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  1. Book ; Thesis: Das Auftreten eines postthrombotischen Syndroms nach Beinvenenthrombose - Vergleich von Villalta-Score, Duplexsonographie und Lichtreflexionsrheographie (PTS VILDER)

    Vogler, Mirko / Weiss, Norbert / Reeps, Christian Georg Horst

    2021  

    Institution Medizinische Klinik und Poliklinik III
    Author's details von Mirko Vogler aus Freital ; Medizinische Klinik und Poliklinik III [Dresden]
    Language German
    Size 93 Blätter, Illustrationen, Diagramme
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Technische Universität Dresden, Medizinische Fakultät, 2022
    HBZ-ID HT021732760
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 E 310 order for loan Magazin

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  2. Article: PI(4,5)P

    Fujita, Naonobu / Girada, Shravan / Vogler, Georg / Bodmer, Rolf / Kiger, Amy A

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Transverse (T)-tubules - vast, tubulated domains of the muscle plasma membrane - are critical to maintain healthy skeletal and heart contractions. How the intricate T-tubule membranes are formed is not well understood, with challenges to systematically ... ...

    Abstract Transverse (T)-tubules - vast, tubulated domains of the muscle plasma membrane - are critical to maintain healthy skeletal and heart contractions. How the intricate T-tubule membranes are formed is not well understood, with challenges to systematically interrogate in muscle. We established the use of intact Drosophila larval body wall muscles as an ideal system to discover mechanisms that sculpt and maintain the T-tubule membrane network. A muscle-targeted genetic screen identified specific phosphoinositide lipid regulators necessary for T-tubule organization and muscle function. We show that a
    Summary: T-tubules - vast, tubulated domains of the muscle plasma membrane - are critical to maintain skeletal and heart contractions. Fujita
    Key findings: PI4KIIIα
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.31.578124
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online: Wurzeln und Wasser – Gesunde Pflanzen in der Schwammstadt

    Feldmann, Falko / Henkel, Georg / Balder, Hartmut / Quambusch, Mona / Vogler, Ute

    Bericht über die VIII. Urbane Pflanzen Konferenz „Wie funktioniert Stadtgrün besser?“, 25. September 2023, Universität Göttingen ; "Roots and Water – Healthy Plants in the Sponge City" Report on the VIII Urban Plants Conference "How Does Urban Greenery Work Better?" on September 25, 2023, at the University of Göttingen

    2024  

    Abstract: Ein Weg, Städte an den Klimawandel anzupassen, ist die Umsetzung des Prinzips der „Schwammstadt“. Überflutungen durch Starkregen und Trockenheit durch Hitzeperioden soll durch phytotechnische und naturbasierte Maßnahmen entgegengewirkt werden. Die Stadt ... ...

    Abstract Ein Weg, Städte an den Klimawandel anzupassen, ist die Umsetzung des Prinzips der „Schwammstadt“. Überflutungen durch Starkregen und Trockenheit durch Hitzeperioden soll durch phytotechnische und naturbasierte Maßnahmen entgegengewirkt werden. Die Stadt soll die Fähigkeit bekommen, große Mengen an plötzlich auftretendem Wasser aufzusaugen, dieses Wasser zu speichern und es dann durch Verdunstung und gezielte Bewässerung wieder abzugeben. Doch wie reagieren Pflanzen, wenn ihre Wurzeln überstaut werden? Wie lange darf ein solcher Zustand währen? Wie sollte die Kontaktzone zwischen Wurzelraum und gespeichertem Wasser gestaltet werden? Fördert man durch die Schwammstadt bodenbürtige Schaderreger der Wurzeln? Wie wirken sich Schadstofffrachten im Wasser auf die Pflanzengesundheit aus? Müssen wir besondere Pflanzen auswählen, die an den Wechsel von einem Zuviel zu einem Zuwenig an Wasser angepasst sind? Diesen Fragen ging die Tagung in Vorträgen und gemeinsamem Austausch nach.

    One way to adapt cities to climate change is to implement the "sponge city” principle. Floods caused by heavy rainfall and droughts resulting from heatwaves is intended to be mitigated through phytotechnical and nature-based measures. The city should acquire the ability to absorb large amounts of sudden water, store it, and then release it through evaporation and targeted irrigation. But how do plants react when their roots are waterlogged? How long can such a condition last? How should the contact zone between the root zone and the stored water be designed? Does the sponge city promote soil-borne root pathogens? How does water pollution affect plant health? Do we need to select specific plants that are adapted to frequent changes from excess to insufficient water? These questions were addressed during the conference through presentations and joint discussions.
    Keywords Text ; ddc:630 ; Schwammstadt -- Pflanzenschäden -- Wurzelraum ; Sponge city -- plant damage -- root space
    Subject code 801
    Language German
    Publishing country de
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  4. Article: Neues Eckpunktepapier: Was die deutsche Schmerzmedizin jetzt braucht

    Horlemann, Johannes / Kippels, Georg / Maurer, Silvia / Stamm-Fibich, Martina / Vogler, Kathrin

    Schmerzmedizin - angewandte Schmerztherapie und Palliativmedizin

    2023  Volume 39, Issue 4, Page(s) 37

    Language German
    Document type Article
    ZDB-ID 2822543-0
    ISSN 2194-2536
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6367: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Nascent polypeptide-Associated Complex and Signal Recognition Particle have cardiac-specific roles in heart development and remodeling.

    Schroeder, Analyne M / Nielsen, Tanja / Lynott, Michaela / Vogler, Georg / Colas, Alexandre R / Bodmer, Rolf

    PLoS genetics

    2022  Volume 18, Issue 10, Page(s) e1010448

    Abstract: Establishing a catalog of Congenital Heart Disease (CHD) genes and identifying functional networks would improve our understanding of its oligogenic underpinnings. Our studies identified protein biogenesis cofactors Nascent polypeptide-Associated Complex ...

    Abstract Establishing a catalog of Congenital Heart Disease (CHD) genes and identifying functional networks would improve our understanding of its oligogenic underpinnings. Our studies identified protein biogenesis cofactors Nascent polypeptide-Associated Complex (NAC) and Signal-Recognition-Particle (SRP) as disease candidates and novel regulators of cardiac differentiation and morphogenesis. Knockdown (KD) of the alpha- (Nacα) or beta-subunit (bicaudal, bic) of NAC in the developing Drosophila heart disrupted cardiac developmental remodeling resulting in a fly with no heart. Heart loss was rescued by combined KD of Nacα with the posterior patterning Hox gene Abd-B. Consistent with a central role for this interaction in cardiogenesis, KD of Nacα in cardiac progenitors derived from human iPSCs impaired cardiac differentiation while co-KD with human HOXC12 and HOXD12 rescued this phenotype. Our data suggest that Nacα KD preprograms cardioblasts in the embryo for abortive remodeling later during metamorphosis, as Nacα KD during translation-intensive larval growth or pupal remodeling only causes moderate heart defects. KD of SRP subunits in the developing fly heart produced phenotypes that targeted specific segments and cell types, again suggesting cardiac-specific and spatially regulated activities. Together, we demonstrated directed function for NAC and SRP in heart development, and that regulation of NAC function depends on Hox genes.
    MeSH term(s) Animals ; Humans ; Signal Recognition Particle/metabolism ; Ribosomes/metabolism ; Heart ; Genes, Homeobox ; Drosophila/genetics ; Drosophila/metabolism ; Peptides/metabolism
    Chemical Substances Signal Recognition Particle ; Peptides
    Language English
    Publishing date 2022-10-14
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 2186725-2
    ISSN 1553-7404 ; 1553-7390
    ISSN (online) 1553-7404
    ISSN 1553-7390
    DOI 10.1371/journal.pgen.1010448
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Über den Gartenbau der Zukunft

    Backhaus, Georg F. / Vogler, Ute Katharina

    2018  

    Keywords Text ; ddc:630
    Language German
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: The nutrient sensor CRTC & Sarcalumenin / Thinman represent a new pathway in cardiac hypertrophy.

    Dondi, Cristiana / Vogler, Georg / Gupta, Anjali / Walls, Stanley M / Kervadec, Anaïs / Romero, Michaela R / Diop, Soda B / Goode, Jason / Thomas, John B / Colas, Alexandre R / Bodmer, Rolf / Montminy, Marc / Ocorr, Karen

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Obesity and type 2 diabetes are at epidemic levels and a significant proportion of these patients are diagnosed with left ventricular hypertrophy. ...

    Abstract Obesity and type 2 diabetes are at epidemic levels and a significant proportion of these patients are diagnosed with left ventricular hypertrophy.
    Language English
    Publishing date 2023-10-02
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.10.02.560407
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: A single DPE core promoter motif contributes to

    Sloutskin, Anna / Itzhak, Dekel / Vogler, Georg / Ideses, Diana / Alter, Hadar / Shachar, Hadar / Doniger, Tirza / Frasch, Manfred / Bodmer, Rolf / Duttke, Sascha H / Juven-Gershon, Tamar

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Transcription is initiated at the core promoter, which confers specific functions depending on the unique combination of core promoter elements. The downstream core promoter element (DPE) is found in many genes related to heart and mesodermal development. ...

    Abstract Transcription is initiated at the core promoter, which confers specific functions depending on the unique combination of core promoter elements. The downstream core promoter element (DPE) is found in many genes related to heart and mesodermal development. However, the function of these core promoter elements has thus far been studied primarily in isolated,
    Language English
    Publishing date 2023-06-12
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.06.11.544490
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Cellular Mechanisms of Drosophila Heart Morphogenesis.

    Vogler, Georg / Bodmer, Rolf

    Journal of cardiovascular development and disease

    2015  Volume 2, Issue 1, Page(s) 2–16

    Abstract: Many of the major discoveries in the fields of genetics and developmental biology have been made using the fruit fly, ...

    Abstract Many of the major discoveries in the fields of genetics and developmental biology have been made using the fruit fly,
    Language English
    Publishing date 2015-07-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2777082-5
    ISSN 2308-3425
    ISSN 2308-3425
    DOI 10.3390/jcdd2010002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Overexpression of

    Akasaka, Takeshi / Ocorr, Karen / Lin, Lizhu / Vogler, Georg / Bodmer, Rolf / Grossfeld, Paul

    Journal of cardiovascular development and disease

    2020  Volume 7, Issue 2

    Abstract: Left-sided congenital heart defects (CHDs) are among the most common forms of congenital heart disease, but a disease-causing gene has only been identified in a minority of cases. Here, we identified a candidate gene for CHDs, ...

    Abstract Left-sided congenital heart defects (CHDs) are among the most common forms of congenital heart disease, but a disease-causing gene has only been identified in a minority of cases. Here, we identified a candidate gene for CHDs,
    Language English
    Publishing date 2020-06-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2777082-5
    ISSN 2308-3425 ; 2308-3425
    ISSN (online) 2308-3425
    ISSN 2308-3425
    DOI 10.3390/jcdd7020022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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