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Article ; Online: Treatment of lymphangioleiomyomatosis and Camões.

Rufino, Rogério

Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia

2015 Volume 41, Issue 4, Page(s) 295–296

MeSH term(s)	Everolimus/therapeutic use ; Humans ; Immunosuppressive Agents/therapeutic use ; Lung Transplantation ; Lymphangioleiomyomatosis/diagnosis ; Lymphangioleiomyomatosis/therapy ; Rare Diseases/diagnosis ; Rare Diseases/therapy ; Sirolimus/therapeutic use ; TOR Serine-Threonine Kinases/antagonists & inhibitors
Chemical Substances	Immunosuppressive Agents ; Everolimus (9HW64Q8G6G) ; TOR Serine-Threonine Kinases (EC 2.7.1.1) ; Sirolimus (W36ZG6FT64)
Language	Portuguese
Publishing date	2015-07
Publishing country	Brazil
Document type	Editorial
ZDB-ID	2223157-2
ISSN	1806-3756 ; 1806-3713
ISSN (online)	1806-3756
ISSN	1806-3713
DOI	10.1590/S1806-37132015000400001
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Article ; Online: Treatment of lymphangioleiomyomatosis and Camões

Rogério Rufino

Jornal Brasileiro de Pneumologia, Vol 41, Iss 4, Pp 295-

2015 Volume 296

Keywords	Diseases of the respiratory system ; RC705-779 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
Language	Portuguese
Publishing date	2015-08-01T00:00:00Z
Publisher	Sociedade Brasileira de Pneumologia e Tisiologia
Document type	Article ; Online
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Article ; Online: Strength training for arterial hypertension treatment: a systematic review and meta-analysis of randomized clinical trials.

Correia, Rafael Ribeiro / Veras, Allice Santos Cruz / Tebar, William Rodrigues / Rufino, Jéssica Costa / Batista, Victor Rogério Garcia / Teixeira, Giovana Rampazzo

Scientific reports

2023 Volume 13, Issue 1, Page(s) 201

Abstract: Cardiovascular diseases are the leading cause of death in the world and arterial hypertension (AH) accounts for 13.8% of deaths caused by cardiovascular diseases. Strength training interventions could be an important alternative tool for blood pressure ... ...

Abstract	Cardiovascular diseases are the leading cause of death in the world and arterial hypertension (AH) accounts for 13.8% of deaths caused by cardiovascular diseases. Strength training interventions could be an important alternative tool for blood pressure control, however, consistent evidence and the most effective training protocol for this purpose are yet to be established. The current study used the Cochrane methodology to systematically review randomized controlled trials (RCTs) that investigated the effect of strength training on blood pressure in hypertensive patients. A systematic search was conducted in the PubMed, EMBASE, Scopus, Cochrane Library, and World Health Organization databases. This review included controlled trials that evaluated the effect of strength training for 8 weeks or more in adults with arterial hypertension, published up to December 2020. Data are described and reported as the weighted mean difference of systolic and diastolic pressure and a 95% confidence interval. Protocol registration: PROSPERO registration number CRD42020151269. A total of 14 studies were identified, including a combined total of 253 participants with hypertension. The meta-analysis showed that mean values of systolic blood pressure (SBP) and diastolic blood pressure (DBP) decreased significantly after strength training interventions. The strongest effect of strength training on decreasing blood pressure was observed in protocols with a moderate to vigorous load intensity (> 60% of one-repetition maximum-1RM), a frequency of at least 2 times per week, and a minimum duration of 8 weeks. We concluded that strength training interventions can be used as a non-drug treatment for arterial hypertension, as they promote significant decreases in blood pressure.
MeSH term(s)	Adult ; Humans ; Cardiovascular Diseases ; Resistance Training/methods ; Randomized Controlled Trials as Topic ; Hypertension/drug therapy ; Blood Pressure/physiology
Language	English
Publishing date	2023-01-05
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-26583-3
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Article ; Online: Reanalysis and validation of the transcriptional pleural fluid signature in pleural tuberculosis.

Corrêa, Raquel da Silva / Leal-Calvo, Thyago / Mafort, Thiago Thomaz / Santos, Ana Paula / Leung, Janaína / Pinheiro, Roberta Olmo / Rufino, Rogério / Moraes, Milton Ozório / Rodrigues, Luciana Silva

Frontiers in immunology

2024 Volume 14, Page(s) 1256558

Abstract: Introduction: Pleural tuberculosis (PlTB), the most common site of extrapulmonary TB, is characterized by a paucibacillary nature and a compartmentalized inflammatory response in the pleural cavity, both of which make diagnosis and management extremely ... ...

Abstract	Introduction: Pleural tuberculosis (PlTB), the most common site of extrapulmonary TB, is characterized by a paucibacillary nature and a compartmentalized inflammatory response in the pleural cavity, both of which make diagnosis and management extremely challenging. Although transcriptional signatures for pulmonary TB have already been described, data obtained by using this approach for extrapulmonary tuberculosis and, specifically, for pleural tuberculosis are scarce and heterogeneous. In the present study, a set of candidate genes previously described in pulmonary TB was evaluated to identify and validate a transcriptional signature in clinical samples from a Brazilian cohort of PlTB patients and those with other exudative causes of pleural effusion. Methods: As a first step, target genes were selected by a random forest algorithm with recursive feature elimination (RFE) from public microarray datasets. Then, peripheral blood (PB) and pleural fluid (PF) samples from recruited patients presenting exudative pleural effusion were collected during the thoracentesis procedure. Transcriptional analysis of the selected top 10 genes was performed by quantitative RT-PCR (RT-qPCR). Results: Reanalysis of the public datasets identified a set of candidate genes ( Conclusion: CARD17
MeSH term(s)	Humans ; Tuberculosis, Pleural/diagnosis ; Tuberculosis, Pleural/genetics ; Exudates and Transudates ; Tuberculosis, Pulmonary ; Pleural Effusion/diagnosis ; Pleural Effusion/genetics ; Pleural Effusion/metabolism ; Brazil ; Butyrophilins ; Antigens, CD
Chemical Substances	BTN3A1 protein, human ; Butyrophilins ; Antigens, CD
Language	English
Publishing date	2024-01-15
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1256558
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Article ; Online: Small airway evaluation in three subjects with alpha-1 antitrypsin deficiency without diagnosed lung disease.

Ferrari da Cruz, Thais / Rufino, Rogério / Lopes, Agnaldo / Henrique Costa, Cláudia

BMJ case reports

2021 Volume 14, Issue 3

Abstract: We describe three cases of female subjects (aged 16, 44 and 41 years) with no respiratory symptoms, who have alpha-1 antitripsyn mutation (PiSZ, PiZZ and PiZZ) and who performed traditional pulmonary function tests and the single breath nitrogen washout ... ...

Abstract	We describe three cases of female subjects (aged 16, 44 and 41 years) with no respiratory symptoms, who have alpha-1 antitripsyn mutation (PiSZ, PiZZ and PiZZ) and who performed traditional pulmonary function tests and the single breath nitrogen washout test. They still did not have chronic obstructive pulmonary disease (COPD) or any identifiable change in traditional pulmonary function tests but already have change in nitrogen washout tests. Alpha-1 antitrypsin deficiency is a genetic disorder associated with early-onset COPD. There is evidence that although patients who have well-preserved FEV
MeSH term(s)	Adolescent ; Adult ; Female ; Humans ; Lung Diseases ; Phenotype ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Emphysema/diagnostic imaging ; alpha 1-Antitrypsin/genetics ; alpha 1-Antitrypsin Deficiency/complications ; alpha 1-Antitrypsin Deficiency/diagnosis ; alpha 1-Antitrypsin Deficiency/genetics
Chemical Substances	alpha 1-Antitrypsin
Language	English
Publishing date	2021-03-30
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2020-239146
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Article ; Online: Follow-up of a cohort of patients with noncystic fibrosis bronchiectasis for 1 year.

Mateus, Simone Paulo / Salles, Raquel Esteves Brandão / Costa, Walter / Costa, Claudia Henrique da / Lopes, Agnaldo José / Tura, Bernardo Rangel / Rufino, Rogério

Revista da Associacao Medica Brasileira (1992)

2022 Volume 68, Issue 3, Page(s) 329–336

Abstract: Objective: The objective of this study was to evaluate the quality of life of patients with noncystic fibrosis bronchiectasis during a 1-year follow-up by using the EuroQol - 5 Dimensions - 3 Levels (EQ-5D-3L) questionnaire.: Methods: A cohort study ... ...

Abstract	Objective: The objective of this study was to evaluate the quality of life of patients with noncystic fibrosis bronchiectasis during a 1-year follow-up by using the EuroQol - 5 Dimensions - 3 Levels (EQ-5D-3L) questionnaire. Methods: A cohort study was conducted with 100 patients with noncystic fibrosis bronchiectasis and followed up with face-to-face visits or by telephone contact every 3 months for 1 year. All patients were recruited from a single referral center for bronchiectasis. At the time of recruiting and at the end of 1 year, the EQ-5D-3L questionnaire was applied to evaluate the patients' quality of life. Variables, such as exacerbation, emergency care, comorbidities, hemoptysis, colonization, and hospitalization, were assessed. Results: Of the 100 patients, 99 completed the study and 72% were women. There were no marked limitations in the mobility and self-care domains during the follow-up. At the end of the follow-up, 32 patients were extremely anxious or depressed. The quality of life assessed by using EQ-5D-3L had an initial mean score of 0.545 and of 0.589 after 1 year, which was statistically significant (p=0.011). Conclusion: Patients with noncystic fibrosis bronchiectasis have a poor quality of life, and the EQ-5D-3L questionnaire may be a tool for monitoring patients with bronchiectasis.
MeSH term(s)	Bronchiectasis ; Cohort Studies ; Female ; Fibrosis ; Follow-Up Studies ; Humans ; Male ; Quality of Life ; Surveys and Questionnaires
Language	English
Publishing date	2022-04-15
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	731969-1
ISSN	1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
ISSN (online)	1806-9282
ISSN	0104-4230 ; 0004-5241 ; 0102-843X
DOI	10.1590/1806-9282.20210710
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Article ; Online: Use of fractional exhaled nitric oxide as a potential predictor of bronchodilator response.

Provenzano, Bruna Cuoco / Bartholo, Thiago Prudente / Kirk, Kennedy Martins / Neves, Mario Fritsch / Ribeiro-Alves, Marcelo / Barreto, Ana Paula Ramos / Graça, Nadja Polisseni / Coelho, Paulo Roberto Chauvet / Costa, Claudia Henrique da / Rufino, Rogerio

Medicine

2023 Volume 102, Issue 28, Page(s) e34073

Abstract: Nitric oxide (NO) is an important product of eosinophilic metabolism, and its increase is associated with bronchial remodeling and airway hyperresponsiveness. Fractional exhaled NO (FENO) in the expired air of patients with suspected or diagnosed asthma ... ...

Abstract	Nitric oxide (NO) is an important product of eosinophilic metabolism, and its increase is associated with bronchial remodeling and airway hyperresponsiveness. Fractional exhaled NO (FENO) in the expired air of patients with suspected or diagnosed asthma has been used as a marker for eosinophilic inflammation. This cohort study included asthmatic patients classified under steps 3, 4, or 5 of the global strategy for asthma management and prevention. In the morning of the same day, all patients underwent blood collection for eosinophil counts, followed by FENO measurement and spirometry. We considered 2 groups based on the bronchodilation (BD) response on spirometry (>10% of FVC or FEV1): positive (BD+) and negative (BD-). Differences between the 2 groups were analyzed for demographic features, FENO values, and predictive correlations between FENO and BD. Both groups of patients showed an increase in the eosinophil count (BD+, P = .03; BD-, P = .04) and FENO values (P = .015 for both) with an increase in the asthma severity from step 3 to step 5 of the global strategy for asthma management and prevention. The correlations of FENO and eosinophils as well as FENO values and BD + were 0.127 (95% confidence interval,-0.269 to -0.486) and 0.696 (95% confidence interval, 0.246-0.899; P = .007), respectively. Measuring FENO levels may be useful for identifying patients with BD+.
MeSH term(s)	Humans ; Bronchodilator Agents/pharmacology ; Bronchodilator Agents/therapeutic use ; Fractional Exhaled Nitric Oxide Testing ; Cohort Studies ; Breath Tests ; Asthma/diagnosis ; Asthma/drug therapy ; Asthma/metabolism ; Nitric Oxide/metabolism ; Exhalation
Chemical Substances	Bronchodilator Agents ; Nitric Oxide (31C4KY9ESH)
Language	English
Publishing date	2023-07-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000034073
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Article ; Online: Association between clinical, serological, functional and radiological findings and ventilatory distribution heterogeneity in patients with rheumatoid arthritis.

Bessa, Elizabeth Jauhar Cardoso / Ribeiro, Felipe de Miranda Carbonieri / Rodrigues, Rosana Souza / Henrique da Costa, Cláudia / Rufino, Rogério / Pinheiro, Geraldo da Rocha Castelar / Lopes, Agnaldo José

PloS one

2023 Volume 18, Issue 10, Page(s) e0291659

Abstract: Background: In rheumatoid arthritis (RA), the involvement of the pulmonary interstitium can lead to structural changes in the small airways and alveoli, leading to reduced airflow and maldistribution of ventilation. The single-breath nitrogen washout ( ... ...

Abstract	Background: In rheumatoid arthritis (RA), the involvement of the pulmonary interstitium can lead to structural changes in the small airways and alveoli, leading to reduced airflow and maldistribution of ventilation. The single-breath nitrogen washout (SBN2W) test is a measure of the ventilatory distribution heterogeneity and evaluates the small airways. This study aimed to find out which clinical, serological, functional and radiological findings are useful to identify RA patients with pathological values of the phase III slope (SIII) measured by the SBN2W test. Methods: This was a cross-sectional study in which RA patients were assessed using the Health Assessment Questionnaire-Disability Index (HAQ-DI) and the Clinical Disease Activity Index (CDAI) and underwent serological analysis of autoantibodies and inflammatory markers. In addition, they underwent pulmonary function tests (including the SBN2W test) and chest computed tomography (CT). Results: Of the 60 RA patients evaluated, 39 (65%) had an SIII >120% of the predicted value. There were significant correlations between SIII and age (r = 0.56, p<0.0001), HAQ-DI (r = 0.34, p = 0.008), forced vital capacity (FVC, r = -0.67, p<0.0001), total lung capacity (r = -0.46, p = 0.0002), residual volume/total lung capacity (TLC) (r = 0.44, p = 0.0004), and diffusing capacity of the lungs for carbon monoxide (r = -0.45, p = 0.0003). On CT scans, the subgroup with moderate/severe disease had a significantly higher SIII than the normal/minimal/mild subgroup (662 (267-970) vs. 152 (88-283)% predicted, p = 0.0004). In the final multiple regression model, FVC, extent of moderate/severe involvement and age were associated with SIII, explaining 59% of its variability. Conclusions: In patients with RA, FVC, extent of lung involvement and age, all of which are easily obtained variables in clinical practice, identify poorly distributed ventilation. In addition, the presence of respiratory symptoms and deteriorated physical function are closely related to the distribution of ventilation in these patients.
MeSH term(s)	Humans ; Cross-Sectional Studies ; Lung/diagnostic imaging ; Vital Capacity ; Arthritis, Rheumatoid/diagnostic imaging ; Lung Volume Measurements
Language	English
Publishing date	2023-10-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0291659
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Article ; Online: Translation and cultural adaptation of the Sleep Apnea Clinical Score for use in Brazil.

Lapas, Verônica Sobral Camara / Faria, Anamelia Costa / Rufino, Rogério Lopes / Costa, Cláudia Henrique da

Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia

2020 Volume 46, Issue 5, Page(s) e20190230

Abstract: Objective: To translate the Sleep Apnea Clinical Score (SACS) into Brazilian Portuguese and adapt it to the cultural setting, validating it for use as a screening method for polysomnography and as a tool to quantify the risk of obstructive sleep apnea ... ...

Abstract	Objective: To translate the Sleep Apnea Clinical Score (SACS) into Brazilian Portuguese and adapt it to the cultural setting, validating it for use as a screening method for polysomnography and as a tool to quantify the risk of obstructive sleep apnea syndrome in individuals in Brazil. Methods: The translation was performed by two professionals, with subsequent synthesis of the translations. From that version, a back-translation was prepared, revised, and compared with the original by a team of experts. As a pre-test, a consensus version was applied in 20 patients randomly selected from among those under treatment at outpatient clinics at the Piquet Carneiro Polyclinic of the State University of Rio de Janeiro, in the city of Rio de Janeiro, to assess their understanding of the questions. In the validation phase, the Brazilian-Portuguese version of the SACS was applied in 86 patients who subsequently underwent polysomnography, regardless of the SACS result. Results: The analyses of the pre-test phase showed that the SACS was easily understood by the patients. In the validation phase, the SACS showed a sensitivity of 45.3% (95% CI: 32.8-58.2%), a specificity of 90.9% (95% CI: 70.8-98.9%), a positive predictive value of 93.5% (95% CI: 79.0-98.2%), a negative predictive value of 36.4% (95% CI: 30.6-42.5%), and an accuracy of 57.0% (95% CI: 45.8-67.6%). Conclusions: The Brazilian-Portuguese version of the SACS can be used in order to assess the risk of obstructive sleep apnea syndrome.
MeSH term(s)	Aged ; Aged, 80 and over ; Brazil ; Cross-Cultural Comparison ; Cultural Characteristics ; Humans ; Language ; Male ; Middle Aged ; Psychometrics ; Reproducibility of Results ; Sleep Apnea Syndromes/diagnosis ; Surveys and Questionnaires/standards ; Translating ; Translations
Language	English
Publishing date	2020-07-17
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2223157-2
ISSN	1806-3756 ; 1806-3713
ISSN (online)	1806-3756
ISSN	1806-3713
DOI	10.36416/1806-3756/e20190230
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Article ; Online: Association between clinical, serological, functional and radiological findings and ventilatory distribution heterogeneity in patients with rheumatoid arthritis.

Elizabeth Jauhar Cardoso Bessa / Felipe de Miranda Carbonieri Ribeiro / Rosana Souza Rodrigues / Cláudia Henrique da Costa / Rogério Rufino / Geraldo da Rocha Castelar Pinheiro / Agnaldo José Lopes

PLoS ONE, Vol 18, Iss 10, p e

2023 Volume 0291659

Abstract: Background In rheumatoid arthritis (RA), the involvement of the pulmonary interstitium can lead to structural changes in the small airways and alveoli, leading to reduced airflow and maldistribution of ventilation. The single-breath nitrogen washout ( ... ...

Abstract	Background In rheumatoid arthritis (RA), the involvement of the pulmonary interstitium can lead to structural changes in the small airways and alveoli, leading to reduced airflow and maldistribution of ventilation. The single-breath nitrogen washout (SBN2W) test is a measure of the ventilatory distribution heterogeneity and evaluates the small airways. This study aimed to find out which clinical, serological, functional and radiological findings are useful to identify RA patients with pathological values of the phase III slope (SIII) measured by the SBN2W test. Methods This was a cross-sectional study in which RA patients were assessed using the Health Assessment Questionnaire-Disability Index (HAQ-DI) and the Clinical Disease Activity Index (CDAI) and underwent serological analysis of autoantibodies and inflammatory markers. In addition, they underwent pulmonary function tests (including the SBN2W test) and chest computed tomography (CT). Results Of the 60 RA patients evaluated, 39 (65%) had an SIII >120% of the predicted value. There were significant correlations between SIII and age (r = 0.56, p<0.0001), HAQ-DI (r = 0.34, p = 0.008), forced vital capacity (FVC, r = -0.67, p<0.0001), total lung capacity (r = -0.46, p = 0.0002), residual volume/total lung capacity (TLC) (r = 0.44, p = 0.0004), and diffusing capacity of the lungs for carbon monoxide (r = -0.45, p = 0.0003). On CT scans, the subgroup with moderate/severe disease had a significantly higher SIII than the normal/minimal/mild subgroup (662 (267-970) vs. 152 (88-283)% predicted, p = 0.0004). In the final multiple regression model, FVC, extent of moderate/severe involvement and age were associated with SIII, explaining 59% of its variability. Conclusions In patients with RA, FVC, extent of lung involvement and age, all of which are easily obtained variables in clinical practice, identify poorly distributed ventilation. In addition, the presence of respiratory symptoms and deteriorated physical function are closely related to the distribution ...
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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