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Article: Tumor targeted alpha particle therapy with an actinium-225 labelled antibody for carbonic anhydrase IX.

Morgan, Katherine A / Wichmann, Christian W / Osellame, Laura D / Cao, Zhipeng / Guo, Nancy / Scott, Andrew M / Donnelly, Paul S

Chemical science

2024 Volume 15, Issue 9, Page(s) 3372–3381

Abstract: Selective antibody targeted delivery of α particle emitting actinium-225 to tumors has significant therapeutic potential. This work highlights the design and synthesis of a new bifunctional macrocyclic diazacrown ether chelator, ... ...

Abstract	Selective antibody targeted delivery of α particle emitting actinium-225 to tumors has significant therapeutic potential. This work highlights the design and synthesis of a new bifunctional macrocyclic diazacrown ether chelator, H
Language	English
Publishing date	2024-01-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2559110-1
ISSN	2041-6539 ; 2041-6520
ISSN (online)	2041-6539
ISSN	2041-6520
DOI	10.1039/d3sc06365h
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Evaluating Cefoperazone-Induced Gut Metabolic Functional Changes in MR1-Deficient Mice.

Sun, Jinchun / Cao, Zhijun / Smith, Ashley D / Carlson, Paul E / Coryell, Michael / Chen, Huizhong / Beger, Richard D

Metabolites

2022 Volume 12, Issue 5

Abstract: Mucosal-associated invariant T cells are activated following the recognition of bacterial antigens presented by the major histocompatibility complex class I-related molecule (MR1). Previous metagenomics data showed that ... ...

Abstract	Mucosal-associated invariant T cells are activated following the recognition of bacterial antigens presented by the major histocompatibility complex class I-related molecule (MR1). Previous metagenomics data showed that MR1
Language	English
Publishing date	2022-04-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662251-8
ISSN	2218-1989
ISSN	2218-1989
DOI	10.3390/metabo12050380
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Article ; Online: Effect of Micro-Patterned Mucin on Quinolone and Rhamnolipid Profiles of Mucoid

Jia, Jin / Parmar, Dharmeshkumar / Ellis, Joanna F / Cao, Tianyuan / Cutri, Allison R / Shrout, Joshua D / Sweedler, Jonathan V / Bohn, Paul W

ACS infectious diseases

2022 Volume 9, Issue 1, Page(s) 150–161

Abstract: Pseudomonas ... ...

Abstract	Pseudomonas aeruginosa
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Pseudomonas aeruginosa ; Quinolones/pharmacology ; Mucins ; Biofilms ; Tobramycin/pharmacology ; Virulence Factors
Chemical Substances	Anti-Bacterial Agents ; rhamnolipid ; Quinolones ; Mucins ; Tobramycin (VZ8RRZ51VK) ; Virulence Factors
Language	English
Publishing date	2022-12-20
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	2373-8227
ISSN (online)	2373-8227
DOI	10.1021/acsinfecdis.2c00519
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Article ; Online: Spatiotemporal Distribution of Pseudomonas aeruginosa Alkyl Quinolones under Metabolic and Competitive Stress.

Cao, Tianyuan / Sweedler, Jonathan V / Bohn, Paul W / Shrout, Joshua D

mSphere

2020 Volume 5, Issue 4

Abstract: Pseudomonas ... ...

Abstract	Pseudomonas aeruginosa
MeSH term(s)	Escherichia coli/metabolism ; Microbial Interactions ; Principal Component Analysis ; Pseudomonas aeruginosa/metabolism ; Quinolones/metabolism ; Quorum Sensing/physiology ; Signal Transduction ; Spatio-Temporal Analysis ; Spectrum Analysis, Raman ; Stress, Physiological
Chemical Substances	Quinolones
Language	English
Publishing date	2020-07-22
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	2379-5042
ISSN (online)	2379-5042
DOI	10.1128/mSphere.00426-20
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Article ; Online: Abundant binary promoter switches in lineage-determining transcription factors indicate a digital component of cell fate determination.

Li, Hongchuan / Rahman, Md Ahasanur / Ruesch, Michael / Eisele, Caprice D / Anderson, Erik M / Wright, Paul W / Cao, Jennie / Ratnayake, Shashikala / Chen, Qingrong / Yan, Chunhua / Meerzaman, Daoud / Abraham, Roshini S / Freud, Aharon G / Anderson, Stephen K

Cell reports

2023 Volume 42, Issue 11, Page(s) 113454

Abstract: Previous studies of the murine Ly49 and human KIR gene clusters implicated competing sense and antisense promoters in the control of variegated gene expression. In the current study, an examination of transcription factor genes defines an abundance of ... ...

Abstract	Previous studies of the murine Ly49 and human KIR gene clusters implicated competing sense and antisense promoters in the control of variegated gene expression. In the current study, an examination of transcription factor genes defines an abundance of convergent and divergent sense/antisense promoter pairs, suggesting that competing promoters may control cell fate determination. Differentiation of CD34
MeSH term(s)	Mice ; Humans ; Animals ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Cell Differentiation/genetics ; Promoter Regions, Genetic/genetics ; GATA1 Transcription Factor/metabolism ; GATA2 Transcription Factor/genetics ; GATA2 Transcription Factor/metabolism
Chemical Substances	Transcription Factors ; GATA1 Transcription Factor ; GATA2 Transcription Factor
Language	English
Publishing date	2023-11-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2023.113454
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Article: Heterogeneities of the perceptual-motor style during locomotion at height.

Wang, Danping / Bargiotas, Ioannis / Cao, Jiuwen / Vayatis, Nicolas / Oudre, Laurent / Vidal, Pierre-Paul

Frontiers in human neuroscience

2024 Volume 17, Page(s) 1228195

Abstract: In a recent review, we summarized the characteristics of perceptual-motor style in humans. Style can vary from individual to individual, task to task and pathology to pathology, as sensorimotor transformations demonstrate considerable adaptability and ... ...

Abstract	In a recent review, we summarized the characteristics of perceptual-motor style in humans. Style can vary from individual to individual, task to task and pathology to pathology, as sensorimotor transformations demonstrate considerable adaptability and plasticity. Although the behavioral evidence for individual styles is substantial, much remains to be done to understand the neural and mechanical substrates of inter-individual differences in sensorimotor performance. In this study, we aimed to investigate the modulation of perceptual-motor style during locomotion at height in 16 persons with no history of fear of heights or acrophobia. We used an inexpensive virtual reality (VR) video game. In this VR game, Richie's Plank, the person progresses on a narrow plank placed between two buildings at the height of the 30th floor. Our first finding was that the static markers (head, trunk and limb configurations relative to the gravitational vertical) and some dynamic markers (jerk, root mean square, sample entropy and two-thirds power law at head, trunk and limb level) we had previously identified to define perceptual motor style during locomotion could account for fear modulation during VR play. Our second surprising result was the heterogeneity of this modulation in the 16 young, healthy individuals exposed to moving at a height. Finally, 56% of participants showed a persistent change in at least one variable of their skeletal configuration and 61% in one variable of their dynamic control during ground locomotion after exposure to height.
Language	English
Publishing date	2024-01-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2425477-0
ISSN	1662-5161
ISSN	1662-5161
DOI	10.3389/fnhum.2023.1228195
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Article ; Online: Parallel engineering of environmental bacteria and performance over years under jungle-simulated conditions.

Chemla, Yonatan / Dorfan, Yuval / Yannai, Adi / Meng, Dechuan / Cao, Paul / Glaven, Sarah / Gordon, D Benjamin / Elbaz, Johann / Voigt, Christopher A

PloS one

2022 Volume 17, Issue 12, Page(s) e0278471

Abstract: Engineered bacteria could perform many functions in the environment, for example, to remediate pollutants, deliver nutrients to crops or act as in-field biosensors. Model organisms can be unreliable in the field, but selecting an isolate from the ... ...

Abstract	Engineered bacteria could perform many functions in the environment, for example, to remediate pollutants, deliver nutrients to crops or act as in-field biosensors. Model organisms can be unreliable in the field, but selecting an isolate from the thousands that naturally live there and genetically manipulating them to carry the desired function is a slow and uninformed process. Here, we demonstrate the parallel engineering of isolates from environmental samples by using the broad-host-range XPORT conjugation system (Bacillus subtilis mini-ICEBs1) to transfer a genetic payload to many isolates in parallel. Bacillus and Lysinibacillus species were obtained from seven soil and water samples from different locations in Israel. XPORT successfully transferred a genetic function (reporter expression) into 25 of these isolates. They were then screened to identify the best-performing chassis based on the expression level, doubling time, functional stability in soil, and environmentally-relevant traits of its closest annotated reference species, such as the ability to sporulate and temperature tolerance. From this library, we selected Bacillus frigoritolerans A3E1, re-introduced it to soil, and measured function and genetic stability in a contained environment that replicates jungle conditions. After 21 months of storage, the engineered bacteria were viable, could perform their function, and did not accumulate disruptive mutations.
MeSH term(s)	Conjugation, Genetic ; Bacillus subtilis/genetics ; Bacillus subtilis/metabolism ; Soil ; Israel
Chemical Substances	Soil
Language	English
Publishing date	2022-12-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0278471
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Article: CTLA-4 tail fusion enhances CAR-T anti-tumor immunity.

Zhou, Xiaoyu / Cao, Hanbing / Fang, Shao-Yu / Chow, Ryan D / Tang, Kaiyuan / Majety, Medha / Bai, Meizhu / Dong, Matthew B / Renauer, Paul A / Shang, Xingbo / Suzuki, Kazushi / Levchenko, Andre / Chen, Sidi

bioRxiv : the preprint server for biology

2023

Abstract: Chimeric antigen receptor (CAR) T cells are powerful therapeutics; however, their efficacy is often hindered by critical hurdles. Here, utilizing the endocytic feature of the cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) cytoplasmic tail (CT), we ... ...

Abstract	Chimeric antigen receptor (CAR) T cells are powerful therapeutics; however, their efficacy is often hindered by critical hurdles. Here, utilizing the endocytic feature of the cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) cytoplasmic tail (CT), we reprogram CAR function and substantially enhance CAR-T efficacy
Language	English
Publishing date	2023-03-15
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.03.14.532655
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Article ; Online: Depth distributions of signaling molecules in Pseudomonas aeruginosa biofilms mapped by confocal Raman microscopy.

Cao, Tianyuan / Weaver, Abigail A / Baek, Seol / Jia, Jin / Shrout, Joshua D / Bohn, Paul W

The Journal of chemical physics

2021 Volume 154, Issue 20, Page(s) 204201

Abstract: Pseudomonas aeruginosa is an opportunistic human pathogen implicated in both acute and chronic diseases, which resists antibiotic treatment, in part by forming physical and chemical barriers such as biofilms. Here, we explore the use of confocal Raman ... ...

Abstract	Pseudomonas aeruginosa is an opportunistic human pathogen implicated in both acute and chronic diseases, which resists antibiotic treatment, in part by forming physical and chemical barriers such as biofilms. Here, we explore the use of confocal Raman imaging to characterize the three-dimensional (3D) spatial distribution of alkyl quinolones (AQs) in P. aeruginosa biofilms by reconstructing depth profiles from hyperspectral Raman data. AQs are important to quorum sensing (QS), virulence, and other actions of P. aeruginosa. Three-dimensional distributions of three different AQs (PQS, HQNO, and HHQ) were observed to have a significant depth, suggesting 3D anisotropic shapes-sheet-like rectangular solids for HQNO and extended cylinders for PQS. Similar to observations from 2D imaging studies, spectral features characteristic of AQs (HQNO or PQS) and the amide I vibration from peptide-containing species were found to correlate with the PQS cylinders typically located at the tips of the HQNO rectangular solids. In the QS-deficient mutant lasIrhlI, a small globular component was observed, whose highly localized nature and similarity in size to a P. aeruginosa cell suggest that the feature arises from HHQ localized in the vicinity of the cell from which it was secreted. The difference in the shapes and sizes of the aggregates of the three AQs in wild-type and mutant P. aeruginosa is likely related to the difference in the cellular response to growth conditions, environmental stress, metabolic levels, or other structural and biochemical variations inside biofilms. This study provides a new route to characterizing the 3D structure of biofilms and shows the potential of confocal Raman imaging to elucidate the nature of heterogeneous biofilms in all three spatial dimensions. These capabilities should be applicable as a tool in studies of infectious diseases.
MeSH term(s)	Biofilms/drug effects ; Biofilms/growth & development ; Microscopy, Confocal ; Pseudomonas aeruginosa/drug effects ; Quinolones/chemistry ; Quinolones/pharmacology ; Spectrum Analysis, Raman
Chemical Substances	Quinolones
Language	English
Publishing date	2021-07-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	3113-6
ISSN	1089-7690 ; 0021-9606
ISSN (online)	1089-7690
ISSN	0021-9606
DOI	10.1063/5.0052785
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Article ; Online: A statistical method for image-mediated association studies discovers genes and pathways associated with four brain disorders.

He, Jingni / Antonyan, Lilit / Zhu, Harold / Ardila, Karen / Li, Qing / Enoma, David / Zhang, William / Liu, Andy / Chekouo, Thierry / Cao, Bo / MacDonald, M Ethan / Arnold, Paul D / Long, Quan

American journal of human genetics

2023 Volume 111, Issue 1, Page(s) 48–69

Abstract: Brain imaging and genomics are critical tools enabling characterization of the genetic basis of brain disorders. However, imaging large cohorts is expensive and may be unavailable for legacy datasets used for genome-wide association studies (GWASs). ... ...

Abstract	Brain imaging and genomics are critical tools enabling characterization of the genetic basis of brain disorders. However, imaging large cohorts is expensive and may be unavailable for legacy datasets used for genome-wide association studies (GWASs). Using an integrated feature selection/aggregation model, we developed an image-mediated association study (IMAS), which utilizes borrowed imaging/genomics data to conduct association mapping in legacy GWAS cohorts. By leveraging the UK Biobank image-derived phenotypes (IDPs), the IMAS discovered genetic bases underlying four neuropsychiatric disorders and verified them by analyzing annotations, pathways, and expression quantitative trait loci (eQTLs). A cerebellar-mediated mechanism was identified to be common to the four disorders. Simulations show that, if the goal is identifying genetic risk, our IMAS is more powerful than a hypothetical protocol in which the imaging results were available in the GWAS dataset. This implies the feasibility of reanalyzing legacy GWAS datasets without conducting additional imaging, yielding cost savings for integrated analysis of genetics and imaging.
MeSH term(s)	Humans ; Genome-Wide Association Study/methods ; Genetic Predisposition to Disease ; Quantitative Trait Loci/genetics ; Phenotype ; Brain Diseases/genetics ; Polymorphism, Single Nucleotide/genetics
Language	English
Publishing date	2023-12-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	219384-x
ISSN	1537-6605 ; 0002-9297
ISSN (online)	1537-6605
ISSN	0002-9297
DOI	10.1016/j.ajhg.2023.11.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

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