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  1. Article ; Online: COVID-19 - Considerations for the paediatric rheumatologist.

    Hedrich, Christian M

    Clinical immunology (Orlando, Fla.)

    2020  Volume 214, Page(s) 108420

    Abstract: The novel coronavirus SARS-CoV2 is a threat to the health and well-being of millions of lifes across the globe. A significant proportion of adult patients require hospitalisation and may develop severe life-threatening complications. Children, on the ... ...

    Abstract The novel coronavirus SARS-CoV2 is a threat to the health and well-being of millions of lifes across the globe. A significant proportion of adult patients require hospitalisation and may develop severe life-threatening complications. Children, on the other hand, can carry and transmit the virus, but usually do not develop severe disease. Mortality in the paediatric age-group is relatively low. Differences in virus containment and clearance, as well as reduced inflammation-related tissue and organ damage may be caused by age-specific environmental and host factors. Since severe complications in adults are frequently caused by uncontrolled immune responses and a resulting "cytokine storm" that may be controlled by targeted blockade of cytokines, previously established treatment with immunosuppressive treatments may indeed protect children from complications.
    MeSH term(s) Age Factors ; Betacoronavirus ; COVID-19 ; Child ; Coinfection/virology ; Comorbidity ; Coronavirus Infections/epidemiology ; Coronavirus Infections/pathology ; Cytokines/immunology ; Humans ; Immune Evasion ; Immunosuppressive Agents/administration & dosage ; Pandemics ; Pediatrics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/pathology ; Rheumatology ; SARS-CoV-2
    Chemical Substances Cytokines ; Immunosuppressive Agents
    Keywords covid19
    Language English
    Publishing date 2020-04-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2020.108420
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Updates zur chronisch nichtbakteriellen Osteomyelitis (CNO)

    Hahn, Gabriele / Hedrich, Christian M.

    Arthritis und Rheuma

    2023  Volume 43, Issue 06, Page(s) 393–402

    Abstract: Die chronisch nichtbakterielle Osteomyelitis (CNO) ist eine nicht infektiöse, (auto)-inflammatorische Knochenerkrankung, die zumeist Kinder und Jugendliche betrifft. Das klinische Bild reicht von singulären, manchmal selbstlimitierten Knochenherden bis ... ...

    Abstract Die chronisch nichtbakterielle Osteomyelitis (CNO) ist eine nicht infektiöse, (auto)-inflammatorische Knochenerkrankung, die zumeist Kinder und Jugendliche betrifft. Das klinische Bild reicht von singulären, manchmal selbstlimitierten Knochenherden bis zu chronisch aktiven oder rekurrierenden multifokalen Verläufen mit Hyperostosen und/oder Frakturen. Wichtige Differenzialdiagnosen beinhalten Infektionen, maligne und benigne Tumoren sowie Stoffwechselerkrankungen. In den letzten Jahren wurden signifikante Fortschritte im Verständnis der molekularen Pathophysiologie gemacht, die das Ansprechen auf Therapien erklären und neue therapeutische Ansatzpunkte ins Spiel bringen. Dieser Artikel fasst neueste Erkenntnisse zusammen und diskutiert das diagnostische und therapeutische Herangehen der Autoren im Kontext der vorliegenden Literatur.
    Keywords CNO ; CRMO ; nichtbakterielle Osteomyelitis ; Knochen ; Inflammation ; Diagnose ; Therapie
    Language German
    Publishing date 2023-12-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2223481-0
    ISSN 2567-5753 ; 0176-5167
    ISSN (online) 2567-5753
    ISSN 0176-5167
    DOI 10.1055/a-2198-2295
    Database Thieme publisher's database

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  3. Article ; Online: COVID-19 – Considerations for the paediatric rheumatologist

    Hedrich, Christian M.

    Clinical Immunology

    2020  Volume 214, Page(s) 108420

    Keywords Immunology ; Immunology and Allergy ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2020.108420
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Systemischer Lupus erythematodes – sind Kinder kleine Erwachsene?

    Alexander, Tobias / Hedrich, Christian M

    Zeitschrift fur Rheumatologie

    2021  Volume 81, Issue 1, Page(s) 28–35

    Abstract: Systemic lupus erythematosus (SLE) is a systemic inflammatory disease that can affect any organ of the human body and cause significant damage. As compared to patients with adult-onset SLE, children and young people (juvenile SLE) more frequently ... ...

    Title translation Systemic lupus erythematosus-are children small adults?
    Abstract Systemic lupus erythematosus (SLE) is a systemic inflammatory disease that can affect any organ of the human body and cause significant damage. As compared to patients with adult-onset SLE, children and young people (juvenile SLE) more frequently experience extensive diffuse organ involvement, more organ damage at diagnoses, and resistance to immunomodulatory treatment. This manuscript emphasizes parallels and differences between the clinical pictures, known pathomechanisms, and available treatment options of juvenile and adult-onset SLE.
    MeSH term(s) Adolescent ; Adult ; Age of Onset ; Child ; Humans ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/drug therapy ; Severity of Illness Index
    Language German
    Publishing date 2021-11-08
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 124985-x
    ISSN 1435-1250 ; 0340-1855 ; 0301-6382
    ISSN (online) 1435-1250
    ISSN 0340-1855 ; 0301-6382
    DOI 10.1007/s00393-021-01116-x
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  5. Article: The Molecular Pathophysiology of Psoriatic Arthritis-The Complex Interplay Between Genetic Predisposition, Epigenetics Factors, and the Microbiome.

    Carvalho, Ana L / Hedrich, Christian M

    Frontiers in molecular biosciences

    2021  Volume 8, Page(s) 662047

    Abstract: Psoriasis is a symmetric autoimmune/inflammatory disease that primarily affects the skin. In a significant proportion of cases, it is accompanied by arthritis that can affect any joint, the spine, and/or include enthesitis. Psoriasis and psoriatic ... ...

    Abstract Psoriasis is a symmetric autoimmune/inflammatory disease that primarily affects the skin. In a significant proportion of cases, it is accompanied by arthritis that can affect any joint, the spine, and/or include enthesitis. Psoriasis and psoriatic arthritis are multifactor disorders characterized by aberrant immune responses in genetically susceptible individuals in the presence of additional (environmental) factors, including changes in microbiota and/or epigenetic marks. Epigenetic changes can be heritable or acquired (e.g., through changes in diet/microbiota or as a response to therapeutics) and, together with genetic factors, contribute to disease expression. In psoriasis, epigenetic alterations are mainly related to cell proliferation, cytokine signaling and microbial tolerance. Understanding the complex interplay between heritable and acquired pathomechanistic factors contributing to the development and maintenance of psoriasis is crucial for the identification and validation of diagnostic and predictive biomarkers, and the introduction of individualized effective and tolerable new treatments. This review summarizes the current understanding of immune activation, genetic, and environmental factors that contribute to the pathogenesis of psoriatic arthritis. Particular focus is on the interactions between these factors to propose a multifactorial disease model.
    Language English
    Publishing date 2021-04-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2021.662047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Systemic lupus erythematosus - Are children miniature adults?

    Alexander, Tobias / Hedrich, Christian M

    Clinical immunology (Orlando, Fla.)

    2021  Volume 234, Page(s) 108907

    Abstract: Systemic lupus erythematosus (SLE) is a systemic autoimmune/inflammatory disease that can affect any organ system and cause significant damage and organ failure. Disease-onset during childhood (juvenile-onset SLE) is associated with less typical ... ...

    Abstract Systemic lupus erythematosus (SLE) is a systemic autoimmune/inflammatory disease that can affect any organ system and cause significant damage and organ failure. Disease-onset during childhood (juvenile-onset SLE) is associated with less typical autoantibody patterns, diffuse organ involvement, more damage already at diagnoses, and a higher need of immunomodulating treatment, including corticosteroids, when compared to adult-onset SLE. Differences in the molecular pathophysiology within SLE, and over-representation of patients with "genetic SLE" contribute to differences in clinical presentation and treatment responses between children and adults. This manuscript summarizes currently available literature focusing on parallels and differences between clinical pictures, known pathomechanisms, and available treatment options in juvenile- versus adult-onset SLE.
    MeSH term(s) Adult ; Child ; Humans ; Lupus Erythematosus, Systemic/classification ; Lupus Erythematosus, Systemic/drug therapy ; Lupus Erythematosus, Systemic/etiology ; Lupus Erythematosus, Systemic/immunology ; Prognosis
    Language English
    Publishing date 2021-12-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2021.108907
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: COVID-19 in children and young people.

    Felsenstein, Susanna / Hedrich, Christian M

    The Lancet. Rheumatology

    2020  Volume 2, Issue 9, Page(s) e514–e516

    Keywords covid19
    Language English
    Publishing date 2020-06-29
    Publishing country England
    Document type Journal Article
    ISSN 2665-9913
    ISSN (online) 2665-9913
    DOI 10.1016/S2665-9913(20)30212-5
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  8. Article: COVID-19 - Considerations for the paediatric rheumatologist

    Hedrich, Christian M

    Clin Immunol

    Abstract: The novel coronavirus SARS-CoV2 is a threat to the health and well-being of millions of lifes across the globe. A significant proportion of adult patients require hospitalisation and may develop severe life-threatening complications. Children, on the ... ...

    Abstract The novel coronavirus SARS-CoV2 is a threat to the health and well-being of millions of lifes across the globe. A significant proportion of adult patients require hospitalisation and may develop severe life-threatening complications. Children, on the other hand, can carry and transmit the virus, but usually do not develop severe disease. Mortality in the paediatric age-group is relatively low. Differences in virus containment and clearance, as well as reduced inflammation-related tissue and organ damage may be caused by age-specific environmental and host factors. Since severe complications in adults are frequently caused by uncontrolled immune responses and a resulting "cytokine storm" that may be controlled by targeted blockade of cytokines, previously established treatment with immunosuppressive treatments may indeed protect children from complications.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32283324
    Database COVID19

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  9. Article: Neuropsychiatric involvement in juvenile-onset systemic lupus erythematosus (jSLE).

    Natoli, Valentina / Charras, Amandine / Hahn, Gabriele / Hedrich, Christian M

    Molecular and cellular pediatrics

    2023  Volume 10, Issue 1, Page(s) 5

    Abstract: Systemic lupus erythematosus (SLE) is a rare autoimmune/inflammatory disease with significant morbidity and mortality. Approximately 15-20% of SLE patients develop the disease during childhood or adolescence (juvenile-onset SLE/jSLE). Patients with jSLE ... ...

    Abstract Systemic lupus erythematosus (SLE) is a rare autoimmune/inflammatory disease with significant morbidity and mortality. Approximately 15-20% of SLE patients develop the disease during childhood or adolescence (juvenile-onset SLE/jSLE). Patients with jSLE exhibit more variable and severe disease when compared to patients with disease-onset during adulthood. Neuropsychiatric (NP) involvement is a clinically heterogenous and potentially severe complication. Published reports on the incidence and prevalence of NP-jSLE are scarce, and the exact pathophysiology is poorly understood.This manuscript provides a review of the existing literature, suggesting NP involvement in 13.5-51% of jSLE patients. Among patients with NP-jSLE affecting the CNS, we propose two main subgroups: (i) a chronic progressive, predominantly type 1 interferon-driven form that poorly responds to currently used treatments, and (ii) an acutely aggressive form that usually presents early during the disease that may be primarily mediated by auto-reactive effector lymphocytes. While this hypothesis requires to be tested in large collaborative international cohort studies, it may offer future patient stratification and individualised care.
    Language English
    Publishing date 2023-08-09
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2785551-X
    ISSN 2194-7791
    ISSN 2194-7791
    DOI 10.1186/s40348-023-00161-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: cAMP responsive element modulator α promotes effector T cells in systemic autoimmune diseases.

    Carlsson, Emil / Cowell-McGlory, Taylor / Hedrich, Christian M

    Immunology

    2023  Volume 170, Issue 4, Page(s) 470–482

    Abstract: T lymphocytes play a crucial role in adaptive immunity. Dysregulation of T cell-derived inflammatory cytokine expression and loss of self-tolerance promote inflammation and tissue damage in several autoimmune/inflammatory diseases, including systemic ... ...

    Abstract T lymphocytes play a crucial role in adaptive immunity. Dysregulation of T cell-derived inflammatory cytokine expression and loss of self-tolerance promote inflammation and tissue damage in several autoimmune/inflammatory diseases, including systemic lupus erythematosus (SLE) and psoriasis. The transcription factor cAMP responsive element modulator α (CREMα) plays a key role in the regulation of T cell homeostasis. Increased expression of CREMα is a hallmark of the T cell-mediated inflammatory diseases SLE and psoriasis. Notably, CREMα regulates the expression of effector molecules through trans-regulation and/or the co-recruitment of epigenetic modifiers, including DNA methyltransferases (DNMT3a), histone-methyltransferases (G9a) and histone acetyltransferases (p300). Thus, CREMα may be used as a biomarker for disease activity and/or target for future targeted therapeutic interventions.
    MeSH term(s) Humans ; T-Lymphocytes/metabolism ; Cyclic AMP Response Element Modulator/genetics ; Cyclic AMP Response Element Modulator/metabolism ; Lupus Erythematosus, Systemic ; Autoimmune Diseases/metabolism ; Psoriasis/metabolism ; Methyltransferases/metabolism
    Chemical Substances Cyclic AMP Response Element Modulator (135844-64-3) ; Methyltransferases (EC 2.1.1.-)
    Language English
    Publishing date 2023-07-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80124-0
    ISSN 1365-2567 ; 0019-2805 ; 0953-4954
    ISSN (online) 1365-2567
    ISSN 0019-2805 ; 0953-4954
    DOI 10.1111/imm.13680
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