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Article ; Online: Adolescent THC Treatment Does Not Potentiate the Behavioral Effects in Adulthood of Maternal Immune Activation.

Stollenwerk, Todd M / Hillard, Cecilia J

2021 Volume 10, Issue 12

Abstract: Both in utero exposure to maternal immune activation and cannabis use during adolescence have been associated with increased risk for the development of schizophrenia; however, whether these exposures exert synergistic effects on brain function is not ... ...

Abstract	Both in utero exposure to maternal immune activation and cannabis use during adolescence have been associated with increased risk for the development of schizophrenia; however, whether these exposures exert synergistic effects on brain function is not known. In the present study, mild maternal immune activation (MIA) was elicited in mice with prenatal exposure to polyinosinic-polycytidylic acid (poly(I:C)), and ∆
MeSH term(s)	Aging/physiology ; Amphetamine ; Animals ; Behavior, Animal/drug effects ; Conditioning, Classical ; Dronabinol/pharmacology ; Extinction, Psychological/drug effects ; Fear/drug effects ; Female ; Locomotion/drug effects ; Male ; Maze Learning/physiology ; Mice, Inbred C57BL ; Pregnancy ; Prenatal Exposure Delayed Effects/immunology ; Prepulse Inhibition/drug effects ; Rats, Sprague-Dawley ; Reflex, Startle/drug effects ; Swimming ; Mice ; Rats
Chemical Substances	Dronabinol (7J8897W37S) ; Amphetamine (CK833KGX7E)
Language	English
Publishing date	2021-12-11
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells10123503
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Cannabinoid CB

Guenther, Kelsey G / Lin, Xiaoyan / Xu, Zhili / Makriyannis, Alexandros / Romero, Julian / Hillard, Cecilia J / Mackie, Ken / Hohmann, Andrea G

bioRxiv : the preprint server for biology

2024

Abstract: Cannabinoid ... ...

Abstract	Cannabinoid CB
Language	English
Publishing date	2024-03-10
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.03.05.583426
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Peripherally restricted cannabinoid type 1 receptor (CB1R) antagonist, AM6545, potentiates stress-induced hypothalamic-pituitary-adrenal axis activation via a non-CB1R mechanism.

Roberts, Christopher J / Hillard, Cecilia J

Endocrine

2020 Volume 72, Issue 1, Page(s) 297–300

MeSH term(s)	Animals ; Cannabinoid Receptor Antagonists/pharmacology ; Female ; Hypothalamo-Hypophyseal System ; Male ; Mice, Inbred ICR ; Morpholines ; Pituitary-Adrenal System ; Pyrazoles ; Receptor, Cannabinoid, CB1 ; Mice
Chemical Substances	AM6545 ; Cannabinoid Receptor Antagonists ; Morpholines ; Pyrazoles ; Receptor, Cannabinoid, CB1
Language	English
Publishing date	2020-11-20
Publishing country	United States
Document type	Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1194484-5
ISSN	1559-0100 ; 1355-008X ; 0969-711X
ISSN (online)	1559-0100
ISSN	1355-008X ; 0969-711X
DOI	10.1007/s12020-020-02549-1
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Zs.A 3884: Show issues

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Article ; Online: Circulating Endocannabinoids: From Whence Do They Come and Where are They Going?

Hillard, Cecilia J

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

2017 Volume 43, Issue 1, Page(s) 155–172

Abstract: The goal of this review is to summarize studies in which concentrations of circulating endocannabinoids in humans have been examined in relationship to physiological measurements and pathological status. The roles of endocannabinoids in the regulation of ...

Abstract	The goal of this review is to summarize studies in which concentrations of circulating endocannabinoids in humans have been examined in relationship to physiological measurements and pathological status. The roles of endocannabinoids in the regulation of energy intake and storage have been well studied and the data obtained consistently support the hypothesis that endocannabinoid signaling is associated with increased consumption and storage of energy. Physical exercise mobilizes endocannabinoids, which could contribute to refilling of energy stores and also to the analgesic and mood-elevating effects of exercise. Circulating concentrations of 2-arachidonoylglycerol are very significantly circadian and dysregulated when sleep is disrupted. Other conditions under which circulating endocannabinoids are altered include inflammation and pain. A second important role for endocannabinoid signaling is to restore homeostasis following stress. Circulating endocannabinoids are stress-responsive and there is evidence that their concentrations are altered in disorders associated with excessive stress, including post-traumatic stress disorder. Although determination of circulating endocannabinoids can provide important information about the state of endocannabinoid signaling and thus allow for hypotheses to be defined and tested, the large number of physiological factors that contribute to their circulating concentrations makes it difficult to use them in isolation as a biomarker for a specific disorder.
MeSH term(s)	Animals ; Endocannabinoids/blood ; Humans
Chemical Substances	Endocannabinoids
Language	English
Publishing date	2017-06-27
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	639471-1
ISSN	1740-634X ; 0893-133X
ISSN (online)	1740-634X
ISSN	0893-133X
DOI	10.1038/npp.2017.130
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Zs.A 2379: Show issues

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Article ; Online: Conditional deletion of CB2 cannabinoid receptors from peripheral sensory neurons eliminates CB2-mediated antinociceptive efficacy in a mouse model of carrageenan-induced inflammatory pain.

Guenther, Kelsey G / Xu, Zhili / Romero, Julian / Hillard, Cecilia J / Mackie, Ken / Hohmann, Andrea G

Neuropharmacology

2023 Volume 237, Page(s) 109601

Abstract: ... ...

Abstract	CB
MeSH term(s)	Animals ; Female ; Male ; Mice ; Analgesics/pharmacology ; Analgesics/therapeutic use ; Carrageenan/adverse effects ; Hyperalgesia/chemically induced ; Hyperalgesia/drug therapy ; Hyperalgesia/metabolism ; Pain/drug therapy ; Receptor, Cannabinoid, CB1 ; Receptor, Cannabinoid, CB2/genetics ; Receptors, Cannabinoid ; Sensory Receptor Cells
Chemical Substances	Analgesics ; Carrageenan (9000-07-1) ; Receptor, Cannabinoid, CB1 ; Receptor, Cannabinoid, CB2 ; Receptors, Cannabinoid ; Cnr2 protein, mouse
Language	English
Publishing date	2023-06-05
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	218272-5
ISSN	1873-7064 ; 0028-3908
ISSN (online)	1873-7064
ISSN	0028-3908
DOI	10.1016/j.neuropharm.2023.109601
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Ui I Zs.242: Show issues

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Article ; Online: Contribution of the Adenosine 2A Receptor to Behavioral Effects of Tetrahydrocannabinol, Cannabidiol and PECS-101.

Stollenwerk, Todd M / Pollock, Samantha / Hillard, Cecilia J

Molecules (Basel, Switzerland)

2021 Volume 26, Issue 17

Abstract: The cannabis-derived molecules, ∆ ...

Abstract	The cannabis-derived molecules, ∆
MeSH term(s)	Animals ; Cannabidiol/analogs & derivatives ; Cannabidiol/pharmacology ; Dronabinol/administration & dosage ; Dronabinol/pharmacology ; Exploratory Behavior/drug effects ; Injections, Intraperitoneal ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Receptor, Adenosine A2A/deficiency ; Receptor, Adenosine A2A/metabolism
Chemical Substances	Receptor, Adenosine A2A ; Cannabidiol (19GBJ60SN5) ; Dronabinol (7J8897W37S)
Language	English
Publishing date	2021-09-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26175354
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Zs.MO 81: Show issues

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Article ; Online: The endocannabinoid system as a putative target for the development of novel drugs for the treatment of psychiatric illnesses.

Hill, Matthew N / Haney, Margaret / Hillard, Cecilia J / Karhson, Debra S / Vecchiarelli, Haley A

Psychological medicine

2023 Volume 53, Issue 15, Page(s) 7006–7024

Abstract: Cannabis is well established to impact affective states, emotion and perceptual processing, primarily through its interactions with the endocannabinoid system. While cannabis use is quite prevalent in many individuals afflicted with psychiatric illnesses, ...

Abstract	Cannabis is well established to impact affective states, emotion and perceptual processing, primarily through its interactions with the endocannabinoid system. While cannabis use is quite prevalent in many individuals afflicted with psychiatric illnesses, there is considerable controversy as to whether cannabis may worsen these conditions or provide some form of therapeutic benefit. The development of pharmacological agents which interact with components of the endocannabinoid system in more localized and discrete ways then via phytocannabinoids found in cannabis, has allowed the investigation if direct targeting of the endocannabinoid system itself may represent a novel approach to treat psychiatric illness without the potential untoward side effects associated with cannabis. Herein we review the current body of literature regarding the various pharmacological tools that have been developed to target the endocannabinoid system, their impact in preclinical models of psychiatric illness and the recent data emerging of their utilization in clinical trials for psychiatric illnesses, with a specific focus on substance use disorders, trauma-related disorders, and autism. We highlight several candidate drugs which target endocannabinoid function, particularly inhibitors of endocannabinoid metabolism or modulators of cannabinoid receptor signaling, which have emerged as potential candidates for the treatment of psychiatric conditions, particularly substance use disorder, anxiety and trauma-related disorders and autism spectrum disorders. Although there needs to be ongoing clinical work to establish the potential utility of endocannabinoid-based drugs for the treatment of psychiatric illnesses, the current data available is quite promising and shows indications of several potential candidate diseases which may benefit from this approach.
MeSH term(s)	Humans ; Endocannabinoids ; Mental Disorders/drug therapy ; Anxiety ; Anxiety Disorders ; Cannabis ; Cannabinoid Receptor Agonists ; Hallucinogens
Chemical Substances	Endocannabinoids ; Cannabinoid Receptor Agonists ; Hallucinogens
Language	English
Publishing date	2023-09-06
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	217420-0
ISSN	1469-8978 ; 0033-2917
ISSN (online)	1469-8978
ISSN	0033-2917
DOI	10.1017/S0033291723002465
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Zs.B 1003: Show issues

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Article ; Online: The Endocannabinoid Signaling System in the CNS: A Primer.

Hillard, Cecilia J

International review of neurobiology

2015 Volume 125, Page(s) 1–47

Abstract: The purpose of this chapter is to provide an introduction to the mechanisms for the regulation of endocannabinoid signaling through CB1 cannabinoid receptors in the central nervous system. The processes involved in the synthesis and degradation of the ... ...

Abstract	The purpose of this chapter is to provide an introduction to the mechanisms for the regulation of endocannabinoid signaling through CB1 cannabinoid receptors in the central nervous system. The processes involved in the synthesis and degradation of the two most well-studied endocannabinoids, 2-arachidonoylglycerol and N-arachidonylethanolamine are outlined along with information regarding the regulation of the proteins involved. Signaling mechanisms and pharmacology of the CB1 cannabinoid receptor are outlined, as is the paradigm of endocannabinoid/CB1 receptor regulation of neurotransmitter release. The reader is encouraged to appreciate the importance of the endocannabinoid/CB1 receptor signaling system in the regulation of synaptic activity in the brain.
MeSH term(s)	Animals ; Central Nervous System/physiology ; Endocannabinoids/physiology ; Humans ; Signal Transduction/physiology
Chemical Substances	Endocannabinoids
Language	English
Publishing date	2015-11-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	209876-3
ISSN	2162-5514 ; 0074-7742
ISSN (online)	2162-5514
ISSN	0074-7742
DOI	10.1016/bs.irn.2015.10.001
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Ui II Zs.180: Show issues

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Article: Endocannabinoids and the Endocrine System in Health and Disease.

Hillard, Cecilia J

Handbook of experimental pharmacology

2015 Volume 231, Page(s) 317–339

Abstract: Some of the earliest reports of the effects of cannabis consumption on humans were related to endocrine system changes. In this review, the effects of cannabinoids and the role of the CB1 cannabinoid receptor in the regulation of the following endocrine ... ...

Abstract	Some of the earliest reports of the effects of cannabis consumption on humans were related to endocrine system changes. In this review, the effects of cannabinoids and the role of the CB1 cannabinoid receptor in the regulation of the following endocrine systems are discussed: the hypothalamic-pituitary-gonadal axis, prolactin and oxytocin, thyroid hormone and growth hormone, and the hypothalamic-pituitary-adrenal axis. Preclinical and human study results are presented.
MeSH term(s)	Animals ; Endocannabinoids/metabolism ; Female ; Growth Hormone/metabolism ; Humans ; Hypothalamo-Hypophyseal System/metabolism ; Hypothalamo-Hypophyseal System/physiopathology ; Lactation/metabolism ; Male ; Oxytocin/metabolism ; Pituitary-Adrenal System/metabolism ; Pituitary-Adrenal System/physiopathology ; Prolactin/metabolism ; Receptor, Cannabinoid, CB1/metabolism ; Signal Transduction ; Thyroid Gland/metabolism ; Thyroid Gland/physiopathology ; Thyroid Hormones/metabolism
Chemical Substances	Endocannabinoids ; Receptor, Cannabinoid, CB1 ; Thyroid Hormones ; Oxytocin (50-56-6) ; Prolactin (9002-62-4) ; Growth Hormone (9002-72-6)
Language	English
Publishing date	2015-06-23
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ISSN	0171-2004
ISSN	0171-2004
DOI	10.1007/978-3-319-20825-1_11
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Article ; Online: Adolescent THC Treatment Does Not Potentiate the Behavioral Effects in Adulthood of Maternal Immune Activation

Todd M. Stollenwerk / Cecilia J. Hillard

Cells, Vol 10, Iss 3503, p

2021 Volume 3503

Abstract	Both in utero exposure to maternal immune activation and cannabis use during adolescence have been associated with increased risk for the development of schizophrenia; however, whether these exposures exert synergistic effects on brain function is not known. In the present study, mild maternal immune activation (MIA) was elicited in mice with prenatal exposure to polyinosinic-polycytidylic acid (poly(I:C)), and ∆ 9 -tetrahydrocannabinol (THC) was provided throughout adolescence in cereal (3 mg/kg/day for 5 days). Neither THC nor MIA pretreatments altered activity in assays used to characterize hyperdopaminergic states in adulthood: amphetamine hyperlocomotion and prepulse inhibition of the acoustic startle reflex. Adolescent THC treatment elicited deficits in spatial memory and enhanced spatial reversal learning in adult female mice in the Morris water maze, while exposure to MIA elicited female-specific deficits in fear extinction learning in adulthood. There were no effects in these assays in adult males, nor were there interactions between THC and MIA in adult females. While doses of poly(I:C) and THC were sufficient to elicit behavioral effects, particularly relating to cognitive performance in females, there was no evidence that adolescent THC exposure synergized with the risk imposed by MIA to worsen behavioral outcomes in adult mice of either sex.
Keywords	polyinosinic-polycytidylic acid ; schizophrenia ; amphetamine hyperlocomotion ; prepulse inhibition ; Morris water maze ; fear conditioning ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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