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Article ; Online: Cisplatin in cancer treatment.

Romani, Andrea M P

2022 Volume 206, Page(s) 115323

Abstract: Cisplatin is a widely used chemotherapy agent in the treatment of various forms of carcinomas and sarcomas. Its effectiveness in delaying negative outcome in cancer patients has been amply documented, and attributed primarily to its ability to crosslink ... ...

Abstract	Cisplatin is a widely used chemotherapy agent in the treatment of various forms of carcinomas and sarcomas. Its effectiveness in delaying negative outcome in cancer patients has been amply documented, and attributed primarily to its ability to crosslink DNA purine bases, thus interfering with DNA repair mechanisms in cancer cells. Ultimately, this interference causes DNA damage and leads to cell apoptosis. However, the chemotherapy use of cisplatin and cisplatin-derivatives is hampered by the occurrence of major side effects in a significant percentage of cancer patients, thus limiting considerably its prolonged utilization. Acute kidney injury, gastrointestinal disorders, hemorrhage, and decreased immune response to infections are among the most common side-effects observed. On the other hand, synergistic utilization of cisplatin with other anti-cancer agents and especially its ability to induce immunomodulation in otherwise immune-depressed patients has gained significant therapeutic traction in recent times, validating the continuing clinical utilization of this agent and its derivatives. In this review, we will examine the basic physico-chemical properties of cisplatin and related derivatives, and discuss the main molecular mechanisms of actions that results in the therapeutic benefit of this class of anti-cancer agents but also in the development of major organ complications. Lastly, we will address the more recent conceptual utilization of cisplatin-induced anti-cancer immunomodulation in synergistic therapies that can also benefit of the traditional chemotherapy advantages of this class of anti-cancer agents.
MeSH term(s)	Humans ; Cisplatin/adverse effects ; Antineoplastic Agents/adverse effects ; DNA Damage ; DNA Repair ; Neoplasms/drug therapy ; Neoplasms/chemically induced ; Apoptosis
Chemical Substances	Cisplatin (Q20Q21Q62J) ; Antineoplastic Agents
Language	English
Publishing date	2022-11-08
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	208787-x
ISSN	1873-2968 ; 0006-2952
ISSN (online)	1873-2968
ISSN	0006-2952
DOI	10.1016/j.bcp.2022.115323
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Article ; Online: The controversy on the beneficial effect of phytoestrogens in diabetic treatment in postmenopausal women.

Romani, Andrea M P

Biochemical pharmacology

2021 Volume 190, Page(s) 114619

Abstract: Phytoestrogens have been identified as a natural, plant-based alternative to synthetically derived estrogens, to supplement the absence of endogenous estrogens in post-menopausal women, and attenuate the progression of pathologies and side-effects ... ...

Abstract	Phytoestrogens have been identified as a natural, plant-based alternative to synthetically derived estrogens, to supplement the absence of endogenous estrogens in post-menopausal women, and attenuate the progression of pathologies and side-effects associated with menopause. The increased availability of these plant's derived compounds as diet or nutritional supplements makes their ingestion and consumption easier and more accessible as compared to pharmacological alternatives. Further, phytoestrogen intake has shown beneficial effects as estrogens alternatives in attenuating severe complications in diseases such as type 2 diabetes, metabolic syndrome, NAFLD, and obesity. However, in many cases phytoestrogen effectiveness remains largely circumstantial or just anecdotal as significant uncertainties on the relative abundance of different phytoestrogens in a given diet, the need for conversion to an active principle through the gut microbiome, the possibility of an effect threshold, the synergistic effect of different phytoestrogens possible due to different modality of actions still persist. The present article aims at highlighting the main issues and concerns plaguing the field as well as some of the possible causes of inconsistencies observed in the various nutritional and clinical studies attempted so far.
MeSH term(s)	Diabetes Mellitus, Type 2/drug therapy ; Female ; Humans ; Phytoestrogens/therapeutic use ; Phytotherapy ; Postmenopause
Chemical Substances	Phytoestrogens
Language	English
Publishing date	2021-05-26
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	208787-x
ISSN	1873-2968 ; 0006-2952
ISSN (online)	1873-2968
ISSN	0006-2952
DOI	10.1016/j.bcp.2021.114619
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Article ; Online: The Relationship between Obesity and Pre-Eclampsia: Incidental Risks and Identification of Potential Biomarkers for Pre-Eclampsia.

Abraham, Talitha / Romani, Andrea M P

Cells

2022 Volume 11, Issue 9

Abstract: Obesity has been steadily increasing over the past decade in the US and worldwide. Since 1975, the prevalence of obesity has increased by 2% per decade, unabated despite new and more stringent guidelines set by WHO, CDC, and other public health ... ...

Abstract	Obesity has been steadily increasing over the past decade in the US and worldwide. Since 1975, the prevalence of obesity has increased by 2% per decade, unabated despite new and more stringent guidelines set by WHO, CDC, and other public health organizations. Likewise, maternal obesity has also increased worldwide over the past several years. In the United States, pre-pregnancy rates have increased proportionally across all racial groups. Obesity during pregnancy has been directly linked to obstetric complications including gestational diabetes, HTN, hematomas, pre-eclampsia, and congenital defects. In the particular case of pre-eclampsia, the incidence rate across the globe is 2.16%, but the condition accounts for 30% of maternal deaths, and a robust body of evidence underscored the relationship between obesity and pre-eclampsia. More recently, attention has focused on the identification of reliable biomarkers predictive of an elevated risk for pre-eclampsia. The aim of this literature review is to elucidate the relationship between obesity and these predictive biomarkers for future prediction and prevention of pre-eclampsia condition in women at risk.
MeSH term(s)	Biomarkers ; Diabetes, Gestational ; Eclampsia ; Female ; Humans ; Obesity/complications ; Pre-Eclampsia ; Pregnancy ; United States
Chemical Substances	Biomarkers
Language	English
Publishing date	2022-05-05
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11091548
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Article: Beneficial Role of Mg

Romani, Andrea M P

International journal of hypertension

2018 Volume 2018, Page(s) 9013721

Abstract: Hypertension constitutes one of the most widespread pathological conditions in developed and developing countries. Currently, more than 1 billion people worldwide are affected by the condition, either as frank hypertension or as prehypertension, raising ... ...

Abstract	Hypertension constitutes one of the most widespread pathological conditions in developed and developing countries. Currently, more than 1 billion people worldwide are affected by the condition, either as frank hypertension or as prehypertension, raising the risk for major long-term complications and life-threatening pathologies. The costs in terms of health care services, medications for the treatment of hypertension and its complications, and associated loss in productivity represent a major economic burden for the various countries. The necessity of developing treatments that are economically more sustainable and with better compliance has been increasing alongside the incidence of the pathology. Along these lines, attention has been paid to the implementation of affordable but nutritious diets that deliver appropriate levels of macro- and micronutrients as integral part of the diets themselves or as supplements. In particular, experimental and clinical evidence suggests that an appropriate intake of dietary magnesium can be beneficial in controlling blood pressure. Additional advantages of a more diffuse therapeutic and/or preventive utilization of magnesium supplements are the virtual absence of side-effects and their affordable costs. The present review will attempt to frame our knowledge of how magnesium exerts its beneficial effects on blood pressure maintenance, which may lead to the development of more effective treatments of hypertension and its main complications.
Language	English
Publishing date	2018-06-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2573167-1
ISSN	2090-0392 ; 2090-0384
ISSN (online)	2090-0392
ISSN	2090-0384
DOI	10.1155/2018/9013721
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Article ; Online: The Relationship between Obesity and Pre-Eclampsia

Talitha Abraham / Andrea M. P. Romani

Cells, Vol 11, Iss 1548, p

Incidental Risks and Identification of Potential Biomarkers for Pre-Eclampsia

2022 Volume 1548

Abstract	Obesity has been steadily increasing over the past decade in the US and worldwide. Since 1975, the prevalence of obesity has increased by 2% per decade, unabated despite new and more stringent guidelines set by WHO, CDC, and other public health organizations. Likewise, maternal obesity has also increased worldwide over the past several years. In the United States, pre-pregnancy rates have increased proportionally across all racial groups. Obesity during pregnancy has been directly linked to obstetric complications including gestational diabetes, HTN, hematomas, pre-eclampsia, and congenital defects. In the particular case of pre-eclampsia, the incidence rate across the globe is 2.16%, but the condition accounts for 30% of maternal deaths, and a robust body of evidence underscored the relationship between obesity and pre-eclampsia. More recently, attention has focused on the identification of reliable biomarkers predictive of an elevated risk for pre-eclampsia. The aim of this literature review is to elucidate the relationship between obesity and these predictive biomarkers for future prediction and prevention of pre-eclampsia condition in women at risk.
Keywords	pre-eclampsia ; obesity ; biomarkers ; adipokines ; adiponectin ; leptin ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cisplatin-induced renal toxicity magn…ified: role of magnesium deficiency in AKI onset.

Romani, Andrea M P

American journal of physiology. Renal physiology

2015 Volume 309, Issue 12, Page(s) F1005–6

MeSH term(s)	Acute Kidney Injury/chemically induced ; Animals ; Antineoplastic Agents/adverse effects ; Cisplatin/adverse effects ; Homeostasis/physiology ; Humans ; Magnesium/metabolism ; Magnesium Deficiency/metabolism
Chemical Substances	Antineoplastic Agents ; Magnesium (I38ZP9992A) ; Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2015-12-15
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	603837-2
ISSN	1522-1466 ; 0363-6127
ISSN (online)	1522-1466
ISSN	0363-6127
DOI	10.1152/ajprenal.00212.2015
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Uc I Zs.89: Show issues

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Article: The Antennal Sensory Structures of Female

Sevarika, Milos / Giannotti, Paolo / Lucchi, Andrea / Romani, Roberto

Insects

2022 Volume 13, Issue 12

Abstract: The Encyrtidae (Hymenoptera) encompasses a large group of parasitic wasps widely used in biocontrol programs of scale insects (Hemiptera: Coccoidea). ...

Abstract	The Encyrtidae (Hymenoptera) encompasses a large group of parasitic wasps widely used in biocontrol programs of scale insects (Hemiptera: Coccoidea).
Language	English
Publishing date	2022-12-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662247-6
ISSN	2075-4450
ISSN	2075-4450
DOI	10.3390/insects13121138
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Article ; Online: Effect of acute and prolonged alcohol administration on Mg(2+) homeostasis in cardiac cells.

Romani, Andrea M P

Alcohol (Fayetteville, N.Y.)

2015 Volume 49, Issue 3, Page(s) 265–273

Abstract: Alcoholic cardiomyopathy represents a major clinical complication in chronic alcoholics. Previous studies from our laboratory indicate that acute and chronic exposure of liver cells to ethanol results in a major loss of cellular Mg(2+) as a result of ... ...

Abstract	Alcoholic cardiomyopathy represents a major clinical complication in chronic alcoholics. Previous studies from our laboratory indicate that acute and chronic exposure of liver cells to ethanol results in a major loss of cellular Mg(2+) as a result of alcohol oxidation. We investigated whether exposure to ethanol induces a similar Mg(2+) loss in cardiac cells. The results indicate that chronic exposure to a 6% ethanol-containing diet depleted cardiac myocytes of >25% of their cellular Mg(2+) content. Acute ethanol exposure, instead, induced a time- and dose-dependent manner of Mg(2+) extrusion from perfused hearts and collagenase-dispersed cardiac ventricular myocytes. Pretreatment with chlormethiazole prevented ethanol-induced Mg(2+) loss to a large extent, suggesting a role of ethanol oxidation via cyP4502E1 in the process. Magnesium extrusion across the sarcolemma occurred via the amiloride-inhibited Na(+)/Mg(2+) exchanger. Taken together, our data indicate that Mg(2+) extrusion also occurs in cardiac cells exposed to ethanol as a result of alcohol metabolism by cyP4502E1. The extrusion, which is mediated by the Na(+)/Mg(2+) exchanger, only occurs at doses of ethanol ≥0.1%, and depends on ethanol-induced decline in cellular ATP. The significance of Mg(2+) extrusion for the onset of alcoholic cardiomyopathy remains to be elucidated.
MeSH term(s)	Acid Sensing Ion Channel Blockers/pharmacology ; Adenosine Triphosphate/metabolism ; Amiloride/pharmacology ; Animals ; Central Nervous System Depressants/administration & dosage ; Central Nervous System Depressants/pharmacology ; Cytochrome P-450 CYP2E1/metabolism ; Cytochrome P-450 CYP2E1 Inhibitors/pharmacology ; Ethanol/administration & dosage ; Ethanol/pharmacology ; Heart Ventricles/cytology ; Homeostasis/drug effects ; Ion Exchange ; Magnesium/metabolism ; Male ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Rats ; Rats, Sprague-Dawley ; Sarcolemma/drug effects ; Sarcolemma/metabolism ; Sodium/metabolism
Chemical Substances	Acid Sensing Ion Channel Blockers ; Central Nervous System Depressants ; Cytochrome P-450 CYP2E1 Inhibitors ; Ethanol (3K9958V90M) ; Amiloride (7DZO8EB0Z3) ; Adenosine Triphosphate (8L70Q75FXE) ; Sodium (9NEZ333N27) ; Cytochrome P-450 CYP2E1 (EC 1.14.13.-) ; Magnesium (I38ZP9992A)
Language	English
Publishing date	2015-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	605912-0
ISSN	1873-6823 ; 0741-8329
ISSN (online)	1873-6823
ISSN	0741-8329
DOI	10.1016/j.alcohol.2015.02.002
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Article: Magnesium homeostasis in Mammalian cells.

Romani, Andrea M P

Metal ions in life sciences

2013 Volume 12, Page(s) 69–118

Abstract: Magnesium, the second most abundant cation within the cell, plays an important role in numerous biological functions. Experimental evidence indicates that mammalian cells tightly regulate cellular magnesium ion content through specific mechanisms ... ...

Abstract	Magnesium, the second most abundant cation within the cell, plays an important role in numerous biological functions. Experimental evidence indicates that mammalian cells tightly regulate cellular magnesium ion content through specific mechanisms controlling Mg(2+) entry and efflux across the cell membrane and the membrane of various cellular organelles as well as intracellular Mg(2+) buffering under resting conditions and following hormonal and metabolic stimuli. This chapter will provide an assessment of the various mechanisms controlling cellular Mg(2+) homeostasis and transport, and the implications changes in cellular Mg(2+) content play under physiological and pathological conditions.
MeSH term(s)	Animals ; Cell Membrane/metabolism ; Homeostasis ; Humans ; Magnesium/metabolism
Chemical Substances	Magnesium (I38ZP9992A)
Language	English
Publishing date	2013
Publishing country	Netherlands
Document type	Journal Article
ISSN	1559-0836
ISSN	1559-0836
DOI	10.1007/978-94-007-5561-1_4
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Article: Magnesium in health and disease.

Romani, Andrea M P

Metal ions in life sciences

2013 Volume 13, Page(s) 49–79

Abstract: Mammalian cells tightly regulate cellular Mg(2+) content through a variety of transport and buffering mechanisms under the control of various hormones and cellular second messengers. The effect of these hormones and agents results in dynamic changes in ... ...

Abstract	Mammalian cells tightly regulate cellular Mg(2+) content through a variety of transport and buffering mechanisms under the control of various hormones and cellular second messengers. The effect of these hormones and agents results in dynamic changes in the total content of Mg(2+) being transported across the cell membrane and redistributed within cellular compartments. The importance of maintaining proper cellular Mg(2+) content optimal for the activity of various cellular enzymes and metabolic cycles is underscored by the evidence that several diseases are characterized by a loss of Mg(2+) within specific tissues as a result of defective transport, hormonal stimulation, or metabolic impairment. This chapter will review the key mechanisms regulating cellular Mg(2+) homeostasis and their impairments under the most common diseases associated with Mg(2+) loss or deficiency.
MeSH term(s)	Diabetes Mellitus/metabolism ; Diabetes Mellitus/physiopathology ; Humans ; Hypertension/metabolism ; Hypertension/physiopathology ; Ion Transport ; Magnesium/metabolism ; Neoplasms/metabolism ; Neoplasms/physiopathology
Chemical Substances	Magnesium (I38ZP9992A)
Language	English
Publishing date	2013
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	1559-0836
ISSN	1559-0836
DOI	10.1007/978-94-007-7500-8_3
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