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Article ; Online: Steroid use triggers severe psoriatic reaction.

Wong, Sterling R / Licata, Christine J / Signoff, Eric D

2024 Volume 91, Issue 3, Page(s) 147–149

MeSH term(s)	Humans ; Steroids/adverse effects ; Psoriasis/chemically induced
Chemical Substances	Steroids
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	639116-3
ISSN	1939-2869 ; 0891-1150
ISSN (online)	1939-2869
ISSN	0891-1150
DOI	10.3949/ccjm.91a.23060
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Article: Cutaneous hypersensitivity reaction with acute hepatitis following COVID-19 vaccine.

Wong, Christine Y / Rios, Eon J

JAAD case reports

2021 Volume 16, Page(s) 44–46

Language	English
Publishing date	2021-08-19
Publishing country	United States
Document type	Case Reports
ZDB-ID	2834220-3
ISSN	2352-5126
ISSN	2352-5126
DOI	10.1016/j.jdcr.2021.08.008
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Article ; Online: Better together: An assessor support roadmap.

Wong, Wai Yee Amy / Gormley, Gerard J / Haughey, Sharon / Chong, Sin Wang / Brown Wilson, Christine

The clinical teacher

2023 Volume 21, Issue 1, Page(s) e13640

Language	English
Publishing date	2023-08-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2151518-9
ISSN	1743-498X ; 1743-4971
ISSN (online)	1743-498X
ISSN	1743-4971
DOI	10.1111/tct.13640
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Zs.A 6678: Show issues

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Article ; Online: Beyond Information Design: Designing Health Care Dashboards for Evidence-Driven Decision-Making.

Hysong, Sylvia J / Yang, Christine / Wong, Janine / Knox, Melissa K / O'Mahen, Patrick / Petersen, Laura A

Applied clinical informatics

2023 Volume 14, Issue 3, Page(s) 465–469

MeSH term(s)	Decision Support Techniques ; User-Computer Interface ; Delivery of Health Care
Language	English
Publishing date	2023-04-04
Publishing country	Germany
Document type	Editorial ; Research Support, Non-U.S. Gov't
ISSN	1869-0327
ISSN (online)	1869-0327
DOI	10.1055/a-2068-6699
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Article ; Online: Beyond Hospital-Level Aggregated Data: A Methodology to Adapt Clinical Data From the Electronic Health Record for Nursing Unit-Level Research.

Yang, Christine / Kuebeler, Mark K / Jiang, Rebecca / Knox, Melissa K / Wong, Janine J / Mehta, Paras D / Dorsey, Lynette E / Petersen, Laura A

Medical care

2024 Volume 62, Issue 3, Page(s) 189–195

Abstract: Background: Studies of nurse staffing frequently use data aggregated at the hospital level that do not provide the appropriate context to inform unit-level decisions, such as nurse staffing.: Objectives: Describe a method to link patient data ... ...

Abstract	Background: Studies of nurse staffing frequently use data aggregated at the hospital level that do not provide the appropriate context to inform unit-level decisions, such as nurse staffing. Objectives: Describe a method to link patient data collected during the provision of routine care and recorded in the electronic health record (EHR) to the nursing units where care occurred in a national dataset. Research design: We identified all Veterans Health Administration acute care hospitalizations in the calendar year 2019 nationwide. We linked patient-level EHR and bar code medication administration data to nursing units using a crosswalk. We divided hospitalizations into segments based on the patient's time-stamped location (ward stays). We calculated the number of ward stays and medication administrations linked to a nursing unit and the unit-level and facility-level mean patient risk scores. Results: We extracted data on 1117 nursing units, 3782 EHR patient locations associated with 1,137,391 ward stays, and 67,772 bar code medication administration locations associated with 147,686,996 medication administrations across 125 Veterans Health Administration facilities. We linked 89.46% of ward stays and 93.10% of medication administrations to a nursing unit. The average (standard deviation) unit-level patient severity across all facilities is 4.71 (1.52), versus 4.53 (0.88) at the facility level. Conclusions: Identification of units is indispensable for using EHR data to understand unit-level phenomena in nursing research and can provide the context-specific information needed by managers making frontline decisions about staffing.
MeSH term(s)	Humans ; Personnel Staffing and Scheduling ; Electronic Health Records ; Nursing Staff, Hospital ; Hospitals ; Nursing Research
Language	English
Publishing date	2024-01-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	411646-x
ISSN	1537-1948 ; 0025-7079
ISSN (online)	1537-1948
ISSN	0025-7079
DOI	10.1097/MLR.0000000000001972
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Zs.B 518: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 63: Show issues

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Article ; Online: Stability and consistency of symptom clusters in younger versus older patients receiving chemotherapy.

Morse, Lisa / Cooper, Bruce A / Ritchie, Christine S / Wong, Melisa L / Kober, Kord M / Harris, Carolyn / Shin, Joosun / Oppegaard, Kate / Hammer, Marilyn J / Schimmel, Alejandra Calvo / Paul, Steven M / Conley, Yvette P / Levine, Jon D / Miaskowski, Christine

BMC geriatrics

2024 Volume 24, Issue 1, Page(s) 164

Abstract: Background: By 2035, the number of newly diagnosed cancer cases will double and over 50% will be in older adults. Given this rapidly growing demographic, a need exists to understand how age influences oncology patients' symptom burden. The study ... ...

Abstract	Background: By 2035, the number of newly diagnosed cancer cases will double and over 50% will be in older adults. Given this rapidly growing demographic, a need exists to understand how age influences oncology patients' symptom burden. The study purposes were to evaluate for differences in the occurrence, severity, and distress of 38 symptoms in younger (< 60 years) versus older (≥ 60 years) oncology patients undergoing chemotherapy and to evaluate for differences in the stability and consistency of symptom clusters across the two age groups. Methods: A total of 1329 patients were dichotomized into the younger and older groups. Patients completed demographic and clinical questionnaires prior to the initiation of their second or third cycle of chemotherapy. A modified version of Memorial Symptom Assessment Scale was used to evaluate the occurrence, severity, and distress of 38 common symptoms associated with cancer and its treatment. Differences between the two age groups in demographic and clinical characteristics and ratings of occurrence, severity, and distress for the 38 symptoms were evaluated using parametric and nonparametric tests. Exploratory factor analyses were done within each age group to identify symptom clusters using symptom occurrence rates. Results: Compared to the younger group (14.8 (± 7.0)), older adults reported a lower mean number of symptoms (12.9 (± 7.2)). Older patients experienced lower occurrence rates for almost 50% of the symptoms. Regarding symptom clusters, an eight-factor solution was selected for both age groups. Across the two age groups, the eight symptom clusters (i.e., physical and cognitive fatigue, respiratory, psychological, hormonal, chemotherapy-related toxicity, weight gain, gastrointestinal, epithelial) were stable. However, symptoms within the physical and cognitive, chemotherapy-related toxicity, and gastrointestinal clusters were not consistent across the age groups. Conclusions: To be able to provide tailored and effective symptom management interventions to older oncology patients, routine assessments of the core symptoms unique to the symptom clusters identified for this group warrants consideration. The underlying mechanism(s) for these inconsistencies in symptom burden is an important focus for future studies.
MeSH term(s)	Humans ; Aged ; Antineoplastic Agents/adverse effects ; Syndrome ; Severity of Illness Index ; Longitudinal Studies ; Neoplasms/drug therapy ; Neoplasms/epidemiology ; Neoplasms/psychology
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2024-02-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2059865-8
ISSN	1471-2318 ; 1471-2318
ISSN (online)	1471-2318
ISSN	1471-2318
DOI	10.1186/s12877-024-04755-2
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Article ; Online: Perturbations in inflammatory pathways are associated with shortness of breath profiles in oncology patients receiving chemotherapy.

Shin, Joosun / Miaskowski, Christine / Wong, Melisa L / Yates, Patsy / Olshen, Adam B / Roy, Ritu / Dokiparthi, Vasuda / Cooper, Bruce / Paul, Steven / Conley, Yvette P / Levine, Jon D / Hammer, Marilyn J / Kober, Kord

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

2024 Volume 32, Issue 4, Page(s) 250

Abstract: Purpose: One plausible mechanistic hypothesis is the potential contribution of inflammatory mechanisms to shortness of breath. This study was aimed to evaluate for associations between the occurrence of shortness of breath and perturbations in ... ...

Abstract	Purpose: One plausible mechanistic hypothesis is the potential contribution of inflammatory mechanisms to shortness of breath. This study was aimed to evaluate for associations between the occurrence of shortness of breath and perturbations in inflammatory pathways. Methods: Patients with cancer reported the occurrence of shortness of breath six times over two cycles of chemotherapy. Latent class analysis was used to identify subgroups of patients with distinct shortness of breath occurrence profiles (i.e., none (70.5%), decreasing (8.2%), increasing (7.8%), high (13.5%)). Using an extreme phenotype approach, whole transcriptome differential gene expression and pathway impact analyses were performed to evaluate for perturbed signaling pathways associated with shortness of breath between the none and high classes. Two independent samples (RNA-sequencing (n = 293) and microarray (n = 295) methodologies) were evaluated. Fisher's combined probability method was used to combine these results to obtain a global test of the null hypothesis. In addition, an unweighted knowledge network was created using the specific pathway maps to evaluate for interconnections among these pathways. Results: Twenty-nine Kyoto Encyclopedia of Genes and Genomes inflammatory signaling pathways were perturbed. The mitogen-activated protein kinase signaling pathway node had the highest closeness, betweenness, and degree scores. In addition, five common respiratory disease-related pathways, that may share mechanisms with cancer-related shortness of breath, were perturbed. Conclusions: Findings provide preliminary support for the hypothesis that inflammation contribute to the occurrence of shortness of breath in patients with cancer. In addition, the mechanisms that underlie shortness of breath in oncology patients may be similar to other respiratory diseases.
MeSH term(s)	Humans ; Dyspnea ; Neoplasms
Language	English
Publishing date	2024-03-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1134446-5
ISSN	1433-7339 ; 0941-4355
ISSN (online)	1433-7339
ISSN	0941-4355
DOI	10.1007/s00520-024-08446-x
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Zs.A 3697: Show issues

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Article ; Online: Age-related deficits in retinal autophagy following intraocular pressure elevation in autophagy reporter mouse model.

Afiat, Brianna C / Zhao, Da / Wong, Vickie H Y / Perera, Nirma D / Turner, Bradley J / Nguyen, Christine T O / Bui, Bang V

Neurobiology of aging

2023 Volume 131, Page(s) 74–87

Abstract: This study quantified age-related changes to retinal autophagy using the CAG-RFP-EGFP-LC3 autophagy reporter mice and considered how aging impacts autophagic responses to acute intraocular pressure (IOP) stress. IOP was elevated to 50 mm Hg for 30 ... ...

Abstract	This study quantified age-related changes to retinal autophagy using the CAG-RFP-EGFP-LC3 autophagy reporter mice and considered how aging impacts autophagic responses to acute intraocular pressure (IOP) stress. IOP was elevated to 50 mm Hg for 30 minutes in 3-month-old and 12-month-old CAG-RFP-EGFP-LC3 (n = 7 per age group) and Thy1-YFPh transgenic mice (n = 3 per age group). Compared with younger eyes, older eyes showed diminished basal autophagy in the outer retina, while the inner retina was unaffected. Autophagic flux (red:yellow puncta ratio) was elevated in the inner plexiform layer. Three days following IOP elevation, older eyes showed poorer functional recovery, most notably in ganglion cell responses compared to younger eyes (12 months old: -33.4 ± 5.3% vs. 3 months mice: -13.4 ± 4.5%). This paralleled a reduced capacity to upregulate autophagic puncta volume in the inner retina in older eyes, a response that was seen in younger eyes. Age-related decline in basal and stress-induced autophagy in the retina is associated with greater retinal ganglion cells' susceptibility to IOP elevation.
MeSH term(s)	Mice ; Animals ; Intraocular Pressure ; Retina ; Retinal Ganglion Cells/physiology ; Disease Models, Animal ; Mice, Transgenic ; Autophagy/genetics
Language	English
Publishing date	2023-07-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	604505-4
ISSN	1558-1497 ; 0197-4580
ISSN (online)	1558-1497
ISSN	0197-4580
DOI	10.1016/j.neurobiolaging.2023.07.009
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Zs.A 1685: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 10: Show issues

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Article ; Online: Effects of a change in recall period on reporting severe symptoms: an analysis of a pragmatic multisite trial.

Paudel, Roshan / Enzinger, Andrea C / Uno, Hajime / Cronin, Christine / Wong, Sandra L / Dizon, Don S / Hazard Jenkins, Hannah / Bian, Jessica / Osarogiagbon, Raymond U / Jensen, Roxanne E / Mitchell, Sandra A / Schrag, Deborah / Hassett, Michael J

Journal of the National Cancer Institute

2024

Abstract: Background: Optimal methods for deploying electronic patient-reported outcomes (ePROs) to manage symptoms in routine oncologic practice remain uncertain. The eSyM symptom management program asks chemotherapy and surgery patients to self-report 12 ... ...

Abstract	Background: Optimal methods for deploying electronic patient-reported outcomes (ePROs) to manage symptoms in routine oncologic practice remain uncertain. The eSyM symptom management program asks chemotherapy and surgery patients to self-report 12 symptoms regularly. Feedback from nurses and patients led to changing the recall period from the past 7 days to the past 24 hours. Methods: Using questionnaires submitted during the 16-weeks surrounding the recall period change, we assessed the likelihood of reporting a severe, or a moderate-severe, symptom across all 12 symptoms and separately for the 5 most prevalent symptoms. Interrupted time series analyses modeled the effects of the change using generalized linear mixed-effects models. Surgery and chemotherapy cohorts were analyzed separately. Study-wide effects were estimated using a meta-analysis method. Results: In total, 1,692 patients from 6 institutions submitted 7,823 eSyM assessments during the 16-weeks surrounding the recall period change. Shortening the recall period was associated with lower odds of severe symptom reporting in the surgery cohort (OR 0.65; 95% CI 0.46 to 0.93; p = .02) and lower odds of moderate-severe symptom reporting in the chemotherapy cohort (OR 0.83, 95% CI 0.71 to 0.97; p = .02). Among the most prevalent symptoms, 24-hour recall was associated with lower rate of reporting post-operative constipation, but no differences in reporting rates for other symptoms. Conclusion: A shorter recall period was associated with a reduction in the proportion of patients reporting moderate-severe symptoms. The optimal recall period may vary depending on whether ePROs are collected for active symptom management, as a clinical trial endpoint, or another purpose. (Clinicaltrails.gov (NCT03850912).
Language	English
Publishing date	2024-03-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2992-0
ISSN	1460-2105 ; 0027-8874 ; 0198-0157
ISSN (online)	1460-2105
ISSN	0027-8874 ; 0198-0157
DOI	10.1093/jnci/djae049
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Article ; Online: Collagen Tubular Airway-on-Chip for Extended Epithelial Culture and Investigation of Ventilation Dynamics.

Gao, Wuyang / Kanagarajah, Kayshani R / Graham, Emma / Soon, Kayla / Veres, Teodor / Moraes, Theo J / Bear, Christine E / Veldhuizen, Ruud A / Wong, Amy P / Günther, Axel

Small (Weinheim an der Bergstrasse, Germany)

2024 , Page(s) e2309270

Abstract: The lower respiratory tract is a hierarchical network of compliant tubular structures that are made from extracellular matrix proteins with a wall lined by an epithelium. While microfluidic airway-on-a-chip models incorporate the effects of shear and ... ...

Abstract	The lower respiratory tract is a hierarchical network of compliant tubular structures that are made from extracellular matrix proteins with a wall lined by an epithelium. While microfluidic airway-on-a-chip models incorporate the effects of shear and stretch on the epithelium, week-long air-liquid-interface culture at physiological shear stresses, the circular cross-section, and compliance of native airway walls have yet to be recapitulated. To overcome these limitations, a collagen tube-based airway model is presented. The lumen is lined with a confluent epithelium during two-week continuous perfusion with warm, humid air while presenting culture medium from the outside and compensating for evaporation. The model recapitulates human small airways in extracellular matrix composition and mechanical microenvironment, allowing for the first time dynamic studies of elastocapillary phenomena associated with regular breathing and mechanical ventilation, as well as their impacts on the epithelium. A case study reveales increasing damage to the epithelium during repetitive collapse and reopening cycles as opposed to overdistension, suggesting expiratory flow resistance to reduce atelectasis. The model is expected to promote systematic comparisons between different clinically used ventilation strategies and, more broadly, to enhance human organ-on-a-chip platforms for a variety of tubular tissues.
Language	English
Publishing date	2024-03-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202309270
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