further implicate protein transmembrane domains in intracellular trafficking.
    MeSH term(s) Animals ; Cell Membrane/metabolism ; Cell Membrane/physiology ; Cell Membrane/ultrastructure ; Cytoplasmic Granules/metabolism ; Cytoplasmic Granules/ultrastructure ; E-Selectin/biosynthesis ; E-Selectin/genetics ; E-Selectin/ultrastructure ; Fluorescent Antibody Technique ; Intracellular Fluid/metabolism ; Microscopy, Immunoelectron ; P-Selectin/genetics ; P-Selectin/physiology ; P-Selectin/ultrastructure ; Protein Structure, Tertiary ; Rats ; Recombinant Fusion Proteins/biosynthesis ; Recombinant Fusion Proteins/ultrastructure ; Transfection ; Tumor Cells, Cultured
    Chemical Substances E-Selectin ; P-Selectin ; Recombinant Fusion Proteins
    Language English
    Publishing date 1998-04
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 391967-5
    ISSN 1618-1298 ; 0171-9335 ; 0070-2463
    ISSN (online) 1618-1298
    ISSN 0171-9335 ; 0070-2463
    DOI 10.1016/s0171-9335(98)80066-6
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 667: Show issues Location:
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  10. Article ; Online: The molecular architecture of the ciliary transition zones.

    Mercey, Olivier / Mukherjee, Souradip / Guichard, Paul / Hamel, Virginie

    Current opinion in cell biology

    2024  Volume 88, Page(s) 102361

    Abstract: Cilia and flagella are specialized eukaryotic organelles projecting from the surface of eukaryotic cells that play a central role in various physiological processes, including cell motility, sensory perception, and signal transduction. At the base of ... ...

    Abstract Cilia and flagella are specialized eukaryotic organelles projecting from the surface of eukaryotic cells that play a central role in various physiological processes, including cell motility, sensory perception, and signal transduction. At the base of these structures lies the ciliary transition zone, a pivotal region that functions as a gatekeeper and communication hub for ciliary activities. Despite its crucial role, the intricacies of its architecture remain poorly understood, especially given the variations in its organization across different cell types and species. In this review, we explore the molecular architecture of the ciliary transition zone, with a particular focus on recent findings obtained using cryotomography and super-resolution imaging techniques.
    Language English
    Publishing date 2024-04-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1026381-0
    ISSN 1879-0410 ; 0955-0674
    ISSN (online) 1879-0410
    ISSN 0955-0674
    DOI 10.1016/j.ceb.2024.102361
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    In stock of ZB MED Cologne/Königswinter

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