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Article ; Online: In reaction to: Thuillier P, Benisvy D, Ansquer C, Corvilain B, Mirallie E, Taieb D, et al. Section 5: What is the role of functional imaging and isotopic treatment? Ann Endocrinol (Paris) 2022;83:401-6. https://doi.org/10.1016/j.ando.2022.10.008.

de Koster, Elizabeth J / de Geus-Oei, Lioe-Fee / Oyen, Wim J G / Vriens, Dennis

2022 Volume 84, Issue 2, Page(s) 325–326

Language	English
Publishing date	2022-12-21
Publishing country	France
Document type	Letter ; Comment
ZDB-ID	299-9
ISSN	2213-3941 ; 0003-4266
ISSN (online)	2213-3941
ISSN	0003-4266
DOI	10.1016/j.ando.2022.12.002
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Article ; Online: Imprints of wastewater discharge on trace element dynamics in the Grand River, Ontario.

Pinter, Jacob / Vriens, Bas

Environmental monitoring and assessment

2023 Volume 195, Issue 6, Page(s) 718

Abstract: Discharge of treated wastewater effluent can be an important source of contaminants to downstream environments, but only a handful of specific effluent parameters are regulated and monitored in Canada. Consequently, the importance of effluent discharge ... ...

Abstract	Discharge of treated wastewater effluent can be an important source of contaminants to downstream environments, but only a handful of specific effluent parameters are regulated and monitored in Canada. Consequently, the importance of effluent discharge for the surface water budgets of trace elements remains poorly understood. Here, we report concentrations of > 50 major and trace elements in > 30 riverine and effluent samples collected in the Grand River catchment, Ontario, in an attempt to assess imprints of effluent discharge on riverine trace element loads. We find that effluent-derived loads of major and trace elements generally outweigh those of tributaries when contrasted to their hydraulic contribution at the point of confluence. In particular, effluent-derived loads of conservative elements (> 30-fold the receiving riverine load), but also those of heavy metals and rare earth elements (> tenfold and twofold their receiving riverine loads, respectively) exerted important controls on trace element dynamics in the Grand River. Yet, multiple elemental tracers suggest that detectable imprints of these trace element inputs remain spatially restricted and limited to the catchment's upper reaches, urban areas, and confluences and effluent inputs with low mixing ratios. This study presents important baseline data for trace elements in this complex river system and highlights the need for expanded surface water quality monitoring to disentangle anthropogenic from natural factors affecting trace element budgets.
MeSH term(s)	Ontario ; Trace Elements ; Wastewater ; Environmental Monitoring ; Rivers
Chemical Substances	Trace Elements ; Wastewater
Language	English
Publishing date	2023-05-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	782621-7
ISSN	1573-2959 ; 0167-6369
ISSN (online)	1573-2959
ISSN	0167-6369
DOI	10.1007/s10661-023-11279-6
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Article ; Online: Neurodevelopmental disorders caused by variants in TRPM3.

Roelens, Robbe / Peigneur, Ana Nogueira Freitas / Voets, Thomas / Vriens, Joris

Biochimica et biophysica acta. Molecular cell research

2024 Volume 1871, Issue 5, Page(s) 119709

Abstract: Developmental and epileptic encephalopathies (DEE) are a broad and varied group of disorders that affect the brain and are characterized by epilepsy and comorbid intellectual disability (ID). These conditions have a broad spectrum of symptoms and can be ... ...

Abstract	Developmental and epileptic encephalopathies (DEE) are a broad and varied group of disorders that affect the brain and are characterized by epilepsy and comorbid intellectual disability (ID). These conditions have a broad spectrum of symptoms and can be caused by various underlying factors, including genetic mutations, infections, and other medical conditions. The exact cause of DEE remains largely unknown in the majority of cases. However, in around 25 % of patients, rare nonsynonymous coding variants in genes encoding ion channels, cell-surface receptors, and other neuronally expressed proteins are identified. This review focuses on a subgroup of DEE patients carrying variations in the gene encoding the Transient Receptor Potential Melastatin 3 (TRPM3) ion channel, where recent data indicate that gain-of-function of TRPM3 channel activity underlies a spectrum of dominant neurodevelopmental disorders.
Language	English
Publishing date	2024-03-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	60-7
ISSN	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbamcr.2024.119709
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Article ; Online: The Diagnostic Value of microRNA Expression Analysis in Detecting Intraductal Papillomas in Patients with Pathological Nipple Discharge.

Makineli, Seher / Vriens, Menno R / Witkamp, Arjen J / van Diest, Paul J / Moelans, Cathy B

International journal of molecular sciences

2024 Volume 25, Issue 3

Abstract: Patients with pathological nipple discharge (PND) often undergo local surgical procedures because standard radiologic imaging fails to identify the underlying cause. MicroRNA (MiRNA) expression analysis of nipple fluid holds potential for distinguishing ... ...

Abstract	Patients with pathological nipple discharge (PND) often undergo local surgical procedures because standard radiologic imaging fails to identify the underlying cause. MicroRNA (MiRNA) expression analysis of nipple fluid holds potential for distinguishing between breast diseases. This study aimed to compare miRNA expression levels between nipple fluids from patients with PND to identify possible relevant miRNAs that could differentiate between intraductal papillomas and no abnormalities in the breast tissue. Nipple fluid samples from patients with PND without radiological and pathological suspicion for malignancy who underwent a ductoscopy procedure were analyzed. We used univariate and multivariate regression analyses to identify nipple fluid miRNAs differing between pathologically confirmed papillomas and breast tissue without abnormalities. A total of 27 nipple fluid samples from patients with PND were included for miRNA expression analysis. Out of the 22 miRNAs examined, only miR-145-5p was significantly differentially expressed (upregulated) in nipple fluid from patients with an intraductal papilloma compared to patients showing no breast abnormalities (OR 4.76,
MeSH term(s)	Humans ; Female ; Papilloma, Intraductal/diagnosis ; Papilloma, Intraductal/genetics ; Papilloma, Intraductal/pathology ; Endoscopy/methods ; Nipple Discharge/metabolism ; Breast Neoplasms/diagnosis ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Breast Diseases/metabolism ; Nipples/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Papilloma/diagnosis ; Papilloma/genetics ; Papilloma/metabolism
Chemical Substances	MicroRNAs ; MIRN145 microRNA, human
Language	English
Publishing date	2024-02-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25031812
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Article ; Online: Identifying postoperative complications after inguinal hernia repair with a smartphone application: a comparative cohort study.

van Hout, L / Harker, M J R / Vriens, P W H E / Bökkerink, W J V

Hernia : the journal of hernias and abdominal wall surgery

2024

Abstract: Purpose: The Q1.6 Inguinal Hernia application continuously measures patient-reported outcomes (PROs) by sampling experiences through brief, digital and condition-specific questions, utilising micro-moments. This can overcome the limitations of current ... ...

Abstract	Purpose: The Q1.6 Inguinal Hernia application continuously measures patient-reported outcomes (PROs) by sampling experiences through brief, digital and condition-specific questions, utilising micro-moments. This can overcome the limitations of current paper questionnaires and give real-time insight into patient recovery. This exploratory study compares data from the application with retrospective data from electronic medical records (EMRs) to provide information on its accuracy in detecting postoperative complications after inguinal hernia repair. Methods: Patients were asked to use the application in addition to their usual care. The application employs twitch crowdsourcing to gather PROs. Questions from validated and frequently used questionnaires were integrated. A retrospective assessment of EMRs was combined with an additional telephone interview. The primary endpoints were the sensitivity and specificity of the application in detecting chronic postoperative inguinal pain, recurrence and surgical-site infection (SSI). Results: A total of 215 patients were analysed. The sensitivity and specificity for detecting chronic postoperative inguinal pain were 100% (95% CI [47.8%, 100%]) and 93.7% (95% CI [88.3%, 97.1%]), respectively. For recurrence, the sensitivity was 77.8% (95% CI [40.0%, 97.2%]), and the specificity was 81.3% (95% CI [75.0%, 86.5%]). For SSI, the sensitivity and specificity were 75.0% (95% CI [19.4%, 99.4%]) and 89.8% (95% CI [84.8%, 93.6%]), respectively. Conclusion: This study demonstrates satisfactory measurement capabilities of the Q1.6 Inguinal Hernia application for identifying postoperative complications following inguinal hernia repair. However, certain aspects require further improvement, such as addressing error-prone questions, enhancing long-term compliance, and validating (pain) measurements through prospective control data. Trail registration number: NL7813 (Dutch Trial Registry), 19 May 2019.
Language	English
Publishing date	2024-03-20
Publishing country	France
Document type	Journal Article
ZDB-ID	1388125-5
ISSN	1248-9204 ; 1265-4906
ISSN (online)	1248-9204
ISSN	1265-4906
DOI	10.1007/s10029-024-03019-7
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Article ; Online: Preoperative stratification of cytologically indeterminate thyroid nodules by [

Vriens, Dennis / de Koster, Elizabeth J / de Geus-Oei, Lioe-Fee / Oyen, Wim J G

European journal of nuclear medicine and molecular imaging

2023 Volume 50, Issue 4, Page(s) 975–979

MeSH term(s)	Humans ; Thyroid Nodule/diagnostic imaging ; Thyroid Nodule/surgery ; Fluorodeoxyglucose F18 ; Thyroid Neoplasms/diagnostic imaging ; Thyroid Neoplasms/surgery ; Radiopharmaceuticals
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Radiopharmaceuticals
Language	English
Publishing date	2023-01-20
Publishing country	Germany
Document type	Letter ; Comment
ZDB-ID	8236-3
ISSN	1619-7089 ; 0340-6997 ; 1619-7070
ISSN (online)	1619-7089
ISSN	0340-6997 ; 1619-7070
DOI	10.1007/s00259-022-06093-0
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Article: A Second Ductoscopy Procedure in Patients with Recurrent and Persistent Pathological Nipple Discharge.

Makineli, Seher / Filipe, Mando D / Vriens, Menno R / van Diest, Paul J / Witkamp, Arjen J

Breast care (Basel, Switzerland)

2023 Volume 18, Issue 4, Page(s) 256–261

Abstract: Background: Most patients suffering from pathological nipple discharge (PND) undergo local surgical procedures because standard radiological imaging often fails to reveal the cause. Ductoscopy is a minimally invasive endoscopic technique that enables ... ...

Abstract	Background: Most patients suffering from pathological nipple discharge (PND) undergo local surgical procedures because standard radiological imaging often fails to reveal the cause. Ductoscopy is a minimally invasive endoscopic technique that enables direct intraductal visualization and can avoid unnecessary diagnostic surgical procedures. Hence, patients with recurrent or persistent PND after an unsuccessful ductoscopy procedure still undergo unnecessary surgery. This study describes the experience of a second ductoscopy procedure in patients with recurrent or persistent PND without suspicious radiological findings. Methods: Patients with recurrent or persistent PND who underwent two ductoscopy procedures between 2010 and 2017 were retrospectively analyzed. The second ductoscopy was performed when the first ductoscopic attempt was unsuccessful due to technical problems. The primary outcome was the number of preventable surgical procedures. Results: A total of 17 patients underwent two ductoscopy procedures. The first ductoscopy showed a polypoid lesion in 10 patients (58.8%), no abnormalities in 3 patients (17.6%), and in 4 patients (23.5%), it was not possible to visualize the ductal tree. Post-procedure, all patients suffered from PND. After two ductoscopic attempts, PND stopped in 10 patients (58.8%), and 7 patients (41.2%) still suffered from PND and were operated on. Pathology of the resection specimens showed no abnormalities in 1 patient, a papilloma in 5 patients, and ductal carcinoma in situ in 1 patient. Conclusion: A second ductoscopy procedure can be considered in the diagnostic work-up of patients suffering from persistent or recurrent PND after an unsuccessful first ductoscopic attempt to avoid unnecessary surgery in about 59% of the cases.
Language	English
Publishing date	2023-04-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2202236-3
ISSN	1661-3805 ; 1661-3791
ISSN (online)	1661-3805
ISSN	1661-3791
DOI	10.1159/000530817
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Article ; Online: Clinical feasibility of the Q1.6 Inguinal Hernia application: a prospective cohort study.

van Hout, L / Bökkerink, W J V / Vriens, P W H E

Hernia : the journal of hernias and abdominal wall surgery

2022 Volume 27, Issue 2, Page(s) 449–458

Abstract: Purpose: Patient-reported outcomes (PROs) are essential to evaluate inguinal hernia surgery. There is a need for digital and disease-specific PRO measurement. Current measuring instruments (PROMs) have several disadvantages, for example, fixed measuring ...

Abstract	Purpose: Patient-reported outcomes (PROs) are essential to evaluate inguinal hernia surgery. There is a need for digital and disease-specific PRO measurement. Current measuring instruments (PROMs) have several disadvantages, for example, fixed measuring moments with a chance of recall bias. The Q1.6 Inguinal Hernia application has been developed to overcome these challenges. This pilot study reports the first clinical feasibility results. Methods: All surgically treated inguinal hernia patients were eligible for inclusion. The application uses "twitch crowdsourcing"; after unlocking a smartphone or tablet, a single short question is asked. This can easily be repeated multiple times a day/week/month. Questions from validated questionnaires were implemented. The adaptive question engine generates an individualised set of questions. Alerts are generated when a complication is suspected. Results: A total of 229 patients were given over 50.000 questions of which 92% were answered. Pre- and postoperative patient characteristics and their reported clinical outcomes confirmed a standard inguinal hernia population. Compliance with the application was 91.7% after 14 days, 69.0% after 3 months and 28.8% after one year. After months 3, 6 and 11, respectively, 3.0%, 4.4% and 4.5% of patients reported inguinal pain or discomfort (NRS ≥ 4). Patients were highly satisfied (92.8% preferred the app over standard care). Conclusions: This smartphone application shows promising results for clinical practice. It might allow for continuous digital patient-reported outcome measurement using non-intrusive, concise questions. Remote monitoring may become standard postoperative care after (inguinal hernia) surgery. The current application will be further improved and evaluated for cost-effectiveness, safety and validity.
MeSH term(s)	Humans ; Hernia, Inguinal/surgery ; Pilot Projects ; Prospective Studies ; Feasibility Studies ; Herniorrhaphy/methods ; Pain, Postoperative/etiology ; Surgical Mesh/adverse effects ; Treatment Outcome
Language	English
Publishing date	2022-07-16
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1388125-5
ISSN	1248-9204 ; 1265-4906
ISSN (online)	1248-9204
ISSN	1265-4906
DOI	10.1007/s10029-022-02646-2
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Article ; Online: Heat sensing involves a TRiPlet of ion channels.

Vriens, Joris / Voets, Thomas

British journal of pharmacology

2019 Volume 176, Issue 20, Page(s) 3893–3898

Abstract: Detecting and avoiding noxious heat is crucial to prevent burn injury. While the nociceptor neurons involved in conveying heat-induced pain were identified more than a century ago, the molecular sensors responsible for detecting noxious heat had remained ...

Abstract	Detecting and avoiding noxious heat is crucial to prevent burn injury. While the nociceptor neurons involved in conveying heat-induced pain were identified more than a century ago, the molecular sensors responsible for detecting noxious heat had remained elusive. In a recent study, important progress was made in our understanding of the molecular basis of acute noxious heat sensing, with the identification of a set of three transient receptor potential (TRP) ion channels, TRPV1, TRPA1, and TRPM3, which have crucial but largely redundant roles in acute heat sensing. Most strikingly, combined elimination of all three TRP channels causes a complete loss of the acute avoidance reaction to noxious heat, without affecting pain responses to painful mechanical or cold stimuli. Here, we provide a brief account of the current model of acute, noxious heat sensing and discuss possible implications for analgesic drug development.
MeSH term(s)	Analgesics/pharmacology ; Animals ; Hot Temperature ; Humans ; Models, Molecular ; Transient Receptor Potential Channels/antagonists & inhibitors ; Transient Receptor Potential Channels/metabolism
Chemical Substances	Analgesics ; Transient Receptor Potential Channels
Language	English
Publishing date	2019-09-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	80081-8
ISSN	1476-5381 ; 0007-1188
ISSN (online)	1476-5381
ISSN	0007-1188
DOI	10.1111/bph.14812
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Article ; Online: Loads and elimination of trace elements in wastewater in the Great Lakes basin.

Pinter, Jacob / Jones, Bailey S / Vriens, Bas

Water research

2021 Volume 209, Page(s) 117949

Abstract: The growing use of trace elements in industrialized societies is driving an increase in the occurrence of trace elements in anthropogenic waste streams globally. Yet, the large-scale sources of many trace elements to wastewater and their elimination ... ...

Abstract	The growing use of trace elements in industrialized societies is driving an increase in the occurrence of trace elements in anthropogenic waste streams globally. Yet, the large-scale sources of many trace elements to wastewater and their elimination during treatment remain poorly understood and potential environmental impacts on freshwater systems therefore unclear. We screened 42 wastewater treatment facilities in the North American Great Lakes basin and deployed a black-box approach to calculate representative estimates for average per-capita trace element loads and basin-scale effluent discharge rates, as well as trace element removal efficiencies across different treatment technologies. Our results show different removal of specific groups of trace elements during wastewater treatment: average removal efficiencies were 25% for alkali metals, 50% for alkaline earth metals, 74% for transition metals, and 85% for rare earth elements. Higher elimination of the majority of trace elements was generally achieved by more advanced, tertiary treatment types. Elemental loads generally followed natural abundance patterns, but anomalous loading rates were observed for various trace elements across the sampled facilities. By examining geospatial attributes of the sampled sewersheds, trends in select trace element loads were qualitatively tied to possible point sources and diffuse sources. Overall, these results illustrate the potential of wastewater surveillance to inform environmental management of emerging trace element contaminants.
Language	English
Publishing date	2021-12-07
Publishing country	England
Document type	Journal Article
ZDB-ID	202613-2
ISSN	1879-2448 ; 0043-1354
ISSN (online)	1879-2448
ISSN	0043-1354
DOI	10.1016/j.watres.2021.117949
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