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  1. Article: Novel GIRlncRNA Signature for Predicting the Clinical Outcome and Therapeutic Response in NSCLC.

    Zhang, Qiangzhe / Liu, Xicheng / Chen, Zhinan / Zhang, Sihe

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 937531

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-08-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.937531
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  2. Article: TNFSF15 facilitates the differentiation of CD11b

    Gu, Xiangxiang / Zhu, Yipan / Zhao, Cancan / Cao, Yixin / Wang, Jingying / Zhang, Qiangzhe / Li, Luyuan

    Cancer biology & medicine

    2023  Volume 20, Issue 11

    Abstract: Objective: Immature vasculature lacking pericyte coverage substantially contributes to tumor growth, drug resistance, and cancer cell dissemination. We previously demonstrated that tumor necrosis factor superfamily 15 (TNFSF15) is a cytokine with ... ...

    Abstract Objective: Immature vasculature lacking pericyte coverage substantially contributes to tumor growth, drug resistance, and cancer cell dissemination. We previously demonstrated that tumor necrosis factor superfamily 15 (TNFSF15) is a cytokine with important roles in modulating hematopoiesis and vascular homeostasis. The main purpose of this study was to explore whether TNFSF15 might promote freshly isolated myeloid cells to differentiate into CD11b
    Methods: A model of Lewis lung cancer was established in mice with red fluorescent bone marrow. After TNFSF15 treatment, CD11b
    Results: We observed elevated percentages of bone marrow-derived CD11b
    Conclusions: TNFSF15 facilitates the production of CD11b
    MeSH term(s) Animals ; Humans ; Mice ; Cell Differentiation ; Endothelial Cells ; Mice, Inbred C57BL ; Myeloid Cells/metabolism ; Neoplasms/metabolism ; Pericytes/metabolism ; Tumor Necrosis Factor Ligand Superfamily Member 15/metabolism ; Tumor Necrosis Factor Ligand Superfamily Member 15/pharmacology ; Tumor Necrosis Factors/metabolism ; Tumor Necrosis Factors/pharmacology
    Chemical Substances TNFSF15 protein, human ; Tumor Necrosis Factor Ligand Superfamily Member 15 ; Tumor Necrosis Factors ; Tnfsf15 protein, mouse
    Language English
    Publishing date 2023-11-06
    Publishing country China
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2676322-9
    ISSN 2095-3941
    ISSN 2095-3941
    DOI 10.20892/j.issn.2095-3941.2023.0245
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  3. Article ; Online: Signaling in TNFSF15-mediated Suppression of VEGF Production in Endothelial Cells.

    Zhao, Huanyu / Zhang, Qiangzhe

    Methods in molecular biology (Clifton, N.J.)

    2020  Volume 2248, Page(s) 1–18

    Abstract: Vascular endothelial growth factor (VEGF) plays a pivotal role in promoting neovascularization. Tumor necrosis factor superfamily 15 (TNFSF15) is an antiangiogenic cytokine prominently produced by endothelial cells in a normal vasculature. In this study, ...

    Abstract Vascular endothelial growth factor (VEGF) plays a pivotal role in promoting neovascularization. Tumor necrosis factor superfamily 15 (TNFSF15) is an antiangiogenic cytokine prominently produced by endothelial cells in a normal vasculature. In this study, Western blot, quantitative polymerase chain reaction (qPCR), and dual luciferase reporter gene assay were used to validate the mechanisms of TNFSF15-mediated suppression of VEGF production in endothelial cells. We report that TNFSF15 inhibits VEGF production via microRNA-29b (miR-29b) targeting the 3'-UTR of VEGF transcript in mouse endothelial cell line bEnd.3. Neutralizing antibody against TNFSF15, 4-3H, inhibits the level of miR-29b and reinvigorates VEGF. In addition, TNFSF15 activates the JNK signaling pathway as well as the transcription factor GATA3, resulting in enhanced miR-29b production. SP600125, an inhibitor of JNK, eradicates TNFSF15-induced GATA3 expression. Moreover, GATA3 siRNA suppressed TNFSF15-induced miR-29b expression. Together, this study provides evidence and method of activation of the JNK-GATA3 signaling pathway by TNFSF15 that suppresses VEGF gene expression, which gives rise to upregulation of miR-29b.
    MeSH term(s) Animals ; Cell Line ; Endothelial Cells/metabolism ; GATA3 Transcription Factor ; Gene Expression ; Gene Expression Regulation ; Genes, Reporter ; Humans ; MAP Kinase Signaling System/drug effects ; Mice ; MicroRNAs/genetics ; Plasmids/genetics ; RNA Interference ; Real-Time Polymerase Chain Reaction ; Signal Transduction ; Transfection ; Tumor Necrosis Factor Ligand Superfamily Member 15/metabolism ; Vascular Endothelial Growth Factor A/biosynthesis ; Vascular Endothelial Growth Factor A/genetics
    Chemical Substances GATA3 Transcription Factor ; GATA3 protein, human ; MIRN29 microRNA, mouse ; MicroRNAs ; TNFSF15 protein, human ; Tumor Necrosis Factor Ligand Superfamily Member 15 ; Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2020-11-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1130-2_1
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  4. Article: Nanoparticle approaches against SARS-CoV-2 infection.

    Duan, Yaou / Wang, Shuyan / Zhang, Qiangzhe / Gao, Weiwei / Zhang, Liangfang

    Current opinion in solid state & materials science

    2021  Volume 25, Issue 6, Page(s) 100964

    Abstract: Coronavirus disease 2019 (COVID-19), caused by the highly contagious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become the worst pandemic disease of the current millennium. To address this crisis, therapeutic nanoparticles, ... ...

    Abstract Coronavirus disease 2019 (COVID-19), caused by the highly contagious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become the worst pandemic disease of the current millennium. To address this crisis, therapeutic nanoparticles, including inorganic nanoparticles, lipid nanoparticles, polymeric nanoparticles, virus-like nanoparticles, and cell membrane-coated nanoparticles, have all offered compelling antiviral strategies. This article reviews these strategies in three categories: (1) nanoparticle-enabled detection of SARS-CoV-2, (2) nanoparticle-based treatment for COVID-19, and (3) nanoparticle vaccines against SARS-CoV-2. We discuss how nanoparticles are tailor-made to biointerface with the host and the virus in each category. For each nanoparticle design, we highlight its structure-function relationship that enables effective antiviral activity. Overall, nanoparticles bring numerous new opportunities to improve our response to the current COVID-19 pandemic and enhance our preparedness for future viral outbreaks.
    Language English
    Publishing date 2021-10-25
    Publishing country England
    Document type Journal Article
    ISSN 1359-0286
    ISSN 1359-0286
    DOI 10.1016/j.cossms.2021.100964
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  5. Article ; Online: Lure-and-kill macrophage nanoparticles alleviate the severity of experimental acute pancreatitis

    Qiangzhe Zhang / Julia Zhou / Jiarong Zhou / Ronnie H. Fang / Weiwei Gao / Liangfang Zhang

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 12

    Abstract: Phospholipase A2 (PLA2) inhibitors have been shown to be able to treat acute pancreatitis, but are toxic with systemic application. Here the authors design a nanoparticle with macrophage membrane components to carry PLA2 inhibitor to macrophages and ... ...

    Abstract Phospholipase A2 (PLA2) inhibitors have been shown to be able to treat acute pancreatitis, but are toxic with systemic application. Here the authors design a nanoparticle with macrophage membrane components to carry PLA2 inhibitor to macrophages and treat pancreatitis in mice, with no evidence of toxicity.
    Keywords Science ; Q
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: A Supramolecular Strategy to Engineering a Non-photobleaching and Near-Infrared Absorbing Nano-J-Aggregate for Efficient Photothermal Therapy.

    Su, Meihui / Han, Qiuju / Yan, Xiaosa / Liu, Yanan / Luo, Pei / Zhai, Wenhao / Zhang, Qiangzhe / Li, Luyuan / Li, Changhua

    ACS nano

    2021  Volume 15, Issue 3, Page(s) 5032–5042

    Abstract: The design of organic photothermal agents (PTAs) ... ...

    Abstract The design of organic photothermal agents (PTAs) for
    MeSH term(s) Cell Line, Tumor ; Photobleaching ; Phototherapy ; Photothermal Therapy ; Polymers
    Chemical Substances Polymers
    Language English
    Publishing date 2021-02-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.0c09993
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  7. Article ; Online: A Biomimetic Nanoparticle to "Lure and Kill" Phospholipase A2.

    Zhang, Qiangzhe / Fang, Ronnie H / Gao, Weiwei / Zhang, Liangfang

    Angewandte Chemie (International ed. in English)

    2020  Volume 59, Issue 26, Page(s) 10461–10465

    Abstract: Inhibition of phospholipase A2 (PLA2) has long been considered for treating various diseases associated with an elevated PLA2 activity. However, safe and effective PLA2 inhibitors remain unavailable. Herein, we report a biomimetic nanoparticle design ... ...

    Abstract Inhibition of phospholipase A2 (PLA2) has long been considered for treating various diseases associated with an elevated PLA2 activity. However, safe and effective PLA2 inhibitors remain unavailable. Herein, we report a biomimetic nanoparticle design that enables a "lure and kill" mechanism designed for PLA2 inhibition (denoted "L&K-NP"). The L&K-NPs are made of polymeric cores wrapped with modified red blood cell membrane with two inserted key components: melittin and oleyloxyethyl phosphorylcholine (OOPC). Melittin acts as a PLA2 attractant that works together with the membrane lipids to "lure" in-coming PLA2 for attack. Meanwhile, OOPC acts as inhibitor that "kills" PLA2 upon enzymatic attack. Both compounds are integrated into the L&K-NP structure, which voids toxicity associated with free molecules. In the study, L&K-NPs effectively inhibit PLA2-induced hemolysis. In mice administered with a lethal dose of venomous PLA2, L&K-NPs also inhibit hemolysis and confer a significant survival benefit. Furthermore, L&K-NPs show no obvious toxicity in mice. and the design provides a platform technology for a safe and effective anti-PLA2 approach.
    MeSH term(s) Animals ; Biomimetic Materials/chemistry ; Biomimetic Materials/pharmacology ; Biomimetic Materials/toxicity ; Erythrocyte Membrane/chemistry ; Hemolysis/drug effects ; Human Umbilical Vein Endothelial Cells ; Humans ; Male ; Melitten/chemistry ; Melitten/pharmacology ; Melitten/toxicity ; Mice, Inbred ICR ; Nanoparticles/chemistry ; Nanoparticles/toxicity ; Phospholipase A2 Inhibitors/chemistry ; Phospholipase A2 Inhibitors/pharmacology ; Phospholipase A2 Inhibitors/toxicity ; Phospholipases A2/metabolism ; Phosphorylcholine/analogs & derivatives ; Phosphorylcholine/chemistry ; Phosphorylcholine/pharmacology ; Phosphorylcholine/toxicity
    Chemical Substances Phospholipase A2 Inhibitors ; Phosphorylcholine (107-73-3) ; Melitten (20449-79-0) ; oleyloxyethylphosphorylcholine (96720-06-8) ; Phospholipases A2 (EC 3.1.1.4)
    Language English
    Publishing date 2020-04-15
    Publishing country Germany
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202002782
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  8. Article ; Online: Lure-and-kill macrophage nanoparticles alleviate the severity of experimental acute pancreatitis.

    Zhang, Qiangzhe / Zhou, Julia / Zhou, Jiarong / Fang, Ronnie H / Gao, Weiwei / Zhang, Liangfang

    Nature communications

    2021  Volume 12, Issue 1, Page(s) 4136

    Abstract: Acute pancreatitis is a disease associated with suffering and high lethality. Although the disease mechanism is unclear, phospholipase A2 (PLA2) produced by pancreatic acinar cells is a known pathogenic trigger. Here, we show macrophage membrane-coated ... ...

    Abstract Acute pancreatitis is a disease associated with suffering and high lethality. Although the disease mechanism is unclear, phospholipase A2 (PLA2) produced by pancreatic acinar cells is a known pathogenic trigger. Here, we show macrophage membrane-coated nanoparticles with a built-in 'lure and kill' mechanism (denoted 'MΦ-NP(L&K)') for the treatment of acute pancreatitis. MΦ-NP(L&K) are made with polymeric cores wrapped with natural macrophage membrane doped with melittin and MJ-33. The membrane incorporated melittin and MJ-33 function as a PLA2 attractant and a PLA2 inhibitor, respectively. These molecules, together with membrane lipids, work synergistically to lure and kill PLA2 enzymes. These nanoparticles can neutralize PLA2 activity in the sera of mice and human patients with acute pancreatitis in a dose-dependent manner and suppress PLA2-induced inflammatory response accordingly. In mouse models of both mild and severe acute pancreatitis, MΦ-NP(L&K) confer effective protection against disease-associated inflammation, tissue damage and lethality. Overall, this biomimetic nanotherapeutic strategy offers an anti-PLA2 treatment option that might be applicable to a wide range of PLA2-mediated inflammatory disorders.
    MeSH term(s) Acute Disease/therapy ; Animals ; Cytokines ; Disease Models, Animal ; Female ; Humans ; Inflammation ; Macrophages ; Melitten ; Mice ; Nanoparticles/therapeutic use ; Pancreatitis/therapy ; Phospholipases A2/blood ; THP-1 Cells
    Chemical Substances Cytokines ; Melitten (20449-79-0) ; Phospholipases A2 (EC 3.1.1.4)
    Language English
    Publishing date 2021-07-06
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-021-24447-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: CD4

    Zhang, Gang / Campbell, Grant R / Zhang, Qiangzhe / Maule, Erin / Hanna, Jonathan / Gao, Weiwei / Zhang, Liangfang / Spector, Stephen A

    mBio

    2020  Volume 11, Issue 5

    Abstract: Therapeutic strategies that provide effective and broad-spectrum neutralization against HIV-1 infection are highly desirable. Here, we investigate the potential of nanoengineered ... ...

    Abstract Therapeutic strategies that provide effective and broad-spectrum neutralization against HIV-1 infection are highly desirable. Here, we investigate the potential of nanoengineered CD4
    Keywords covid19
    Language English
    Publishing date 2020-09-15
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.00903-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Nanotoxoid vaccination protects against opportunistic bacterial infections arising from immunodeficiency.

    Zhou, Jiarong / Krishnan, Nishta / Guo, Zhongyuan / Ventura, Christian J / Holay, Maya / Zhang, Qiangzhe / Wei, Xiaoli / Gao, Weiwei / Fang, Ronnie H / Zhang, Liangfang

    Science advances

    2022  Volume 8, Issue 36, Page(s) eabq5492

    Abstract: The rise in nosocomial infections caused by multidrug-resistant pathogens is a major public health concern. Patients taking immunosuppressants or chemotherapeutics are naturally more susceptible to infections. Thus, strategies for protecting ... ...

    Abstract The rise in nosocomial infections caused by multidrug-resistant pathogens is a major public health concern. Patients taking immunosuppressants or chemotherapeutics are naturally more susceptible to infections. Thus, strategies for protecting immunodeficient individuals from infections are of great importance. Here, we investigate the effectiveness of a biomimetic nanotoxoid vaccine in defending animals with immunodeficiency against
    MeSH term(s) Animals ; Bacterial Infections ; Pneumonia ; Pseudomonas aeruginosa ; Vaccination/methods ; Virulence Factors
    Chemical Substances Virulence Factors
    Language English
    Publishing date 2022-09-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.abq5492
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