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Book ; Online: New Insights into Food Fermentation

Bernini, Valentina / Lindner, Juliano De Dea

2022

Keywords	Research & information: general ; Biology, life sciences ; Microbiology (non-medical) ; traditional alcoholic beverage ; Ethiopia ; processing ; physicochemical ; fermentative microorganisms ; Arthrospira platensis ; fermentation ; lactic acid bacteria ; food supplement ; aromatic profile ; L. plantarum EM ; rice bran fermentation ; cholesterol removal ; antimicrobial activity ; sensory quality ; lactofermentation ; probiotic ; date fruit bars ; functional snack ; polyphenols ; Grana Padano cheese ; generical hard cheeses ; bacterial diversity ; DNA metabarcoding ; DNA (meta)fingerprinting ; predictive models ; neural network ; swine and pork production chain ; Hepatitis E virus ; Rotavirus-A ; metagenomic analysis ; food safety ; ethnobiology ; ethnozymology ; Mesoamerican biocultural heritage ; traditional food systems ; thyme microcapsules ; Proteus bacillus ; histamine ; histidine decarboxylation pathway ; smoked horsemeat sausage ; fermented fish ; Proteus ; lipase ; volatile compounds ; aldehydes ; esters ; natto ; nattokinase ; combination fermentation ; thrombolytic property ; fish sauce ; biogenic amines ; microbial community dynamics ; starter ; correlation analysis ; natural fermentation ; dry fermented sausages ; microbial biodiversity ; CNC ; 16S metagenomics ; red radish ; cabbage ; fermented foods ; microbial ecology ; flavor components ; n/a
Language	0\|e
Size	1 electronic resource (226 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021608757
ISBN	9783036539195 ; 3036539190
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Chemical Manipulation of the Endosome Trafficking Machinery: Implications for Oligonucleotide Delivery.

Juliano, Rudolph L

Biomedicines

2021 Volume 9, Issue 5

Abstract: Antisense oligonucleotides (ASOs), siRNA and splice switching oligonucleotides (SSOs) all have immense potential as therapeutic agents, potential that is now being validated as oligonucleotides enter the clinic. However, progress in oligonucleotide-based ...

Abstract	Antisense oligonucleotides (ASOs), siRNA and splice switching oligonucleotides (SSOs) all have immense potential as therapeutic agents, potential that is now being validated as oligonucleotides enter the clinic. However, progress in oligonucleotide-based therapeutics has been limited by the difficulty in delivering these complex molecules to their sites of action in the cytosol or nucleus of cells within specific tissues. There are two aspects to the delivery problem. The first is that most types of oligonucleotides have poor uptake into non-hepatic tissues. The second is that much of the oligonucleotide that is taken up by cells is entrapped in endosomes where it is pharmacologically inert. It has become increasingly recognized that endosomal trapping is a key constraint on oligonucleotide therapeutics. Thus, many approaches have been devised to address this problem, primarily ones based on various nanoparticle technologies. However, recently an alternative approach has emerged that employs small molecules to manipulate intracellular trafficking processes so as to enhance oligonucleotide actions. This review presents the current status of this chemical biology approach to oligonucleotide delivery and seeks to point out possible paths for future development.
Language	English
Publishing date	2021-05-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines9050512
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Article ; Online: Intracellular Trafficking and Endosomal Release of Oligonucleotides: What We Know and What We Don't.

Juliano, R L

Nucleic acid therapeutics

2018 Volume 28, Issue 3, Page(s) 166–177

Abstract: Understanding the cellular uptake and intracellular trafficking of oligonucleotides provides an important basic underpinning for the developing field of oligonucleotide-based therapeutics. Whether delivered as "free" oligonucleotides, as ligand- ... ...

Abstract	Understanding the cellular uptake and intracellular trafficking of oligonucleotides provides an important basic underpinning for the developing field of oligonucleotide-based therapeutics. Whether delivered as "free" oligonucleotides, as ligand-oligonucleotide conjugates, or in association with various nanocarriers, all forms of oligonucleotide enter cells by endocytosis and are initially ensconced within membrane-limited vesicles. Accordingly, the locus and extent of release to the cytosol and nucleus are key determinants of the pharmacological actions of oligonucleotides. A number of recent studies have explored the intracellular trafficking of various forms of oligonucleotides and their release from endomembrane compartments. These studies reveal a surprising convergence on an early-intermediate compartment in the trafficking pathway as the key locus of release for oligonucleotides administered in "free" form as well as those delivered with lipid complexes. Thus, oligonucleotide release from multivesicular bodies or from late endosomes seems to be the crucial endogenous process for attaining pharmacological effects. This intrinsic process of oligonucleotide release may be amplified by delivery agents such as lipid complexes or small molecule enhancers.
MeSH term(s)	Biological Transport/drug effects ; Cell Nucleus/drug effects ; Cell Nucleus/metabolism ; Cytosol/drug effects ; Cytosol/metabolism ; Endocytosis/drug effects ; Endosomal Sorting Complexes Required for Transport/genetics ; Endosomal Sorting Complexes Required for Transport/metabolism ; Endosomes/drug effects ; Endosomes/metabolism ; Eukaryotic Cells/drug effects ; Eukaryotic Cells/metabolism ; Gene Transfer Techniques ; Genetic Therapy/methods ; Humans ; Lipids/chemistry ; Nanoparticles/chemistry ; Nanoparticles/metabolism ; Oligonucleotides, Antisense/genetics ; Oligonucleotides, Antisense/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/pharmacology
Chemical Substances	Endosomal Sorting Complexes Required for Transport ; Lipids ; Oligonucleotides, Antisense ; RNA, Small Interfering ; Small Molecule Libraries
Language	English
Publishing date	2018-04-30
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2639888-6
ISSN	2159-3345 ; 2159-3337
ISSN (online)	2159-3345
ISSN	2159-3337
DOI	10.1089/nat.2018.0727
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Article ; Online: Addressing cancer signal transduction pathways with antisense and siRNA oligonucleotides.

Juliano, Rudolph L

NAR cancer

2020 Volume 2, Issue 3, Page(s) zcaa025

Abstract: Signal transduction pathways play key roles in the initiation, progression and dissemination of cancer. Thus, signaling molecules are attractive targets for cancer therapeutics and enormous efforts have gone into the development of small molecule ... ...

Abstract	Signal transduction pathways play key roles in the initiation, progression and dissemination of cancer. Thus, signaling molecules are attractive targets for cancer therapeutics and enormous efforts have gone into the development of small molecule inhibitors of these pathways. However, regrettably, there has been only moderate progress to date, primarily in connection with the RAS signaling pathway. Oligonucleotide-based drugs potentially offer several advantages for addressing signaling pathways, including their exquisite selectivity and their ability to exploit both enzymatic and nonenzymatic targets. Nonetheless, there are problems inherent in the oligonucleotide approach, not the least being the challenge of effectively delivering these complex molecules to intracellular sites within tumors. This survey article will provide a selective review of recent studies where oligonucleotides were used to address cancer signaling and will discuss both positive aspects and limitations of those studies. This will be set in the context of an overview of various cancer signaling pathways and small molecule approaches to regulate those pathways. The survey will also evaluate the challenges and opportunities implicit in the oligonucleotide-based approach to cancer signaling and will point out several possibilities for future research.
Language	English
Publishing date	2020-09-25
Publishing country	England
Document type	Journal Article
ISSN	2632-8674
ISSN (online)	2632-8674
DOI	10.1093/narcan/zcaa025
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Article ; Online: Collision Induced Unfolding Enables the Quantitation of Isomass Biotherapeutics in Complex Biological Matrices.

Juliano, Brock R / Ruotolo, Brandon T

Journal of the American Society for Mass Spectrometry

2023 Volume 34, Issue 10, Page(s) 2350–2357

Abstract: Quantitative mass spectrometry has been widely used to evaluate the concentrations of molecules within a variety of biological matrices. Typically, such quantitative mass spectrometry analyses are predicated upon the production of mass-resolved precursor ...

Abstract	Quantitative mass spectrometry has been widely used to evaluate the concentrations of molecules within a variety of biological matrices. Typically, such quantitative mass spectrometry analyses are predicated upon the production of mass-resolved precursor or fragment ions, leading to challenges surrounding the quantification of isomeric or conformationally distinct analytes. As such, new approaches are required for the label-free quantification of isomass proteins. Native ion-mobility MS (nIM-MS) in combination with collision induced unfolding (CIU) is a potentially enabling approach for such quantitative mass spectrometry methods as the technique can rapidly separate and detect many biomacromolecule isoforms. CIU uses collisional activation to capture the unfolding trajectory of ions in the gas phase, producing different intermediate structures that can be leveraged to distinguish protein structures that exhibit identical sizes at lower energies. Here we describe the deployment of quantitative CIU methodology to measure the concentrations of isomass pairs of biotherapeutics and sequence homologues in both standard and biological matrices. Our results cover three antibody pairs and include examples of mixed therapies where multiple biologics are commonly provided to patients. In all cases, CIU enables the production of resolved features for each antibody mixture probed, producing calibration curves with correlation coefficients ranging from 0.92 to 0.99, limits of detection ranging from 300 to 5000 nM and sensitivities ranging from 8.7 × 10
MeSH term(s)	Humans ; Ion Mobility Spectrometry/methods ; Protein Unfolding ; Biological Products/analysis ; Biological Products/chemistry ; Mass Spectrometry/methods ; Protein Isoforms/analysis ; Protein Isoforms/chemistry ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/analysis
Chemical Substances	Biological Products ; Protein Isoforms ; Antibodies, Monoclonal
Language	English
Publishing date	2023-08-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	1073671-2
ISSN	1879-1123 ; 1044-0305
ISSN (online)	1879-1123
ISSN	1044-0305
DOI	10.1021/jasms.3c00234
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Article ; Online: The delivery of therapeutic oligonucleotides.

Juliano, Rudolph L

Nucleic acids research

2016 Volume 44, Issue 14, Page(s) 6518–6548

Abstract: The oligonucleotide therapeutics field has seen remarkable progress over the last few years with the approval of the first antisense drug and with promising developments in late stage clinical trials using siRNA or splice switching oligonucleotides. ... ...

Abstract	The oligonucleotide therapeutics field has seen remarkable progress over the last few years with the approval of the first antisense drug and with promising developments in late stage clinical trials using siRNA or splice switching oligonucleotides. However, effective delivery of oligonucleotides to their intracellular sites of action remains a major issue. This review will describe the biological basis of oligonucleotide delivery including the nature of various tissue barriers and the mechanisms of cellular uptake and intracellular trafficking of oligonucleotides. It will then examine a variety of current approaches for enhancing the delivery of oligonucleotides. This includes molecular scale targeted ligand-oligonucleotide conjugates, lipid- and polymer-based nanoparticles, antibody conjugates and small molecules that improve oligonucleotide delivery. The merits and liabilities of these approaches will be discussed in the context of the underlying basic biology.
MeSH term(s)	Animals ; Gene Transfer Techniques ; Humans ; Ligands ; Nucleic Acids/therapeutic use ; Oligonucleotides/therapeutic use ; Receptors, Cell Surface/metabolism
Chemical Substances	Ligands ; Nucleic Acids ; Oligonucleotides ; Receptors, Cell Surface
Language	English
Publishing date	2016-08-19
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkw236
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Article ; Online: Anthropometric, neuromuscular, physiologic and training variables as determinants to laboratory cycling performance.

Lanferdini, Fábio J / Kons, Rafael L / Detanico, Daniele / Dal Pupo, Juliano / DE Lucas, Ricardo D / Vaz, Marco A

The Journal of sports medicine and physical fitness

2024 Volume 64, Issue 5, Page(s) 432–438

Abstract: ... evaluated of both legs.: Results: Cyclists' height (r: Conclusions: These results suggest ...

Abstract	Background: The goal of this study was to verify whether anthropometric, physiological and neuromuscular factors, as well as training characteristics, could predict cycling performance during maximal incremental and time-to-exhaustion tests. Methods: Twenty cyclists were evaluated: Anthropometric variables, knee extensor muscle activation and architecture, training history, and training volume were assessed. Second ventilatory threshold (VT<inf>2</inf>), maximal oxygen uptake (VO<inf>2MAX</inf>), and maximal power output (PO<inf>MAX</inf>) were assessed during the incremental test. Muscle architecture of the vastus lateralis (VL) and rectus femoris (RF) muscles was evaluated bilaterally to calculate the mean thighs' muscle thickness, pennation angle and fascicle length, at rest condition. After that, time-to-exhaustion test at PO<inf>MAX</inf> was performed. Muscle activation of the VL, RF and vastus medialis (VM) was evaluated of both legs. Results: Cyclists' height (r Conclusions: These results suggest that training characteristics and experience are important when training for incremental cycling conditions, whereas cadence (and its determinant variables) should be looked at during maximal and exhaustive conditions.
MeSH term(s)	Humans ; Bicycling/physiology ; Male ; Adult ; Athletic Performance/physiology ; Oxygen Consumption/physiology ; Exercise Test ; Muscle, Skeletal/physiology ; Anthropometry ; Quadriceps Muscle/physiology ; Young Adult
Language	English
Publishing date	2024-02-27
Publishing country	Italy
Document type	Journal Article
ZDB-ID	410823-1
ISSN	1827-1928 ; 0022-4707
ISSN (online)	1827-1928
ISSN	0022-4707
DOI	10.23736/S0022-4707.24.15547-8
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Article ; Online: Role of Cav2.3 (R-type) Calcium Channel in Pain and Analgesia: A Scoping Review.

de Amorim Ferreira, Marcella / Ferreira, Juliano

Current neuropharmacology

2023

Abstract: ... the participation of Cav2.3 (that gives rise to R-type calcium currents) in pain and analgesia remains incompletely ...

Abstract	Background: Voltage-gated calcium channels (VGCCs) play an important role in pain development and maintenance. As Cav2.2 and Cav3.2 channels have been identified as potential drug targets for analgesics, the participation of Cav2.3 (that gives rise to R-type calcium currents) in pain and analgesia remains incompletely understood. Objective: Identify the participation of Cav2.3 in pain and analgesia. Methods: To map research in this area as well as to identify any existing gaps in knowledge on the potential role of Cav2.3 in pain signalling, we conducted this scoping review. We searched PubMed and SCOPUS databases, and 40 articles were included in this study. Besides, we organized the studies into 5 types of categories within the broader context of the role of Cav2.3 in pain and analgesia. Results: Some studies revealed the expression of Cav2.3 in pain pathways, especially in nociceptive neurons at the sensory ganglia. Other studies demonstrated that Cav2.3-mediated currents could be in-hibited by analgesic/antinociceptive drugs either indirectly or directly. Some articles indicated that Cav2.3 modulates nociceptive transmission, especially at the pre-synaptic level at spinal sites. There are studies using different rodent pain models and approaches to reduce Cav2.3 activity or expression and mostly demonstrated a pro-nociceptive role of Cav2.3, despite some contradictory findings and deficiencies in the description of study design quality. There are three studies that reported the association of single-nucleotide polymorphisms in the Cav2.3 gene (CACNA1E) with postoperative pain and opioid consumption as well as with the prevalence of migraine in patients. Conclusion: Cav2.3 is a target for some analgesic drugs and has a pro-nociceptive role in pain.
Language	English
Publishing date	2023-08-11
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2192352-8
ISSN	1875-6190 ; 1570-159X
ISSN (online)	1875-6190
ISSN	1570-159X
DOI	10.2174/1570159X21666230811102700
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Article: Pharmacological stimulation of infralimbic cortex after fear conditioning facilitates subsequent fear extinction.

Bayer, Hugo / Hassell, James E / Oleksiak, Cecily R / Garcia, Gabriela M / Vaughan, Hollis L / Juliano, Vitor A L / Maren, Stephen

bioRxiv : the preprint server for biology

2024

Abstract: The infralimbic (IL) division of the medial prefrontal cortex (mPFC) is a crucial site for extinction of conditioned fear memories in rodents. Recent work suggests that neuronal plasticity in the IL that occurs during (or soon after) fear conditioning ... ...

Abstract	The infralimbic (IL) division of the medial prefrontal cortex (mPFC) is a crucial site for extinction of conditioned fear memories in rodents. Recent work suggests that neuronal plasticity in the IL that occurs during (or soon after) fear conditioning enables subsequent IL-dependent extinction learning. We therefore hypothesized that pharmacological activation of the IL after fear conditioning would promote the extinction of conditioned fear. To test this hypothesis, we characterized the effects of post-conditioning infusions of the GABA
Language	English
Publishing date	2024-03-27
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.03.23.586410
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Article ; Online: Recent Developments in Oligonucleotide Based Therapeutics. Preface.

Juliano, R L / Ming, Xin

Advanced drug delivery reviews

2015 Volume 87, Page(s) 1–2

MeSH term(s)	Biotechnology ; Drug Discovery ; Oligonucleotides/administration & dosage ; Oligonucleotides/therapeutic use
Chemical Substances	Oligonucleotides
Language	English
Publishing date	2015-06-29
Publishing country	Netherlands
Document type	Introductory Journal Article
ZDB-ID	639113-8
ISSN	1872-8294 ; 0169-409X
ISSN (online)	1872-8294
ISSN	0169-409X
DOI	10.1016/j.addr.2015.06.010
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