Article ; Online: Gut hormone analogues and skeletal health in diabetes and obesity: Evidence from preclinical models.
2024 Volume 177, Page(s) 171228
Abstract: Diabetes mellitus and obesity are rapidly growing worldwide. Aside from metabolic disturbances, these two disorders also affect bone with a higher prevalence of bone fractures. In the last decade, a growing body of evidence suggested that several gut ... ...
| Abstract | Diabetes mellitus and obesity are rapidly growing worldwide. Aside from metabolic disturbances, these two disorders also affect bone with a higher prevalence of bone fractures. In the last decade, a growing body of evidence suggested that several gut hormones, including ghrelin, gastrin, glucose-dependent insulinotropic polypeptide (GIP), glucagon, and glucagon-like peptide-1 and 2 (GLP-1 and GLP-2, respectively) may affect bone physiology. Several gut hormone analogues have been developed for the treatment of type 2 diabetes and obesity, and could represent a new alternative in the therapeutic arsenal against bone fragility. In the present review, a summary of the physiological roles of these gut hormones and their analogues is presented at the cellular level but also in several preclinical models of bone fragility disorders including type 2 diabetes mellitus, especially on bone mineral density, microarchitecture and bone material properties. The present review also summarizes the impact of GLP-1 receptor agonists approved for the treatment of type 2 diabetes mellitus and the more recent dual or triple analogue on bone physiology and strength. |
|---|---|
| Language | English |
| Publishing date | 2024-04-23 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 769028-9 |
| ISSN | 1873-5169 ; 0196-9781 |
| ISSN (online) | 1873-5169 |
| ISSN | 0196-9781 |
| DOI | 10.1016/j.peptides.2024.171228 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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