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Article ; Online: A novel compression approach for truck GPS trajectory data

Sijing Liu / Gang Chen / Long Wei / Guoqi Li

IET Intelligent Transport Systems, Vol 15, Iss 1, Pp 74-

2021 Volume 83

Abstract: Abstract Nowadays, the application of location‐aware devices, such as global positioning system (GPS)‐enabled mobile phones and personal digital assistants (PDAs) is increasing. Based on this, a new demand for efficiently storing trajectory data has ... ...

Abstract	Abstract Nowadays, the application of location‐aware devices, such as global positioning system (GPS)‐enabled mobile phones and personal digital assistants (PDAs) is increasing. Based on this, a new demand for efficiently storing trajectory data has arisen. Trajectory compression reduces the storage space and cost, the cost and time of data transmission by retaining critical trajectory points and effectively eliminating redundant data. Herein, a novel trajectory compression method based on stay points (TCSP) is proposed. By using the road network data and the stay points of GPS trajectory data to compress the GPS trajectory data, this method can greatly improve the ratio and accuracy of compression. Experimental results based on real data sets show that the compression rate of this method can stably reach 8.61%, and the compression effect can be restored to the original trajectory route. Compared with the critical point algorithm and the Douglas–Peucker (DP) algorithm, the TCSP method can reach a better compression effect and compression ratio.
Keywords	Transportation engineering ; TA1001-1280 ; Electronic computers. Computer science ; QA75.5-76.95
Subject code	670
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Implication of geriatric nutritional risk index on treatment response and long-term prognosis in patients with cardiac resynchronization therapy.

Huang, Hao / Fu, Bingqi / Long, Tianxin / Yu, Yu / Cheng, Sijing / Gu, Min / Cai, Chi / Chen, Xuhua / Niu, Hongxia / Hua, Wei

International journal of cardiology

2024 , Page(s) 132064

Abstract: ... response and long-term clinical outcomes in heart failure (HF) patients receiving ... Conclusion: Higher GNRI was associated with better treatment response and long-term prognosis in HF patients ...

Abstract	Purpose: Geriatric Nutritional Risk Index (GNRI) is a simple tool for assessing the nutritional status of the aging population. This study aims to explore the clinical implication of GNRI on treatment response and long-term clinical outcomes in heart failure (HF) patients receiving cardiac resynchronization therapy (CRT). Methods: Patients who underwent CRT implantation or upgrade at our hospital were retrospectively included. The association of GNRI and its tertiles with the echocardiographic response, all-cause mortality or heart transplantation, and the first hospitalization due to HF were investigated. Results: Totally, 647 patients were enrolled, with a median age of 60 [Interquartile Range (IQR): 52-67] years and mean score of GNRI at 107.9 ± 23.7. Super-response rates increased significantly among the GNRI T1, T2, and T3 groups (25.1%, 29.8% vs. 41.1%, P = 0.002). Patients with higher GNRI were more likely to have better LVEF improvement after multiple adjustments (OR = 1.13, 95% CI: 1.04-1.23, P = 0.010). Higher GNRI was independently associated with a lower risk of all-cause mortality or heart implantation (HR = 0.95, 95% CI: 0.93-0.96, P < 0.001) and HF hospitalization (HR = 0.96, 95% CI: 0.95-0.98, P < 0.001). The inclusion of GNRI enhanced the predictability of all-cause mortality based on traditional model, including sex, New York Heart Association functional class, left bundle branch block, QRS reduction, and N-terminal pro-B-type natriuretic peptide level (C statistics improved from 0.785 to 0.813, P = 0.007). Conclusion: Higher GNRI was associated with better treatment response and long-term prognosis in HF patients with CRT. Evaluation of nutritional status among CRT population is necessary for individualized choice of potential responders.
Language	English
Publishing date	2024-04-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2024.132064
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Article ; Online: Epstein-Barr Virus Synergizes with BRD7 to Conquer c-Myc-Mediated Viral Latency Maintenance via Chromatin Remodeling.

Li, Shen / Yang, Li / Li, Yanling / Yue, Wenxing / Xin, Shuyu / Li, Jing / Long, Sijing / Zhang, Wentao / Cao, Pengfei / Lu, Jianhong

Microbiology spectrum

2023 , Page(s) e0123722

Abstract: Epstein-Barr virus (EBV) switches between latent and lytic phases in hosts, which is important in the development of related diseases. However, the underlying mechanism of controlling the viral biphasic life cycle and how EBV mediates this regulation ... ...

Abstract	Epstein-Barr virus (EBV) switches between latent and lytic phases in hosts, which is important in the development of related diseases. However, the underlying mechanism of controlling the viral biphasic life cycle and how EBV mediates this regulation remain largely unknown. This study identified bromodomain-containing protein 7 (BRD7) as a crucial host protein in EBV latent infection. Based on the chromatin immunoprecipitation (ChIP) sequencing of endogenous BRD7 in Burkitt lymphoma cells, we found that EBV drove BRD7 to regulate cellular and viral genomic loci, including the transcriptional activation of c-Myc, a recently reported regulator of EBV latency. Additionally, EBV-mediated BRD7 signals were enriched around the FUSE (far-upstream sequence element) site in chromosome 8 and the enhancer LOC108348026 in the
Language	English
Publishing date	2023-02-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.01237-22
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Article ; Online: PLOD2 promotes colorectal cancer progression by stabilizing USP15 to activate the AKT/mTOR signaling pathway.

Lan, Jiawen / Zhang, Sijing / Zheng, Lin / Long, Xiaoli / Chen, Jianxiong / Liu, Xunhua / Zhou, Miao / Zhou, Jun

Cancer science

2023 Volume 114, Issue 8, Page(s) 3190–3202

Abstract: Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2) has been reported as an oncogenic gene, affecting various malignant tumors, including endometrial carcinoma, osteosarcoma, and gastric cancer. These effects are mostly due to the enhanced ... ...

Abstract	Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2) has been reported as an oncogenic gene, affecting various malignant tumors, including endometrial carcinoma, osteosarcoma, and gastric cancer. These effects are mostly due to the enhanced deposition of collagen precursors. However, more studies need to be conducted on how its lysyl hydroxylase function affects cancers like colorectal carcinoma (CRC). Our present results showed that PLOD2 expression was elevated in CRC, and its higher expression was associated with poorer survival. Overexpression of PLOD2 also facilitated CRC proliferation, invasion, and metastasis in vitro and in vivo. In addition, PLOD2 interacted with USP15 by stabilizing it in the cytoplasm and then activated the phosphorylation of AKT/mTOR, thereby promoting CRC progression. Meanwhile, minoxidil was demonstrated to downregulate the expression of PLOD2 and suppress USP15, and the phosphorylation of AKT/mTOR. Our study reveals that PLOD2 plays an oncogenic role in colorectal carcinoma, upregulating USP15 and subsequently activating the AKT/mTOR pathway.
MeSH term(s)	Female ; Humans ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; Endometrial Neoplasms ; Bone Neoplasms ; TOR Serine-Threonine Kinases/metabolism ; Colorectal Neoplasms/genetics ; Cell Line, Tumor ; Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase/genetics ; Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase/metabolism ; Ubiquitin-Specific Proteases/metabolism
Chemical Substances	Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; PLOD2 protein, human (EC 1.14.11.4) ; Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase (EC 1.14.11.4) ; USP15 protein, human (EC 3.4.19.12) ; Ubiquitin-Specific Proteases (EC 3.4.19.12)
Language	English
Publishing date	2023-05-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2115647-5
ISSN	1349-7006 ; 1349-7006
ISSN (online)	1349-7006
ISSN	1349-7006
DOI	10.1111/cas.15851
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Article ; Online: LARP6 suppresses colorectal cancer progression through ZNF267/SGMS2-mediated imbalance of sphingomyelin synthesis.

Long, Xiaoli / Liu, Xunhua / Deng, Ting / Chen, Jianxiong / Lan, Jiawen / Zhang, Sijing / Zhou, Miao / Guo, Dan / Zhou, Jun

Journal of experimental & clinical cancer research : CR

2023 Volume 42, Issue 1, Page(s) 33

Abstract: Background: With increasing incidence and mortality, colorectal cancer (CRC) seriously endangers human health. LARP6, a member of La-related protein (LARP) family, is a RNA binding protein and probably associates with CRC progression, but its specific ... ...

Abstract	Background: With increasing incidence and mortality, colorectal cancer (CRC) seriously endangers human health. LARP6, a member of La-related protein (LARP) family, is a RNA binding protein and probably associates with CRC progression, but its specific roles and mechanisms in CRC still remain unknown. Method: Quantitative real-time PCR (qPCR), western blot, and immunohistochemistry were employed to examine LARP6 expression in CRC tissues. Using the stable LARP6 overexpression or interference CRC cell lines, the effect of LARP6 on CRC progression were evaluated. High-throughput RNA immunoprecipitation sequencing (RIP-seq) and a series of relevant experiments were conducted to explain how LARP6 functions. SPSS software was used for statistical analysis. Result: In this study, we found that LARP6 expression is downregulated in CRC and correlates with patients' overall survival and relapse-free survival. Furthermore, altered LARP6 expression influences CRC cells invasion and metastasis. Mechanically, we discovered that LARP6 bind ZNF267 mRNA and regulated its stability and translation. LARP6 inhibited expression of SGMS2, a downstream target of ZNF267, resulting in ceramide and sphingomyelin imbalance in CRC cells. Interestingly, LARP6 also enhances autophagy activity of CRC cells, and the effect was at least partially determined by the inhibition of SGMS2-mediated sphingomyelin synthesis. Conclusion: Our study showed how LARP6/ZNF267/SGMS2 axis influence CRC progression, which contributes to further understanding of the molecular mechanisms underlying CRC development.
MeSH term(s)	Humans ; Cell Line, Tumor ; Cell Proliferation ; Colorectal Neoplasms/pathology ; Gene Expression Regulation, Neoplastic ; MicroRNAs/genetics ; RNA, Messenger/genetics ; RNA-Binding Proteins/genetics ; Sphingomyelins ; Transferases (Other Substituted Phosphate Groups)/metabolism ; Ribonucleoproteins/metabolism ; Repressor Proteins/metabolism ; SS-B Antigen
Chemical Substances	MicroRNAs ; RNA, Messenger ; RNA-Binding Proteins ; Sphingomyelins ; SGMS2 protein, human (EC 2.7.8.-) ; Transferases (Other Substituted Phosphate Groups) (EC 2.7.8.-) ; Ribonucleoproteins ; ZNF267 protein, human ; Repressor Proteins
Language	English
Publishing date	2023-01-24
Publishing country	England
Document type	Journal Article
ZDB-ID	803138-1
ISSN	1756-9966 ; 0392-9078
ISSN (online)	1756-9966
ISSN	0392-9078
DOI	10.1186/s13046-023-02605-4
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Article ; Online: Exports Widen the Regional Inequality of Health Burdens and Economic Benefits in India.

Long, Xinyi / Chen, Bin / Wang, Peng / Zhang, Mengyuan / Yu, Huajun / Wang, Sijing / Zhang, Hongliang / Wang, Yutao

Environmental science & technology

2022 Volume 56, Issue 19, Page(s) 14099–14108

Abstract: Both the ever-complex international and subnational supply chains could relocate health burdens and economic benefits across India, leading to the widening of regional inequality. Here, we simultaneously track the unequal distribution of fine particle ... ...

Abstract	Both the ever-complex international and subnational supply chains could relocate health burdens and economic benefits across India, leading to the widening of regional inequality. Here, we simultaneously track the unequal distribution of fine particle matter (PM
MeSH term(s)	Air Pollutants/analysis ; Air Pollution ; China ; Environmental Pollution ; India ; Mortality, Premature ; Particulate Matter/analysis
Chemical Substances	Air Pollutants ; Particulate Matter
Language	English
Publishing date	2022-09-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.2c04722
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Article ; Online: Pharmacological effects of the Cassia Seed on atherosclerosis: A meta-analysis based on network pharmacology.

Zhang, Sen / Rao, Sijing / Yang, Mei Wen / Huang, Ya-Ting / Hong, Fen-Fang / Yang, Shu-Long

Medicine

2022 Volume 101, Issue 36, Page(s) e30411

Abstract: Background: The aim of this study was to shed light on the active ingredients and potential targets of Cassia Seed about anti-atherosclerosis based on network pharmacology.: Methods: The active ingredients and potential targets of Cassia Seed were ... ...

Abstract	Background: The aim of this study was to shed light on the active ingredients and potential targets of Cassia Seed about anti-atherosclerosis based on network pharmacology. Methods: The active ingredients and potential targets of Cassia Seed were obtained from traditional Chinese medicine systems pharmacology database and analysis platform (TCMSP) and SwissTargetPrediction database. Then, atherosclerosis-related targets were screened via GeneCards, online mendelian inheritance in man, therapeutic target database and DrugBank database. The common targets and protein-protein interaction (PPI) network was later identified and built. Furthermore, we used the database for annotation, visualization and integrated discovery (DAVID) database server to accomplish the enrichment analysis. The compounds-targets-pathways network was ultimately constructed by Cytoscape. Results: A total of 14 active ingredients and 475 related targets were sifted from Cassia Seed. Among 574 potential atherosclerotic targets, there were 99 targets overlapped with those of Cassia Seed. Topological analysis with Cytoscape revealed that proto-oncogene tyrosine-protein kinase proto-oncogene tyrosine-protein kinase Src, transcription factor AP-1 (JUN), mitogen-activated protein kinase 8 (MAPK8), mitogen-activated protein kinase 14 (MAPK14) and catenin beta-1 were considered as the hub gene. Gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) enrichment analysis suggested that the Cassia Seed had the potential to influence varieties of biological processes and pathways, including positive regulation of smooth muscle cell proliferation, inflammatory response, tumor necrosis factor (TNF) signaling pathway, vascular endothelial growth factor (VEGF) signaling pathway and arachidonic acid (ARA) metabolism. Conclusion: Taken together, our findings support that anti-atherosclerosis effects of Cassia Seed are characterized by multi-component, multi-target and multi-path mechanism of action.
MeSH term(s)	Cassia ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Mitogen-Activated Protein Kinases ; Network Pharmacology ; Seeds ; Tyrosine ; Vascular Endothelial Growth Factor A
Chemical Substances	Drugs, Chinese Herbal ; Vascular Endothelial Growth Factor A ; Tyrosine (42HK56048U) ; Mitogen-Activated Protein Kinases (EC 2.7.11.24)
Language	English
Publishing date	2022-08-17
Publishing country	United States
Document type	Journal Article ; Meta-Analysis
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000030411
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Article ; Online: Efficacy and safety evaluation of Ginkgo biloba dropping pill (GBDP) on stable angina pectoris complicated with depression: A placebo-controlled, randomized, double-blind, multicenter study.

He, Xingling / Liu, Donghua / Ni, Shihao / Li, Ziru / Li, Sijing / Wu, Tingchun / Dong, Xiaoming / Zhang, Xiaojiao / Tang, Yaqin / Ling, Yan / Liao, Huili / Kang, Jinhua / Li, Yue / Wu, Hongyan / Luo, Jing / Wan, Xianming / Zhang, Dan / Lu, Lu / Long, Wenjie /

Yang, Zhongqi

Phytomedicine : international journal of phytotherapy and phytopharmacology

2024 Volume 126, Page(s) 155264

Abstract: Background: Stable angina pectoris (SAP) is a clinical condition characterized by reversible and temporary myocardial ischemia and hypoxia. A majority of SAP patients also experience depressive disorders, which adversely affect their disease prognosis ... ...

Abstract	Background: Stable angina pectoris (SAP) is a clinical condition characterized by reversible and temporary myocardial ischemia and hypoxia. A majority of SAP patients also experience depressive disorders, which adversely affect their disease prognosis and overall quality of life. However, the clinical utility of existing antidepressants is constrained by their side effects. Ginkgo biloba dropping pill (GBDP), a Chinese patented medication, has demonstrated efficacy in the treatment of both coronary heart disease and mental disorders. This prospective, randomized, double-blind, multicenter clinical trial aimed to assess the effectiveness and safety of GBDP as an adjuvant therapy for SAP complicated by depression. Methods: Participants were randomly assigned in a 1:1 ratio to receive either GBDP or a placebo (5 pills, three times a day) in addition to standard therapy for a duration of 12 weeks. The Seattle Angina Questionnaire (SAQ) was administered every 4 weeks during the treatment, and angina event frequency was assessed weekly. The 36-item Short-Form (SF-36) and Hamilton Depression Scale (HAMD) scores were measured both before and after the treatment. Results: Out of the 72 patients, 68 (n = 34 per group) completed the entire study. At the first visit (4 weeks ± 3 days), the SAQ-Angina Stability score in the GBDP group was significantly higher than that in the placebo group (p < 0.05). While the average weekly frequency of angina episodes in the placebo group notably increased after 12 weeks of treatment (p < 0.05), it displayed an improving trend in the GBDP group (p > 0.05). By the endpoint, each subcategory score of SF-36 in the GBDP group exhibited significant improvement compared to baseline (p < 0.05). The comparison of score improvement between the two groups revealed that the SF-PCS score of the GBDP group was higher than that of the placebo group (p < 0.05). HAMD scores in both groups significantly increased after treatment (p < 0.05). No discernible difference in the incidence of adverse reactions was observed between the two groups (p > 0.05). Conclusion: In patients with SAP complicated by depression, GBDP, when combined with standard treatment, rapidly and safely alleviates angina pectoris symptoms. It demonstrates therapeutic potential in enhancing the quality of life and alleviating depressive symptoms.
MeSH term(s)	Humans ; Angina, Stable/drug therapy ; Ginkgo biloba ; Quality of Life ; Prospective Studies ; Depression ; Double-Blind Method ; Plant Extracts/adverse effects ; Treatment Outcome
Chemical Substances	Plant Extracts
Language	English
Publishing date	2024-01-11
Publishing country	Germany
Document type	Randomized Controlled Trial ; Multicenter Study ; Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2023.155264
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Article: Efficacy and Safety of QiShen YiQi Dripping Pills in the Treatment of Coronary Heart Disease Complicating Chronic Heart Failure (Syndrome of Qi Deficiency with Blood Stasis): Study Protocol for a Randomized, Placebo-Controlled, Double-Blind and Multi-Centre Phase II Clinical Trial.

He, Xingling / Jiang, Yanhui / Li, Sijing / Liu, Donghua / Li, Ziru / Han, Xiaowei / Zhang, Xiaojiao / Dong, Xiaoming / Liu, Haohui / Huang, Jie / Wang, Xiaojing / Long, Wenjie / Ni, Shihao / Yang, Zhongqi / Ye, Taochun

International journal of general medicine

2023 Volume 16, Page(s) 6177–6188

Abstract: Background: Heart failure (HF) is a serious and terminal stage of various cardiac diseases and the most common complication of coronary heart disease (CHD). Previous clinical studies have shown that Qishen Yiqi dropping pills (QSYQ) have the effect of ... ...

Abstract	Background: Heart failure (HF) is a serious and terminal stage of various cardiac diseases and the most common complication of coronary heart disease (CHD). Previous clinical studies have shown that Qishen Yiqi dropping pills (QSYQ) have the effect of treating chronic heart failure. This study aims to evaluate the clinical efficacy, safety and optimal effective dose of QSYQ in treating CHD complicating chronic HF with reduced ejection fraction (HFrEF). Methods: We will conduct a randomized, double-blind, placebo controlled, multicenter clinical trial. A total of 228 individuals from 16 hospitals in China will be randomly assigned to the low-dose, high-dose, and placebo groups in a ratio of 1:1:1. The trial consists of a screening period (standard medical treatment for at least 2 weeks) and a 12-week treatment period. After randomization, follow-up will be conducted at the 4th, 8th and 12th week. The primary outcomes will be the 6-Minute Walk Test (6MWT) at Week 12. Secondary outcomes will include 6MWT distance at Week 4 and 8, New York Heart Association (NYHA) functional classification, Traditional Chinese Medicine (TCM) Syndrome score, echocardiography indices, N-terminal pro-B-type natriuretic peptide (NT-proBNP), oxyhemoglobin saturation, Minnesota living with heart failure questionnaire (MLHFQ) score, grasp strength body mass index test and cardiovascular adverse events (AE). Ethics and dissemination: This trial has been approved by the Research Ethics Committee of the First Affiliated Hospital of Guangzhou University of Chinese Medicine, China (approval number: ZYYEC [2021]005). Written informed consent will be obtained from all participants. The results of this trial will be publicly shared through academic conferences and peer-reviewed journals. Study registration: Clinical Trials Registry (NCT04983043, Date: 07/08/2021, https://clinicaltrials.gov/ct2/show/NCT04983043).
Language	English
Publishing date	2023-12-28
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2452220-X
ISSN	1178-7074
ISSN	1178-7074
DOI	10.2147/IJGM.S436999
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Article: A Simplified Herbal Formula Improves Cardiac Function and Reduces Inflammation in Mice Through the TLR-Mediated NF-κB Signaling Pathway.

Dong, Xiaoming / Han, Xiaowei / Zhang, Xiaojiao / Li, Sijing / Li, Ziru / Kang, Jinhua / Jiang, Jialin / Ni, Shihao / Lu, Lu / He, Zhiling / Huang, Haoming / Xian, Shaoxiang / Yuan, Tianhui / Yang, Zhongqi / Long, Wenjie / Wan, Zemin

Frontiers in pharmacology

2022 Volume 13, Page(s) 865614

Abstract: Nuanxinkang tablet (NXK), a Chinese herbal formula, can improve heart function and quality of life in patients with chronic heart failure (CHF). However, the mechanisms of action of NXK are not fully understood. In this study, we investigated the effects ...

Abstract	Nuanxinkang tablet (NXK), a Chinese herbal formula, can improve heart function and quality of life in patients with chronic heart failure (CHF). However, the mechanisms of action of NXK are not fully understood. In this study, we investigated the effects of NXK on inflammation in the CHF mouse model. This model was established by transverse aortic constriction (TAC) and treated with NXK for 8 weeks. Then, the cardiac function and myocardial fibrosis were evaluated. The monocytes/macrophages were evaluated by immunofluorescence. The mRNA levels of
Language	English
Publishing date	2022-06-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.865614
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