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  1. Article: Fibrosis: from mechanisms to novel treatments.

    Yoshimura, Akihiko

    Inflammation and regeneration

    2024  Volume 44, Issue 1, Page(s) 1

    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Editorial
    ZDB-ID 2051471-2
    ISSN 1880-9693 ; 0389-4290
    ISSN 1880-9693 ; 0389-4290
    DOI 10.1186/s41232-023-00314-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2929: Show issues Location:
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  2. Book: Emerging concepts targeting immune checkpoints in cancer and autoimmunity

    Yoshimura, Akihiko

    (Current topics in microbiology and immunology ; volume 410 ; Biomedicine)

    2017  

    Author's details Akihiko Yoshimura, editor
    Series title Current topics in microbiology and immunology ; volume 410
    Biomedicine
    Collection
    Language English
    Size viii, 267 Seiten, Diagramme
    Publisher Springer
    Publishing place Cham, Switzerland
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT019555495
    ISBN 978-3-319-68928-9 ; 9783319689296 ; 3-319-68928-2 ; 3319689290
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Ud II Zs 24 -410- verfügbar in Königswinter Königswinter

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  3. Book ; Online ; E-Book: Emerging concepts targeting immune checkpoints in cancer and autoimmunity

    Yoshimura, Akihiko

    (Current topics in microbiology and immunology ; 410)

    2018  

    Abstract: This volume reviews the current state of research on immune checkpoints and offers novel concepts. It discusses the two most important immune checkpoints: T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1). It shows that ... ...

    Author's details Akihiko Yoshimura editor ; responsible series editor: Tasuku Honjo
    Series title Current topics in microbiology and immunology ; 410
    Collection
    Abstract "This volume reviews the current state of research on immune checkpoints and offers novel concepts. It discusses the two most important immune checkpoints: T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1). It shows that antagonistic antibodies against these two molecules are highly effective in the treatment of various cancers and that PD-1 and CTLA-4 have been linked to the suppression of T-cell receptor signaling and co-stimulatory molecules. Further, the volume examines other agents, a number of cells, receptors and signaling molecules, that are also involved in the regulation of T-cell activation and extends the concept of immune checkpoints to 'molecules and cells that negatively regulate T-cell activation'. Playing essential roles in immune homeostasis, they could offer new targets for cancer immunotherapy, and for the therapy of autoimmune diseases. Written by internationally respected scientists, this book will appeal to basic scientists, clinicians, drug development researchers, and advanced students alike." -- Back cover
    Keywords Neoplasms / therapy ; Cell Cycle Checkpoints / immunology ; Immunotherapy / methods
    Language English
    Size 1 Online-Ressource (viii, 267 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019704574
    ISBN 978-3-319-68929-6 ; 9783319689289 ; 3-319-68929-0 ; 3319689282
    DOI 10.1007/978-3-319-68929-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Editorial: Non-lymphoid functions of regulatory T cells in health and disease.

    Bos, Paula D / Yoshimura, Akihiko / Rudra, Dipayan

    Frontiers in immunology

    2023  Volume 14, Page(s) 1109245

    MeSH term(s) T-Lymphocytes, Regulatory/physiology ; Lymphoid Tissue ; Forkhead Transcription Factors
    Chemical Substances Forkhead Transcription Factors
    Language English
    Publishing date 2023-01-16
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1109245
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Neuroimmune mechanisms and therapies mediating post-ischaemic brain injury and repair.

    Shichita, Takashi / Ooboshi, Hiroaki / Yoshimura, Akihiko

    Nature reviews. Neuroscience

    2023  Volume 24, Issue 5, Page(s) 299–312

    Abstract: The nervous and immune systems control whole-body homeostasis and respond to various types of tissue injury, including stroke, in a coordinated manner. Cerebral ischaemia and subsequent neuronal cell death activate resident or infiltrating immune cells, ... ...

    Abstract The nervous and immune systems control whole-body homeostasis and respond to various types of tissue injury, including stroke, in a coordinated manner. Cerebral ischaemia and subsequent neuronal cell death activate resident or infiltrating immune cells, which trigger neuroinflammation that affects functional prognosis after stroke. Inflammatory immune cells exacerbate ischaemic neuronal injury after the onset of brain ischaemia; however, some of the immune cells thereafter change their function to neural repair. The recovery processes after ischaemic brain injury require additional and close interactions between the nervous and immune systems through various mechanisms. Thus, the brain controls its own inflammation and repair processes after injury via the immune system, which provides a promising therapeutic opportunity for stroke recovery.
    MeSH term(s) Humans ; Neuroimmunomodulation ; Stroke ; Brain Ischemia ; Brain/metabolism ; Brain Injuries
    Language English
    Publishing date 2023-03-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2034150-7
    ISSN 1471-0048 ; 1471-0048 ; 1471-003X
    ISSN (online) 1471-0048
    ISSN 1471-0048 ; 1471-003X
    DOI 10.1038/s41583-023-00690-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5473: Show issues Location:
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    Zs.MG 47: Show issues

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  6. Article ; Online: Disruption of Post-thymic tolerance in Skin-Reactive TCR Transgenic Mice through the Interaction of Lymphopenia and Intestinal Microbiota.

    Hayabuchi, Hodaka / Tokifuji, Yukiko / Takahashi, Hayato / Amagai, Masayuki / Yoshimura, Akihiko / Chikuma, Shunsuke

    International immunology

    2024  

    Abstract: Autoimmune diseases often arise from conditions where the immune system is compromised. While lymphopenia-induced proliferation (LIP) is crucial for immune system development and maturation, it is also caused by environmental insult, such as infection ... ...

    Abstract Autoimmune diseases often arise from conditions where the immune system is compromised. While lymphopenia-induced proliferation (LIP) is crucial for immune system development and maturation, it is also caused by environmental insult, such as infection and becomes a risk factor for autoimmunity in adults. We used Dsg3H1 TCR Transgenic mice, whose T cells are designed to recognize desmogrein-3, a skin antigen, to explore the impact of lymphopenia on post-thymic tolerance. Dsg3H1 mice are known to delete the most highly autoreactive T cells in thymus, and develop only subtle immune-mediated pathology in a steady state. However, we found that a transient lymphopenia by total body irradiation or cyclophosphamide, results in massive dermatitis in Dsg3H1 mice. The symptoms included expansion and development of self-reactive T cells, their differentiation into CD44 high IL-17 producing helper T cells, and severe neutrophilic inflammation. Repopulation of FOXP3+ T regulatory cells after lymphopenia normally occurred, suggesting escape of skin-reactive conventional T cells from control by regulatory T cell. Furthermore, we found that a depletion of the intestinal microbiota by antibiotics prevents the cyclophosphamide induced dermatitis, indicating roles of commensal intestinal microbiota in LIP and Th17 development in vivo. The current data suggested that post thymic tolerance of Dsg3H1 mice is established on a fragile balance in lymphoreplete immune environment and broken by interplay between lymphopenia and intestinal microbiota. The dynamic phenotypes observed in Dsg3H1 mice prompts a reevaluation of opportunistic lymphopenia together with microbiota as pivotal environmental factors, impacting individuals with genetic predispositions of autoimmune diseases.
    Language English
    Publishing date 2024-04-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1013745-2
    ISSN 1460-2377 ; 0953-8178
    ISSN (online) 1460-2377
    ISSN 0953-8178
    DOI 10.1093/intimm/dxae018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2619: Show issues Location:
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  7. Article ; Online: Aberrant expression of suppressor of cytokine signaling (SOCS) molecules contributes to the development of allergic diseases.

    Jafarzadeh, Abdollah / Chauhan, Prashant / Nemati, Maryam / Jafarzadeh, Sara / Yoshimura, Akihiko

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

    2023  Volume 53, Issue 11, Page(s) 1147–1161

    Abstract: Suppressor of cytokine signalling (SOCS) proteins bind to certain cytokine receptors, Janus kinases and signalling molecules to regulate signalling pathways, thus controlling immune and inflammatory responses. Dysregulated expression of various types of ... ...

    Abstract Suppressor of cytokine signalling (SOCS) proteins bind to certain cytokine receptors, Janus kinases and signalling molecules to regulate signalling pathways, thus controlling immune and inflammatory responses. Dysregulated expression of various types of SOCS molecules was indicated in multiple types of allergic diseases. SOCS1, SOCS2, SOCS3, SOCS5, and cytokine-inducible SH2 domain protein (CISH) can differentially exert anti-allergic impacts through different mechanisms, such as suppressing Th2 cell development and activation, reducing eosinophilia, decreasing IgE production, repressing production of pro-allergic chemokines, promoting Treg cell differentiation and activation, suppressing Th17 cell differentiation and activation, increasing anti-allergic Th1 responses, inhibiting M2 macrophage polarization, modulating survival and development of mast cells, reducing pro-allergic activity of keratinocytes, and suppressing pulmonary fibrosis. Although some anti-allergic effects were attributed to SOCS3, it can perform pro-allergic impacts through several pathways, such as promoting Th2 cell development and activation, supporting eosinophilia, boosting pro-allergic activity of eosinophils, increasing IgE production, enhancing the expression of the pro-allergic chemokine receptor, reducing Treg cell differentiation, increasing pro-allergic Th9 responses, as well as supporting mucus secretion and collagen deposition. In this review, we discuss the contrasting roles of SOCS proteins in contexts of allergic disorders to provide new insights regarding the pathophysiology of these diseases and possibly explore SOCS proteins as potential therapeutic targets for alleviating allergies.
    MeSH term(s) Humans ; Hypersensitivity/metabolism ; Suppressor of Cytokine Signaling Proteins/genetics ; Suppressor of Cytokine Signaling Proteins/metabolism ; Cytokines/metabolism ; Eosinophilia ; Anti-Allergic Agents ; Immunoglobulin E/metabolism
    Chemical Substances Suppressor of Cytokine Signaling Proteins ; Cytokines ; Anti-Allergic Agents ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2023-08-28
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 645204-8
    ISSN 1365-2222 ; 0954-7894 ; 0960-2178
    ISSN (online) 1365-2222
    ISSN 0954-7894 ; 0960-2178
    DOI 10.1111/cea.14385
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    Zs.A 767: Show issues Location:
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  8. Article ; Online: NR4a1/2 deletion promotes accumulation of TCF1

    Srirat, Tanakorn / Hayakawa, Taeko / Mise-Omata, Setsuko / Nakagawara, Kensuke / Ando, Makoto / Shichino, Shigeyuki / Ito, Minako / Yoshimura, Akihiko

    Cell reports

    2024  Volume 43, Issue 3, Page(s) 113898

    Abstract: T cell exhaustion impairs tumor immunity and contributes to resistance against immune checkpoint inhibitors. The nuclear receptor subfamily 4 group A (NR4a) family of nuclear receptors plays a crucial role in driving T cell exhaustion. In this study, we ... ...

    Abstract T cell exhaustion impairs tumor immunity and contributes to resistance against immune checkpoint inhibitors. The nuclear receptor subfamily 4 group A (NR4a) family of nuclear receptors plays a crucial role in driving T cell exhaustion. In this study, we observe that NR4a1 and NR4a2 deficiency in CD8
    MeSH term(s) Animals ; Mice ; CD8-Positive T-Lymphocytes ; Lymphocytes, Tumor-Infiltrating ; Neoplasms/genetics ; Tumor Microenvironment
    Chemical Substances Nr4a1 protein, mouse ; Nr4a2 protein, mouse
    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2024.113898
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  9. Article ; Online: T cells in the brain inflammation.

    Yoshimura, Akihiko / Ohyagi, Masaki / Ito, Minako

    Advances in immunology

    2022  Volume 157, Page(s) 29–58

    Abstract: The immune system is deeply involved in autoimmune diseases of the central nervous system (CNS), such as multiple sclerosis, N-methyl-d-aspartate (NMDA) receptor encephalitis, and narcolepsy. Additionally, the immune system is involved in various brain ... ...

    Abstract The immune system is deeply involved in autoimmune diseases of the central nervous system (CNS), such as multiple sclerosis, N-methyl-d-aspartate (NMDA) receptor encephalitis, and narcolepsy. Additionally, the immune system is involved in various brain diseases including cerebral infarction and neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). In particular, reports related to T cells are increasing. T cells may also play important roles in brain deterioration and dementia that occur with aging. Our understanding of the role of immune cells in the context of the brain has been greatly improved by the use of acute ischemic brain injury models. Additionally, similar neural damage and repair events are shown to occur in more chronic brain neurodegenerative brain diseases. In this review, we focus on the role of T cells, including CD4
    MeSH term(s) Humans ; CD8-Positive T-Lymphocytes ; Alzheimer Disease ; Neurodegenerative Diseases ; Infectious Encephalitis ; Encephalitis ; Cerebral Infarction ; Inflammation
    Language English
    Publishing date 2022-11-24
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80226-8
    ISSN 1557-8445 ; 0065-2776
    ISSN (online) 1557-8445
    ISSN 0065-2776
    DOI 10.1016/bs.ai.2022.10.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Comparative study of methods for detecting extraterrestrial life in exploration mission of Mars and the solar system.

    Enya, Keigo / Yamagishi, Akihiko / Kobayashi, Kensei / Yoshimura, Yoshitaka

    Life sciences in space research

    2022  Volume 34, Page(s) 53–67

    Abstract: The detection and analysis of extraterrestrial life are important issues of space science. Mars is among the most important planets to explore for extraterrestrial life, owing both to its physical properties and to its ancient and present environments as ...

    Abstract The detection and analysis of extraterrestrial life are important issues of space science. Mars is among the most important planets to explore for extraterrestrial life, owing both to its physical properties and to its ancient and present environments as revealed by previous exploration missions. In this paper, we present a comparative study of methods for detecting extraterrestrial life and life-related substances. To this end, we have classified and summarized the characteristics targeted for the detection of extraterrestrial life in solar system exploration mission and the methods used to evaluate them. A summary table is presented. We conclude that at this moment (i) there is no realistic single detection method capable of concluding the discovery of extraterrestrial life, (ii) no single method has an advantage over the others in all respects, and (iii) there is no single method capable of distinguishing extraterrestrial life from terrestrial life. Therefore, a combination of complementary methods is essential. We emphasize the importance of endeavoring to detect extraterrestrial life without overlooking possible alien life forms, even at the cost of tolerating false positives. Summaries of both the targets and the detection methods should be updated continuously, and comparative studies of both should be pursued. Although this study assumes Mars to be a model site for the primary environment for life searches, both the targets and detection methods described herein will also be useful for searching for extraterrestrial life in any celestial environment and for the initial inspection of returned samples.
    MeSH term(s) Exobiology ; Extraterrestrial Environment ; Mars ; Planets ; Solar System ; Space Flight
    Language English
    Publishing date 2022-07-09
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2214-5532
    ISSN (online) 2214-5532
    DOI 10.1016/j.lssr.2022.07.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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